Stacking Pyrilutamide with RU58841?

[Deleted member 2268]

Thoughts on doing this when blasting AAS? Can I get the pyril powder make solution and apply it after RU?

 

[Deleted member 19798]

Wtf are these alien compounds. Only thing I recognize is RU

 

[Realism]

No, pick one. They work similarly except pyrilutamide has a higher binding affinity and can compete with both DHT and testosterone. On paper, less systemic absorption as well.

 

[Deleted member 2268]

No, pick one. They work similarly except pyrilutamide has a higher binding affinity and can compete with both DHT and testosterone. On paper, less systemic absorption as well.

Why not stack?

 

[Realism]

Why not stack?

Because they have a similar mechanism of action. Say you wanna make a toast, it would be like putting toast bread on your toast bread.

 

[Deleted member 19944]

No, pick one. They work similarly except pyrilutamide has a higher binding affinity and can compete with both DHT and testosterone. On paper, less systemic absorption as well.

so the point of ru and pyril is supposed to stop the binding of both test and dht. does it also lower test?

 

[Realism]

so the point of ru and pyril is supposed to stop the binding of both test and dht. does it also lower test?

Yes, the idea is the block the Test/DHT to bind to the androgen receptors in the hair follicle to prevent miniaturization of the hair follicle.
However, I've been reading some comments on the tressless subreddit, I can't manage to find it right now unfortunately, that Pyrilutamide might have a slightly lower binding affinity than DHT, opposite of what has been reported.

So the best course of action will probably always be to take a multi approach, reducing DHT systemically with fin or DUT, and then a scalp specific targeted approach with either RU or Pyri.

They do not lower testosterone no as far as I'm aware.

 

[Deleted member 19944]

Yes, the idea is the block the Test/DHT to bind to the androgen receptors in the hair follicle to prevent miniaturization of the hair follicle.
However, I've been reading some comments on the tressless subreddit, I can't manage to find it right now unfortunately, that Pyrilutamide might have a slightly lower binding affinity than DHT, opposite of what has been reported.

So the best course of action will probably always be to take a multi approach, reducing DHT systemically with fin or DUT, and then a scalp specific targeted approach with either RU or Pyri.

They do not lower testosterone no as far as I'm aware.

what about taking minoxidil alongside ru or pyri. which helps blood flow go up rather than only blocking dht

 

[Realism]

what about taking minoxidil alongside ru or pyri. which helps blood flow go up rather than only blocking dht

Of course, minoxidil works with a complete separate mechanism of action though.

If you're prone to MPB, you don't escape finasteride or dutasteride as of now.

You can do all of these things or some of them, depending on the severity of your AGA:
1)Finasteride or dutasteride.
2)Pyrilutamide or ru58841.
3)Topical and/or oral minoxidil.
4)Microneedling.

I'll just refer to this guy who was norwood 7.
He based his treatment protocol on this paper.

He had absolute remarkable results (monthly comparison):

 

[Deleted member 19944]

Of course, minoxidil works with a complete separate mechanism of action though.

If you're prone to MPB, you don't escape finasteride or dutasteride as of now.

You can do all of these things or some of them, depending on the severity of your AGA:
1)Finasteride or dutasteride.
2)Pyrilutamide or ru58841.
3)Topical and/or oral minoxidil.
4)Microneedling.

I'll just refer to this guy who was norwood 7.
He based his treatment protocol on this paper.

He had absolute remarkable results (monthly comparison):
View attachment 2028864

should you use minoxidil and pyr/ru evrywhere on the head/ even if you're not nw7

 

[Realism]

should you use minoxidil and pyr/ru evrywhere on the head/ even if you're not nw7

If you got AGA, the earlier you intervent the better chance of recovery of course.

 

[Deleted member 19944]

If you got AGA, the earlier you intervent the better chance of recovery of course.

right but will it be good to use it all over the head evne though that's a ton of solution on the head added

 

[max_frisch]

right but will it be good to use it all over the head evne though that's a ton of solution on the head added

yes i think so.
you need to adjust the dosis then though

 

[Realism]

right but will it be good to use it all over the head evne though that's a ton of solution on the head added

Just on the areas sensitive to DHT, should be 1ML max.
Basically top of your entire head and crown

 

[Deleted member 19944]

Just on the areas sensitive to DHT, should be 1ML max.
Basically top of your entire head and crown

what if more than 1ml.
you recommend tapping with the dropper?

 

[Deleted member 19944]

Of course, minoxidil works with a complete separate mechanism of action though.

If you're prone to MPB, you don't escape finasteride or dutasteride as of now.

You can do all of these things or some of them, depending on the severity of your AGA:
1)Finasteride or dutasteride.
2)Pyrilutamide or ru58841.
3)Topical and/or oral minoxidil.
4)Microneedling.

I'll just refer to this guy who was norwood 7.
He based his treatment protocol on this paper.

He had absolute remarkable results (monthly comparison):
View attachment 2028864

i hear somewhere minox negates ru mechanism.
what does ru actually do tho? stops anything from binding to the follicle? but how lol

 

[Realism]

i hear somewhere minox negates ru mechanism.
what does ru actually do tho? stops anything from binding to the follicle? but how lol

It stops DHT binding to the androgen receptors in hair follicles, in theory. Somewhat arguable though as the binding affinity have been discussed.
But in the real world you definitely do see substantial results from people using it, so it is working to a degree.

 

[Deleted member 19944]

It stops DHT binding to the androgen receptors in hair follicles, in theory. Somewhat arguable though as the binding affinity have been discussed.
But in the real world you definitely do see substantial results from people using it, so it is working to a degree.

But ru and minox don’t cancel each other out? I heard if they’re thrown in together for a while they can if mixed in one solution

 

[Realism]

But ru and minox don’t cancel each other out? I heard if they’re thrown in together for a while they can if mixed in one solution

I haven't heard about that for RU, there's concerns for that with Pyri indeed, that water degrades it.
Doesn't matter too much, like, if you use pyri, just put minox on and wait 30 mins or so and then put on pyri.