Sachlichkeit
Bronze
- Joined
- May 11, 2025
- Posts
- 334
- Reputation
- 293
DHT, the downstream of testosterone is the primary cause for hairloss and the (permanent) breaking down of skin elastin through hypertrophy of sebaceous glands.
Skin elastin = more youthful look, once gone, cannot be replaced.
The solution for both has been to repeatedly shill 5alphareductase inhibitors finasteride and dutasteride to SYSTEMATICALLY eradicate DHT in order to preserve skin and prevent norwooding.
We ignore fin, (4 now) which is weaker 5alpha inhibitor, most here are on dutasteride
.5mg dut will wipe out 85%-90% of DHT in the body 2.5mg will wipe out 99%.
here is problem, 5alpha inhibitors don't just block DHT
Testosterone >>>5a >>>> DHT (Prostate, hair, bigger dick ((in puberty,)) pro bone through preservation similar to estrogen.)
DHT >>> 5a >>> 3a-androstanediol anti anxiety, lowers stress, enhances sex
DHT >>> 5A >>> 3b-androstanediol stabilizes mood, neuroprotective (good 4 brain,)
DHT >>> 5a >>> androsterone relax, + social pheromone
DHT >>> 5a >>> Etiocholanolone gives u fevers lmao (triggers immune response)
So half of DHT downstreams are directly linked to mental health other 2 dont care
5alpha blockers don't just inhibit DHT downstreams but every other thing in body that uses 5alpha reductase inhibitors
PROGESTERONE 5alpha downstream. Progesterone converts to bunch of other stuff but we only care about 5alpha conversions
prog >>> 5alpha >>>Allopregnanolone. STRONG antidepressant, anti anxiety, anti stress, pro libido. basically Mental health
prog >>> 5a >>> isopregnanolone. regulator of allopregnanolone.
Deoxycorticosterone
Deoxy >>> 5a >>> 5a-Dihydrodeoxycorticosterone >>>Tetrahydrodeoxycorticosterone. Anti anxiety, pro mood stabilizer
K so like over half the stuff 5alphareductase inhibitors block regulate mood/mental health in some fashion also paired with libido
PFSD post finasteride syndrome is medical condition prompted by use of finasteride that induces anhedonia, (total flattening of sexual drive,) increased anxiety, depression, mood instability.
Avg Testosterone of man has decreased little over 1% every year since ~1970, then doctor tells them to get on fin/dut for hairloss and poor hormonal profile oneshots them
PFSD is similar to PSSD, post ssri sexual disfunction which flattens mood, exasperates depression anxiety, anhedonia blablabla
ok, what do?
Hair
Topical anti androgen RU58841 to prevent ((any)) hairloss stemming from androgens
Topical dut/fin
Topical minoxidil to REGROW hair, not to keep it
Topical KY19382 as a secondary less researched alternative to minoxidil
Topical minox only worked in 60% of people, this is low. We can improve its effectiveness by
DMSO (riskier)
Microneedling
preformulated stacks via telemedicine (most optimal.) You can get a dut + minox + tret + caffeine + whatever else foam/gel
Skin
GHK-CU subQ / GHK-CU
Topical tretinoin .025/.050 upregulating skin turnover
estriol cream NOT estradiol gel.
All either boost or prompt elastin + collagen in the skin.
Accutane low dose or standard to permanently prevent sebaceous gland hypertrophy from DHT through atrophy.
Anything north of 500test/wk + .5mg dutasteride will give you normal DHT levels.
But because 5alpha inhib, there wont be any progesterone or deoxycortisone downstream. This will result in eleveated progesterone and deoxycortisone being "dammed up" (progesterone in high doses is estrogenic, used in europe for MTF HRT.)
FINASTERIDE Partially blocks the progesterone and deoxycortisone branches making it preferable over dutasteride for systemic protection against hairloss though it will do nothing for skin.
Skin elastin = more youthful look, once gone, cannot be replaced.
The solution for both has been to repeatedly shill 5alphareductase inhibitors finasteride and dutasteride to SYSTEMATICALLY eradicate DHT in order to preserve skin and prevent norwooding.
We ignore fin, (4 now) which is weaker 5alpha inhibitor, most here are on dutasteride
.5mg dut will wipe out 85%-90% of DHT in the body 2.5mg will wipe out 99%.
here is problem, 5alpha inhibitors don't just block DHT
Testosterone >>>5a >>>> DHT (Prostate, hair, bigger dick ((in puberty,)) pro bone through preservation similar to estrogen.)
DHT >>> 5a >>> 3a-androstanediol anti anxiety, lowers stress, enhances sex
DHT >>> 5A >>> 3b-androstanediol stabilizes mood, neuroprotective (good 4 brain,)
DHT >>> 5a >>> androsterone relax, + social pheromone
DHT >>> 5a >>> Etiocholanolone gives u fevers lmao (triggers immune response)
So half of DHT downstreams are directly linked to mental health other 2 dont care
5alpha blockers don't just inhibit DHT downstreams but every other thing in body that uses 5alpha reductase inhibitors
PROGESTERONE 5alpha downstream. Progesterone converts to bunch of other stuff but we only care about 5alpha conversions
prog >>> 5alpha >>>Allopregnanolone. STRONG antidepressant, anti anxiety, anti stress, pro libido. basically Mental health
prog >>> 5a >>> isopregnanolone. regulator of allopregnanolone.
Deoxycorticosterone
Deoxy >>> 5a >>> 5a-Dihydrodeoxycorticosterone >>>Tetrahydrodeoxycorticosterone. Anti anxiety, pro mood stabilizer
K so like over half the stuff 5alphareductase inhibitors block regulate mood/mental health in some fashion also paired with libido
PFSD post finasteride syndrome is medical condition prompted by use of finasteride that induces anhedonia, (total flattening of sexual drive,) increased anxiety, depression, mood instability.
Avg Testosterone of man has decreased little over 1% every year since ~1970, then doctor tells them to get on fin/dut for hairloss and poor hormonal profile oneshots them
PFSD is similar to PSSD, post ssri sexual disfunction which flattens mood, exasperates depression anxiety, anhedonia blablabla
ok, what do?
Hair
Topical anti androgen RU58841 to prevent ((any)) hairloss stemming from androgens
Topical dut/fin
Topical minoxidil to REGROW hair, not to keep it
Topical KY19382 as a secondary less researched alternative to minoxidil
Topical minox only worked in 60% of people, this is low. We can improve its effectiveness by
DMSO (riskier)
Microneedling
preformulated stacks via telemedicine (most optimal.) You can get a dut + minox + tret + caffeine + whatever else foam/gel
Skin
GHK-CU subQ / GHK-CU
Topical tretinoin .025/.050 upregulating skin turnover
estriol cream NOT estradiol gel.
All either boost or prompt elastin + collagen in the skin.
Accutane low dose or standard to permanently prevent sebaceous gland hypertrophy from DHT through atrophy.
Anything north of 500test/wk + .5mg dutasteride will give you normal DHT levels.
But because 5alpha inhib, there wont be any progesterone or deoxycortisone downstream. This will result in eleveated progesterone and deoxycortisone being "dammed up" (progesterone in high doses is estrogenic, used in europe for MTF HRT.)
FINASTERIDE Partially blocks the progesterone and deoxycortisone branches making it preferable over dutasteride for systemic protection against hairloss though it will do nothing for skin.
Last edited:
