Stopping & Reversing Aging

[Alexanderr]

Reversal of biological clock restores vision in old mice

‘Reprogramming’ approach seems to make old cells young again.

www.nature.com

Researchers have restored vision in old mice and in mice with damaged retinal nerves by resetting some of the thousands of chemical marks that accumulate on DNA as cells age. The work, published on 2 December in Nature1, suggests a new approach to reversing age-related decline, by reprogramming some cells to a ‘younger’ state in which they are better able to repair or replace damaged tissue.

How To Slow Down The Aging Process | Goop

At a young age, David Sinclair learned that everybody and everything will one day die. This sober fact kick-started a fascination with biology—and now, as a professor of genetics at Harvard, Sinclair is advancing our understanding of how we age and how to slow—or even reverse—aging.

goop.com

There are two main types of information in our body’s cells: The first is genetic information, and the second is epigenetic information. Epigenetics are chemical changes that occur on our genome that dictate when genes are turned on and off. We know that the environment—how we’ve lived our lives, if we’ve been fasting or exercising, and so on—slows down or accelerates the ticking of that epigenetic clock.

TLDR: In the future, we might be able to not only stop aging but reverse it as well.

Thoughts?

 

[AlwaysHaveQuestions]

i will be a subhuman forever

 

[Deleted member 4430]

reminder OP is 17 YO and even now he is afraid of aging

 

[Alexanderr]

reminder OP is 17 YO and even now he is afraid of aging

Stop making retarded conclusions, the topic is interesting regardless of your age.

 

[wannabenormie]

Probably won't be available in our lifetimes.
There was a very small chance for the opposite before covid but it is probably harder for scientists to get money for that kind of research now.

 

[lepo2317]

Same with reversing balding, reversing blindness in blind people etc. I heard about that shit 10+ years ago and we still have nothing close. Maybe in 300 years.

 

[Deleted member 9699]

brb locking myself in an ice capsule until the world develops tech to reverse aging so i can live forever

 

[quakociaptockh]

Those who haven't yet: jump on C60.

The properties of C60 were discovered by accident. First, they gave it to rats to see if they die. They didn't. Then they gave the same rodents a lethal dose of CCl4. The suckers didn't die. That's how it was discovered that C60 prevents cell damage.

Technically it's an antioxidant, so the same action as vitamins C and E, which are called the vitamins of youth. Except it's 1000 times stronger and more durable. Vitamins stop to work once you stop taking them. C60 stays in the cell for very long.

 

[datboijj]

I'm already gonna be negli in a few months

 

[Deleted member 439]

encourage you all to watch this video

The message I have taken from this is how complex supplements are, and how little we know about them. I am going to stay away from all supplements for the time being. Just know these things are extremely complex its not as simple as taking a few supplements after reading looksmax threads.

despite this anti-aging looks like a super interesting and legit looksmax, and we are seeing lots of new legit methods

 

[grimy]

Those who haven't yet: jump on C60.

The properties of C60 were discovered by accident. First, they gave it to rats to see if they die. They didn't. Then they gave the same rodents a lethal dose of CCl4. The suckers didn't die. That's how it was discovered that C60 prevents cell damage.

Technically it's an antioxidant, so the same action as vitamins C and E, which are called the vitamins of youth. Except it's 1000 times stronger and more durable. Vitamins stop to work once you stop taking them. C60 stays in the cell for very long.

I haven't done my research, but in general why aren't these things pushed to the masses? Surely it'd be a multi billion dollar industry. Also if you're using it, where do you purchase it and how do you ensure it's purity?

 

[eduardkoopman]

slowing down aging.
Is a a better tittle.

 

[quakociaptockh]

I haven't done my research, but in general why aren't these things pushed to the masses? Surely it'd be a multi billion dollar industry. Also if you're using it, where do you purchase it and how do you ensure it's purity?

The pharmacy industry stalled because of too much regulation. In order to push a new drug to a market, you have to pay 1^9$. Big pharma will not push a new drug that would render their old drugs obsolete. Small labs don't have enough money, all they can hope is to sell the patent to some big player.

Big pharma is part of the "evil corporation" territory, they are actually the problem of this world. We see it now as I'm typing. The covid hysteria is their marketing campaign to force an unproven experimental vaccine on us, which will not be available on free market despite its production costs in the range of a fraction of a penny.

We are the real researchers of today. This very forum is where medical progress happens.

 

[quakociaptockh]

Bought in on OwnDoc. The shit is pure if it's almost deep red, not brown.

 

[LastHopeForNorman]

Those who haven't yet: jump on C60.

The properties of C60 were discovered by accident. First, they gave it to rats to see if they die. They didn't. Then they gave the same rodents a lethal dose of CCl4. The suckers didn't die. That's how it was discovered that C60 prevents cell damage.

Technically it's an antioxidant, so the same action as vitamins C and E, which are called the vitamins of youth. Except it's 1000 times stronger and more durable. Vitamins stop to work once you stop taking them. C60 stays in the cell for very long.

can you tell more about it? How your body reacted to it?
seems very intresting

 

[quakociaptockh]

can you tell more about it? How your body reacted to it?
seems very intresting

Nothing happened. But when we meet in 10 years (unless I rope) I will look 5 yrs younger than you.

By the way I look very young, which I can attribute to taking EGCg since the age of 27. I am 39 yrs old, but nobody in the world give me more than 35, and the usual guess is 33. If I manage to youngmax, get my hair back, fix teeth, leanmax and grow some beard, I could pass as 30.

This is another lookspill: nobody cares how old you are, only how old you look. I can still pull foids under 30, sometimes as young as 24. This works only irl, because on Tinder I give my true age and I possibly get filtered away.

Covid fucked everything, but my life was almost getting better just before the pandemic, damnit.

 

[LastHopeForNorman]

Nothing happened. But when we meet in 10 years (unless I rope) I will look 5 yrs younger than you.

By the way I look very young, which I can attribute to taking EGCg since the age of 27. I am 39 yrs old, but nobody in the world give me more than 35, and the usual guess is 33. If I manage to youngmax, get my hair back, fix teeth, leanmax and grow some beard, I could pass as 30.

This is another lookspill: nobody cares how old you are, only how old you look. I can still pull foids under 30, sometimes as young as 24. This works only irl, because on Tinder I give my true age and I possibly get filtered away.

Covid fucked everything, but my life was almost getting better just before the pandemic, damnit.

ok thx

 

[ifyouwannabemylover]

if he was on the joe cuckan show he's probably full of crap

 

[grimy]

The pharmacy industry stalled because of too much regulation. In order to push a new drug to a market, you have to pay 1^9$. Big pharma will not push a new drug that would render their old drugs obsolete. Small labs don't have enough money, all they can hope is to sell the patent to some big player.

Big pharma is part of the "evil corporation" territory, they are actually the problem of this world. We see it now as I'm typing. The covid hysteria is their marketing campaign to force an unproven experimental vaccine on us, which will not be available on free market despite its production costs in the range of a fraction of a penny.

We are the real researchers of today. This very forum is where medical progress happens.

I don’t agree with your last sentence. This forum is where a lot of shitposting happens, so it’s cool to see some posts like yours with substance.

 

[AsGoodAsItGets]

EGCg

4hb?

 

[Deleted member 4106]

Amazing

 

[Seth Walsh]

If only my idea for an anti-aging/longevity section wasn’t turned down in 2019

So much more popular now and I do have a lot of new info that I came across when I left x30001 which I’ve been experimenting with for anecdotal reference in the future.

Hopefully in like 2 months I’ll drop a mega thread with tons of new info backed by studies and anecdotal input too.

NNMT inhibitors (5-amino-1-methylquinolinium looks extremely promising) and might make Sinclair’s NMN approach useless if it does what it claims.

There’s a lot of things I haven’t talked about because I’m reserving the mindset that nothing is worth discussing until there’s little doubt that a compound/supplement regime isn’t a gimmick. I’ve still been researching anti-aging/longevity since, but need to see impressive outcomes from human trials, not rats.

Great thread OP, thanks for keeping the interest alive

 

[noodlelover]

If only my idea for an anti-aging/longevity section wasn’t turned down in 2019

So much more popular now and I do have a lot of new info that I came across when I left x30001 which I’ve been experimenting with for anecdotal reference in the future.

Hopefully in like 2 months I’ll drop a mega thread with tons of new info backed by studies and anecdotal input too.

NNMT inhibitors (5-amino-1-methylquinolinium looks extremely promising) and might make Sinclair’s NMN approach useless if it does what it claims.

There’s a lot of things I haven’t talked about because I’m reserving the mindset that nothing is worth discussing until there’s little doubt that a compound/supplement regime isn’t a gimmick. I’ve still been researching anti-aging/longevity since, but need to see impressive outcomes from human trials, not rats.

Great thread OP, thanks for keeping the interest alive

What's your opinion on ECGC?

 

[Deleted member 15827]

Same with reversing balding, reversing blindness in blind people etc. I heard about that shit 10+ years ago and we still have nothing close. Maybe in 300 years.

I thought fin and minox reversed it

 

[Seth Walsh]

What's your opinion on ECGC?

Not the best for anti aging tbh. Decent anti-oxidant. JBSNF-000088 looks pretty interesting for anti-aging, along with things like 5A1MQ which I'm trialling very soon.

 

[noodlelover]

Not the best for anti aging tbh. Decent anti-oxidant. JBSNF-000088 looks pretty interesting for anti-aging, along with things like 5A1MQ which I'm trialling very soon.

Doesn't oxidative damage age you? I know it's not the only cause of aging, but I think it's one cause. I also know you need a mix of anti-oxidants, otherwise they're harmful but I eat lots of veggies as well.

Those other two sound interesting. I just ordered a NMN Resveratrol mix, so I assume it's basically the same thing, boosting NADs. I know there's some back and forth controversy on Resveratrol, where Sinclair claims he did unpublished research that shows it still works even those some research on it was discredited. Not sure if I'll get resveratrol again in the future.

 

[Seth Walsh]

Doesn't oxidative damage age you? I know it's not the only cause of aging, but I think it's one cause. I also know you need a mix of anti-oxidants, otherwise they're harmful but I eat lots of veggies as well.

Those other two sound interesting. I just ordered a NMN Resveratrol mix, so I assume it's basically the same thing, boosting NADs. I know there's some back and forth controversy on Resveratrol, where Sinclair claims he did unpublished research that shows it still works even those some research on it was discredited. Not sure if I'll get resveratrol again in the future.

Yeah I don't believe in resveratrol anymore tbh. 5A1MQ is like NMN on steroids.. inhibits NNMT so that you keep more NAD.

I'm not a fan of consuming too much antioxidants though. Dipping into autophagy semi-regularly will make your body produce enough anti-oxidants and shutting off mTOR / activating AMPK helps with adaptations that aid in longevity which can't be achieved by taking antioxidants alone. I don't see much need for EGCG anymore tbh. It doesn't really fit in anywhere.

 

[noodlelover]

Yeah I don't believe in resveratrol anymore tbh. 5A1MQ is like NMN on steroids.. inhibits NNMT so that you keep more NAD. View attachment 1557804
I'm not a fan of consuming too much antioxidants though. Dipping into autophagy semi-regularly will make your body produce enough anti-oxidants

Our bodies produce some kinds of antioxidants but we need to get other kinds through vegetables. I know we need a variety of different types because if we have too much of any one kind they bind to each other and explode causing more damage than they fix. I am going to stop taking resveratrol after I finish this NMN resveratrol mix I paid for.

I do take a Vitamin C supplement, but not for it's antioxidant properties, just because it's so useful for collagen, the immune and so many other things in the body, and there's no danger of taking 1000mg a day because if your body doesn't need as much that day the liver filters out the rest, and 1000mg is not a big stress on the liver. Plus it's low cost.

and shutting off mTOR / activating AMPK helps with adaptations that aid in longevity which can't be achieved by taking antioxidants alone. I don't see much need for EGCG anymore tbh. It doesn't really fit in anywhere.

I wouldn't want to inhibit anything that my body chooses to produce. If the body is choosing to produce it, it must have evolved for a purpose.

The only benefit I see to the body, is giving it more resources to use in the right quantities and balanced in the right ways. After I'm done with with the NMN I purchased, I'm probably going to switch to Niacin so that my body can more properly regulate how much NMN is produced.

 

[horizontallytall]

The pharmacy industry stalled because of too much regulation. In order to push a new drug to a market, you have to pay 1^9$. Big pharma will not push a new drug that would render their old drugs obsolete. Small labs don't have enough money, all they can hope is to sell the patent to some big player.

Big pharma is part of the "evil corporation" territory, they are actually the problem of this world. We see it now as I'm typing. The covid hysteria is their marketing campaign to force an unproven experimental vaccine on us, which will not be available on free market despite its production costs in the range of a fraction of a penny.

We are the real researchers of today. This very forum is where medical progress happens.

But i did not cost anything