shitposting/random memes megathread (NSFW)

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Now, we resume normally.

 

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First, we review how simple SNP influences higher intelligence in East Asians.

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Search:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	65622	C=0.61295	T=0.38705
European	Sub	46144	C=0.67573	T=0.32427
African	Sub	5836	C=0.4231	T=0.5769
African Others	Sub	202	C=0.371	T=0.629
African American	Sub	5634	C=0.4249	T=0.5751
Asian	Sub	502	C=0.189	T=0.811
East Asian	Sub	402	C=0.169	T=0.831

 

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Dementia:

https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.052514

Result​

Of all participants, 2689(57.2%) carried the KIBRA rs17070145 TT polymorphism in intron 9, 1719(36.6%) carried CT polymorphism, and 292(6.2%) were homozygous CC carriers. The multi-adjusted odds ratio (95% CI) of dementia associated with C allele and genotype CC was 1.27 (1.02-1.58) and 1.78 (1.07-2.97), respectively. The association of KIBRA genotype CC with VaD was significantly, but not with AD. However, the association of genotype CC with VaD was reduced and became non-significant when further adjusting for cerebrovascular diseases.

Conclusion​

KIBRA rs17070145 genotype CC is associated with an increased likelihood of dementia among rural-dwelling Chinese older adults, driven largely by the association with VaD. Cerebrovascular disease may partly explain the association of genotype CC with VaD.

 

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Background​

In order to retrieve episodic past events, the missing information needs to be reconstructed using information stored in semantic memory. Failures in these reconstructive processes are expressed as false memories. KIBRA single nucleotide polymorphism (rs17070145) has been linked to episodic memory performance as well as an increased risk of Alzheimer’s disease and post-traumatic stress disorder (PTSD).

Methods​

Here, the role of KIBRA rs17070145 polymorphism (male and female CC vs. CT/TT carriers) in reconstructive episodic memory in the Deese-Roediger-McDermott (DRM) paradigm was investigated in N = 219 healthy individuals.

Discussion and conclusion​

Our findings suggest that the T-allele of KIBRA rs17070145 supports recollection based episodic memory retrieval and contributes to memory accuracy in a gender dependent manner. Findings are discussed in the context of the specific contribution of KIBRA related SNPs to reconstructive episodic memory and its implications for cognitive and emotional symptoms in dementia and PTSD.

 

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Background: Studies implicate single nucleotide polymorphism (SNP) rs17070145, a common T → C polymorphism on the KIBRA gene, in mediating differences in episodic memory. In healthy adults, T-allele carriers perform better than non-carriers on episodic memory measures. However, this association is reversed in adults with subjective memory complaints and populations vulnerable to memory deficits, a problem common in traumatic brain injury (TBI).

Methods: This study assessed associations between variation in the KIBRA gene and cognitive function in 129 adults with severe TBI. In addition to other executive functioning and functional/global outcomes, the Buschke Selective Reminding Test (SRT), Rey-Osterrieth Complex Figure Test and California Verbal Learning Test-II (CVLT-II) were administered 6 and 12 months post-injury.

Results: T-allele non-carriers performed better than carriers on multiple episodic memory measures. At 6 months, T-allele non-carriers performed better for delayed recall measures on the SRT. At 12 months, T-allele non-carriers performed better on multiple SRT measures and on List-B learning with CVLT-II. No associations occurred with executive function or global outcome measures.

Conclusion: These results suggest that rs17070145 T-allele effects are specific to episodic memory and support the hypothesis that associations between rs17070145 variation and memory are disparate between healthy and impaired populations.

A common T/C polymorphism within the ninth intron of the KIBRA gene (rs17070145) is thought to influence memory in humans. Since cognitive impairment, including memory, is a core feature of schizophrenia, we attempted to investigate this association in an independent sample of adolescent patients with early-onset schizophrenia (EOS; onset before age 18) probands and their healthy siblings. In a sample of 25 pairs of EOS proband-healthy full sibling, we sought to investigate the association of KIBRA with memory performance. Episodic memory was measured using immediate and delayed recall measures of the California Verbal Learning Test. EOS underperformed at immediate and delayed recall compared with siblings. In a combined analysis (TT vs. TC/CC) assuming a C dominant model of inheritance, we found a main effect of genotype where individuals with TT genotype outperformed non-TT-carriers at immediate and delayed recall. A genotype by group interaction showed that EOS with TT genotype did not show a memory advantage over siblings with TT or non-TT-carriers at immediate or delayed recall. Siblings with TT genotype showed enhanced immediate recall (not delayed recall) compared with non-TT-carriers. This study demonstrates an association between the KIBRA gene and episodic memory (immediate free recall) and suggests a differential effect of this genetic variant in EOS and healthy siblings.

 

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Now, we begin the next chapter.

"Dancing with Dullness"

 

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"Yeah...It's Math. I've been staring at those cool East Asian kids all day. Man...can't wait to get entry"

 

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"Honey...the admission process hasn't even begun. Chill out a bit first."

 

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"Mail's here. Let me see..."

 

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"Hello. I'm writing to inform you that we've sent your application back after reviewing the ethnicity selection. It is not a good fit for your people. Please contact the main academic directory for advice"

 

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"What they mean momma? I've been waiting for two weeks!"

 

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"Ethnicity? Anti-Nigguh Shid! I'm as capable as any albinoid!"

 

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"Remember what happened to your great-great grandfather honey."

 

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"Lemme see"

 

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"No son"

 

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"Please, we can still-"

 

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"Wait man. Placement? I can do placement. Got it right here Nigguh"

 

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"Where's Binet?"

 

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"Shid...Ok man"

 

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"12? What is the scale range son?"

 

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"High average is not Gifted."

(Background Laughter)

 

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"Damn....Wait Nigguh!"

On SAT, ACT, IQ, and other psychometric test correlations​

June 18, 2015by rcafdm

Although I touched on this topic briefly before, I seem to have forgotten some relevant plots and data and don’t feel like editing the last one, so this post is somewhat redundant…
Both the SAT and ACT are quite well correlated with IQ tests, so much so that you can make good guesses about someone’s IQ if you know their SAT/ACT score and vice versa.

 

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"A bit closer looker man, again"

"Does look pretty average Nigguh, till you realize I aint takin no pill daily"

 

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• Strattera is a non-stimulant medication that is used to treat ADHD in children and adults
• Unlike its stimulant counterparts, Strattera has no risk of abuse, misuse, or dependence.
• It will take 4 to 6 weeks to see the full effects of Strattera.
• Strattera can cause changes in mental health, increase suicidal thoughts and ideations. If you or someone you know experiences a worrisome change in behavior, please contact your doctor or seek emergency medical care.

 

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d. People with ADHD can be overactive with difficulty focusing. Being unable to control impulsive behaviors is another hallmark of ADHD. Children and adolescents with ADHD do not grow out of these behaviors without treatment. The symptoms can worsen over time, resulting in poor performance at school, work, low self-esteem, and unstable relationships.

 

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As the brain plans movements, the middle frontal gyrus is listening​

A brain-computer interface study reveals one brain region’s surprising role in planning movements exclusively in response to sounds.

As the brain plans movements, the middle frontal gyrus is listening

A brain-computer interface study reveals one brain region’s surprising role in planning movements exclusively in response to sounds.

www.brown.edu

 

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Rostral Middle Frontal Gyrus Thickness is Associated with Perceived Stress and Depressive Symptomatology

sitive affect at levels approaching significance after correcting for multiple testing (p=.0196). Follow-up simultaneous linear models revealed unique associations between bilateral RMFG cortical thickness and perceived stress when accounting for associations with positive affect and depressive symptoms. Heritability analyses showed that bilateral RMFG thickness, depressive symptoms, and perceived stress were all significantly heritable. After decomposing variability between the constructs, shared genetic and environmental contributions to variability were observed among self-reported sadness, positive affect, and perceived stress, as well as between right and left RMFG cortical thickness. Collectively, these findings suggest that increased RMFG cortical thickness is associated with depressive symptoms and linked to the subjective perception of stress. More broadly, these results suggest that stress perception and depressive symptoms share a common underlying biology. What remains unclear from this cross-sectional study is the origin of individual differences in RMFG cortical thickness: it is possible that stress exposure and/or the presence of depressive symptoms may give rise to differences in brain structure, or it may be the case that increased RMFG thickness contributes to stress-related cognitive biases that promote vulnerability to depression.

 

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The dominant (left) middle frontal gyrus plays a key role in the development of literacy, while the nondominant (right) middle frontal gyrus is responsible for numeracy.[5] Within the caudal portion of the middle frontal gyrus, at the intersection with the precentral gyrus, is the frontal eye fields (Brodmann area 8). The frontal eye fields control saccadic eye movements, rapid, conjugate eye movements that allow the central vision to scan numerous details within a scene or image.[6] The inferior frontal gyrus is the lowest gyrus of the frontal lobe, separated from the middle frontal gyrus by the inferior frontal sulcus. The caudal portion of the dominant (left) inferior frontal gyrus contains Broca's area (Brodmann area 44 and 45), which is responsible for speech production.

 

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Spic

 

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...

https://image.shutterstock.com/shutterstock/photos/25343998/display_1500/stock-vector-japanese-kanji-chinese-symbols-25343998.jpg

Spic

 

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Spic

 

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