Studies: Taking antihistamine with accutane provides better results and reduces the side-effects

[a.i.ngel]

2 Studies confirming this:

Efficacy of Isotretinoin and Antihistamine versus Isotretinoin Alone in the Treatment of Moderate to Severe Acne: A Randomised Control Trial - PubMed

Background Acne vulgaris has considerable impact on physical and psychological health. Isotretinoin is considered most effective drug available for acne therapy but with limited acceptance because of its adverse effects. Antihistamine inhibits inflammatory mediators, Propionibacterium acne...

pubmed.ncbi.nlm.nih.gov

Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study - PubMed

This results provide early evidence that antihistamine has a synergic effect with minimizing the side-effect of isotretinoin, and may be used as an adjuvant treatment of moderate acne.

pubmed.ncbi.nlm.nih.gov

Personally have been taking this combo for 5 months and have nice results with mild side-effects (compared to some people on the internet) - pretty much only dry mouth/skin and lower back pain from time to time.

So I think it's a good idea to take it.

PS: Some people say antihistamine makes you a bit more sleepy (personally haven't noticed that), so you might take it just before bed - no need to take it with food what is the case for accutane.

 

[Lorsss]

then why is acne treated with antybiotics too?
anthistamines suppress immune system which kills bacteria

 

[a.i.ngel]

then why is acne treated with antybiotics too?

No idea. They never helped me and even made things worse after stopping them.

 

[Hero of the Imperium]

Use non drowsy

Some Alzheimer's drugs increase acetylcholine, which sedating antihistamines suppress. Long term sedating antihistamine use is correlated with dementia.

 

[balding17yomanletcel]

ion remember asking