SEX HORMONES QUESTION HIGH IQ MFS GTFIH

Endocrinology

Endocrinology

Iron
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Why is fertility not kept when running test cycles (250-500) with hcg and rFSH because all stimulis: (Leydig cells sertolli cells, High testicular serum testosterone) are met. I know it is kept for long periods of time but why not indefinitely? I heard it was because of pulsation but could you guys give more nuance?
 
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Jimcel
hCG + rFSH preserves fertility on 250-500mg testosterone cycles for long periods (often 1–2+ years) by restoring high intratesticular testosterone and supporting Sertoli cells.

It is not indefinite mainly because natural LH/FSH is pulsatile; continuous hCG causes gradual Leydig cell desensitization and less efficient signaling than natural pulses. Supraphysiological T and individual factors can also contribute to slow decline over time. Regular semen analysis is key.

Mark as solution by clicking the checkmark on right :feelsautistic:
hCG + rFSH preserves fertility on 250-500mg testosterone cycles for long periods (often 1–2+ years) by restoring high intratesticular testosterone and supporting Sertoli cells.

It is not indefinite mainly because natural LH/FSH is pulsatile; continuous hCG causes gradual Leydig cell desensitization and less efficient signaling than natural pulses. Supraphysiological T and individual factors can also contribute to slow decline over time. Regular semen analysis is key.

Mark as solution by clicking the checkmark on right :feelsautistic:
 
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Solution
Thanks G, I think I am going to run a cycle coming school year (september 2026- september 2027) and do semen analysis. I will keep you guys updated because there really arent many guys doin this regement because most are iqlets.
 
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hCG + rFSH preserves fertility on 250-500mg testosterone cycles for long periods (often 1–2+ years) by restoring high intratesticular testosterone and supporting Sertoli cells.

It is not indefinite mainly because natural LH/FSH is pulsatile; continuous hCG causes gradual Leydig cell desensitization and less efficient signaling than natural pulses. Supraphysiological T and individual factors can also contribute to slow decline over time. Regular semen analysis is key.

Mark as solution by clicking the checkmark on right :feelsautistic:W
wait if repeated stimulus is the reason it doesn't work, why cant we have an LH and FSH pump just like diabetes pumps work? this would grant you high test ( as long as it isn't enough to cause scaring of the testicular cells) and fertility.
 
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wait if repeated stimulus is the reason it doesn't work, why cant we have an LH and FSH pump just like diabetes pumps work? this would grant you high test ( as long as it isn't enough to cause scaring of the testicular cells) and fertility.
mainly for medical infertility—not high-dose exogenous testosterone use.
 
mainly for medical infertility—not high-dose exogenous testosterone use.
A lot of studies do point out the amount of testosterone we can tolerate before testicular atrophy accurs is quite high. So I think it could be viable even above trt dosages.
 

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