Reverse Agepill

[Deleted member 2933]

This is a thread that a i wish it should be pinned.

If you are 20 years now or more, its time to Reverse Agepill, you grow what u had to grow, your facial bones are done, your puberty is over, now you gotta keep your hair and collagen for as long as you can in your life, your goal is to looks like 10 years younger than u are always.

Reverse Agepill:

2g Vit C
1g MSM
Retin-A 0,05
Redlight Lamp in home 40 mins daily
Cleanser
Moisturizer
Sunscreen
2lt Water
Finasteride 1mg(If NWcel)

DAILY

 

[sadakiyo]

 

[x30001]

500mg vitC and countless other things not mentioned here and never mentioned on this forum or on lookism.

 

[Deleted member 2933]

500mg vitC and countless other things not mentioned here and never mentioned on this forum or on lookism.

2g or coping, all those stuffs are from lookism btw

 

[x30001]

2g or coping, all those stuffs are from lookism btw

No I mean, anti aging stuff has never been mentioned on here or on lookism. And 500mg per day is more than enough vitamin C

 

[Deleted member 2933]

No I mean, anti aging stuff has never been mentioned on here or on lookism. And 500mg per day is more than enough vitamin C

500mg is cope.

 

[BigBiceps]

500mg vitC and countless other things not mentioned here and never mentioned on this forum or on lookism.

You mean 1500mg?

 

[Deleted member 2527]

metformin (prescription) + nicotinamide riboside + resveratrol are the real anti-agingmaxxers

 

[Deleted member 616]

How old are you OP?

 

[Deleted member 2933]

metformin (prescription) + nicotinamide riboside + resveratrol are the real anti-agingmaxxers

This is expensive stuff

How old are you OP?

24,5

 

[Lorsss]

This is a thread that a i wish it should be pinned.

If you are 20 years now or more, its time to Reverse Agepill, you grow what u had to grow, your facial bones are done, your puberty is over, now you gotta keep your hair and collagen for as long as you can in your life, your goal is to looks like 10 years younger than u are always.

Reverse Agepill:

2g Vit C
1g MSM
Retin-A 0,05
Redlight Lamp in home 40 mins daily
Cleanser
Moisturizer
Sunscreen
2lt Water
Finasteride 1mg(If NWcel)

DAILY

2 grams of vitamin c won't improve your collagen production and may fuck up your stomach and kidneys

 

[x30001]

You mean 1500mg?

500mg

metformin (prescription) + nicotinamide riboside + resveratrol are the real anti-agingmaxxers

Nice one. Berberine is the perfect replacement for metformin. Same effects, possibly more effective. Pterostilbene instead of resveratrol due to better bioavailability and basically being the same as resveratrol itself. NMN and NR really not needed unless you're an oldcel since calorie restriction and exercise can increase NAD+ levels anyways.

PQQ for PGC1 alpha activation and mitochondrial biogenesis + free radical scavanging.
Pterostilbene/Resveratrol for SIRT1 activation.
Berberine for AMPK, SIRT1 and TBC1D1 activation
Exposure to extremities in pressure and temperature for hormetic adaptions (saunas) + to activate FOXO3
CoQ10, ALCAR, methylcobalamin for mitochondrial performance (included in PQQ energy NOW foods supplement)
Blueberries to increase cyclic AMP
Coleus Forskohlli to activate CREB (cyclic AMP response-element binding protein) and to activate PKA (protein kinase A). AKT being PKB (Protein Kinase B). Rapamycin shouldn't be used since caloric restriction, exercise and Berberine can inhibit mTOR and activate AMPK at the same time whilst Metformin alone cannot.

Exercising in an energy deficit is incredibly underrated. Hormetic upregulation is also incredibly misunderstood and underrated. Fasting for autophagic benefits is also very important.

Creating senescent cells and preventing apoptosis and protein misfoldings is also incredibly important. Being aware of what causes DNA damage and using Astragalus to prevent telomere shortening is also very important as once you've reached your hayflick limit, your DNA will be damaged due to there not being any telomeres to protect you chromosomes anymore. But your telomeres degrade at different rates on each chromosome anyways. Using fisetin can also repair DNA damage. But all this info is useless unless used in an extremely specific protocol anyways. Using CRISPR (eventually) to prevent genetic diseases and to activate the ACTN3 gene, changing the MSTN gene to have 1 or 2 G-Alleles rather than being Thymine/Adinene would also cause a mutation allowing you to hold more skeletal muscle due to having less myostatin, which'll have pro-longevity effects.

As you get older, supplementing with NMN (Nicotinamide Mononucleotide) will help you maintain high NAD+ levels to allow you to metabolize energy in a more efficient way and to keep you healthier even if you can't exercise as much as you'd like (like David Sinclair). NMN enters the outer membrane of cells but gets transported to the inner membrane through an enzyme called Slc12a8. Direct supplementation with NAD+ does not work since the molecule is too large for pretty much every cell. Pyrroloquinoline Quinone is pretty much the best supplement for mitochondrial biogenesis and PGC1 alpha activation, but needs to be used in a very specific protocol. Even helps muscle growth due to increased mitochondrial density and functioning, especially when coupled with CoQ10 or Ubiquitinol (the active form of CoQ10). NR isn't anywhere near as effective as NMN since NR can't convert to NMN or NAD+ directly and cannot enter the inner membrane of cells since Slc12a8 can only transport 1 Nicotinamide Nucleotide (as NMN) and not Nicotinamide Riboside. NR converts to Nicotinamide Adenine Mononeuclotide (NAM) and then to a far less available form of NAD.

Lots of people talk about loss of DNA methylation as a reason for "closed growth plates" which is such rubbish. Loss of DNA methylation is a serious problem and MSM / SAM-e supplementation does not prevent a loss of DNA methylation. IDK who started all that nonsense but loss of MTHFR functioning and hence low amounts of methylated B vitamins, especially B9 which is a precursor to Thymine will cause a loss of DNA methylation over time. Just because MSM is a methyl donor and direct SAM-e supplementation can circumvent the homocysteine -> methionine (SAM-e) conversion, does not assure you can fix the root problem, being MTHFR gene disfunction. If your MTHFR is working properly in the first place, supplementation with those compounds without rhyme or reason can actually lead to problems with MTHFR functioning and hence loss of DNA methylation. And I don't know how loss of DNA methylation can directly cause your growth plates to close because I haven't read up on that. But if you're deficient in the precursor to Thymine, that being MethylFolate (B9), then you're bound to have problems with your DNA since Thymine is one of the 4 nucleotide bases of Deoxyribosenucleic Acid (Thymine, Guanine, Cytosine, Adenine).

Also look into epigenetic practices. Meditation etc. Your environment can definitely influence gene expression in a good or bad way, dependant on your environment. That's one of the reasons why meditation and lack of stress is so important. MTHFR disfunction can also prevent your body from turning genes off. So it's really important that your methylation is in check.

This is just a brief rundown of the Anti-Age pill. The rabbithole is never ending. David Sinclair's work on resveratrol and NMN have been ground breaking. But NMN is definitely not needed until older age and exercise and fasting is certainly underlooked, as he stated himself. Instead of frequent eating and infrequent exercise (Office job visiting the bagel stand at lunch), you should be doing the opposite; Frequent exercise and infrequent eating; eating inherently good foods when you need to eat. Avoiding sugar, carbohydrates etc.

Things that decline as you grow older:

CoQ10 levels
NAD+ levels
GHK-cu levels
BDNF levels (Brain Derived Neurotrophic Factor)

2 grams of vitamin c won't improve your collagen production and may fuck up your stomach and kidneys

It's way too much. You don't even need 500mg EVERY day. 2g EVERYDAY is just silly.

 

[Deleted member 2933]

500mg

Nice one. Berberine is the perfect replacement for metformin. Same effects, possibly more effective. Pterostilbene instead of resveratrol due to better bioavailability and basically being the same as resveratrol itself. NMN and NR really not needed unless you're an oldcel since calorie restriction and exercise can increase NAD+ levels anyways.

PQQ for PGC1 alpha activation and mitochondrial biogenesis + free radical scavanging.
Pterostilbene/Resveratrol for SIRT1 activation.
Berberine for AMPK, SIRT1 and TBC1D1 activation
Exposure to extremities in pressure and temperature for hormetic adaptions (saunas) + to activate FOXO3
CoQ10, ALCAR, methylcobalamin for mitochondrial performance (included in PQQ energy NOW foods supplement)
Blueberries to increase cyclic AMP
Coleus Forskohlli to activate CREB (cyclic AMP response-element binding protein) and to activate PKA (protein kinase A). AKT being PKB (Protein Kinase B). Rapamycin shouldn't be used since caloric restriction, exercise and Berberine can inhibit mTOR and activate AMPK at the same time whilst Metformin alone cannot.

Exercising in an energy deficit is incredibly underrated. Hormetic upregulation is also incredibly misunderstood and underrated. Fasting for autophagic benefits is also very important.

Creating senescent cells and preventing apoptosis and protein misfoldings is also incredibly important. Being aware of what causes DNA damage and using Astragalus to prevent telomere shortening is also very important as once you've reached your hayflick limit, your DNA will be damaged due to there not being any telomeres to protect you chromosomes anymore. But your telomeres degrade at different rates on each chromosome anyways. Using fisetin can also repair DNA damage. But all this info is useless unless used in an extremely specific protocol anyways. Using CRISPR (eventually) to prevent genetic diseases and to activate the ACTN3 gene, changing the MSTN gene to have 1 or 2 G-Alleles rather than being Thymine/Adinene would also cause a mutation allowing you to hold more skeletal muscle due to having less myostatin, which'll have pro-longevity effects.

As you get older, supplementing with NMN (Nicotinamide Mononucleotide) will help you maintain high NAD+ levels to allow you to metabolize energy in a more efficient way and to keep you healthier even if you can't exercise as much as you'd like (like David Sinclair). NMN enters the outer membrane of cells but gets transported to the inner membrane through an enzyme called Slc12a8. Direct supplementation with NAD+ does not work since the molecule is too large for pretty much every cell. Pyrroloquinoline Quinone is pretty much the best supplement for mitochondrial biogenesis and PGC1 alpha activation, but needs to be used in a very specific protocol. Even helps muscle growth due to increased mitochondrial density and functioning, especially when coupled with CoQ10 or Ubiquitinol (the active form of CoQ10). NR isn't anywhere near as effective as NMN since NR can't convert to NMN or NAD+ directly and cannot enter the inner membrane of cells since Slc12a8 can only transport 1 Nicotinamide Nucleotide (as NMN) and not Nicotinamide Riboside. NR converts to Nicotinamide Adenine Mononeuclotide (NAM) and then to a far less available form of NAD.

Lots of people talk about loss of DNA methylation as a reason for "closed growth plates" which is such rubbish. Loss of DNA methylation is a serious problem and MSM / SAM-e supplementation does not prevent a loss of DNA methylation. IDK who started all that nonsense but loss of MTHFR functioning and hence low amounts of methylated B vitamins, especially B9 which is a precursor to Thymine will cause a loss of DNA methylation over time. Just because MSM is a methyl donor and direct SAM-e supplementation can circumvent the homocysteine -> methionine (SAM-e) conversion, does not assure you can fix the root problem, being MTHFR gene disfunction. If your MTHFR is working properly in the first place, supplementation with those compounds without rhyme or reason can actually lead to problems with MTHFR functioning and hence loss of DNA methylation. And I don't know how loss of DNA methylation can directly cause your growth plates to close because I haven't read up on that. But if you're deficient in the precursor to Thymine, that being MethylFolate (B9), then you're bound to have problems with your DNA since Thymine is one of the 4 nucleotide bases of Deoxyribosenucleic Acid (Thymine, Guanine, Cytosine, Adenine).

Also look into epigenetic practices. Meditation etc. Your environment can definitely influence gene expression in a good or bad way, dependant on your environment. That's one of the reasons why meditation and lack of stress is so important. MTHFR disfunction can also prevent your body from turning genes off. So it's really important that your methylation is in check.

This is just a brief rundown of the Anti-Age pill. The rabbithole is never ending. David Sinclair's work on resveratrol and NMN have been ground breaking. But NMN is definitely not needed until older age and exercise and fasting is certainly underlooked, as he stated himself. Instead of frequent eating and infrequent exercise (Office job visiting the bagel stand at lunch), you should be doing the opposite; Frequent exercise and infrequent eating; eating inherently good foods when you need to eat. Avoiding sugar, carbohydrates etc.

Things that decline as you grow older:

CoQ10 levels
NAD+ levels
GHK-cu levels
BDNF levels (Brain Derived Neurotrophic Factor)

It's way too much. You don't even need 500mg EVERY day. 2g EVERYDAY is just silly.

High IQ stuff, i will add it to my future buyings

 

[Deusmaximus]

nicotinamide riboside + resveratrol

Dosages? Thanks

 

[x30001]

High IQ stuff, i will add it to my future buyings

PQQ and not exercising and/or restricting calories will work against you. It needs to be used in a very specific protocol. You should look into:

cAMP
CREB
PKA
PKB
MTOR
AMPK
SIRT1
FOXO3
PGC1 alpha

PQQ and not exercising and/or restricting calories will work against you. It needs to be used in a very specific protocol. You should look into:

cAMP
CREB
PKA
PKB
MTOR
AMPK
SIRT1
FOXO3
PGC1 alpha

PKB=AKT

Also look into L-Arginine to achieve protein synthesis without AKT signalling. The presence of insulin activates the AKT pathway but berberine can inhibit AKT and activate AMPK and SIRT1 and also act as an insulin mimetic though TBC1D1 activation which'll do insulin's job of transporting glucose to cells, without any insulin being present, preventing possible insulin resistance and achieving protein synthesis in an energy deficit with only a small momentary amount of that 1 amino-acid.

The research in the following thread is outdated since I didn't know berberine could inhibit AKT signalling whilst activating AMPK. But now I know protein synthesis is completely possible even without the insulin signalling cascade and AKT activation.

https://looksmax.org/threads/build-muscle-and-burn-fat-at-the-same-time-as-a-natty.23953

 

[OCDMaxxing]

source needed.

Yes, sunscreen works for like 95% of anti age efforts.

Stuff like Vitamin C and MSM has to be bullshit unless you can prove otherwise.

Nice one. Berberine is the perfect replacement for metformin. Same effects, possibly more effective. Pterostilbene instead of resveratrol due to better bioavailability and basically being the same as resveratrol itself. NMN and NR really not needed unless you're an oldcel since calorie restriction and exercise can increase NAD+ levels anyways.

Where did you get this info on berberine and pteristilbene?

 

[x30001]

source needed.

Yes, sunscreen works for like 95% of anti age efforts.

Stuff like Vitamin C and MSM has to be bullshit unless you can prove otherwise.

Where did you get this info on berberine and pteristilbene?

VitC not bullshit but not needed in high doses at all or needed everyday. MSM will do more harm then good unless your using it to make up for a sulphur deficiency or to chelate mercury, iron etc out of the body. Using it everyday is also not needed, and using it in high amounts is just a waste. I don't use sunscreen myself but I tan well now since I used melanotan2 in the past and it's effects are somewhat permanent luckily, so I don't burn or get damaged skin just from a little UV exposure. Pterostilbene is just a cousin of resveratrol, basically the same but just more bioavailable. It's also known as "dimethoxyresveratrol" I think.

 

[her]

500mg

Nice one. Berberine is the perfect replacement for metformin. Same effects, possibly more effective. Pterostilbene instead of resveratrol due to better bioavailability and basically being the same as resveratrol itself. NMN and NR really not needed unless you're an oldcel since calorie restriction and exercise can increase NAD+ levels anyways.

PQQ for PGC1 alpha activation and mitochondrial biogenesis + free radical scavanging.
Pterostilbene/Resveratrol for SIRT1 activation.
Berberine for AMPK, SIRT1 and TBC1D1 activation
Exposure to extremities in pressure and temperature for hormetic adaptions (saunas) + to activate FOXO3
CoQ10, ALCAR, methylcobalamin for mitochondrial performance (included in PQQ energy NOW foods supplement)
Blueberries to increase cyclic AMP
Coleus Forskohlli to activate CREB (cyclic AMP response-element binding protein) and to activate PKA (protein kinase A). AKT being PKB (Protein Kinase B). Rapamycin shouldn't be used since caloric restriction, exercise and Berberine can inhibit mTOR and activate AMPK at the same time whilst Metformin alone cannot.

Exercising in an energy deficit is incredibly underrated. Hormetic upregulation is also incredibly misunderstood and underrated. Fasting for autophagic benefits is also very important.

Creating senescent cells and preventing apoptosis and protein misfoldings is also incredibly important. Being aware of what causes DNA damage and using Astragalus to prevent telomere shortening is also very important as once you've reached your hayflick limit, your DNA will be damaged due to there not being any telomeres to protect you chromosomes anymore. But your telomeres degrade at different rates on each chromosome anyways. Using fisetin can also repair DNA damage. But all this info is useless unless used in an extremely specific protocol anyways. Using CRISPR (eventually) to prevent genetic diseases and to activate the ACTN3 gene, changing the MSTN gene to have 1 or 2 G-Alleles rather than being Thymine/Adinene would also cause a mutation allowing you to hold more skeletal muscle due to having less myostatin, which'll have pro-longevity effects.

As you get older, supplementing with NMN (Nicotinamide Mononucleotide) will help you maintain high NAD+ levels to allow you to metabolize energy in a more efficient way and to keep you healthier even if you can't exercise as much as you'd like (like David Sinclair). NMN enters the outer membrane of cells but gets transported to the inner membrane through an enzyme called Slc12a8. Direct supplementation with NAD+ does not work since the molecule is too large for pretty much every cell. Pyrroloquinoline Quinone is pretty much the best supplement for mitochondrial biogenesis and PGC1 alpha activation, but needs to be used in a very specific protocol. Even helps muscle growth due to increased mitochondrial density and functioning, especially when coupled with CoQ10 or Ubiquitinol (the active form of CoQ10). NR isn't anywhere near as effective as NMN since NR can't convert to NMN or NAD+ directly and cannot enter the inner membrane of cells since Slc12a8 can only transport 1 Nicotinamide Nucleotide (as NMN) and not Nicotinamide Riboside. NR converts to Nicotinamide Adenine Mononeuclotide (NAM) and then to a far less available form of NAD.

Lots of people talk about loss of DNA methylation as a reason for "closed growth plates" which is such rubbish. Loss of DNA methylation is a serious problem and MSM / SAM-e supplementation does not prevent a loss of DNA methylation. IDK who started all that nonsense but loss of MTHFR functioning and hence low amounts of methylated B vitamins, especially B9 which is a precursor to Thymine will cause a loss of DNA methylation over time. Just because MSM is a methyl donor and direct SAM-e supplementation can circumvent the homocysteine -> methionine (SAM-e) conversion, does not assure you can fix the root problem, being MTHFR gene disfunction. If your MTHFR is working properly in the first place, supplementation with those compounds without rhyme or reason can actually lead to problems with MTHFR functioning and hence loss of DNA methylation. And I don't know how loss of DNA methylation can directly cause your growth plates to close because I haven't read up on that. But if you're deficient in the precursor to Thymine, that being MethylFolate (B9), then you're bound to have problems with your DNA since Thymine is one of the 4 nucleotide bases of Deoxyribosenucleic Acid (Thymine, Guanine, Cytosine, Adenine).

Also look into epigenetic practices. Meditation etc. Your environment can definitely influence gene expression in a good or bad way, dependant on your environment. That's one of the reasons why meditation and lack of stress is so important. MTHFR disfunction can also prevent your body from turning genes off. So it's really important that your methylation is in check.

This is just a brief rundown of the Anti-Age pill. The rabbithole is never ending. David Sinclair's work on resveratrol and NMN have been ground breaking. But NMN is definitely not needed until older age and exercise and fasting is certainly underlooked, as he stated himself. Instead of frequent eating and infrequent exercise (Office job visiting the bagel stand at lunch), you should be doing the opposite; Frequent exercise and infrequent eating; eating inherently good foods when you need to eat. Avoiding sugar, carbohydrates etc.

Things that decline as you grow older:

CoQ10 levels
NAD+ levels
GHK-cu levels
BDNF levels (Brain Derived Neurotrophic Factor)

It's way too much. You don't even need 500mg EVERY day. 2g EVERYDAY is just silly.

I just want to thank you for all the info you are giving us. You are probably the only person in here that is really giving us legit anti aging advice. Thank you so much. By the way, have you looked into Shilajit? It has the benefits I mentioned in PM, and from what I’ve researched it has no side effects at all. I don’t think it is needed or worth though, but what do you think?

 

[x30001]

I just want to thank you for all the info you are giving us. You are probably the only person in here that is really giving us legit anti aging advice. Thank you so much. By the way, have you looked into Shilajit? It has the benefits I mentioned in PM, and from what I’ve researched it has no side effects at all. I don’t think it is needed or worth though, but what do you think?

No problem. I only write this shit when I'm wired on ritalin and have some time at home where I cba to write this stuff. I looked into Shilajit and it's a great herb/adaptagen but doesn't help with anything that other herbs like astragalus do. PQQ+CoQ10(Ubiquitinol form)+ALCAR=methylb12 is enough to make sure mitochondrial density and functioning is top notch, (along with exercising, caloric restriction and everything else non supplement-wise). I write this stuff because I real feel it's the foundation of looksmaxing; and that can be proven objectively. Applying all the anti-aging techniques and practices helps out a lot more than looking for quick fixes and one offs, as it's never ending progression opposed to a lot of gimmicky "stop-start" stuff that's always been shared on here. I've been apprehensive to share this stuff and I haven't shared absolutely everything I've learned. But understanding it is the most important thing and I want people who really want to better themselves, to understand this stuff and apply it to themselves for the better.

Also @her I appreciate you giving credit/acknowledgement because a lot of the time it feels like it's not worth sharing information at all

The ideal looksmaxing "stack" imo for a teen or young adult would be:

Berberine
Pterostilbene
PQQ energy (Pyrroloquinoline Quinone, ALCAR, methylB12, CoQ10)
Fisetin
Coleus Forskholli

... That's it for the supplements.

Then the most important part is everything else. Because literally everything matters.

Intermittent Fasting
Perfect Sleep
Low Carb
Getting enough omega3s, avoiding omega6s like sunflower oil etc, getting enough vitamin E.
Getting into autophagy from time to time but not too often. Understanding the role of endogenous anti-inflammatory cytokines and the role of the NRF2 and ULK1 pathways.
Understanding that microneedling is a form of autophagy selective to skin cells. (using derminator2 and not some shit device)
Exercising everyday you can. Resistance (weight training), HIIT, sauna bathing, cold showers, nofap.
Using Stinging Nettle Root and Diindolylmethane if you need to.
Understanding that acne can be treated at a cellular level and Retinoids are just treating a symptom and are better applied to skin which doesn't have dead cells or dysfunctional mitochondria and proteins.

And a lot lot more

 

[SurgerySoon]

500mg

Nice one. Berberine is the perfect replacement for metformin. Same effects, possibly more effective. Pterostilbene instead of resveratrol due to better bioavailability and basically being the same as resveratrol itself. NMN and NR really not needed unless you're an oldcel since calorie restriction and exercise can increase NAD+ levels anyways.

PQQ for PGC1 alpha activation and mitochondrial biogenesis + free radical scavanging.
Pterostilbene/Resveratrol for SIRT1 activation.
Berberine for AMPK, SIRT1 and TBC1D1 activation
Exposure to extremities in pressure and temperature for hormetic adaptions (saunas) + to activate FOXO3
CoQ10, ALCAR, methylcobalamin for mitochondrial performance (included in PQQ energy NOW foods supplement)
Blueberries to increase cyclic AMP
Coleus Forskohlli to activate CREB (cyclic AMP response-element binding protein) and to activate PKA (protein kinase A). AKT being PKB (Protein Kinase B). Rapamycin shouldn't be used since caloric restriction, exercise and Berberine can inhibit mTOR and activate AMPK at the same time whilst Metformin alone cannot.

Exercising in an energy deficit is incredibly underrated. Hormetic upregulation is also incredibly misunderstood and underrated. Fasting for autophagic benefits is also very important.

Creating senescent cells and preventing apoptosis and protein misfoldings is also incredibly important. Being aware of what causes DNA damage and using Astragalus to prevent telomere shortening is also very important as once you've reached your hayflick limit, your DNA will be damaged due to there not being any telomeres to protect you chromosomes anymore. But your telomeres degrade at different rates on each chromosome anyways. Using fisetin can also repair DNA damage. But all this info is useless unless used in an extremely specific protocol anyways. Using CRISPR (eventually) to prevent genetic diseases and to activate the ACTN3 gene, changing the MSTN gene to have 1 or 2 G-Alleles rather than being Thymine/Adinene would also cause a mutation allowing you to hold more skeletal muscle due to having less myostatin, which'll have pro-longevity effects.

As you get older, supplementing with NMN (Nicotinamide Mononucleotide) will help you maintain high NAD+ levels to allow you to metabolize energy in a more efficient way and to keep you healthier even if you can't exercise as much as you'd like (like David Sinclair). NMN enters the outer membrane of cells but gets transported to the inner membrane through an enzyme called Slc12a8. Direct supplementation with NAD+ does not work since the molecule is too large for pretty much every cell. Pyrroloquinoline Quinone is pretty much the best supplement for mitochondrial biogenesis and PGC1 alpha activation, but needs to be used in a very specific protocol. Even helps muscle growth due to increased mitochondrial density and functioning, especially when coupled with CoQ10 or Ubiquitinol (the active form of CoQ10). NR isn't anywhere near as effective as NMN since NR can't convert to NMN or NAD+ directly and cannot enter the inner membrane of cells since Slc12a8 can only transport 1 Nicotinamide Nucleotide (as NMN) and not Nicotinamide Riboside. NR converts to Nicotinamide Adenine Mononeuclotide (NAM) and then to a far less available form of NAD.

Lots of people talk about loss of DNA methylation as a reason for "closed growth plates" which is such rubbish. Loss of DNA methylation is a serious problem and MSM / SAM-e supplementation does not prevent a loss of DNA methylation. IDK who started all that nonsense but loss of MTHFR functioning and hence low amounts of methylated B vitamins, especially B9 which is a precursor to Thymine will cause a loss of DNA methylation over time. Just because MSM is a methyl donor and direct SAM-e supplementation can circumvent the homocysteine -> methionine (SAM-e) conversion, does not assure you can fix the root problem, being MTHFR gene disfunction. If your MTHFR is working properly in the first place, supplementation with those compounds without rhyme or reason can actually lead to problems with MTHFR functioning and hence loss of DNA methylation. And I don't know how loss of DNA methylation can directly cause your growth plates to close because I haven't read up on that. But if you're deficient in the precursor to Thymine, that being MethylFolate (B9), then you're bound to have problems with your DNA since Thymine is one of the 4 nucleotide bases of Deoxyribosenucleic Acid (Thymine, Guanine, Cytosine, Adenine).

Also look into epigenetic practices. Meditation etc. Your environment can definitely influence gene expression in a good or bad way, dependant on your environment. That's one of the reasons why meditation and lack of stress is so important. MTHFR disfunction can also prevent your body from turning genes off. So it's really important that your methylation is in check.

This is just a brief rundown of the Anti-Age pill. The rabbithole is never ending. David Sinclair's work on resveratrol and NMN have been ground breaking. But NMN is definitely not needed until older age and exercise and fasting is certainly underlooked, as he stated himself. Instead of frequent eating and infrequent exercise (Office job visiting the bagel stand at lunch), you should be doing the opposite; Frequent exercise and infrequent eating; eating inherently good foods when you need to eat. Avoiding sugar, carbohydrates etc.

Things that decline as you grow older:

CoQ10 levels
NAD+ levels
GHK-cu levels
BDNF levels (Brain Derived Neurotrophic Factor)

It's way too much. You don't even need 500mg EVERY day. 2g EVERYDAY is just silly.

No problem. I only write this shit when I'm wired on ritalin and have some time at home where I cba to write this stuff. I looked into Shilajit and it's a great herb/adaptagen but doesn't help with anything that other herbs like astragalus do. PQQ+CoQ10(Ubiquitinol form)+ALCAR=methylb12 is enough to make sure mitochondrial density and functioning is top notch, (along with exercising, caloric restriction and everything else non supplement-wise). I write this stuff because I real feel it's the foundation of looksmaxing; and that can be proven objectively. Applying all the anti-aging techniques and practices helps out a lot more than looking for quick fixes and one offs, as it's never ending progression opposed to a lot of gimmicky "stop-start" stuff that's always been shared on here. I've been apprehensive to share this stuff and I haven't shared absolutely everything I've learned. But understanding it is the most important thing and I want people who really want to better themselves, to understand this stuff and apply it to themselves for the better.

Also @her I appreciate you giving credit/acknowledgement because a lot of the time it feels like it's not worth sharing information at all

The ideal looksmaxing "stack" imo for a teen or young adult would be:

Berberine
Pterostilbene
PQQ energy (Pyrroloquinoline Quinone, ALCAR, methylB12, CoQ10)
Fisetin
Coleus Forskholli

... That's it for the supplements.

Then the most important part is everything else. Because literally everything matters.

Intermittent Fasting
Perfect Sleep
Low Carb
Getting enough omega3s, avoiding omega6s like sunflower oil etc, getting enough vitamin E.
Getting into autophagy from time to time but not too often. Understanding the role of endogenous anti-inflammatory cytokines and the role of the NRF2 and ULK1 pathways.
Understanding that microneedling is a form of autophagy selective to skin cells. (using derminator2 and not some shit device)
Exercising everyday you can. Resistance (weight training), HIIT, sauna bathing, cold showers, nofap.
Using Stinging Nettle Root and Diindolylmethane if you need to.
Understanding that acne can be treated at a cellular level and Retinoids are just treating a symptom and are better applied to skin which doesn't have dead cells or dysfunctional mitochondria and proteins.

And a lot lot more

@x30001 This is a shit-ton of great information; please know that your contributions are appreciated. As a 31-y/o incel male who has been seriously pursuing invasive looksmaxxing interventions for the past year (had custom midface + chin implant surgery back in March), I really appreciate it.

I have a few brief questions for you. Would you still recommend the stack you listed in your post I quoted above (berberine, pterostilbene, PQQ, fisetin, coleus f.) for a guy my age who is looking to do everything he can to not only looksmax, but to do so with the goal of looking younger? Or would you recommend additional supplements as well?

Also, I noticed that you said that retinoids are just treating a symptom and not taking care of acne at a cellular level. For those of us who don't have acne and are just applying tretinoin every night for anti-aging purposes, what's your opinion on using it? Is there anything else you'd recommend for skin/collagen-specific looksmaxing?

BTW, what's your opinion on running cycles of injectable Epithalon (which allegedly confers similar benefits to astragalus) and GHK-Cu 2-3x/year?

 

[oldcell]

Some people recently were asking me for skin routine, but here its summed pretty well, good thread

 

[Deleted member 616]

24,5

Lay count?

 

[Chadelite]

No problem. I only write this shit when I'm wired on ritalin and have some time at home where I cba to write this stuff. I looked into Shilajit and it's a great herb/adaptagen but doesn't help with anything that other herbs like astragalus do. PQQ+CoQ10(Ubiquitinol form)+ALCAR=methylb12 is enough to make sure mitochondrial density and functioning is top notch, (along with exercising, caloric restriction and everything else non supplement-wise). I write this stuff because I real feel it's the foundation of looksmaxing; and that can be proven objectively. Applying all the anti-aging techniques and practices helps out a lot more than looking for quick fixes and one offs, as it's never ending progression opposed to a lot of gimmicky "stop-start" stuff that's always been shared on here. I've been apprehensive to share this stuff and I haven't shared absolutely everything I've learned. But understanding it is the most important thing and I want people who really want to better themselves, to understand this stuff and apply it to themselves for the better.

Also @her I appreciate you giving credit/acknowledgement because a lot of the time it feels like it's not worth sharing information at all

The ideal looksmaxing "stack" imo for a teen or young adult would be:

Berberine
Pterostilbene
PQQ energy (Pyrroloquinoline Quinone, ALCAR, methylB12, CoQ10)
Fisetin
Coleus Forskholli

... That's it for the supplements.

Then the most important part is everything else. Because literally everything matters.

Intermittent Fasting
Perfect Sleep
Low Carb
Getting enough omega3s, avoiding omega6s like sunflower oil etc, getting enough vitamin E.
Getting into autophagy from time to time but not too often. Understanding the role of endogenous anti-inflammatory cytokines and the role of the NRF2 and ULK1 pathways.
Understanding that microneedling is a form of autophagy selective to skin cells. (using derminator2 and not some shit device)
Exercising everyday you can. Resistance (weight training), HIIT, sauna bathing, cold showers, nofap.
Using Stinging Nettle Root and Diindolylmethane if you need to.
Understanding that acne can be treated at a cellular level and Retinoids are just treating a symptom and are better applied to skin which doesn't have dead cells or dysfunctional mitochondria and proteins.

And a lot lot more

wow, im 16 and this info is like gold. thanks for posting on this site. Where can i buy items from the"looksmaxing" stack online?

 

[autistic_tendencies]

Vit c is a long time psl meme

 

[oldcell]

Vit c is a long time psl meme

No its not
I am using it almost every day and i debloated kinda , was much more bloated before

 

[Looksmaxer-van-NL]

When you have to put so much effort into this to result in getting a crumb of pussy that has been railed by chads better looking than you and a foid that lost all pair bonding ability... you know it's over. honk for looksmaxing

 

[2peasinapod]

When you have to put so much effort into this to result in getting a crumb of pussy that has been railed by chads better looking than you and a foid that lost all pair bonding ability... you know it's over. honk for looksmaxing

also, its not a meme that someone can do everything to improve and still be inferior to another who does nothing

genetics will always be the dominant factor, ive seen it with my own father who is constantly told how good he looks and his lifestyle is bottom 1%

i think socialising has extreme antiaging benefits personally, unfortunately you cant buy it in a capsule

 

[Looksmaxer-van-NL]

also, its not a meme that someone can do everything to improve and still be inferior to another who does nothing

genetics will always be the dominant factor, ive seen it with my own father who is constantly told how good he looks and his lifestyle is bottom 1%

i think socialising has extreme antiaging benefits personally, unfortunately you cant buy it in a capsule

Is there any research for this claim? I'm curious

 

[2peasinapod]

Is there any research for this claim? I'm curious

what research? you mean studies?

you realise what studies are? completely meaningless and at best agendas

 

[Looksmaxer-van-NL]

what research? you mean studies?

you realise what studies are? completely meaningless and at best agendas

If studies are meaningless and anekdotes from real life just as meaningless, I don't know what's true anymore.

 

[2peasinapod]

If studies are meaningless and anekdotes from real life just as meaningless, I don't know what's true anymore.

pretty much every study has gone full 180 at one point or another, i have a published study of my own and have been involved in others during my time at uni

real life is real life, how you feel is how you feel

listening to a journal over your own body...just normal 20th century things

what a brilliant method to convince desperate sheep to invest in your product/ protocal/ lifestyle

 

[Deleted member 3073]

View attachment 109640

Gigacope

 

[Deleted member 502]

This is a thread that a i wish it should be pinned.

You got to learn to spell first my nigga. Also thread is too generic and low effort for a pin. Try harder next time.

 

[Deleted member 2933]

You got to learn to spell first my nigga. Also thread is too generic and low effort for a pin. Try harder next time.

My spel is gey.

 

[chadpreetcel123]

1. be ethnic

2. excercise for 20 minutes a day minimum

that's how u look young even when ur old

 

[x30001]

wow, im 16 and this info is like gold. thanks for posting on this site. Where can i buy items from the"looksmaxing" stack online?

Taking these supplements without any rhyme or reason would work against you. You really need to figure it all out. Then you'll be flying. But I literally can't explain everything on here. It's not as simple as just "taking pills". Life just isn't like that. Everything needs to work together, in a very specific way, which you control and understand.

@x30001 This is a shit-ton of great information; please know that your contributions are appreciated. As a 31-y/o incel male who has been seriously pursuing invasive looksmaxxing interventions for the past year (had custom midface + chin implant surgery back in March), I really appreciate it.

I have a few brief questions for you. Would you still recommend the stack you listed in your post I quoted above (berberine, pterostilbene, PQQ, fisetin, coleus f.) for a guy my age who is looking to do everything he can to not only looksmax, but to do so with the goal of looking younger? Or would you recommend additional supplements as well?

Also, I noticed that you said that retinoids are just treating a symptom and not taking care of acne at a cellular level. For those of us who don't have acne and are just applying tretinoin every night for anti-aging purposes, what's your opinion on using it? Is there anything else you'd recommend for skin/collagen-specific looksmaxing?

BTW, what's your opinion on running cycles of injectable Epithalon (which allegedly confers similar benefits to astragalus) and GHK-Cu 2-3x/year?

Shared a shit ton of info to many people in PM so it's hard to keep writing here and ensuring I give useful info.

The groundworks are good sleep, regular exercise (weights, HIIT and sauna every day), diet, etc. The supplements on their own won't work in your favour if you're jeapordising other, more fundamental things and don't have specific routines in place.

I don't take Pterostilbene/Resveratrol at the moment.

Focusing on caloric restriction, aiming to upregulate hormesis, meditating, daily exercises and exposure to extreme temperatures and pressures consistently is what works best. Saunas, cold showers. Staying in the sauna long enough to cause mild hormetic stress on your body. It'll also activate heat shock protiens and FOXO3. Everything matters. And for your life, everything has to matter. I don't have everything figured out. There's more things I can be doing. But there's no way around not being consistent. Cop outs backfire. Work with time and don't disrespect/abuse it.

Epitalon is useful for correcting circadian rhythm; ie: making sure your cortisol and melatonin fire at the correct times. Good for fixing jet lag or a fucked up sleep cycle. It really doesn't do anything concerning telomere lengthening or some longevity solution like some people proclaim it to be.

GHK-cu is awesome but fucking expensive. I can't say anything bad about it. Ton of benefits and really no downsides. Helps the skin and hair. If you've got money, then using GHK-cu would be a good idea. You don't need to inject it. The foam/cream works well too. But the injection benefits the whole body.

My main supplement focus is PQQ and Berberine.

RE Retinoids:

I wouldn't advise using them on bad skin since your skin may have apoptotic cells and some dysfunctions which autophagy can take care of. Retin-A works only on the Alpha receptor in skin cells. Adapalene(and Tazorac) work selectively on the Beta and Gamma receptors. I advise people to use Retin-A and Adapalene on healthy skin. Tazorac is too strong and Adapalene is just all round better.

...

Oh I also mew because there's no reason not to. And the people who say it's cope can just keep saying what they want.

 

[oldcell]

I already reversed agepill but i dont really care..its like it is
Just dont go fat, keep hair thats it..and so some moderate sport...no big science

 

[x30001]

I already reversed agepill but i dont really care..its like it is
Just dont go fat, keep hair thats it..and so some moderate sport...no big science

Fat is inflammatory and skeletal muscle is pro-longevity. So yeah, get in shape (without steroids). An improved body composition will impact you in other positive ways aside from the aesthetics of it.

 

[Okiwaga]

After 40s you become a daddy and you can fuck girls even being obese
You can see it anywhere

 

[her]

Taking these supplements without any rhyme or reason would work against you. You really need to figure it all out. Then you'll be flying. But I literally can't explain everything on here. It's not as simple as just "taking pills". Life just isn't like that. Everything needs to work together, in a very specific way, which you control and understand.

Shared a shit ton of info to many people in PM so it's hard to keep writing here and ensuring I give useful info.

The groundworks are good sleep, regular exercise (weights, HIIT and sauna every day), diet, etc. The supplements on their own won't work in your favour if you're jeapordising other, more fundamental things and don't have specific routines in place.

I don't take Pterostilbene/Resveratrol at the moment.

Focusing on caloric restriction, aiming to upregulate hormesis, meditating, daily exercises and exposure to extreme temperatures and pressures consistently is what works best. Saunas, cold showers. Staying in the sauna long enough to cause mild hormetic stress on your body. It'll also activate heat shock protiens and FOXO3. Everything matters. And for your life, everything has to matter. I don't have everything figured out. There's more things I can be doing. But there's no way around not being consistent. Cop outs backfire. Work with time and don't disrespect/abuse it.

Epitalon is useful for correcting circadian rhythm; ie: making sure your cortisol and melatonin fire at the correct times. Good for fixing jet lag or a fucked up sleep cycle. It really doesn't do anything concerning telomere lengthening or some longevity solution like some people proclaim it to be.

GHK-cu is awesome but fucking expensive. I can't say anything bad about it. Ton of benefits and really no downsides. Helps the skin and hair. If you've got money, then using GHK-cu would be a good idea. You don't need to inject it. The foam/cream works well too. But the injection benefits the whole body.

My main supplement focus is PQQ and Berberine.

RE Retinoids:

I wouldn't advise using them on bad skin since your skin may have apoptotic cells and some dysfunctions which autophagy can take care of. Retin-A works only on the Alpha receptor in skin cells. Adapalene(and Tazorac) work selectively on the Beta and Gamma receptors. I advise people to use Retin-A and Adapalene on healthy skin. Tazorac is too strong and Adapalene is just all round better.

...

Oh I also mew because there's no reason not to. And the people who say it's cope can just keep saying what they want.

One question, how long should I fast for at my age (16)? 16 hours? And isn't it going to minimize my chances of growing taller? I know that at 16-17 most growth is done, but because my dad was a late bloomer, I am hoping that I can get a few more inches with perfect sleep, diet and daily exercise.

 

[x30001]

One question, how long should I fast for at my age (16)? 16 hours? And isn't it going to minimize my chances of growing taller? I know that at 16-17 most growth is completed, but because my dad was a late bloomer, I am hoping that I can get a few more inches with perfect sleep, diet and daily exercise.

I would leave out intermittent fasting until you're 18-19. Just eat healthy foods. Lots of wild caught fish, eggs, vegetables etc. It's probably better to eat more frequently when you're growing. But you still should manipulate insulin and your blood sugar levels to your advantage, and exercise a lot and very frequently. Fasting for autophagy probably isn't the best idea for someone who hasn't fully grown.

 

[Mansnob]

Looking 5 years younger is suicide fuel when you're below 20. But I know my life will get better soon.

 

[her]

I would leave out intermittent fasting until you're 18-19. Just eat healthy foods. Lots of wild caught fish, eggs, vegetables etc. It's probably better to eat more frequently when you're growing. But you still should manipulate insulin and your blood sugar levels to your advantage, and exercise a lot and very frequently. Fasting for autophagy probably isn't the best idea for someone who hasn't fully grown.

Oh, okay. It's because my skin and collagen is really bad right now, but I'll just stick to microneedling, retinoids, skincare, supplements etc then.

 

[x30001]

Oh, okay. It's because my skin and collagen is really bad right now, but I'll just stick to microneedling, retinoids, skincare, supplements etc then.

Don't do that shit until your skin becomes healthy. You likely have dead cells you need to get rid of, and autophagy will do that. Derminator2 is useful but never do it more than once a week.

 

[her]

Don't do that shit until your skin becomes healthy. You likely have dead cells you need to get rid of, and autophagy will do that. Derminator2 is useful but never do it more than once a week.

Fuck... So Derminator 2 once a week and healthy lifestyle until my skin becomes healthy? Do I need something else, like a cleanser and a moisturizer?

 

[x30001]

Fuck... So Derminator 2 once a week and healthy lifestyle until my skin becomes healthy? Do I need something else, like a cleanser and a moisturizer?

It's the low blood glucose, berberine, exercise, HIIT, saunas and PQQ which'll help your skin get healthy. That should be done indefinitely and then you should use the retinoids when your skin looks better, to make it look even better. Derminator2 once per week should be fine. Just don't put peppermint oil on your face after. The best aftercare for derminator2 would be ascorbic acid powder + water. If you can't do that then just use infadolan. Ascorbic acid+GHK-cu+RetinA+Adapalene+Snap8+Matrixyl3000+Pentrapeptide18+Agireline+VitaminE+JojobaOil+Infadolan is probably the best possible aftercare. But should only be used once your skin is actually good and healthy. If not, then just microneedle alone.

Fuck... So Derminator 2 once a week and healthy lifestyle until my skin becomes healthy? Do I need something else, like a cleanser and a moisturizer?

Should follow the Nibba skincare video advice with the cleanser+exfoliator+jergens but make sure you don't over exfoliate. Keeping a consistent skincare routine is important and his advice was actually legit.

 

[her]

It's the low blood glucose, berberine, exercise, HIIT, saunas and PQQ which'll help your skin get healthy. That should be done indefinitely and then you should use the retinoids when your skin looks better, to make it look even better. Derminator2 once per week should be fine. Just don't put peppermint oil on your face after. The best aftercare for derminator2 would be ascorbic acid powder + water. If you can't do that then just use infadolan. Ascorbic acid+GHK-cu+RetinA+Adapalene+Snap8+Matrixyl3000+Pentrapeptide18+Agireline+VitaminE+JojobaOil+Infadolan is probably the best possible aftercare. But should only be used once your skin is actually good and healthy. If not, then just microneedle alone.

Should follow the Nibba skincare video advice with the cleanser+exfoliator+jergens but make sure you don't over exfoliate. Keeping a consistent skincare routine is important and his advice was actually legit.

Yeah, supplementing PQQ energy and berberine without caloric restriction (just daily exercise, cold showers, saunas and keeping blood sugar level low) should be fine, right? I'll be doing that + Derminator 2 alone once a week, and when my skin gets better, I'll start following your skincare advice.

 

[x30001]

Yeah, supplementing PQQ energy and berberine without caloric restriction (just daily exercise, cold showers, saunas and keeping blood sugar level low) should be fine, right? I'll be doing that + Derminator 2 alone once a week, and when my skin gets better, I'll start following your skincare advice.

Get some sort of exercise in. In an energy depleted state. The Berberine will shut off AKT and use the AMPK fuel channel. Doing all sorts of exercise while taking PQQ is the best case scenario. Get a gym membership if you can and do weights and some HIIT. Being in a hot sauna for a long time can mimic some of the effects of mild exercise. But I really advise exercise and energy deprivation while on Berberine and PQQ.

Yeah, supplementing PQQ energy and berberine without caloric restriction (just daily exercise, cold showers, saunas and keeping blood sugar level low) should be fine, right? I'll be doing that + Derminator 2 alone once a week, and when my skin gets better, I'll start following your skincare advice.

Misread the first time. Yes that should be fine so long as you exercise a lot and frequently. Avoid carbs the best you can. You don't want your pancreas to secrete too much insulin. Berberine should take care of the GLUT4 processes through TBC1D1. Then when you eat some carbs (Low-GI), you'll be extremely insulin sensitive and your body won't secrete a lot of insulin, so it will likely be used to store more glucose in cells and to do it's own job in binding to insulin receptors, rather than transporting the glucose to adipose tissue due to the fact that your body doesn't sense you have an energy abundance (caloric energy abundance).

 

[her]

Get some sort of exercise in. In an energy depleted state. The Berberine will shut off AKT and use the AMPK fuel channel. Doing all sorts of exercise while taking PQQ is the best case scenario. Get a gym membership if you can and do weights and some HIIT. Being in a hot sauna for a long time can mimic some of the effects of mild exercise. But I really advise exercise and energy deprivation while on Berberine and PQQ.

Misread the first time. Yes that should be fine so long as you exercise a lot and frequently. Avoid carbs the best you can. You don't want your pancreas to secrete too much insulin. Berberine should take care of the GLUT4 processes through TBC1D1. Then when you eat some carbs (Low-GI), you'll be extremely insulin sensitive and your body won't secrete a lot of insulin, so it will likely be used to store more glucose in cells and to do it's own job in binding to insulin receptors, rather than transporting the glucose to adipose tissue due to the fact that your body doesn't sense you have an energy abundance (caloric energy abundance).

Thanks for your help, I appreciate it.

 

[x30001]

Thanks for your help, I appreciate it.

No prob