test without fusing growth plates

[Boshitoshi]

For what? If you mean there’s no way to permanently halt growth plate closure, then yes, there’s no fix. Even if you nuked androgens and aromatase they’re still closing— just very late.

I didn’t even mention the other half a dozen factors that contribute to growth plate senescence like DNA methylation, finite proliferation capacity of the chrondocytes (growth plates), etc.

Fact is we cannot fully halt cellular aging and as a consequence they will fuse eventually.

This doesn’t mean you can’t keep them open for a long time, just that it’s retarded to speed up the aging process by pinning androgens like test.

fuck man brutal i was on for 4 weeks but i stopped now 14 5'8 im a fucking dumbass

 

[Boshitoshi]

For what? If you mean there’s no way to permanently halt growth plate closure, then yes, there’s no fix. Even if you nuked androgens and aromatase they’re still closing— just very late.

I didn’t even mention the other half a dozen factors that contribute to growth plate senescence like DNA methylation, finite proliferation capacity of the chrondocytes (growth plates), etc.

Fact is we cannot fully halt cellular aging and as a consequence they will fuse eventually.

This doesn’t mean you can’t keep them open for a long time, just that it’s retarded to speed up the aging process by pinning androgens like test.

i got a plate scan a week ago my plates still open they look basically identical to before i hopped on so dodged a bullet maybe

 

[Quetila]

For what? If you mean there’s no way to permanently halt growth plate closure, then yes, there’s no fix. Even if you nuked androgens and aromatase they’re still closing— just very late.

I didn’t even mention the other half a dozen factors that contribute to growth plate senescence like DNA methylation, finite proliferation capacity of the chrondocytes (growth plates), etc.

Fact is we cannot fully halt cellular aging and as a consequence they will fuse eventually.

This doesn’t mean you can’t keep them open for a long time, just that it’s retarded to speed up the aging process by pinning androgens like test.

bro please check dms

 

[Alexanderr]

SO DIRECT ANDROGENIC FUSION IS REAL I WASNT RETARDED??

You’re less retarded than the others, that’s for sure.

fuck man brutal i was on for 4 weeks but i stopped now 14 5'8 im a fucking dumbass

You’re fine, consider some AI like aromasin. At 14 your natural puberty hormones are already far more impactful than those 4 weeks of test.

You don’t need to figure it all out now, you don’t need to have the perfect regimen, you just need to give yourself a bit more time to figure it out— AIs will do that.

Of course, it’s not so simple, like I said there’s other factors that contribute but aromatase is the major driver and you can no doubt slow the closure by months or years.

They also don’t all fuse at the same time, some might only fuse by age 25. The ones you’d probably care about as they’re more important for vertical growth do generally close earlier. Like 16-18, but at 14 you’d likely grow taller anyway.

You're not even short.

Only reason I’d be cautious is that you seem like you don’t know enough about what you’re signing up for. Read a bit more.

 

[Boshitoshi]

You’re less retarded than the others, that’s for sure.

You’re fine, consider some AI like aromasin. At 14 your natural puberty hormones are already far more impactful than those 4 weeks of test.

You don’t need to figure it all out now, you don’t need to have the perfect regimen, you just need to give yourself a bit more time to figure it out— AIs will do that.

Of course, it’s not so simple, like I said there’s other factors that contribute but aromatase is the major driver and you can no doubt slow the closure by months or years.

They also don’t all fuse at the same time, some might only fuse by age 25. The ones you’d probably care about as they’re more important for vertical growth do generally close earlier. Like 16-18, but at 14 you’d likely grow taller anyway.

You're not even short.

Only reason I’d be cautious is that you seem like you don’t know enough about what you’re signing up for. Read a bit more.

Thank you for putting time into that reply

I used arimidex 1mg everyday i doubt my plates are even advanced that much im gonna study more compounds for height.

Im new to this forum and a bit of a idiot my parents found my roids that why im off sadly they let me do pct though so goo parents.

are there any posts that could help me?

much love

 

[Alexanderr]

Thank you for putting time into that reply

I used arimidex 1mg everyday i doubt my plates are even advanced that much im gonna study more compounds for height.

Im new to this forum and a bit of a idiot my parents found my roids that why im off sadly they let me do pct though so goo parents.

are there any posts that could help me?

much love

Funny, I recall being about your age in 2019-2020 (I was 15) and my mom and sister found my peptides (which I had to refrigerate). Let’s just say the project was mostly canned after.

Only thing I managed to keep taking was the aromasin I’d purchased, lol.

I think I did grow like 2 inches from age 16 onwards, so like 6’0 -> 6’2. But obviously impossible to tell whether it was any of what I took or just natural.

 

[Zagro]

No one back then was advocating to run test to heightmax— it’s just retarded.

Heightmaxxing knowledge on this forum has actually regressed.

I don’t even need to get my computer, I’ll just do it now:

Androgens accelerate growth plate closure through multiple pathways, not just aromatase/estrogen conversion.

While estrogen (via aromatase) is a major driver, androgen receptors in growth plate cartilage can independently promote senescence.

This is literally well-established in endocrinology.

See, growth plate chondrocytes have their own androgen receptors. Testosterone and DHT can bind these directly. This then triggers IGF 1 and GH related signaling that independently promotes closure. Literally zero aromatase conversion needed.

Last point: if aromatase/estrogen were the only pathway controlling plate closure, people with aromatase deficiency would never fuse their plates but clinically, they just fuse them much later, not never. This proves androgens contribute independently.

That is called proliferative exhaustion, not closure, that just means that there aren't any chondrocytes left to proliferate nor to deplete from the germinal zone. Trust me no one here will reach a state similar to that nor does that means closure, that just means that there are no chondrocytes left to proliferate further, if you can delay the differentiation/cell-cycling from the proliferative zone to the hypertrophic zone, you can prevent this.

AR signalling directly in the chondrocytes has been refuted for 2 years already unc, the knowledge hasn't regressed and many people got fucked over because of retards like yourself spreading bullshit on the forum.

Are you aware that aromatase deficient patient get estrogen treatment to fuse their plates? Their plates stay open till mid to late 20s, but the growth plate has intrinsic mechanisms by which it closes the plates independent of anything else, like telomerase for example, otherwise humans would be immortal but cells aren't immortal, they go through apoptosis after a certain point. Also mr all-knowing glowy name og guy, aromatase deficient means that the enzyme for aromatisation CYP19A1 is gone, not the estrogen receptors which have ligand-independent actions by which they can induce epiphyseal closure.

You have balls to call me retarded when you aren't even as knowledgeable as a random retard from tiktok.

Your own words "testosterone can bind these directly", tell me what process testosterone goes through? Aromatisation.

" Androgen action on the growth plate is, however, clearly mediated via aromatization in estrogens and interaction with ERalpha."

"Expression of ERα and ERβ in the human growth plate makes it possible that androgens also indirectly affect pubertal growth or epiphyseal closure via aromatization to estrogen"

"Because almost all studies of hypogonadal men have used aromatizable androgens for hormone replacement, it is difficult to determine whether the benefits seen are due to the testosterone administered or to the estradiol aromatized from testosterone."

"Androgens stimulate bone formation and growth early in puberty, and epiphyseal closure later in puberty, with androgen effects on growth plate closure mediated by aromatization to estrogens and binding to ERα."

"they were 24 and 38 years old, 204 and 190 cm tall" 38 year old btw not even mid-late 20s

'low-dose estrogen replacement in an aromatase-deficient man."

 

[Alexanderr]

Thank you for putting time into that reply

I used arimidex 1mg everyday i doubt my plates are even advanced that much im gonna study more compounds for height.

Im new to this forum and a bit of a idiot my parents found my roids that why im off sadly they let me do pct though so goo parents.

are there any posts that could help me?

much love

I’ll try to find some old threads.

 

[Zagro]

SO DIRECT ANDROGENIC FUSION IS REAL I WASNT RETARDED??

It isn't real he literally has zero knowledge and is just like you, reads off the forums does zero research himself and goes on to spread that same bullshit information

 

[darodiddler]

It isn't real he literally has zero knowledge and is just like you, reads off the forums does zero research himself and goes on to spread that same bullshit information

i dont know who to bellive


One thing made sense like the aromatose defcient people why cant they grow for ever if its just dependent on it?

 

[Zagro]

For what? If you mean there’s no way to permanently halt growth plate closure, then yes, there’s no fix. Even if you nuked androgens and aromatase they’re still closing— just very late.

I didn’t even mention the other half a dozen factors that contribute to growth plate senescence like DNA methylation, finite proliferation capacity of the chrondocytes (growth plates), etc.

Fact is we cannot fully halt cellular aging and as a consequence they will fuse eventually.

This doesn’t mean you can’t keep them open for a long time, just that it’s retarded to speed up the aging process by pinning androgens like test.

You are genuinely a different species no way

Why would you nuke androgens? To stunt your growth through medically giving yourself hypogonadism? Aromatase isn't the only thing receptors also exist and upstream pathways of if that can also contribute.

DNY methylation can be changed with a single med, there is no finite proliferation capacity as skeletal stem cells can go through symmetric self-renewal which expands the stem cell pool, the other dozen factors all work in concert meaning of one gets affected the others will also.

"they will fuse eventually so we shouldn't even try" garbage analogy

"androgens like test" are you retarded enough to not be able to fathom that testosterone and androstenedione are androgens that aromatise, by which they hasten fusion, and non-aromatising androgens do not do that, learn the fucking difference before ever speaking up to me

 

[Zagro]

i dont know who to bellive


One thing made sense like the aromatose defcient people why cant they grow for ever if its just dependent on it?

He's a fucking retard

Nigger chondrocytes are cartilage cells, cells aren't immortal they will die eventually. Aromatase deficient doesn't mean that they don't have the estrogen receptors beta and alpha aswell and those receptors have ligand-independent actions on the growth plate by which then can induce fusion themselves.

Also aromatase deficient people literally receive estrogen-treatment to close their plates and reverse damage/reduce symptoms that come with their condition

He doesn't even know a molecule of what i know

 

[darodiddler]

He's a fucking retard

Nigger chondrocytes are cartilage cells, cells aren't immortal they will die eventually. Aromatase deficient doesn't mean that they don't have the estrogen receptors beta and alpha aswell and those receptors have ligand-independent actions on the growth plate by which then can induce fusion themselves.

Also aromatase deficient people literally receive estrogen-treatment to close their plates and reverse damage/reduce symptoms that come with their condition

He doesn't even know a molecule of what i know

so whats the meta now? a serm with ai and low dose test?

 

[Alexanderr]

@Zagro, before I write a lengthy reply let me clarify your position. A question:

Your cited studies predominantly use aromatizable androgens. How do they establish that aromatization is the exclusive mediating pathway of androgen-driven closure rather than simply the dominant one?

 

[Boshitoshi]

I’ll try to find some old threads.

you have better things to do man but if you do thank you so much it would help

 

[Kojo]

so we all know anyone whos not retarded knows that ai works systemcaly in the blood and doesnt affect the growth plates bon tissue reciptors

and to pervent that i was thinking about a SERM( Selective Estrogen Receptor Modulato)

can directly on estrogen receptors and pervent fusing from the growth plates while taking test and not fusing the growth plates

am i correct

You need a serd.

 

[Kojo]

Yeah it doesnt affect any receptors it lowers estrogen, which is what causes your plates to fuse. Less estrogen = Less bone plates fusing, SERMS wont decrease estrogen just do AIs

Uh no, it lowers e2 locally it wouldn't have to affect the receptors directly.

Also trace e2 is already enough to fuse plates locally I believe