The Big Vitamin D Mistake

[Deleted member 3990]

This should not be an animation to take copious amount of vitamin D3.
I tried to not bring my own opinion into this topic because I do not want to be held accountable.

Vitamin D3 seems to be a vitamin/secosteroid which is mostly associated with environmental factors of the day/bluelight spectrum, like Melatonin is associated with darkness and night. UV Rays form cholesterol in your body into the previtamin D and external heat/warmth converts the previtamin to the active form.

With supplementation you are probably tricking your body into thinking that you are in a warm environment or that your body is thermoregulated. This could mean that the body is not releasing uncoupling proteins anymore (oxidative phosphorylation?). Metabolic rate/oxidation drops.
Some may feel fatigue or gain weight after taking a significant amount of D3, over a certain period of time, likely due to this mechanism.

Just wanted to put this out there

 

[Whaddup]

@Dr Shekelberg the question remains do we take vitamin D and K2 together or separated?

 

[EmilKing]

7000 iu Vit D
200mcg K2 (MK7)

How Ideal is this?

Also can you do something similar for Zinc/Copper
as well as Mag

Thanks OP

 

[aleksandr]

This should not be an animation to take copious amount of vitamin D3.
I tried to not bring my own opinion into this topic because I do not want to be held accountable.

Vitamin D3 seems to be a vitamin/secosteroid which is mostly associated with environmental factors of the day/bluelight spectrum, like Melatonin is associated with darkness and night. UV Rays form cholesterol in your body into the previtamin D and external heat/warmth converts the previtamin to the active form.

With supplementation you are probably tricking your body into thinking that you are in a warm environment or that your body is thermoregulated. This could mean that the body is not releasing uncoupling proteins anymore (oxidative phosphorylation?). Metabolic rate/oxidation drops.
Some may feel fatigue or gain weight after taking a significant amount of D3, over a certain period of time, likely due to this mechanism.

Just wanted to put this out there

I agree with this - everything needs to be balanced. If you're a skinny kid with a high metabolism, or even just a regular joe who isnt overweight you could benefit from supplementing g especially in winter.

+ you could argue one needs to fix the reason why they're fat in the first place (over eating, crap diet, emotional eating etc), and then maybe the argument could be made to supplement the D.

 

[anti caking agents]

Been taking 10,000 IU of Vitamin D3 daily for over a year now and aside from glowing in the dark I have never felt better. Started a multi-level marketing scheme that I am now pivoting into a cult.

Imagine wanting your body to go into hibernation mode JFL.

 

[everydayfun]

If you take Vitamin D3 alone after a few weeks you'll have muscle soreness, this is because it depletes magnesium. If you're going to supplement D3 you need to supplement with magnesium citrate as well.

 

[lutte]

Dont need no supplements the sun was up for 4 hours here today good enough for me

 

[Deleted member 439]

you forgot this post

A very interesting study, not only because of its obvious social implications but also because it confirms the anabolic effects of the vitamin D/K combination, as well as the likely androgenic effects of vitamin D. I could not help but pronounce the D/K combo in my head as "dee-k" : Another interesting finding of the study below was that both length and thickness were increased - a reliable sign of androgenic effects of the vitamin D/K combo, which are also corroborated by the increased libido and sense of vitality of the patients. I think that vitamin K also has androgenic effects considering the masculine changes it elicits on male jaws and that if higher doses were used (e.g. the study used 100mcg daily) the effects would have been much more pronounced. The only drawback of this study was that the daily dose of vitamin D used was high (50,000 IU). However, the authors were well-aware of the risks for hypercalcemia and tracked their patients closely yet, fortunately, no such side effects occurred. Duration of treatment was 3-6 months. I would personally be more comfortable with a vitamin D dose around 5,000 IU daily and a higher vitamin K2 (MK-4) dose in the range of 10mg-15mg daily, as the study on muscle anabolism linked above calls for. In fact, according to the same study above, doses of K2 as low as 1mg may be sufficient. However, I have a read a number of other human studies with vitamin K2 (MK-4) and they all claim bone/muscle/brain benefits robustly increase up to at least 5mg daily doses, and, considering vitamin K2 has really no known drawbacks (other than price) I think trying 10mg-15mg daily may accelerate the materialization of the "benefits" mentioned in the study below :
Btw, it may be even more effective if the D/K combo is used topically (on the penis) and this may also both increase the effectiveness as well as decrease the risks of side effects from D3 (hypercalcemia).

https://www.researchgate.net/public...ed_Growth_of_the_Adult_Penis_With_Vitamin_D_3
"...Fourteen male friends were invited to participate in a research project. They signed an informed consent form which explained the project and agreed to have blood drawn initially and whenever possible at 3 and 6 months after taking daily 50,000 units of D 3 and 100 mcg of vitamin K2. K2 is generally considered to be synergistic with D3 in enhancing deposits of calcium into bone. They were instructed to take no calcium supplements while on the D 3. They also agreed to have the senior author measure their flaccid stretched penis or to provide digital photos showing length and circumference of their erect penis initially and at 3 and 6 months."

"...The two earlier studies, which demonstrated penis enlargement,5,6 used vacuum pumps that required 30 minutes of daily vacuum pumping to achieve enlargement of up to 1 inch in length (average 0.67 inches) up to 0.75 inches in circumference (average 0.55 inches). Interestingly, it is reported that surgical enhancement results in only 1-2 cm increase in length and 2.5 cm augmentation in circumference! [7] In the current study, average increase in length of 0.46 inches and circumference of 0.523 inches is highly statistically significant and approximately equal to that obtained with vacuum pumps or surgical augmentation."

"...The only known risk of large dosages of vitamin D3 is excessive blood calcium levels with potential kidney damage. For that reason, individuals taking the large dosage of D3 are advised to avoid calcium supplements. In this current study, serum calcium levels at 3 and 6 months were all within the normal range. The physiological explanation for apparent androgenic effects of vitamin D3 are not simple, although plasma levels of vitamin D metabolites have been reported to have an effect upon sexual maturation and growth.11 There is some evidence that vitamin D3 is an androgen agonist and binds to Androgen Receptors.12,13 Much further work will be needed to explore this as a possible mechanism for enhanced penis augmentation with vitamin D."

 

[PURE ARYAN GENETICS]

7000 iu Vit D
200mcg K2 (MK7)

How Ideal is this?

Also can you do something similar for Zinc/Copper
as well as Mag

Thanks OP

500mcg mk7 raped me so I wouldn't take more than 100mcg. 7000iu d3 feels pretty good tbh but I'm no expert

 

[Deleted member 3990]

500mcg mk7 raped me so I wouldn't take more than 100mcg. 7000iu d3 feels pretty good tbh but I'm no expert

lowering phosphorus or increasing calcium intake to a ca : p ratio of at least 1:1 can actually increased D3 levels by itself (while also lowering Parathyroidhormone and in general prevent gouts, tatar or other signs of calcification to a certain degree).

 

[PURE ARYAN GENETICS]

lowering phosphorus or increasing calcium intake to a ca : p ratio of at least 1:1 can actually increased D3 levels by itself (while also lowering Parathyroidhormone and in general prevent gouts, tatar or other signs of calcification to a certain degree).

increased calcium lowers chance of calcification? maybe I'm retard here

 

[Deleted member 3990]

increased calcium lowers chance of calcification? maybe I'm retard here

Oh, incidentally I was writing this post the very moment lol

Osteopetrosis - Implications of CO2 in Bone Formation?

Osteopetrosis, or Marble bone disease, is essentially the lack of (enough) Carbonic anhydrase enzymes This means that the CO2, an endproduct of cellular respiration, is not broken down that easily into carbonic acid etc. It is not a good state of health but this condition can be used to maybe...

looksmax.org

“All cell death is characterized by an increase of intracellular calcium….” “Increase of cytoplasmic free calcium may therefore be called ‘the final common path’ of cell disease and cell death. Aging as a background of diseases is also characterized by an increase of intracellular calcium. Diseases typically associated with aging include hypertension, arteriosclerosis, diabetes mellitus and dementia.” -Fujita, 1991


For those who want references:

High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females - PubMed

Ca and P are both essential nutrients for bone and are known to affect one of the most important regulators of bone metabolism, parathyroid hormone (PTH). Too ample a P intake, typical of Western diets, could be deleterious to bone through the increased PTH secretion. Few controlled...

www.ncbi.nlm.nih.gov

Ca and P are both essential nutrients for bone and are known to affect one of the most important regulators of bone metabolism, parathyroid hormone (PTH). Too ample a P intake, typical of Western diets, could be deleterious to bone through the increased PTH secretion. Few controlled dose-response studies are available on the effects of high P intake in man. We studied the short-term effects of four P doses on Ca and bone metabolism in fourteen healthy women, 20-28 years of age, who were randomized to four controlled study days; thus each study subject served as her own control. P supplement doses of 0 (placebo), 250, 750 or 1500 mg were taken, divided into three doses during the study day. The meals served were exactly the same during each study day and provided 495 mg P and 250 mg Ca. The P doses affected the serum PTH (S-PTH) in a dose-dependent manner (P=0.0005). There was a decrease in serum ionized Ca concentration only in the highest P dose (P=0.004). The marker of bone formation, bone-specific alkaline phosphatase, decreased (P=0.05) and the bone resorption marker, N-terminal telopeptide of collagen type I, increased in response to the P doses (P=0.05). This controlled dose-response study showed that P has a dose-dependent effect on S-PTH and increases PTH secretion significantly when Ca intake is low. Acutely high P intake adversely affects bone metabolism by decreasing bone formation and increasing bone resorption, as indicated by the bone metabolism markers.

Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females - PubMed

A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is...

www.ncbi.nlm.nih.gov

A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.

Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake - PubMed

Excessive dietary P intake alone can be deleterious to bone through increased parathyroid hormone (PTH) secretion, but adverse effects on bone increase when dietary Ca intake is low. In many countries, P intake is abundant, whereas Ca intake fails to meet recommendations; an optimal dietary Ca:P...

www.ncbi.nlm.nih.gov

Excessive dietary P intake alone can be deleterious to bone through increased parathyroid hormone (PTH) secretion, but adverse effects on bone increase when dietary Ca intake is low. In many countries, P intake is abundant, whereas Ca intake fails to meet recommendations; an optimal dietary Ca ratio is therefore difficult to achieve. Our objective was to investigate how habitual dietary Ca ratio affects serum PTH (S-PTH) concentration and other Ca metabolism markers in a population with generally adequate Ca intake. In this cross-sectional analysis of 147 healthy women aged 31-43 years, fasting blood samples and three separate 24-h urinary samples were collected. Participants kept a 4-d food record and were divided into quartiles according to their dietary Ca ratios. The 1st quartile with Ca molar ratio < or = 0.50 differed significantly from the 2nd (Ca molar ratio 0.51-0.57), 3rd (Ca molar ratio 0.58-0.64) and 4th (Ca molar ratio > or = 0.65) quartiles by interfering with Ca metabolism. In the 1st quartile, mean S-PTH concentration (P = 0.021) and mean urinary Ca (U-Ca) excretion were higher (P = 0.051) than in all other quartiles. These findings suggest that in habitual diets low Ca ratios may interfere with homoeostasis of Ca metabolism and increase bone resorption, as indicated by higher S-PTH and U-Ca levels. Because low habitual dietary Ca ratios are common in Western diets, more attention should be focused on decreasing excessively high dietary P intake and increasing Ca intake to the recommended level.

Calcium paradox: consequences of calcium deficiency manifested by a wide variety of diseases - PubMed

Calcium deficiency is a global problem, especially in the aging population. Among various nutrients, calcium is one of the few that is still deficient in industrialized countries such as Japan and many Western countries. Calcium deficiency is readily connected with osteoporosis, which is a...

www.ncbi.nlm.nih.gov

Calcium deficiency is a global problem, especially in the aging population. Among various nutrients, calcium is one of the few that is still deficient in industrialized countries such as Japan and many Western countries. Calcium deficiency is readily connected with osteoporosis, which is a decrease of bone calcium content. Less well known is the calcium outflow from bone that occurs to prevent decrease of blood calcium in calcium deficiency caused by the parathyroid hormone, with consequent calcium overflow into soft tissues and the intracellular compartment. Such intracellular paradoxical Ca overload as a consequence of nutritional calcium deficiency may give rise to a number of diseases common in old age: hypertension, arteriosclerosis, diabetes mellitus, neurodegenerative diseases, malignancy, and degenerative joint disease.

Calcium, parathyroids and aging - PubMed

Calcium is unique in its distribution in living organisms with an extremely high hard and soft tissue and extra- intracellular concentration gradient. Calcium deficiency through stimulating parathyroid hormone secretion tends to blunt such a difference by paradoxically increasing the calcium...

www.ncbi.nlm.nih.gov

Calcium is unique in its distribution in living organisms with an extremely high hard and soft tissue and extra- intracellular concentration gradient. Calcium deficiency through stimulating parathyroid hormone secretion tends to blunt such a difference by paradoxically increasing the calcium concentration in the soft tissue and intracellular compartment. Since aging is associated with the progressive aggravation of calcium deficiency, such blunting also progresses with aging. The dysfunction, damage and death of cells occurring in all diseases is always associated with a blunting of the extra- and intracellular calcium components. Calcium supplement especially with highly biologically available active absorbable calcium, was associated with the suppression of parathyroid hormone secretion and the normalization of a such blunting of intercompartmental distribution of calcium examples in hypertension and diabetes mellitus with evident improvement of clinical manifestations and laboratory tests.

Aging and calcium metabolism - PubMed

It is imperative to understand calcium metabolism under a unified concept, despite the vast concentration difference among the three major calcium compartments in human body. Total body calcium homeostasis supported by adequate calcium intake and normal skeletal metabolism is quite important to...

www.ncbi.nlm.nih.gov

It is imperative to understand calcium metabolism under a unified concept, despite the vast concentration difference among the three major calcium compartments in human body. Total body calcium homeostasis supported by adequate calcium intake and normal skeletal metabolism is quite important to maintain adequate extra- and intracellular calcium concentration gradient and consequent signal transduction system mediated by calcium entry into the cell. Aging and diseases are associated with blunting of the calcium concentration gradient, due to calcium deficiency and consequent secondary hyperparathyroidism.

Aging and calcium as an environmental factor - PubMed

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age. Low calcium and vitamin D intake, short solar exposure, decreased intestinal absorption, and falling...

www.ncbi.nlm.nih.gov

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age. Low calcium and vitamin D intake, short solar exposure, decreased intestinal absorption, and falling renal function with insufficient 1,25(OH)2 vitamin D biosynthesis all contribute to calcium deficiency, secondary hyperparathyroidism, bone loss and possibly calcium shift from the bone to soft tissue, and from the extracellular to the intracellular compartment, blunting the sharp concentration gap between these compartments. The consequences of calcium deficiency might thus include not only osteoporosis, but also arteriosclerosis and hypertension due to the increase of calcium in the vascular wall, amyotrophic lateral sclerosis and senile dementia due to calcium deposition in the central nervous system, and a decrease in cellular function, because of blunting of the difference in extracellular-intracellular calcium, leading to diabetes mellitus, immune deficiency and others

[Changes in calcium regulating hormone in osteoporosis] - PubMed

We summarized the changes of humoral factors, vitamin D, parathyroid hormone, and calcitonin in blood concentration, which are cooperatively regulating calcium homeostasis in aging and osteoporosis. Although these factors may play a important role on pathogenesis of osteoporosis in aged and...

www.ncbi.nlm.nih.gov

Age-dependent change in calcium metabolism is affected by nutritional factors like calcium and vitamin D as well as by endocrine factors including parathyroid hormone. Because calcium deficiency could deteriorate bone metabolisms and cardiovascular systems, adequate intakes of calcium and vitamin D are important for anti-aging.

The calcium paradox of essential hypertension - PubMed

Three disparate observations--that calcium mediates vascular smooth muscle contraction, that calcium channel blockers lower blood pressure, and that increased dietary calcium intake can also ameliorate hypertension--constitute somewhat of a paradox. The complex interrelationships between calcium...

www.ncbi.nlm.nih.gov

Three disparate observations–that calcium mediates vascular smooth muscle contraction, that calcium channel blockers lower blood pressure, and that increased dietary calcium intake can also ameliorate hypertension–constitute somewhat of a paradox. This evidence, and the paradoxical therapeutic efficacy of both calcium channel blockers and supplemental dietary calcium, can be integrated into a single theoretic construct.

Enhanced parathyroid function in essential hypertension: a homeostatic response to a urinary calcium leak - PubMed

Disorders of calcium metabolism are not generally considered important either clinically or pathophysiologically in essential hypertension. Recent reports, though, suggest that increased parathyroid gland function may be one of the more common endocrine disturbances associated with hypertension...

www.ncbi.nlm.nih.gov

Recent reports, though, suggest that increased parathyroid gland function may be one of the more common endocrine disturbances associated with hypertension. Compared to a second age- and sex-matched normotensive population, the hypertensives demonstrated a significant (p less than 0.005) relative hypercalciuria. For any level of urinary sodium, hypertensives excreted more calcium. These preliminary data suggest that parathyroid gland function may be enhanced in essential hypertension.

Blood pressure and nutrient intake in the United States - PubMed

A data base of the National Center for Health Statistics, Health and Nutrition Examination Survey I (HANES I), was used to perform a computer-assisted, comprehensive analysis of the relation of 17 nutrients to the blood pressure profile of adult Americans. Subjects were 10,372 individuals, 18 to...

www.ncbi.nlm.nih.gov

A data base of the National Center for Health Statistics, Health and Nutrition Examination Survey I (HANES I), was used to perform a computer-assisted, comprehensive analysis of the relation of 17 nutrients to the blood pressure profile of adult Americans. Subjects were 10,372 individuals, 18 to 74 years of age, who denied a history of hypertension and intentional modification of their diet. Significant decreases in the consumption of calcium, potassium, vitamin A, and vitamin C were identified as the nutritional factors that distinguished hypertensive from normotensive subjects. Lower calcium intake was the most consistent factor in hypertensive individuals. Across the population, higher intakes of calcium, potassium, and sodium were associated with lower mean systolic blood pressure and lower absolute risk of hypertension. Increments of dietary calcium were also negatively correlated with body mass. Even though these correlations cannot be accepted as proof of causation, they have implications for future studies of the association of nutritional factors and dietary patterns with hypertension in America.

Regulation of parathyroid hormone and vitamin D in essential hypertension - PubMed

Patients with essential hypertension have been reported to have a higher serum concentration of parathyroid hormone (PTH) than normotensive individuals although this finding is not universal among studies. To further characterize the status of the calcium regulating hormones in essential...

www.ncbi.nlm.nih.gov

The maximal stimulated PTH level was significantly higher in hypertensive than normotensive subjects in the absence of measured differences in serum ionized calcium concentration, serum 1,25(OH)2-vitamin D concentration, and creatinine clearance.

 

[PURE ARYAN GENETICS]

Oh, incidentally I was writing this post the very moment lol

Osteopetrosis - Implications of CO2 in Bone Formation?

Osteopetrosis, or Marble bone disease, is essentially the lack of (enough) Carbonic anhydrase enzymes This means that the CO2, an endproduct of cellular respiration, is not broken down that easily into carbonic acid etc. It is not a good state of health but this condition can be used to maybe...

looksmax.org

“All cell death is characterized by an increase of intracellular calcium….” “Increase of cytoplasmic free calcium may therefore be called ‘the final common path’ of cell disease and cell death. Aging as a background of diseases is also characterized by an increase of intracellular calcium. Diseases typically associated with aging include hypertension, arteriosclerosis, diabetes mellitus and dementia.” -Fujita, 1991


For those who want references:

High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females - PubMed

Ca and P are both essential nutrients for bone and are known to affect one of the most important regulators of bone metabolism, parathyroid hormone (PTH). Too ample a P intake, typical of Western diets, could be deleterious to bone through the increased PTH secretion. Few controlled...

www.ncbi.nlm.nih.gov

Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females - PubMed

A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is...

www.ncbi.nlm.nih.gov

Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake - PubMed

Excessive dietary P intake alone can be deleterious to bone through increased parathyroid hormone (PTH) secretion, but adverse effects on bone increase when dietary Ca intake is low. In many countries, P intake is abundant, whereas Ca intake fails to meet recommendations; an optimal dietary Ca:P...

www.ncbi.nlm.nih.gov

Calcium paradox: consequences of calcium deficiency manifested by a wide variety of diseases - PubMed

Calcium deficiency is a global problem, especially in the aging population. Among various nutrients, calcium is one of the few that is still deficient in industrialized countries such as Japan and many Western countries. Calcium deficiency is readily connected with osteoporosis, which is a...

www.ncbi.nlm.nih.gov

Calcium, parathyroids and aging - PubMed

Calcium is unique in its distribution in living organisms with an extremely high hard and soft tissue and extra- intracellular concentration gradient. Calcium deficiency through stimulating parathyroid hormone secretion tends to blunt such a difference by paradoxically increasing the calcium...

www.ncbi.nlm.nih.gov

Aging and calcium metabolism - PubMed

It is imperative to understand calcium metabolism under a unified concept, despite the vast concentration difference among the three major calcium compartments in human body. Total body calcium homeostasis supported by adequate calcium intake and normal skeletal metabolism is quite important to...

www.ncbi.nlm.nih.gov

Aging and calcium as an environmental factor - PubMed

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age. Low calcium and vitamin D intake, short solar exposure, decreased intestinal absorption, and falling...

www.ncbi.nlm.nih.gov

[Changes in calcium regulating hormone in osteoporosis] - PubMed

We summarized the changes of humoral factors, vitamin D, parathyroid hormone, and calcitonin in blood concentration, which are cooperatively regulating calcium homeostasis in aging and osteoporosis. Although these factors may play a important role on pathogenesis of osteoporosis in aged and...

www.ncbi.nlm.nih.gov

The calcium paradox of essential hypertension - PubMed

Three disparate observations--that calcium mediates vascular smooth muscle contraction, that calcium channel blockers lower blood pressure, and that increased dietary calcium intake can also ameliorate hypertension--constitute somewhat of a paradox. The complex interrelationships between calcium...

www.ncbi.nlm.nih.gov

Enhanced parathyroid function in essential hypertension: a homeostatic response to a urinary calcium leak - PubMed

Disorders of calcium metabolism are not generally considered important either clinically or pathophysiologically in essential hypertension. Recent reports, though, suggest that increased parathyroid gland function may be one of the more common endocrine disturbances associated with hypertension...

www.ncbi.nlm.nih.gov

Blood pressure and nutrient intake in the United States - PubMed

A data base of the National Center for Health Statistics, Health and Nutrition Examination Survey I (HANES I), was used to perform a computer-assisted, comprehensive analysis of the relation of 17 nutrients to the blood pressure profile of adult Americans. Subjects were 10,372 individuals, 18 to...

www.ncbi.nlm.nih.gov

Regulation of parathyroid hormone and vitamin D in essential hypertension - PubMed

Patients with essential hypertension have been reported to have a higher serum concentration of parathyroid hormone (PTH) than normotensive individuals although this finding is not universal among studies. To further characterize the status of the calcium regulating hormones in essential...

www.ncbi.nlm.nih.gov

damn buyo that's a lot of stuff are you suggesting a low meat diet? it seems to me that most foods rich in calcium are also rich or very rich in phosphorus tofu looked like the best ratio ngl. I'm assuming supps are subpar

 

[Deleted member 17768]

On the Trail of the Elusive X-Factor: A Sixty-Two-Year-Old Mystery Finally Solved

🖨️ Print post Translations: Dutch Contents Article Summary On the Trail of the Elusive X-Factor (Main Article) A Sixty-Year Mystery Vitamin K: Three Discoveries Converge Perfect Correspondence Synergy […]

www.westonaprice.org

"Interaction between vitamins A D K (Synergy)
Vitamin K2 is the substance that makes the vitamin A- and vitamin D-dependent proteins come to life. While vitamins A and D act as signalling molecules, telling cells to make certain proteins, vitamin K2 activates these proteins by conferring upon them the physical ability to bind calcium. In some cases these proteins directly coordinate the movement or organization of calcium themselves; in other cases the calcium acts as a glue to hold the protein in a certain shape. In all such cases, the proteins are only functional once they have been activated by vitamin K.
Osteocalcin, for example, is a protein responsible for organizing the deposition of calcium and phosphorus salts in bones and teeth. Cells only produce this protein in the presence of both vitamins A and D; it will only accumulate in the extracellular matrix and facilitate the deposition of calcium salts, however, once it has been activated by vitamin K2. Vitamins A and D regulate the expression of matrix Gla protein (MGP), which is responsible for mineralizing bone and protecting the arteries from calcification; like osteocalcin, however, MGP can only fulfil its function once it has been activated by vitamin K2. While vitamins A and D contribute to growth by stimulating growth factors and promoting the absorption of minerals, vitamin K2 makes its own essential contribution to growth by preventing the premature calcification of the cartilaginous growth zones of bones." - Masterjohn

I wonder what would happen if I used vitamin K while on accutane. Couldn't find anything about the interaction.

 

[Mr.cope]

So we pretty much need to overdose on vitamin d in order to have normal levels

 

[exeight]

i can relate to this
ive lost my job and was over a half year at home.. never left my house
and i felt very sick.. i got problems with my eyes, my skin looked like shit
and muscle twitch all around my body (i didnt know, the problems came from low vit d.. the doc couldnt help me.. he said my vit d is just a lil bit low but its at a normal range

i knew, that i had low vit d in my body and i purchased vit d from amazon (5.000 UI per Pill)
but on the package says "just take 1 pill a week" i do that but than realized thats for healthy people with good amount f vit d

after that i took 1 pill a day (5000 UI a day) for 2 weeks but i had the same problems.. also i was afraid to take too much vit d into my system.. then i felt like i wanna kill my self and i started to take 2 pills a day (10.000 UI a day)

after 3 fucking days my eyes was better and my skin lookd better
after another 3 days my muscle twitching all around the body stopped!!
also after taking 10.000 UI Vit d, i lost easily more BF (im a lil bit overweight) i think it helped my metabolism

the thing is; everywhere in the internet and also the doctors!! says "vIt d jUst tAke 1000 UI a dAy"
and when you hear that and you take the 10x of that, its scares a lil bit but i think this thread shows, how even doctors can be wrong

 

[Kroker]

i can relate to this
ive lost my job and was over a half year at home.. never left my house
and i felt very sick.. i got problems with my eyes, my skin looked like shit
and muscle twitch all around my body (i didnt know, the problems came from low vit d.. the doc couldnt help me.. he said my vit d is just a lil bit low but its at a normal range

i knew, that i had low vit d in my body and i purchased vit d from amazon (5.000 UI per Pill)
but on the package says "just take 1 pill a week" i do that but than realized thats for healthy people with good amount f vit d

after that i took 1 pill a day (5000 UI a day) for 2 weeks but i had the same problems.. also i was afraid to take too much vit d into my system.. then i felt like i wanna kill my self and i started to take 2 pills a day (10.000 UI a day)

after 3 fucking days my eyes was better and my skin lookd better
after another 3 days my muscle twitching all around the body stopped!!
also after taking 10.000 UI Vit d, i lost easily more BF (im a lil bit overweight) i think it helped my metabolism

the thing is; everywhere in the internet and also the doctors!! says "vIt d jUst tAke 1000 UI a dAy"
and when you hear that and you take the 10x of that, its scares a lil bit but i think this thread shows, how even doctors can be wrong

Dr's can be fucking stupid at a certain level.

My D levels were 19 ng/mL and the Dr told me its "fine"

 

[SAR]

How much time do i need to exposure to sun to get >5000ui?

 

[exeight]

Dr's can be fucking stupid at a certain level.

My D levels were 19 ng/mL and the Dr told me its "fine"

haha strange.. my level were 19,3ng/ml too :
that was before my self medication with vit d
it was 6 month ago.. im just curious i think im gonna go again to the doc and check my new vit d level

 

[Kroker]

haha strange.. my level were 19,3ng/ml too :
that was before my self medication with vit d
it was 6 month ago.. im just curious i think im gonna go again to the doc and check my new vit d level

oh what a coincidence!

What improvements did Vit D benefit you?

Hair? skin? bones?

 

[exeight]

oh what a coincidence!

What improvements did Vit D benefit you?

Hair? skin? bones?

I had muscle tremors all over my body and when I drove my car in the evening, the light from the rear lights of the cars burned my eyes for a very long time..

My skin was pale and had dark circles under my eyes.. got a little better

I'm in the process of losing weight and with Vit D it went much faster

I have more energy and before that I woke up 3-4 times every night and now I sleep for about 7 hours (is really new for me^^)

My depression also went down a bit

I know this all sounds like I'm promoting a product but really Vitamin D worked for me! BUT I took a lot more than recommended
Goggle says 1k/day and I was taking 10k daily.. well I had physical ailments.. apparently that's why my Vit D level was very very very low

wait, the Hair;
i think my hair its a lil bit darker and have more volume but im not sure
Bones? hmm never got Problems with my Bones.. i dont know if vit d changed something

But i got still the problem with dark eye area and im thinking to go to a dermatologist or i try 15k for couple days

 

[Kroker]

I had muscle tremors all over my body and when I drove my car in the evening, the light from the rear lights of the cars burned my eyes for a very long time..

My skin was pale and had dark circles under my eyes.. got a little better

I'm in the process of losing weight and with Vit D it went much faster

I have more energy and before that I woke up 3-4 times every night and now I sleep for about 7 hours (is really new for me^^)

My depression also went down a bit

I know this all sounds like I'm promoting a product but really Vitamin D worked for me! BUT I took a lot more than recommended
Goggle says 1k/day and I was taking 10k daily.. well I had physical ailments.. apparently that's why my Vit D level was very very very low

wait, the Hair;
i think my hair its a lil bit darker and have more volume but im not sure
Bones? hmm never got Problems with my Bones.. i dont know if vit d changed something

But i got still the problem with dark eye area and im thinking to go to a dermatologist or i try 15k for couple days

No tbh I think 15k is an over kill... But I'm still a newbie idk much about supplements and shit.

I'm glad it has worked for you!

Do you take K2 with it? its very optimal to combine them both!

Any other vitamins/supplements do you take?

 

[exeight]

No tbh I think 15k is an over kill... But I'm still a newbie idk much about supplements and shit.

I'm glad it has worked for you!

Do you take K2 with it? its very optimal to combine them both!

Any other vitamins/supplements do you take?

i searched about that on google and it seems very safe
i mean someone took 100.000 UI over month (every single day) and nothing negative happened

Quote from google;

"In summary, long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe."

Got my Vit D from Amazon combined with K2 and Omega 3

 

[Kroker]

i searched about that on google and it seems very safe
i mean someone took 100.000 UI over month (every single day) and nothing negative happened

Quote from google;

"In summary, long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe."

Got my Vit D from Amazon combined with K2 and Omega 3

Can you link the amazon product?

 

[exeight]

Can you link the amazon product?

actually i had but it was disappeared on my comment
i'll try again

ohh now i got it^^

(but its german.. you can translate with google)

 

[Kroker]

actually i had but it was disappeared on my comment
i'll try again

ohh now i got it^^

(but its german.. you can translate with google)

Ok upload the pic

 

[exeight]

Ok upload the pic

Link

 

[Kroker]

Link

Good!!! wish they sell stuff like this here... I can't even find D+K2 together jfl

 

[exeight]

Good!!! wish they sell stuff like this here... I can't even find D+K2 together jfl

where are you from?
pharmacy store has vit d too (but more expensive)

i think you are not in the US because you could buy that in a Wal Mart Store lol

 

[Kroker]

where are you from?
pharmacy store has vit d too (but more expensive)

i think you are not in the US because you could buy that in a Wal Mart Store lol

Cyprus

ITS FUCKING EXPANSIVE in pharmacies.

Tbh I dont trust amazom shipping or any outsource because of how they will store it... it might get exposed to heat or cold then it will be useless.

 

[RedstaR]

I take 50,000 IUs 2-3x a week.

 

[Lihito]

If you take Vitamin D3 alone after a few weeks you'll have muscle soreness, this is because it depletes magnesium. If you're going to supplement D3 you need to supplement with magnesium citrate as well.

drink magnesium
reminder*

dont mind this just my reminder

 

[KDA Player]

TBH it was pretty much obvious.

If you read studies on vitamin D you will see that many times the biggest benefits are founds at around 10 000IU / day.

Also RDA is just the minimum advised, it is absolutely not the optimal dosage of a supplement, for this they would have to make studies to find it, between underdosing and overdosing it, but that's not at all what they did to find the RDA.

You add that the fact health corporations will lobby to downplay it, mainly because it is too cheap to sell, and you understand the current mediatic and busness health position on this subject.

 

[Lawton88]

how much vitamin k2 should one take?

200 MCG of k2-Mk4 daily is enough for it to do it's job. Crazy amounts raise test a lot some studies have shown however.

 

[blonde chad]

75 to 100 nmol/L

To get to that level you have to take 10,000IU for a person who gets little sun..I have upped mine to 30,000 IU Iam 43 and don't get alot of sun and I am also gymmaxing

bro be careful, 30k iu is way too much, its crazy, it can kill u