depends on diet, but 1-2 pills is WAY too low, minimum of atleast 2 pills with every meal
I'm only gonna be taking like 3mgs of erda, so is 2 pills per meal really needed? I lowk feel like that's high
Yeah that's what I thought to but I wasn't sure
no matter how many milligrams that's the standard, if u dont want it then cope ur way into kidney stones or dont take erda in the first place
standard is 1400-1600mg per meal, AND the meal is also low phosphate btw, they dont just take sevelamer and eat whatever they want
In the things that I read, normally when they track your phosphate levels and they notice the increase they start you off at 800 mgs and if that doesn't work then they move you up to 1600. This is normally at like 8-9 mgs to and after like 2 weeks so starting off at 1600 seems kinda high?
firstly ur right that they increase the dose at the 2 week mark but that is because its when erda hits its peak accumulation in the blood, ie peak fgfr1 inhibition window, what u dont understand is they have a strict rule of max 600-800mg phosphate daily, they eat like dogshit, + the difference in fgfr1 inhibition between 3-4mg vs 8mg isnt linear, + ur very likely to eat atleast 1g phosphate a day and that phosphate will likely be mostly bioavailable, as the total phosphate cap of 600-800mg in clinical cases doesnt account for differences in bioavailability between foods ( which is dumb but practical for patients), and so even at that point the patients eat rice, boiled chicken ( to strip some phosphorus off of it into the water) and so that is very different than if u eat cheeseburgers for lunch and dinner, even if ur diet hits only 800mg phosphorus, their diet is likely 30-40 percent bioavailable while urs could be 60-80
Ok thank you bhai!! I'll track the phosphate in my food, and take into consideration bioavailability and dose sevelamer accordingly
