Tadalafil 20mg pills vs raw powder

[AlexRz]

I’m wondering whether I should buy 20 mg tadalafil tablets in bulk from China or purchase raw tadalafil powder and make my own solution.

I also debating if I should take 2.5 mg per day, which obviously isn’t possible with 20 mg tablets, or 5 mg per day, which might be possible if I split the tablets into quarters.

Making my own solution seems appealing because it would allow me to adjust the dosage more easily. However, I’m having a hard time finding reliable information about suitable formulations and their bioavailability.

Since tadalafil is lipophilic, I was wondering whether it requires a surfactant or some other solubilizing agent, or whether a simple glycerin + PG solution would actually allow it to be adequately absorbed and remain effective.

Has anyone here had experience with this or knows of any good resources on the subject?

 

[Salouga]

I personally use 5mg tablets i bought from telegram but in theory according to this . A glycerin/PG mix alone won't cut it for adequate bioavailability. Try using PEG 400 as your base solvent (it has the highest solubility for tadalafil) and add a surfactant like Cremophor RH 40 at around 5-10% of your total volume.

 

[AlexRz]

I personally use 5mg tablets i bought from telegram but in theory according to this . A glycerin/PG mix alone won't cut it for adequate bioavailability. Try using PEG 400 as your base solvent (it has the highest solubility for tadalafil) and add a surfactant like Cremophor RH 40 at around 5-10% of your total volume.

Thanks for the info. I guess you're right, maybe glycerin + PG would only be a suspension solution and I'm not sure if that's bioavailable or not. The issue with those other ingredients is that they're not super cost effective or easy to source I guess. How much do you pay for your 5mg tablets if you don't mind me asking?

 

[Salouga]

Thanks for the info. I guess you're right, maybe glycerin + PG would only be a suspension solution and I'm not sure if that's bioavailable or not. The issue with those other ingredients is that they're not super cost effective or easy to source I guess. How much do you pay for your 5mg tablets if you don't mind me asking?

I pay 6.5c per mg 32.5c per tablet i have no idea if i am getting scammed on the price or not

 

[AlexRz]

I pay 6.5c per mg 32.5c per tablet i have no idea if i am getting scammed on the price or not

That’s definitely a higher price point, but I’m guessing it’s because you’re buying smaller quantities? For example the 20mg pills I could buy are 0.15$ per pill, but there’s a fixed 50$ shipping fee meaning I need to order a lot more than I need for the shipping price to be worth it. Maybe like 50$ worth of pills for me to feel like the shipping is worth it?

 

[Salouga]

That’s definitely a higher price point, but I’m guessing it’s because you’re buying smaller quantities? For example the 20mg pills I could buy are 0.15$ per pill, but there’s a fixed 50$ shipping fee meaning I need to order a lot more than I need for the shipping price to be worth it. Maybe like 50$ worth of pills for me to feel like the shipping is worth it?

I buy from eu I pay 8$ shipping
Which means in order for your supplier to be more worth it we have to find your mg cost
0.15 / 20 = 0.0075
let n be your mg
50 + 0.0075n < 8 + 0.065n
That happens at n > 730.43
So after 731 mg you get better value I personally buy 500 mg so an Indian or chineese vendor isnt really worth it for me especially since the tablet itself has some cost so a 5mg version of cialis would have a higher cost per mg even in China
If you get like a years supply or do a group buy. Yours is 100% worth it i am just too scared of customs because even with triangular shipping in eu there is still a 6% chance I dont clear customs and I am scared of getting in trouble

 

[AlexRz]

I buy from eu I pay 8$ shipping
Which means in order for your supplier to be more worth it we have to find your mg cost
0.15 / 20 = 0.0075
let n be your mg
50 + 0.0075n < 8 + 0.065n
That happens at n > 730.43
So after 731 mg you get better value I personally buy 500 mg so an Indian or chineese vendor isnt really worth it for me especially since the tablet itself has some cost so a 5mg version of cialis would have a higher cost per mg even in China
If you get like a years supply or do a group buy. Yours is 100% worth it i am just too scared of customs because even with triangular shipping in eu there is still a 6% chance I dont clear customs and I am scared of getting in trouble

Fair enough. It seems like you can get some pretty good deals within the EU. I wish I could buy from my own country, but it’s overpriced compared to other sources. I haven’t tried tadalafil yet, so I don’t even know if I’ll end up using the year’s worth of supply from the Chinese supplier for $100 However I just can’t justify paying a little less for way fewer pills.