What makes u think this bro
I am been working on it for 2 weeks
I already explained that a dozen times in other posts
No?
This is also not true. You clearly didnt even read the text, I literally mentioned no-ERa and aromatase people and explained this
no it doesnt LOL
And why didnt you mention any?
everythings cope
You are so off with your understanding of hypertrophic size. The longitudinal elongation of bones is controlled precisely by the end-volume of chondrocytes attained during the process of hypertophy, and both HGH and IGF-1 control that very swelling and fluid accumulation process. In the case where either HGH or IGF-1 are increased, in vivo experiments or pre-fusion gigantism, there is evidence of actual increase of the width of the hyperrophic zone and the actal size of chondrocytes themselves. Moreover, during normal growth plate senescence in adolescents, there is a reduction in hypertrophic cell size; exogenous HGH acts on this phenomenon by inducing differentiation and expanding cell size to its full physiological potential, totally falsifying your idea that HGH does not affect hypertrophy at all.No?
Are you retarded
Estrogen pushes senescence
This is also not true. You clearly didnt even read the text, I literally mentioned no-ERa and aromatase people and explained this
no it doesnt LOL
proliferative capacity is exactly what Im talking about HGH doesnt influence the telomeres
Theres no evidence that HGH or it's downstream products increase the final hypertrophic size of chondrocytes, beyond the natural production in healthy teens.
And why didnt you mention any?
yeah i was thinking same thing, i figure there would be a link between more gh and more igf 1 equals more hypertrophic swelling.. in theory hes right about the aspect that there's a certain proliferative capacity to chondrocytes but there's no way to figure out you're reaching that capacity naturally.. that also explains why ghs direct effects on chondrocytes flatlines the higher the dosage but then you can resort to looking at ghs indirect effects of promoting growthYou are so off with your understanding of hypertrophic size. The longitudinal elongation of bones is controlled precisely by the end-volume of chondrocytes attained during the process of hypertophy, and both HGH and IGF-1 control that very swelling and fluid accumulation process. In the case where either HGH or IGF-1 are increased, in vivo experiments or pre-fusion gigantism, there is evidence of actual increase of the width of the hyperrophic zone and the actal size of chondrocytes themselves. Moreover, during normal growth plate senescence in adolescents, there is a reduction in hypertrophic cell size; exogenous HGH acts on this phenomenon by inducing differentiation and expanding cell size to its full physiological potential, totally falsifying your idea that HGH does not affect hypertrophy at all.
Here’s all the good shitNo hate but i feel like it doesn’t go over like the sides to good and also doesn’t explain supplements like berbine ala and that other 1 but i feel like its not too in depth but its really good everything else the layout is extremely good
Loool
im not sure what this is supposed to prove? One look at the top of the first one "Nilsson", literally the same mf focusing on hayflick and developing the model of proliferation induced senescence
Yeah but not solely lol
Id love to see that evidence, significant increase through hormone levels without deficiency is interesting
Without a deficiency I highly doubt they raise the chondrocyte size
That wasnt even my idea
There is but not in the sense of dose dependent size increase reaction
I would argue telomere shortening is quite proven and not just theory
thats true, its slightly individual for every cell and depends on genetics, even normal hormone levels can not be enough
Which again cant surpass hayflick
sad..
There is but not in the sense of dose dependent size increase reaction
I would argue telomere shortening is quite proven and not just theory
thats true, its slightly individual for every cell and depends on genetics, even normal hormone levels can not be enough
Which again cant surpass hayflick
TLoool
Its too large to upload
im not sure what this is supposed to prove? One look at the top of the first one "Nilsson", literally the same mf focusing on hayflick and developing the model of proliferation induced senescence
All these prove is that a) senescence exists, b) it's largely independent of chronological age and c) it's dependent on proliferationcount
Thats literally what I was arguing for in the video lol? The cause by proliferation is due to the telomere shortening...
I see the increased hypertrophic size in gene knockout and brain altered mice but 1 its animals only and 2 theres no cases of adding gh therapy to normal existing levels which then increases hypertrophic size
It proves that gh via igf1 is relevant but nothing about the increase in size in normals
Yeah but not solely lol
cell volume of 1 with a count lf 200 cells is cool but even if the volume is lets say 30% lower (igf1 knockout mice) but their proliferation count is expanded past hayflick, the cell count goes up
Ending up with 350cells with a volume lf 0.7 beats the former example
The importance is not in the end size alone, I would argue it even lies more in cellcount than size.
Id love to see that evidence, significant increase through hormone levels without deficiency is interesting
I already had to slightly update my stance on HGH from 0 gains for normal teens to very slight gains for normal but short teens (same explanation as with the ISS NF), the proliferation rate thats decreased through genetics gets pushed back to normal by GH for a gain of 2.5-2.8cm after long term treatment started before or in early puberty
When I read this post I immediately thought the GH might actually slightly increase hypertrophic size beyond normal and act in addition to increase in proliferation
But not sure, also not sure if an explanation could be genetically reduced hypertrophic size
Regardless, some evidence would be nice
Without a deficiency I highly doubt they raise the chondrocyte size
the decrease in size is absolutely normal in population senescence, do you have any evidence on this actually happening?
And wheres the correlation to differentiation? Its a finding of one of the papers you mentioned but thats all, youre like just listing the findings lool
Differentiation doesnt change hypertrophic size
That wasnt even my idea
I agree that i worded it wrong but it seemed obvious to me that this is about already healthy people, while gh has an influence on the hypertrophic size through igf1 I dont see it as being mlre than a necessary for full development rather than a signal that can increase beyond potential
There is but not in the sense of dose dependent size increase reaction
I would argue telomere shortening is quite proven and not just theory
thats true, its slightly individual for every cell and depends on genetics, even normal hormone levels can not be enough
Again as I said, theres poly and monogenetic cases where GH therapy makes a small difference (see above)
Which again cant surpass hayflick
yE
Your understanding of the relationship between cell count and volume is worng. when it comes to growth plates, the number of cells is not important, since their growth is regulated by the height of the hypertophic chondrocytes. Even if their volume decreases by 30%, adding extra cells would not solve the issue, since the growth plate would be left with a large amount of small cells, which might not contribute to the bone’s elongation. Secondly, it is wrong to claim that cell differentiation has no impact on the size of hypertrophic chondrocytes. In reality, differentiation is the process, during which a proliferative cell transforms into a hypertrophic cell by increasing its volume; thus, the very concept of cell differentiation is directly related to cell size.Loool
Its too large to upload
im not sure what this is supposed to prove? One look at the top of the first one "Nilsson", literally the same mf focusing on hayflick and developing the model of proliferation induced senescence
All these prove is that a) senescence exists, b) it's largely independent of chronological age and c) it's dependent on proliferationcount
Thats literally what I was arguing for in the video lol? The cause by proliferation is due to the telomere shortening...
I see the increased hypertrophic size in gene knockout and brain altered mice but 1 its animals only and 2 theres no cases of adding gh therapy to normal existing levels which then increases hypertrophic size
It proves that gh via igf1 is relevant but nothing about the increase in size in normals
Yeah but not solely lol
cell volume of 1 with a count lf 200 cells is cool but even if the volume is lets say 30% lower (igf1 knockout mice) but their proliferation count is expanded past hayflick, the cell count goes up
Ending up with 350cells with a volume lf 0.7 beats the former example
The importance is not in the end size alone, I would argue it even lies more in cellcount than size.
Id love to see that evidence, significant increase through hormone levels without deficiency is interesting
I already had to slightly update my stance on HGH from 0 gains for normal teens to very slight gains for normal but short teens (same explanation as with the ISS NF), the proliferation rate thats decreased through genetics gets pushed back to normal by GH for a gain of 2.5-2.8cm after long term treatment started before or in early puberty
When I read this post I immediately thought the GH might actually slightly increase hypertrophic size beyond normal and act in addition to increase in proliferation
But not sure, also not sure if an explanation could be genetically reduced hypertrophic size
Regardless, some evidence would be nice
Without a deficiency I highly doubt they raise the chondrocyte size
the decrease in size is absolutely normal in population senescence, do you have any evidence on this actually happening?
And wheres the correlation to differentiation? Its a finding of one of the papers you mentioned but thats all, youre like just listing the findings lool
Differentiation doesnt change hypertrophic size
That wasnt even my idea
I agree that i worded it wrong but it seemed obvious to me that this is about already healthy people, while gh has an influence on the hypertrophic size through igf1 I dont see it as being mlre than a necessary for full development rather than a signal that can increase beyond potential
There is but not in the sense of dose dependent size increase reaction
I would argue telomere shortening is quite proven and not just theory
thats true, its slightly individual for every cell and depends on genetics, even normal hormone levels can not be enough
Again as I said, theres poly and monogenetic cases where GH therapy makes a small difference (see above)
Which again cant surpass hayflick
Besides, there are actual clinical examples, which show that the size of cells can be affected by various growth factors. For instance, people with clinical pre-fusion gigantism and transgenic GH-overexpression models, who normally have appropriate levels of GH, exhibit gigantism and increased cell volume when their growth hormone levels spikes, which demonstrates that GH levels can affect the size of the cells in the hypertrophic zone. In conclusion, there are multiple reasons, why your assumption is incorrect. There is a substantial link between cell differentiation and cell size, and there are actual clinical cases, which demonstrate, that cell size can be altered by various factors. Ultimately, your calculations are wrong, and thus, your conclusion is wrong.
it is. Mine is better imoNo hate but i feel like it doesn’t go over like the sides to good and also doesn’t explain supplements like berbine ala and that other 1 but i feel like its not too in depth but its really good everything else the layout is extremely good
Lowkey is
DNR after saying that a large number of smaller cells will never make the same space as a shorter number of larger cellsYour understanding of the relationship between cell count and volume is worng. when it comes to growth plates, the number of cells is not important, since their growth is regulated by the height of the hypertophic chondrocytes. Even if their volume decreases by 30%, adding extra cells would not solve the issue, since the growth plate would be left with a large amount of small cells, which might not contribute to the bone’s elongation. Secondly, it is wrong to claim that cell differentiation has no impact on the size of hypertrophic chondrocytes. In reality, differentiation is the process, during which a proliferative cell transforms into a hypertrophic cell by increasing its volume; thus, the very concept of cell differentiation is directly related to cell size.
DNR after saying that a large number of smaller cells will never make the same space as a shorter number of larger cells
bullshit lmaoo I literally gave an example
might read when this wont ragebait me anymore, also start mentioning what exactly youre replying to you fucktard
Still provided 0 evidence and only claims
I dont even have to acknowledge or read them, what can be asserted without evidence can be dismissed without evidence
