
max_frisch
The biggest risk is not taking any risk
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Small Methods - 2022 - Wang - PROTAC Degraders of Androgen Receptor%E2%80%90Integrated Dissolving Microneedles for Androgenetic.pdf
www.small-methods.com. PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration Ruxuan Wang, Tengjiang Zhong, Qiong Bian, Sai Zhang, Xiaolu Ma, Liming Li, Yihua Xu, Yueting Gu, Anran Yuan...

„PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration“
it shows two things
1) degrading the androgen receptor through dermal application in DP cells csn and does work and it works better thsn anything in mice who respond well to control(minoxidil)
2) the most important aspect in my opinion is thaz with their delivery mechanism of dissolving microneedles (this is a tiny needle in the microscopic real that cannot be seen with bare eyes. the needle is coated with the drug and the needle actually dissolves within a few minutes in the skin) they achieved non detectable drug concentration at alll times during treatment with multiple applications of the protac. that means it is indeed unlike pyrilutamide or topical finasteride a localized treatment.
kintor is developing a protac too and i am sure itnwill work but personally i am highly sensitive to anti androgens going systemic and they already said that a small amount goes systemic and that might be an issue