inanotherlife.
Iron
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Studies report that in pre-clinical models with significant retatrutide (RETA, LY3437943)-induced weight loss, pancreatic cancer engraftment was reduced, tumor onset was delayed, and progression was attenuated resulting in a 14-fold reduction in tumor volume compared to only 4-fold reduction in single agonist semaglutide-treated mice. Despite weight re-gain after RETA withdrawal, the anti-tumor benefits of RETA persisted. Remarkably, RETA-induced protection extends to a lung cancer model with 50% reduced tumor engraftment, significantly delayed tumor onset, and mitigated tumor progression, with a 17-fold reduction in tumor volume compared to controls. RETA induced immune reprogramming systemically and in the tumor microenvironment with durable anti-tumor immunity evidenced by elevated circulating IL-6, increased antigen presenting cells, reduced immunosuppressive cells, and activation of pro-inflammatory pathways. In sum, our findings suggest that patients with RETA-mediated weight loss may also benefit from reduced cancer risk and improved outcomes.
• The drug "reprograms" the immune system to stay aggressive against cancer cells long-term.
• These anti-tumor benefits persisted even if weight was regained after stopping the drug.
• Basically, RETA-mediated weight loss might come with a massive side effect: a much lower cancer risk.
So….
Not only Crazy Appetite Supression
Not only Fat Burning & Energy Boost (Glucagon)
Not ONLY Improved Insulin Use via mimicking GIP
IT ALSO has
• Superior Tumor Suppression
• it cuts lung cancer engraftment by 50%
• It boosts anti-tumor immunity
TL;DR:
(RETA) significantly outperforms semaglutide in shrinking tumors and delaying cancer onset
cuts cuts lung cancer engraftment by 50%
and is an absolute fat shredder . no Reason NOT to hop on
Source:
https://www.nature.com/articles/s44324-025-00054-5
jitc.bmj.com
• The drug "reprograms" the immune system to stay aggressive against cancer cells long-term.
• These anti-tumor benefits persisted even if weight was regained after stopping the drug.
• Basically, RETA-mediated weight loss might come with a massive side effect: a much lower cancer risk.
So….
Not only Crazy Appetite Supression
Not only Fat Burning & Energy Boost (Glucagon)
Not ONLY Improved Insulin Use via mimicking GIP
IT ALSO has
• Superior Tumor Suppression
• it cuts lung cancer engraftment by 50%
• It boosts anti-tumor immunity
TL;DR:
(RETA) significantly outperforms semaglutide in shrinking tumors and delaying cancer onset
cuts cuts lung cancer engraftment by 50%
and is an absolute fat shredder . no Reason NOT to hop on
Source:
https://www.nature.com/articles/s44324-025-00054-5
661 Retatrutide monotherapy matches the effectiveness of anti-PD-1 immunotherapy in a preclinical model of pancreatic cancer
Background Medical therapies for weight loss are transforming obesity management; however, their impact on obesity-associated cancers such as pancreatic ductal adenocarcinoma (PDAC) remains poorly understood. We previously demonstrated in preclinical models that the triple incretin agonist...
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