Retarded 5alphaReductase hairloss tradeoff

[Sachlichkeit]

DHT, the downstream of testosterone is the primary cause for hairloss and the (permanent) breaking down of skin elastin through hypertrophy of sebaceous glands.

Skin elastin = more youthful look, once gone, cannot be replaced.

The solution for both has been to repeatedly shill 5alphareductase inhibitors finasteride and dutasteride to SYSTEMATICALLY eradicate DHT in order to preserve skin and prevent norwooding.

We ignore fin, (4 now) which is weaker 5alpha inhibitor, most here are on dutasteride

.5mg dut will wipe out 85%-90% of DHT in the body 2.5mg will wipe out 99%.

here is problem, 5alpha inhibitors don't just block DHT

Testosterone >>>5a >>>> DHT (Prostate, hair, bigger dick ((in puberty,)) pro bone through preservation similar to estrogen.)
DHT >>> 5a >>> 3a-androstanediol anti anxiety, lowers stress, enhances sex
DHT >>> 5A >>> 3b-androstanediol stabilizes mood, neuroprotective (good 4 brain,)
DHT >>> 5a >>> androsterone relax, + social pheromone
DHT >>> 5a >>> Etiocholanolone gives u fevers lmao (triggers immune response)

So half of DHT downstreams are directly linked to mental health other 2 dont care

5alpha blockers don't just inhibit DHT downstreams but every other thing in body that uses 5alpha reductase inhibitors

PROGESTERONE 5alpha downstream. Progesterone converts to bunch of other stuff but we only care about 5alpha conversions

prog >>> 5alpha >>>Allopregnanolone. STRONG antidepressant, anti anxiety, anti stress, pro libido. basically Mental health
prog >>> 5a >>> isopregnanolone. regulator of allopregnanolone.

Deoxycorticosterone

Deoxy >>> 5a >>> 5a-Dihydrodeoxycorticosterone >>>Tetrahydrodeoxycorticosterone. Anti anxiety, pro mood stabilizer

K so like over half the stuff 5alphareductase inhibitors block regulate mood/mental health in some fashion also paired with libido

PFSD post finasteride syndrome is medical condition prompted by use of finasteride that induces anhedonia, (total flattening of sexual drive,) increased anxiety, depression, mood instability.

Avg Testosterone of man has decreased little over 1% every year since ~1970, then doctor tells them to get on fin/dut for hairloss and poor hormonal profile oneshots them

PFSD is similar to PSSD, post ssri sexual disfunction which flattens mood, exasperates depression anxiety, anhedonia blablabla

ok, what do?

Hair

Topical anti androgen RU58841 to prevent ((any)) hairloss stemming from androgens
Topical dut/fin
Topical minoxidil to REGROW hair, not to keep it
Topical KY19382 as a secondary less researched alternative to minoxidil

Topical minox only worked in 60% of people, this is low. We can improve its effectiveness by

DMSO (riskier)
Microneedling
preformulated stacks via telemedicine (most optimal.) You can get a dut + minox + tret + caffeine + whatever else foam/gel

Skin

GHK-CU subQ / GHK-CU
Topical tretinoin .025/.050 upregulating skin turnover
estriol cream NOT estradiol gel.
All either boost or prompt elastin + collagen in the skin.
Accutane low dose or standard to permanently prevent sebaceous gland hypertrophy from DHT through atrophy.


Anything north of 500test/wk + .5mg dutasteride will give you normal DHT levels.

But because 5alpha inhib, there wont be any progesterone or deoxycortisone downstream. This will result in eleveated progesterone and deoxycortisone being "dammed up" (progesterone in high doses is estrogenic, used in europe for MTF HRT.)

FINASTERIDE Partially blocks the progesterone and deoxycortisone branches making it preferable over dutasteride for systemic protection against hairloss though it will do nothing for skin.

 

[aids]

“5AR inhibitors are bad!!!”
> Proceeds to recommend topical finasteride which has a molecular weight sub-500 daltons and will go systemic regardless.
Shut up cunt

 

[Abdullahm06]

which has a molecular weight sub-500 daltons

theres really levels to this shit man
i never heard of daltons until now

 

[chadisbeingmade]

Laughable thead.

2.5mg Dut or KYS.

 

[tunisianropemaxxer]

DHT, the downstream of testosterone is the primary cause for hairloss and the (permanent) breaking down of skin elastin through hypertrophy of sebaceous glands.

Skin elastin = more youthful look, once gone, cannot be replaced.

The solution for both has been to repeatedly shill 5alphareductase inhibitors finasteride and dutasteride to SYSTEMATICALLY eradicate DHT in order to preserve skin and prevent norwooding.

We ignore fin, (4 now) which is weaker 5alpha inhibitor, most here are on dutasteride

.5mg dut will wipe out 85%-90% of DHT in the body 2.5mg will wipe out 99%.

here is problem, 5alpha inhibitors don't just block DHT

Testosterone >>>5a >>>> DHT (Prostate, hair, bigger dick ((in puberty,)) pro bone through preservation similar to estrogen.)
DHT >>> 5a >>> 3a-androstanediol anti anxiety, lowers stress, enhances sex
DHT >>> 5A >>> 3b-androstanediol stabilizes mood, neuroprotective (good 4 brain,)
DHT >>> 5a >>> androsterone relax, + social pheromone
DHT >>> 5a >>> Etiocholanolone gives u fevers lmao (triggers immune response)

So half of DHT downstreams are directly linked to mental health other 2 dont care

5alpha blockers don't just inhibit DHT downstreams but every other thing in body that uses 5alpha reductase inhibitors

PROGESTERONE 5alpha downstream. Progesterone converts to bunch of other stuff but we only care about 5alpha conversions

prog >>> 5alpha >>>Allopregnanolone. STRONG antidepressant, anti anxiety, anti stress, pro libido. basically Mental health
prog >>> 5a >>> isopregnanolone. regulator of allopregnanolone.

Deoxycorticosterone

Deoxy >>> 5a >>> 5a-Dihydrodeoxycorticosterone >>>Tetrahydrodeoxycorticosterone. Anti anxiety, pro mood stabilizer

K so like over half the stuff 5alphareductase inhibitors block regulate mood/mental health in some fashion also paired with libido

PFSD post finasteride syndrome is medical condition prompted by use of finasteride that induces anhedonia, (total flattening of sexual drive,) increased anxiety, depression, mood instability.

Avg Testosterone of man has decreased little over 1% every year since ~1970, then doctor tells them to get on fin/dut for hairloss and poor hormonal profile oneshots them

PFSD is similar to PSSD, post ssri sexual disfunction which flattens mood, exasperates depression anxiety, anhedonia blablabla

ok, what do?

Hair

Topical anti androgen RU58841 to prevent ((any)) hairloss stemming from androgens
Topical dut/fin
Topical minoxidil to REGROW hair, not to keep it
Topical KY19382 as a secondary less researched alternative to minoxidil

Topical minox only worked in 60% of people, this is low. We can improve its effectiveness by

DMSO (riskier)
Microneedling
preformulated stacks via telemedicine (most optimal.) You can get a dut + minox + tret + caffeine + whatever else foam/gel

Skin

GHK-CU subQ / GHK-CU
Topical tretinoin .025/.050 upregulating skin turnover
estriol cream NOT estradiol gel.
All either boost or prompt elastin + collagen in the skin.
Accutane low dose or standard to permanently prevent sebaceous gland hypertrophy from DHT through atrophy.


Anything north of 500test/wk + .5mg dutasteride will give you normal DHT levels.

But because 5alpha inhib, there wont be any progesterone or deoxycortisone downstream. This will result in eleveated progesterone and deoxycortisone being "dammed up" (progesterone in high doses is estrogenic, used in europe for MTF HRT.)

FINASTERIDE Partially blocks the progesterone and deoxycortisone branches making it preferable over dutasteride for systemic protection against hairloss though it will do nothing for skin.

I read it but this thread is so fucking ass im gonna lie about not reading so
dnr greycel.

 

[imontheloose]

Laughable thead.

2.5mg Dut or KYS.

You need to give up on these people. Only when purchasing imontheloose research dutasteride for future research discussion is dutasteride ever to be brought up.

 

[Prøphet]

What concentration of topical fin and dut do you recommend?

 

[chadisbeingmade]

You need to give up on these people. Only when purchasing imontheloose research dutasteride for future research discussion is dutasteride ever to be brought up.

Me supposedly depressed, full of anxiety and stress, with no libido and negative mental health after consuming Super Dutasteride™ produced by @imontheloose

 

[imontheloose]

Me supposedly depressed , full of anxiety and stress, with no libido and negative mental health after consuming Super Dutasteride™ produced by @imontheloose

What is this fella doing, is my concern. It’s exactly how I picture you when clubbing too.

More importantly of course, imontheloose Super Dutasteride™ is toxic and nuking both sebum and scalp DHT to the ground using his formulations is going to ruin your life.

 

[´´´´´´´´]

D1 gatekeeping

 

[chadisbeingmade]

What is this fella doing, is my concern. It’s exactly how I picture you when clubbing too.

Probably a third like that, a third on some random ass side quest, and a third with the degenerate females I got with.

Though I only have videos to go off. I don’t remeber much from any night myself. I wake up looking on Snap trying to piece together a puzzle.

 

[Sachlichkeit]

“5AR inhibitors are bad!!!”
> Proceeds to recommend topical finasteride which has a molecular weight sub-500 daltons and will go systemic regardless.
Shut up cunt

ya by roughly half when compared to oral

 

[imontheloose]

Probably a third like that, a third on some random ass side quest, and a third with the degenerate females I got with.

Though I only have videos to go off. I don’t remeber much from any night myself. I wake up looking on Snap trying to piece together a puzzle.

I normally don’t get that mortal. Last night I went out and today I’ve just been rotting, hungover, and ugh, finally about to sleep. I love taking my robe off, getting cozy in bed, ready to sleep!

 

[Sachlichkeit]

What concentration of topical fin and dut do you recommend?

standard fin .025

dut .01-.1

depends on if you're cycling & what you're cycling.

I prefer RU

 

[hamiwts]

DHT, the downstream of testosterone is the primary cause for hairloss and the (permanent) breaking down of skin elastin through hypertrophy of sebaceous glands.

Skin elastin = more youthful look, once gone, cannot be replaced.

The solution for both has been to repeatedly shill 5alphareductase inhibitors finasteride and dutasteride to SYSTEMATICALLY eradicate DHT in order to preserve skin and prevent norwooding.

We ignore fin, (4 now) which is weaker 5alpha inhibitor, most here are on dutasteride

.5mg dut will wipe out 85%-90% of DHT in the body 2.5mg will wipe out 99%.

here is problem, 5alpha inhibitors don't just block DHT

Testosterone >>>5a >>>> DHT (Prostate, hair, bigger dick ((in puberty,)) pro bone through preservation similar to estrogen.)
DHT >>> 5a >>> 3a-androstanediol anti anxiety, lowers stress, enhances sex
DHT >>> 5A >>> 3b-androstanediol stabilizes mood, neuroprotective (good 4 brain,)
DHT >>> 5a >>> androsterone relax, + social pheromone
DHT >>> 5a >>> Etiocholanolone gives u fevers lmao (triggers immune response)

So half of DHT downstreams are directly linked to mental health other 2 dont care

5alpha blockers don't just inhibit DHT downstreams but every other thing in body that uses 5alpha reductase inhibitors

PROGESTERONE 5alpha downstream. Progesterone converts to bunch of other stuff but we only care about 5alpha conversions

prog >>> 5alpha >>>Allopregnanolone. STRONG antidepressant, anti anxiety, anti stress, pro libido. basically Mental health
prog >>> 5a >>> isopregnanolone. regulator of allopregnanolone.

Deoxycorticosterone

Deoxy >>> 5a >>> 5a-Dihydrodeoxycorticosterone >>>Tetrahydrodeoxycorticosterone. Anti anxiety, pro mood stabilizer

K so like over half the stuff 5alphareductase inhibitors block regulate mood/mental health in some fashion also paired with libido

PFSD post finasteride syndrome is medical condition prompted by use of finasteride that induces anhedonia, (total flattening of sexual drive,) increased anxiety, depression, mood instability.

Avg Testosterone of man has decreased little over 1% every year since ~1970, then doctor tells them to get on fin/dut for hairloss and poor hormonal profile oneshots them

PFSD is similar to PSSD, post ssri sexual disfunction which flattens mood, exasperates depression anxiety, anhedonia blablabla

ok, what do?

Hair

Topical anti androgen RU58841 to prevent ((any)) hairloss stemming from androgens
Topical dut/fin
Topical minoxidil to REGROW hair, not to keep it
Topical KY19382 as a secondary less researched alternative to minoxidil

Topical minox only worked in 60% of people, this is low. We can improve its effectiveness by

DMSO (riskier)
Microneedling
preformulated stacks via telemedicine (most optimal.) You can get a dut + minox + tret + caffeine + whatever else foam/gel

Skin

GHK-CU subQ / GHK-CU
Topical tretinoin .025/.050 upregulating skin turnover
estriol cream NOT estradiol gel.
All either boost or prompt elastin + collagen in the skin.
Accutane low dose or standard to permanently prevent sebaceous gland hypertrophy from DHT through atrophy.


Anything north of 500test/wk + .5mg dutasteride will give you normal DHT levels.

But because 5alpha inhib, there wont be any progesterone or deoxycortisone downstream. This will result in eleveated progesterone and deoxycortisone being "dammed up" (progesterone in high doses is estrogenic, used in europe for MTF HRT.)

FINASTERIDE Partially blocks the progesterone and deoxycortisone branches making it preferable over dutasteride for systemic protection against hairloss though it will do nothing for skin.

I like clascoterone works as a weaker topical anti androgen but much more accessible where I’m at and you can use it for skin too which is its primary benefit using this with 0.1 topical fin and keto 2% cream (much better then shampoo)

 

[Sachlichkeit]

I like clascoterone works as a weaker topical anti androgen but much more accessible where I’m at and you can use it for skin too which is its primary benefit using this with 0.1 topical fin and keto 2% cream (much better then shampoo)

haven't heard of softer anti androgen. Keto seems good.

DHT is still competing at the scalp against clasco/RU for androgen receptors, Stacking Fin/dut to topically block 5alpha allows for more blocking of androgen receptors I prefer fin

 

[Aryan Incel]

DHT, the downstream of testosterone is the primary cause for hairloss and the (permanent) breaking down of skin elastin through hypertrophy of sebaceous glands.

Skin elastin = more youthful look, once gone, cannot be replaced.

The solution for both has been to repeatedly shill 5alphareductase inhibitors finasteride and dutasteride to SYSTEMATICALLY eradicate DHT in order to preserve skin and prevent norwooding.

We ignore fin, (4 now) which is weaker 5alpha inhibitor, most here are on dutasteride

.5mg dut will wipe out 85%-90% of DHT in the body 2.5mg will wipe out 99%.

here is problem, 5alpha inhibitors don't just block DHT

Testosterone >>>5a >>>> DHT (Prostate, hair, bigger dick ((in puberty,)) pro bone through preservation similar to estrogen.)
DHT >>> 5a >>> 3a-androstanediol anti anxiety, lowers stress, enhances sex
DHT >>> 5A >>> 3b-androstanediol stabilizes mood, neuroprotective (good 4 brain,)
DHT >>> 5a >>> androsterone relax, + social pheromone
DHT >>> 5a >>> Etiocholanolone gives u fevers lmao (triggers immune response)

So half of DHT downstreams are directly linked to mental health other 2 dont care

5alpha blockers don't just inhibit DHT downstreams but every other thing in body that uses 5alpha reductase inhibitors

PROGESTERONE 5alpha downstream. Progesterone converts to bunch of other stuff but we only care about 5alpha conversions

prog >>> 5alpha >>>Allopregnanolone. STRONG antidepressant, anti anxiety, anti stress, pro libido. basically Mental health
prog >>> 5a >>> isopregnanolone. regulator of allopregnanolone.

Deoxycorticosterone

Deoxy >>> 5a >>> 5a-Dihydrodeoxycorticosterone >>>Tetrahydrodeoxycorticosterone. Anti anxiety, pro mood stabilizer

K so like over half the stuff 5alphareductase inhibitors block regulate mood/mental health in some fashion also paired with libido

PFSD post finasteride syndrome is medical condition prompted by use of finasteride that induces anhedonia, (total flattening of sexual drive,) increased anxiety, depression, mood instability.

Avg Testosterone of man has decreased little over 1% every year since ~1970, then doctor tells them to get on fin/dut for hairloss and poor hormonal profile oneshots them

PFSD is similar to PSSD, post ssri sexual disfunction which flattens mood, exasperates depression anxiety, anhedonia blablabla

ok, what do?

Hair

Topical anti androgen RU58841 to prevent ((any)) hairloss stemming from androgens
Topical dut/fin
Topical minoxidil to REGROW hair, not to keep it
Topical KY19382 as a secondary less researched alternative to minoxidil

Topical minox only worked in 60% of people, this is low. We can improve its effectiveness by

DMSO (riskier)
Microneedling
preformulated stacks via telemedicine (most optimal.) You can get a dut + minox + tret + caffeine + whatever else foam/gel

Skin

GHK-CU subQ / GHK-CU
Topical tretinoin .025/.050 upregulating skin turnover
estriol cream NOT estradiol gel.
All either boost or prompt elastin + collagen in the skin.
Accutane low dose or standard to permanently prevent sebaceous gland hypertrophy from DHT through atrophy.


Anything north of 500test/wk + .5mg dutasteride will give you normal DHT levels.

But because 5alpha inhib, there wont be any progesterone or deoxycortisone downstream. This will result in eleveated progesterone and deoxycortisone being "dammed up" (progesterone in high doses is estrogenic, used in europe for MTF HRT.)

FINASTERIDE Partially blocks the progesterone and deoxycortisone branches making it preferable over dutasteride for systemic protection against hairloss though it will do nothing for skin.

Thai is very contradictating

 

[Sachlichkeit]

Skin

GHK-CU subQ / GHK-CU
Topical tretinoin .025/.050 upregulating skin turnover
estriol cream NOT estradiol gel.
All either boost or prompt elastin + collagen in the skin.
Accutane low dose or standard to permanently prevent sebaceous gland hypertrophy from DHT through atrophy.

Y'allah I forget

Body interprets anabolic steroid use inparticular big dht levels as INFLAMMATION

Because DHT binds to androgen receptors in skin it activates anti inflammatory pathways known as MMP Matrix metalloproteinases which breakdown collagen and elastin.

So big dht triggers big immune/inflammatory response in skin, the body overcompensates by upregulating MMPS

MMPS are the primary cause of elastin loss via androgens

MMP1 cuts collagen
MMP9 eats cut collagen & elastin
MMP12 cuts elastin (worst offender)

bunch of other MMPS but those are big three others we don't care about much though they are moderately activated by androgens as well

2 drugs. MMP inhibitors, doxycycline & minocycline. I write about these before in other post but didn't make connection to skin health

Minocycline accumulates in the face for some reason I forgot why doxycycline is more systemic.

Mino needs to be cycled, doxy can be used long term at sub therapeutic dosages 25-50mg ED

Will inhibit MMP1,9 & 12 though its not as strong for MMP12 as it is for 1 & 9.

 

[Sachlichkeit]

K so like over half the stuff 5alphareductase inhibitors block regulate mood/mental health in some fashion also paired with libido

PFSD post finasteride syndrome is medical condition prompted by use of finasteride that induces anhedonia, (total flattening of sexual drive,) increased anxiety, depression, mood instability.

Avg Testosterone of man has decreased little over 1% every year since ~1970, then doctor tells them to get on fin/dut for hairloss and poor hormonal profile oneshots them

PFSD is similar to PSSD, post ssri sexual disfunction which flattens mood, exasperates depression anxiety, anhedonia blablabla

Turns out inhibiting androgen responsible for penile growth in puberty actually has negative effects on penile tissue in adulthood

"Human biopsies from men with post-finasteride symptoms show reduced AR expression, increased fibrotic change, and increased vascular dysregulation. Overall, tissue appears androgen-deprived and fibrotic, consistent with chronic low-DHT effects"

lmao 5ari making ur dick small by androgen deprivation