Boshitoshi
Dumb grey
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- Jan 29, 2026
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Most people only focus on lowering estrogen when trying to protect height, but there are other pathways that also cause growth plates to close. These include:
Here are the best oral supplements that can help target these pathways (ranked by how useful they actually are for height):
- Direct androgen effects on chondrocytes
- Buildup of senescent (“zombie”) cells
- Inflammation inside the growth plate
- Epigenetic changes (DNA methylation)
- FGF signaling
Here are the best oral supplements that can help target these pathways (ranked by how useful they actually are for height):
| Supplement | Main Pathway(s) It Helps | Effectiveness (Out of 5) | Safety | Notes | Recommendation |
|---|---|---|---|---|---|
| Fisetin | Senescence + Inflammation | 4.0 | Good | One of the best senolytics available orally | Strongly Recommended |
| Quercetin Phytosome | Senescence + Inflammation | 3.5 | Good | Stacks very well with Fisetin | Recommended |
| Spermidine | Autophagy + Cellular Cleanup | 3.0 | Good | Helps clear damaged cells | Recommended |
| Luteolin | Senescence + Inflammation | 3.0 | Good | Good to add on D+Q + Fisetin days | Worth Adding |
| Metformin | mTOR inhibition + Mild Senolytic | 3.0 | Good | Slows cellular aging | Recommended |
| Berberine | mTOR + AMPK activation | 2.5 | Good | Similar to Metformin | Optional |
| High-dose Omega-3 | Inflammation | 3.0 | Very Good | Reduces inflammatory signals in plates | Recommended |
| SAM-e + MSM | DNA Methylation support | 2.0 | Good | May help slow epigenetic aging of plates | Low Priority |
| Glucosamine + Chondroitin | Growth plate matrix support | 2.0 | Very Good | Supports cartilage environment | Supportive only |
| High-quality Resveratrol | Mild senolytic + SIRT1 | 2.0 | Good | Weak but safe | Optional |
| Curcumin (enhanced) | Inflammation | 1.5 | Good | Poor absorption unless using good forms | Low value |
| EGCG (Green Tea Extract) | Weak DNMT inhibition | 1.0 | Good | Effect is too weak | Not worth it |
Quick Summary:
- Best options right now: Fisetin, Quercetin, Spermidine, and Luteolin (for senescence + inflammation).
- Good supportive options: Metformin/Berberine and Omega-3.
- Most other supplements (like EGCG or normal Curcumin) have very weak effects on actual growth plate closure.
