Retin-a making your skin more sensitive to light is a myth

[Dogs]

Doesn't make sense to me. You don't need a full regime if you want to apply retin-a to your skin. But of course you should still be using sunscreen. I should charge for this info but I'll just give it to you for free.

 

[jefferson]

So it's a myth because it "Doesn't make sense to me."

ok bro

 

[TsarTsar444]

So it's a myth because it "Doesn't make sense to me."

ok bro

Caged hard at this

 

[gymislife]

@benignice

 

[Dogs]

So it's a myth because it "Doesn't make sense to me."

ok bro

It's true that retinoids break down in sunlight, which is why they are bottled in opaque packaging and are still best worn at night to make sure they aren't rendered inactive. However, they do not make the skin more prone to sunburn. "This misconception came about because in some early studies, people described putting on a retinoid, walking into the sun, and immediately burning. But that redness is likely related to heat exposure," says Sachs. "Clinical studies have shown pretty definitively that retinoids do not lower the MED — or minimal erythemal dos — of human skin, which is the amount of UV light you can take before the skin burns."

Point is you need proof either way.

 

[her]

@benignice @Seth Walsh

 

[Deleted member 1100]

I trust you bro!

Confirmed psl 8 giga ultimate slayer 170 IQ

if you say, then it's correct

 

[Dogs]

I trust you bro!

Confirmed psl 8 giga ultimate slayer 170 IQ

if you say, then it's correct

Your loss

 

[StoicNihilist]

Yeah dude, retin a is very well known to do that

 

[Dogs]

Yeah dude, retin a is very well known to do that

Can you explain why? Cause if you do ill tell how it doesn't make sense.

 

[Deleted member 2933]

Get a hair transplant and leave us alone

 

[Deleted member 656]

 

[StoicNihilist]

Can you explain why? Cause if you do ill tell how it doesn't make sense.

Retin A is just the topical version of Accutane.

You know what Accutane is right? It's a Retiniod or "Vitamin A" derivative. Going on a course of Accutane is basically just controlled vitamin A poisoning, a symptom of which is extremely dry and sensitive skin.

Vitamin A in excess dries out and shrinks the sebum oil glands in your skin. The effects of which can be permanent.

 

[Dogs]

Retin A is just the topical version of Accutane.

You know what Accutane is right? It's a Retiniod or "Vitamin A" derivative. Going on a course of Accutane is basically just controlled vitamin A poisoning, a symptom of which is extremely dry and sensitive skin.

Vitamin A in excess dries out and shrinks the sebum oil glands in your skin. The effects of which can be permanent.

Not all drug derivatives work the same way, especially if one is topical vs the other oral (for example retin-a doesn't have long lasting permanent effects). Even if both are trying to cure the same thing it doesn't mean their action of curing that thing is similar.

Accutane works by shrinking the sebaceous glands in the skin. Retin-a works by increasing cell turnover rate.

You need to explain how retin-a makes you more susceptible to UV light.

 

[benignice]

I really hate to break it to you, but "doesn't make sense to me" and a quote from a single person does not a proof make.
Also, making a statement and saying "prove me wrong bro" isn't how science works. You make a positive claim, you back that shit up. However, since you're apparently too lazy to do a quick google search, retinoids are thought to cause photosensitivity due to a combination of factors; a thinning of the stratum corneum and their low photostability (the products of photodegradation would be the issue here).

Retin A is just the topical version of Accutane.

Nope. Retin A is tretinoin, Accutane is isotretinoin. That isomerism is enough to make them different drugs (see: methamphetamines).

Not all drug derivatives work the same way, especially if one is topical vs the other oral (for example retin-a doesn't have long lasting permanent effects). Even if both are trying to cure the same thing it doesn't mean their action of curing that thing is similar.

All I'm saying on this one is bare in mind the difference in route of administration here- that's a massive factor.

 

[Dogs]

I really hate to break it to you, but "doesn't make sense to me" and a quote from a single person does not a proof make.
Also, making a statement and saying "prove me wrong bro" isn't how science works. You make a positive claim, you back that shit up. However, since you're apparently too lazy to do a quick google search, retinoids are thought to cause photosensitivity due to a combination of factors; a thinning of the stratum corneum and their low photostability (the products of photodegradation would be the issue here).


Nope. Retin A is tretinoin, Accutane is isotretinoin. That isomerism is enough to make them different drugs (see: methamphetamines).


All I'm saying on this one is bare in mind the difference in route of administration here- that's a massive factor.

We agree on your 2nd and 3rd reply.

"Retin-a makes your skin more sensitive to light" is a positive claim. It needs proof. First you need proof that is causes photosensitivity then you can try and explain why it does that. Or you can find an effect that it has that is proven to increase photosensitivity. You don't start with theories on why it does so and then claim that it does that.

Where is the proof that retin-a thins the skin?

I've done the research which is why I made the claim in the first place.... And here you are with a "quick google search".

Topical all-trans retinoic acid does not influence minimal erythema doses for UVB light in normal skin - PubMed

Topical all-trans retinoic acid does not influence minimal erythema doses for UVB light in normal skin

www.ncbi.nlm.nih.gov

 

[benignice]

We agree on your 2nd and 3rd reply.

"Retin-a makes your skin more sensitive to light" is a positive claim. It needs proof. First you need proof that is causes photosensitivity then you can try and explain why it does that. Or you can find an effect that it has that is proven to increase photosensitivity. You don't start with theories on why it does so and then claim that it does that.

Where is the proof that retin-a thins the skin?

I've done the research which is why I made the claim in the first place.... And here you are with a "quick google search".

Retinoid induced photosensitivity (with a bit of proposed mechanisms):
- Photodecomposition and Phototoxicity of Natural Retinoids (2005) Tolleson et al
- Soybean extract showed modulation of retinoic acid-related gene expression of skin and photo-protective effects in keratinocytes (2012) Park et al
- Retinoid associated phototoxicity and photosensitivity (1989) Ferguson and Johnson
- UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations (2008) Tashtoush et al
- Voriconazole- Inducted Retinoid-Like Photosensitivity in Children (2004) Rubenstein, Levy and Metry
- Topical nanostructured lipid carriers/inorganic sunscreen combination for alleviation of all-trans retinoic acid-induced photosensitivity: Box-Behnken design optimization, in vitro and in vivo evaluation. (2019) Asfour, Kassem and Salama
- Tretinoin Nanogel 0.025% Versus Conventional Gel 0.025% in Patients with Acne Vulgaris: A Randomized, Active Controlled, Multicentre, Parallel Group, Phase IV Clinical Trial (2015) Chandrashekhar et al
- Solubility of all-trans retinoic acid in supercritical carbon dioxide (2015) Rosa et al

Thinning of stratum corneum (not the skin, specifically the SC):
- Skincare Science: Update on Topical Retinoids (2006) Boswell
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety (2006) Mukherjee et al
- Tretinoin 5% peeling versus 0.05% cream for advanced photoaging of the forearms: An open, randomized, evaulator-blinded and comparative study (2017) Sumita et al

No, I'm not here with a quick google search, I'm here as someone who works as a cosmetic chemist. My google search comment was about how easy it was to find the information.

 

[Vermilioncore]

Retinoid induced photosensitivity (with a bit of proposed mechanisms):
- Photodecomposition and Phototoxicity of Natural Retinoids (2005) Tolleson et al
- Soybean extract showed modulation of retinoic acid-related gene expression of skin and photo-protective effects in keratinocytes (2012) Park et al
- Retinoid associated phototoxicity and photosensitivity (1989) Ferguson and Johnson
- UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations (2008) Tashtoush et al
- Voriconazole- Inducted Retinoid-Like Photosensitivity in Children (2004) Rubenstein, Levy and Metry
- Topical nanostructured lipid carriers/inorganic sunscreen combination for alleviation of all-trans retinoic acid-induced photosensitivity: Box-Behnken design optimization, in vitro and in vivo evaluation. (2019) Asfour, Kassem and Salama
- Tretinoin Nanogel 0.025% Versus Conventional Gel 0.025% in Patients with Acne Vulgaris: A Randomized, Active Controlled, Multicentre, Parallel Group, Phase IV Clinical Trial (2015) Chandrashekhar et al
- Solubility of all-trans retinoic acid in supercritical carbon dioxide (2015) Rosa et al

Thinning of stratum corneum (not the skin, specifically the SC):
- Skincare Science: Update on Topical Retinoids (2006) Boswell
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety (2006) Mukherjee et al
- Tretinoin 5% peeling versus 0.05% cream for advanced photoaging of the forearms: An open, randomized, evaulator-blinded and comparative study (2017) Sumita et al

No, I'm not here with a quick google search, I'm here as someone who works as a cosmetic chemist. My google search comment was about how easy it was to find the information.

High IQ

 

[StoicNihilist]

Not all drug derivatives work the same way, especially if one is topical vs the other oral (for example retin-a doesn't have long lasting permanent effects). Even if both are trying to cure the same thing it doesn't mean their action of curing that thing is similar.

Accutane works by shrinking the sebaceous glands in the skin. Retin-a works by increasing cell turnover rate.

You need to explain how retin-a makes you more susceptible to UV light.

You got me there... I ain't a doctor or nothing.

 

[Deleted member 10176]

But that redness is likely related to heat exposure," says Sachs

 

[Deleted member 4562]

This is why you shouldn't trust the colors of names because when they were greycels and bluecels they were posting shit like this.