SSRI Drugs Damage Bone By Increasing Adrenaline

D

Deleted member 20652

Fuchsia
Joined
Jul 11, 2022
Posts
10,928
Reputation
12,650
Written by Haidut

Over the last few years there have been a number of studies linking SSRI use with increased risk of fracture. Subsequent studies found this link to be definitively causal - i.e. SSRI drugs cause those fractures. However, the mechanism of action was officially ascribed to the medical establishment''s favorite category - "unknown". Now this study sheds more light on the mechanism and finds (unsurprisingly) that serotonin crease due to SSRI activates the sympathetic system and it is the increased adrenaline as a result that triggers bone loss. Administering an anti-adrenaline drug (a beta blocker) greatly diminished the bone loss. Aside from the fact that a much safer drug like clonidine could have been used, the study also failed to make the connection between serotonin and cortisol. Cortisol is a much bigger factor in bone and tissue loss then adrenaline and serotonin is perhaps the biggest promoter of cortisol synthesis through the upregulation of ACTH. Adrenaline also promotes cortisol synthesis as part of the sympathetic response. It just so happens that the drug clonidine lowers both adrenaline and cortisol, and as such should be a much better option than the dreaded beta blockers that can leave males impotent and women demented.
Finally, let's not forget Ray's writings about anti-serotonin drugs being very anabolic to the bone. So, instead of taking an SSRI and then trying to reverse its stimulated bone loss, it's much better to take an anti-serotonin drug as that will not only treat the depression but will also give you bones of steel as well :):

Long-Term Bone Loss Linked to Antidepressants May Be Ameliorated By Beta Blockers - MedicalResearch.com

"...When the fluoxetine (SSRI) treatment is extended, however, this beneficial effect is overwhelmed by an action on brain serotonin signaling. Fluoxetine exerts its mood controlling action by enhancing serotonin availability. Unfortunately, this increase ends up neutralizing the serotonin receptor most specifically regulating bone biology. This translates into an increase in sympathetic tone, which in turn impairs bone formation and enhances bone resorption. The net result is bone loss, which is consistent with the increased number of fractures observed in the large clinical studies that analyzed long-term users of SSRIs. Blocking the negative effect of this increase in sympathetic tone on bone cells with a low dose of a commonly used beta-blocker (propranolol) can protect bone mass in mice after a long-term treatment with fluoxetine. This, however, does not appear to alter its effect on behavior."


//Thomas DOM
 
  • +1
Reactions: Deleted member 22124 and Deleted member 23558
New era of bonesmashing is on the horizon
 
  • JFL
Reactions: Danish_Retard, Deleted member 14392, MoggerGaston and 2 others
Clonidine is amazing for sleep as well. Lots of salt before bad and sugar w saturated fat helps greatly alleviate the cortisol spike at 4 am allowing great restful sleep
 
  • Love it
Reactions: Sub0 and Deleted member 20652
Based, adrenaline massively increases neuro plasticity which is often lacking in depressed people.
 

Similar threads

pslgod69
Replies
23
Views
324
pslgod69
pslgod69
Sachlichkeit
Replies
8
Views
712
Faker78611
Faker78611
wiws
Replies
13
Views
676
hej1377
H
coreym1374
Replies
14
Views
269
coreym1374
coreym1374
itoshi rin
Replies
10
Views
716
SQL2VD
SQL2VD

Users who are viewing this thread

Back
Top