FoidEater
Ima Stay Goth
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Most people think bone is static like once its built thats it.
Wrong.
Reality is bone is constantly being broken down and rebuilt.
Your entire frame is in a continuous cycle of resorption against formation and whichever side dominates determines whether youre slowly becoming more robust or more fragile over time
Thats where Teriparatide and Abaloparatide come in
Unlike meds like alendronate and risedronate wich just slow down bone loss (wich obviously is useless lookswise) these do stimulate osteoblast activity wich means that under specific conditions they can push the system towards net bone formation wich is what we want
This is NOT medical advise. Do NOT experiment with strong osteoprosis meds
And Im not responsible if something happens, Im just here to inform.
1
What are teriparatide and abaloparatide
Both Teriparatide and Abaloparatide are synthetic versions of parathyroid hormone signaling
PTH is one of the main regulators of calcium (wich we know bones need) and bone metabolism
Usually people hear "hormone" and instantly think it’s just another random variable (like Test) but PTH is directly involved in telling your body whether to mobilize calcium from bone or support bone formation
Many compounds indirectly help with bone formation BUT teriparatide and abaloparatide directly support bone formation and whats important here is that these arent random compounds, theyre specifically designed to interact with the same pathways your body already uses to regulate bone
2
What is teriparatide and abaloparatide used for
These arent undeground bonemass increasing tools
theyre prescribed for patients with osteoprosis
often prescribed when:
Bone fracture is high
Bone density is reducing/reduced already
Or other meds didnt do enough
3
Mechanism
Both Teriparatide and Abaloparatide work through the PTH1 receptor which directly regulates bone remodeling.
wich is important
This is extremly important
heres why most iqcels lose progress with PTH analogs instead of making progress
continuous PTH exposure promotes bone loss
while intermittent PTH exposure promotes bone formation
This is extremly i
With intermittent signaling these compounds:
Activate osteoblasts
Increase bone formation rate
Shift remodeling balance (net positive bone gain)
4
Differences to other osteoprosis meds
why exactly teriparatide and abaloparatide?
90% of the osteoprosis meds slow down osteoclasts wich break down bone, result is less bone loss but thats not a problem in puberty
Examples:
Alendronate
Zoledronic acid
Denosumab
(useless)
But teriparatide and abaloparatide increase bone formation first and secondarily increase turnover
Studies:
increased BMD + reduced fracture risk vs placebo
improved trabecular bone structure
confirms both increase BMD, with some data favoring abaloparatide in certain sites
5
Wheres the growth
The effects aren’t uniform across the body.
With both Teriparatide and Abaloparatide, the biggest increases in bone mineral density (BMD) are typically seen in the lumbar spine
6
How to use them
Both Teriparatide and Abaloparatide are not pills, not supplements, not casual treatments.
They are:
daily subcutaneous injections
designed for intermittent exposure (this is crucial for the anabolic effect)
The treatments usually take up to 24 months
What happens after the treatment?
patients are often switched to anti resorptive drugs (alendronate, zoledronic acid,denosumab)
to maintain the gained bone mass
VERY IMPORTANT
some of the bone mass can be lost if you dont take anti resorptive drugs.
7
Side effects
Common side effects:
nausea
dizziness
headaches
injection site reactions
Not very rare side effects
hypercalcemia (high blood calcium)
fatigue
weakness
Rare'ish side effects
increased heart rate (sometimes)
blood pressure fluctuations
These compoundsare clinically effective
have real measurable benefits
8
Dossages
Teriparatide
20 µg daily injection
Abaloparatide
80 µg daily injection
The injection time isnt relevant but it should be at the same time daily.
For example: teriparatide and abaloparatide everyday at 6PM
conclusion
bone is not always static
These are not harmless meds, dont even try it if youre too stupid to understand what youre doing
Wrong.
Reality is bone is constantly being broken down and rebuilt.
Your entire frame is in a continuous cycle of resorption against formation and whichever side dominates determines whether youre slowly becoming more robust or more fragile over time
Thats where Teriparatide and Abaloparatide come in
Unlike meds like alendronate and risedronate wich just slow down bone loss (wich obviously is useless lookswise) these do stimulate osteoblast activity wich means that under specific conditions they can push the system towards net bone formation wich is what we want
This is NOT medical advise. Do NOT experiment with strong osteoprosis medsAnd Im not responsible if something happens, Im just here to inform.
1
What are teriparatide and abaloparatide
Both Teriparatide and Abaloparatide are synthetic versions of parathyroid hormone signaling
PTH is one of the main regulators of calcium (wich we know bones need) and bone metabolism
Usually people hear "hormone" and instantly think it’s just another random variable (like Test) but PTH is directly involved in telling your body whether to mobilize calcium from bone or support bone formation
Many compounds indirectly help with bone formation BUT teriparatide and abaloparatide directly support bone formation and whats important here is that these arent random compounds, theyre specifically designed to interact with the same pathways your body already uses to regulate bone
2
What is teriparatide and abaloparatide used for
These arent undeground bonemass increasing tools
theyre prescribed for patients with osteoprosis
often prescribed when:
Bone fracture is high
Bone density is reducing/reduced already
Or other meds didnt do enough
3
Mechanism
Both Teriparatide and Abaloparatide work through the PTH1 receptor which directly regulates bone remodeling.
wich is important
This is extremly important
heres why most iqcels lose progress with PTH analogs instead of making progress
continuous PTH exposure promotes bone loss
while intermittent PTH exposure promotes bone formation
This is extremly i
With intermittent signaling these compounds:
Activate osteoblasts
Increase bone formation rate
Shift remodeling balance (net positive bone gain)
4
Differences to other osteoprosis meds
why exactly teriparatide and abaloparatide?
90% of the osteoprosis meds slow down osteoclasts wich break down bone, result is less bone loss but thats not a problem in puberty
Examples:
Alendronate
Zoledronic acid
Denosumab
(useless)
But teriparatide and abaloparatide increase bone formation first and secondarily increase turnover
Studies:
increased BMD + reduced fracture risk vs placebo
improved trabecular bone structure
confirms both increase BMD, with some data favoring abaloparatide in certain sites
5
Wheres the growth
The effects aren’t uniform across the body.
With both Teriparatide and Abaloparatide, the biggest increases in bone mineral density (BMD) are typically seen in the lumbar spine
6
How to use them
Both Teriparatide and Abaloparatide are not pills, not supplements, not casual treatments.
They are:
daily subcutaneous injections
designed for intermittent exposure (this is crucial for the anabolic effect)
The treatments usually take up to 24 months
What happens after the treatment?
patients are often switched to anti resorptive drugs (alendronate, zoledronic acid,denosumab)
to maintain the gained bone mass
VERY IMPORTANT
some of the bone mass can be lost if you dont take anti resorptive drugs.
7
Side effects
Common side effects:
nausea
dizziness
headaches
injection site reactions
Not very rare side effects
hypercalcemia (high blood calcium)
fatigue
weakness
Rare'ish side effects
increased heart rate (sometimes)
blood pressure fluctuations
These compoundsare clinically effective
have real measurable benefits
8
Dossages
Teriparatide
20 µg daily injection
Abaloparatide
80 µg daily injection
The injection time isnt relevant but it should be at the same time daily.
For example: teriparatide and abaloparatide everyday at 6PM
conclusion
bone is not always static
These are not harmless meds, dont even try it if youre too stupid to understand what youre doing
