LVCK
Aspiring SEMS (super evil mad scientist)
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- Dec 8, 2024
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I randomly discovered this compound while looking into direct stem cell therapies on growth plates, which I might turn into a separate post if I find it interesting enough.
Smoothened Agonist (SAG) stimulates Hedgehog (Hh) signaling, which promotes the activity and proliferation of stem cells in the growth plate, leading to increased bone length rather than premature closure like other remedies involving Hh. Rats and mice with locally implanted beads containing SAG or intra-articular injections increased the proliferation of epiphyseal skeletal stem cells in the growth plate, leading to lengthened limbs compared to controls.
So theoretically, SAG can be used as a topical / local injection to prevent growth plate closure and increase limb length in humans. However, the compound is only used for professional research sourced exclusively through authorized suppliers. If any of you actually has access to some kind of lab or a research facility, please send your orders to me after delivery so I can ascend, thanks in advance.
Sources:
pmc.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
Smoothened Agonist (SAG) stimulates Hedgehog (Hh) signaling, which promotes the activity and proliferation of stem cells in the growth plate, leading to increased bone length rather than premature closure like other remedies involving Hh. Rats and mice with locally implanted beads containing SAG or intra-articular injections increased the proliferation of epiphyseal skeletal stem cells in the growth plate, leading to lengthened limbs compared to controls.
So theoretically, SAG can be used as a topical / local injection to prevent growth plate closure and increase limb length in humans. However, the compound is only used for professional research sourced exclusively through authorized suppliers. If any of you actually has access to some kind of lab or a research facility, please send your orders to me after delivery so I can ascend, thanks in advance.
Sources:
Stimulation of skeletal stem cells in the growth plate promotes linear bone growth - PMC
Recently, skeletal stem cells were shown to be present in the epiphyseal growth plate (epiphyseal skeletal stem cells, epSSCs), but their function in connection with linear bone growth remains unknown. Here, we explore the possibility that ...
pmc.ncbi.nlm.nih.gov
Stimulation of skeletal stem cells in the growth plate promotes linear bone growth - PubMed
Recently, skeletal stem cells were shown to be present in the epiphyseal growth plate (epiphyseal skeletal stem cells, epSSCs), but their function in connection with linear bone growth remains unknown. Here, we explore the possibility that modulating the number of epSSCs can correct differences...
pubmed.ncbi.nlm.nih.gov
