Sachlichkeit
Iron
- Joined
- May 11, 2025
- Posts
- 161
- Reputation
- 105
In men, there is no "hard cap" on the growth of tissue in the same way there is for bones. There are no growth plates for muscle or tissue.
Growth and maintenance of nerve dense tissue (in specifically men) is limited by 3 genetic pathways ranked best to least
1. Androgen sensitivity
2. IGF-1 (Growth hormone)
3. FGF - fibroblast growth factor (blueprints for growth of blood vessels and muscle)
Nerve dense tissue growth ceases because of androgen tolerance and the gradual decrease in IGF-1 and hormonal stabilization. I (think) your body becomes more tolerant of IGF-1 and because you are old, your genes tell your body to use IGF-1 to maintain tissue rather than create new tissue.
K so,
IGF-1 upregulates FGF while simultaneously targeting IGF-1 pathway.
IGF-1 DES
a UGL derivative of HGH, is 20-30x more potent than HGH but has a short half life is localized instead of systemic. it should be injected intramuscular but hitting muscles with a bunch of nerve endings is painful and probably dangerous. Subcutaneous injection, near the nerve dense tissue you want to grow postworkout.
Injection site should be an area with lots of fat, less nerves, veins, things you can damage.
DHT, localized.
This is the primary male hormone driving growth of erogenous nerve dense tissue, testosterone is less important than DHT when it comes to secondary sexual characteristics. Systemic DHT has very little effect on the type of growth wanted so you should directly apply DHT gel (brand name Andractim,) for transdermal administration. About 10-20% of DHT applied will go systemic. DHT makes you go bald, drives hair growth in retarded places, enlarges prostate (I think, I can't remember.) Either topical anti androgens or systemic DHT blockers (5 alpha reductase enzyme inhibitor oral dutasteride,) is something you should look into if you are worried.
Androgen sensitivity upregulation
Because adults are less sensitive to androgens, we need to artificially re-sensitize them.
1. Physical exercise
2. SARMS
3. HDAC Inhibitors sodium Butyrate and Trichostatin A
work out. HIIT specifically. Mentzer's high intensity interval training is the most effective form for androgen sensitivity
Idk anything about sarms but we only want them for localized androgen sensitivity so see if there are UGL "sarm gels" or something. You will probably have to use them systemically though
HDAC inhibitors loosen the chromatin around genes, allowing for more genetic expression. HDAC inhibitors exaggerate the effects of genetic pathways on the human body. Hypothetically, if you loosened the chromatin around your genes and pinned estrogen it would feminize you (more than) somebody on HRT. We are using them for androgen expression so pair them with roids, sarms, DHT gel, etc.
HDACi PCT. This is light gene therapy so it comes with genetic risks. Using Methyl donors (supplements SAMe, Methylated B12, & Folate,) re-tighten the chromatin.
Mechanical tension and hormonal balance
Both test and DHT play integral parts in maintaining sexual function in adults and neither should be ignored. If you inhibit one of them, combined with "lack of exercise," nerve dense tissue will atrophy, becoming smaller. Mechanical tension is needed to stimulate growth in any part of the body including erogenous zones. Somebody that uses their legs more during their growth window (puberty,) will grow taller than somebody who doesn't. Obv genetics and allat but genes are oftentimes overstated and actually working out is understated.
I have to go so im ending thread. Keep hormonal balance and apply mechanical tension to the tissue you want to stimulate growth in.
Growth and maintenance of nerve dense tissue (in specifically men) is limited by 3 genetic pathways ranked best to least
1. Androgen sensitivity
2. IGF-1 (Growth hormone)
3. FGF - fibroblast growth factor (blueprints for growth of blood vessels and muscle)
Nerve dense tissue growth ceases because of androgen tolerance and the gradual decrease in IGF-1 and hormonal stabilization. I (think) your body becomes more tolerant of IGF-1 and because you are old, your genes tell your body to use IGF-1 to maintain tissue rather than create new tissue.
K so,
IGF-1 upregulates FGF while simultaneously targeting IGF-1 pathway.
IGF-1 DES
a UGL derivative of HGH, is 20-30x more potent than HGH but has a short half life is localized instead of systemic. it should be injected intramuscular but hitting muscles with a bunch of nerve endings is painful and probably dangerous. Subcutaneous injection, near the nerve dense tissue you want to grow postworkout.
Injection site should be an area with lots of fat, less nerves, veins, things you can damage.
DHT, localized.
This is the primary male hormone driving growth of erogenous nerve dense tissue, testosterone is less important than DHT when it comes to secondary sexual characteristics. Systemic DHT has very little effect on the type of growth wanted so you should directly apply DHT gel (brand name Andractim,) for transdermal administration. About 10-20% of DHT applied will go systemic. DHT makes you go bald, drives hair growth in retarded places, enlarges prostate (I think, I can't remember.) Either topical anti androgens or systemic DHT blockers (5 alpha reductase enzyme inhibitor oral dutasteride,) is something you should look into if you are worried.
Androgen sensitivity upregulation
Because adults are less sensitive to androgens, we need to artificially re-sensitize them.
1. Physical exercise
2. SARMS
3. HDAC Inhibitors sodium Butyrate and Trichostatin A
work out. HIIT specifically. Mentzer's high intensity interval training is the most effective form for androgen sensitivity
Idk anything about sarms but we only want them for localized androgen sensitivity so see if there are UGL "sarm gels" or something. You will probably have to use them systemically though
HDAC inhibitors loosen the chromatin around genes, allowing for more genetic expression. HDAC inhibitors exaggerate the effects of genetic pathways on the human body. Hypothetically, if you loosened the chromatin around your genes and pinned estrogen it would feminize you (more than) somebody on HRT. We are using them for androgen expression so pair them with roids, sarms, DHT gel, etc.
HDACi PCT. This is light gene therapy so it comes with genetic risks. Using Methyl donors (supplements SAMe, Methylated B12, & Folate,) re-tighten the chromatin.
Mechanical tension and hormonal balance
Both test and DHT play integral parts in maintaining sexual function in adults and neither should be ignored. If you inhibit one of them, combined with "lack of exercise," nerve dense tissue will atrophy, becoming smaller. Mechanical tension is needed to stimulate growth in any part of the body including erogenous zones. Somebody that uses their legs more during their growth window (puberty,) will grow taller than somebody who doesn't. Obv genetics and allat but genes are oftentimes overstated and actually working out is understated.
I have to go so im ending thread. Keep hormonal balance and apply mechanical tension to the tissue you want to stimulate growth in.
