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"Every cope has an end ":psalm 14:3
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The drug combination spiramycin-metronidazole showed an extraordinary efficacy against chronic cerebral toxoplasmosis: there was a 10-fold reduction in brain cysts compared to the spiramycin-treated group, and there was a 15-fold reduction compared to the untreated control group (Fig. 2). Metronidazole, which lacks efficacious activity against toxoplasmosis (21), causes a pharmacokinetic interaction to enhance the spiramycin concentration in the brain that is able to eradicate tachyzoites and greatly decrease the cysts in the brain. Clearly, this effect was not associated with the antimicrobial activity of metronidazole, which did not reduce the number of brain cysts (Fig. 2) and have any effect on their in vitro reactivation (Table 3).