The effect of IGF-1 and growth hormone injections on Height growth, a detailed analysis.

[JOTAROSON]

Can IGF-1-LR3 be used to influence growth?

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)

This is precisely why growth hormone injections do not increase an adult’s final height

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

 

[JOTAROSON]

 

[JOTAROSON]

.

 

[JOTAROSON]

Бump

 

[jotunnr]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

Tough

 

[JOTAROSON]

Жесткий

Thank you bro

 

[Fuldblod]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

Short sweet and simple.
Would probably change the title as it doesn’t clue people in - definitely not me lol

 

[JOTAROSON]

Коротко, ясно и просто.
Наверное, я бы изменил заголовок, так как он ничего не говорит — точно не я, ха-ха.

I don't know what title you want to make?

 

[JOTAROSON]

Можно ли использовать IGF-1-LR3 для влияния на рост?

View attachment 5206959

Краткий ответ: Нет, нельзя. Потому что зона роста — это строго локально регулируемая среда.
View attachment 5206970

Это означает, что аутокринные и паракринные механизмы играют более значительную роль, чем системные факторы (в нашем случае, высокий уровень IGF-1).
View attachment 5206975

Именно поэтому инъекции гормона роста не увеличивают окончательный рост взрослого человека.

View attachment 5206986

Кроме того, сами хондроциты продуцируют IGF-1, который может подвергаться альтернативному сплайсингу с образованием различных изоформ, таких как E, B, I и C.

View attachment 5206996
View attachment 5206997

Альтернативный сплайсинг важен, поскольку зона роста требует различных типов сигнализации IGF-1 в разное время и в разных областях. Именно благодаря этому механизму система обеспечивает столь точную регуляцию; альтернативный сплайсинг определяет стабильность транскрипта, его локализацию и связь с пролиферацией и гипертрофией хондроцитов.

View attachment 5207001

View attachment 5207002

Следовательно, IGF-1 не может связываться с клеточными белками, которые имеют решающее значение для вертикального роста.


Вывод : Превысить свой окончательный рост с помощью инъекций ИФР-1 или гормона роста невозможно без наличия дефицита этого гормона.

@Zagro Bro rate my post

 

[Fuldblod]

I don't know what title you want to make?

People don’t know that HGH has no influence on final height.
Just say some bullshit clickbait like “hgh is cope and doesn’t make you taller, high effort post GTIFH” etc..

 

[miah]

W post. Surly most people have deficiency in igf-1 though?

 

[JOTAROSON]

В посте W говорится, что у большинства людей наверняка наблюдается дефицит IGF-1?

After 12-14 years, I don't see any point in using growth hormone. There are drugs that have much better results.

 

[Zagro]

@Zagro Bro rate my post

0/10 because you got it all wrong

 

[brycen122365]

Totally fabulous day

 

[JOTAROSON]

0/10, потому что вы всё неправильно поняли.

Explain

 

[JOTAROSON]

0/10, потому что вы всё неправильно поняли.

I don't really understand what I did wrong.

 

[Paul.jnxy]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

Straight GPT . Of course w you won’t fucking grow from GH alone

 

[JOTAROSON]

Чистый ГПТ :вынужденнаяулыбка:. Конечно, от одного только гормона роста вы, блин, не вырастете.:вынужденнаяулыбка:

Yeah, yeah, nigga, and the gpt also gave me photos of the research. Dumb nigga.

 

[JOTAROSON]

.

 

[Fuldblod]

0/10 because you got it all wrong

LMFAO all this nigga does is say “ermm ahcktualley” and never elaborates.
Obstinate arguer Final boss

 

[JOTAROSON]

LMFAO all this nigga does is say “ermm ahcktualley” and never elaborates.
Obstinate arguer Final boss
View attachment 5208956

He's pretty smart, I didn't just tag him because the community of this site are clowns, but I don't understand what I did wrong

 

[Fuldblod]

He's pretty smart, I didn't just tag him because the community of this site are clowns, but I don't understand what I did wrong

It’s because hes on a huge cycle rn and needs to cope because of sunk cost fallacy and he’ll have to realize that he fucked up his life for no gains
“HGH 8iu ED
Anavar 25mg ED
Testosterone Enanthate 300mg E3D
Trenbolone Enanthate 200mg E3D
Retatrutide 5mg Weekly
Gluthathione 300mg EOD
BPC-157 500mcg ED
GHK-Cu 2.5mg ED

Aromasin 15mg ED
Isotretinoin 30mg ED
Tadalafil 10mg ED
Caber 0.25mg EOD
T4 20mcg ED
+ More ancillaries and other shit (sartans, statins, supplements and other substances)”

Is his cycle
JFL

 

[Fuldblod]

He's pretty smart, I didn't just tag him because the community of this site are clowns, but I don't understand what I did wrong

Replies on his threads arent doing too much either because it’s all just circlejerk slop like “uhh wow so cool youre doing tren and hgh at 15 so cool, mirin brahh”
Easy to understand why he’s so deadlocked on this mindset / belief because if it’s wrong all that money and hard work would have been for nothing (it already is).

As you can see he’s just 15 and still developing his frontal lobe so he probably cant properly understand the
consequences of his actions

Ego / pride is truly the downfall of so many people @Zagro

 

[JOTAROSON]

Это потому, что сейчас он находится в замкнутом круге и ему нужно справиться с проблемой невозвратных затрат, и ему придётся осознать, что он испортил себе жизнь без всякой пользы.
« HGH 8 МЕ в день»
Анавар 25 мг в день
Тестостерон энантат 300 мг E3D
Тренболон энантат 200 мг E3D
Ретатрутид 5 мг еженедельно
Глутатион 300 мг через день
БПК-157 500 мкг в день
GHK-Cu 2,5 мг в день

Аромазин 15 мг в день
Изотретиноин 30 мг (эректильная дисфункция)
Тадалафил 10 мг эректильная дисфункция
Кабер 0,25 мг через день
Т4 20 мкг в день
+ Ещё больше вспомогательных средств и прочей ерунды (сартаны, статины, добавки и другие вещества)

У него цикл
JFL

Idk

 

[JOTAROSON]

Это потому, что сейчас он находится в замкнутом круге и ему нужно справиться с проблемой невозвратных затрат, и ему придётся осознать, что он испортил себе жизнь без всякой пользы.
« HGH 8 МЕ в день»
Анавар 25 мг в день
Тестостерон энантат 300 мг E3D
Тренболон энантат 200 мг E3D
Ретатрутид 5 мг еженедельно
Глутатион 300 мг через день
БПК-157 500 мкг в день
GHK-Cu 2,5 мг в день

Аромазин 15 мг в день
Изотретиноин 30 мг (эректильная дисфункция)
Тадалафил 10 мг эректильная дисфункция
Кабер 0,25 мг через день
Т4 20 мкг в день
+ Ещё больше вспомогательных средств и прочей ерунды (сартаны, статины, добавки и другие вещества)

У него цикл
JFL

I wonder what the purpose of this course is, if it is his course.

 

[Fuldblod]

I wonder what the purpose of this course is, if it is his course.

Probably not only for height.
He’s doing a lot of other stuff that i think is beneficial, still risky but works nevertheless.
Gotta give credit where credit is due.
But, height? Nuh uh

 

[stw]

gh is cope asf

 

[JOTAROSON]

gh is cope asf

It depends on the purpose, for growth in height for sure

 

[JOTAROSON]

Вероятно, не только из-за роста.
Он занимается множеством других вещей, которые, на мой взгляд, полезны, хотя и рискованны, но тем не менее эффективны.
Нужно отдать должное тем, кто этого заслуживает.
А вот рост? Нет уж, спасибо.

If this is his stack, then honestly, it's complete crap for growth. It's also not so good for facial bones, because there are much better products than btw

 

[stw]

It depends on the purpose, for growth in height for sure

It will help if you are deficient in growth, but it won't do much if you arent

 

[JOTAROSON]

Это поможет, если у вас дефицит роста, но мало что даст, если его нет.

You're right, I think after 12-14 years there's no point in using it.

 

[JOTAROSON]

Это потому, что сейчас он находится в замкнутом круге и ему нужно справиться с проблемой невозвратных затрат, и ему придётся осознать, что он испортил себе жизнь без всякой пользы.
« HGH 8 МЕ в день»
Анавар 25 мг в день
Тестостерон энантат 300 мг E3D
Тренболон энантат 200 мг E3D
Ретатрутид 5 мг еженедельно
Глутатион 300 мг через день
БПК-157 500 мкг в день
GHK-Cu 2,5 мг в день

Аромазин 15 мг в день
Изотретиноин 30 мг (эректильная дисфункция)
Тадалафил 10 мг эректильная дисфункция
Кабер 0,25 мг через день
Т4 20 мкг в день
+ Ещё больше вспомогательных средств и прочей ерунды (сартаны, статины, добавки и другие вещества)

У него цикл
JFL

@Zagro Is this your stack?

 

[stnr74]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

Branlesscell acting like this wasnt obv especially when plates are closed it only grows cartilage and organs

 

[JOTAROSON]

Поведение безпчелиной клетки, подобное тому, что наблюдалось, было неочевидным, особенно когда пластинки закрыты, ведь она наращивает только хрящи и органы.

I don't really understand what you're talking about.

 

[Zagro]

Straight GPT . Of course w you won’t fucking grow from GH alone

Fucking nigger that uses gpt calls out gpt hilarious

@Zagro Is this your stack?

It isn’t i never ran that i ran 2-3x the doses hes a random seeking attention i will delete my account don’t tag me for bullshit anymore hate this fucking forum and its pseudo-intellectual users

 

[JOTAROSON]

Ебаный ниггер, который использует GPT, высмеивает GPT, это смешно.


Дело не в этом, я никогда не принимал дозу в 2-3 раза больше, он просто случайный человек, ищущий внимания. Я удалю свой аккаунт, больше не отмечайте меня в своих постах. Ненавижу этот чертов форум и его псевдоинтеллектуальных пользователей.

What happened? Why are you deleting your account? What did I do wrong?

 

[JOTAROSON]

Это не является достоверным двойным слепым исследованием. Оно не устанавливает ничего, кроме предположений тех, кто его написал.


Мы знаем, что гормон роста может изменить окончательный рост во взрослом возрасте, по крайней мере, у карликов. Так что вы объективно неправы. Насколько сильно он может изменить рост у обычных людей, неизвестно.

I literally attached the studies. I don't believe empty words. I ask for proof of your words. Growth hormone does not increase final height.

 

[JOTAROSON]

Вы, похоже, не понимаете, что такое исследование, хотя я специально указываю на недостатки того, что вы, кажется, считаете исследованием.

Как можно быть таким тупым? Ты вообще читал это перед тем, как опубликовать?

 

[JOTAROSON]

Да, вы не реанимировали это "исследование", мы это понимаем.

Show me studies that say growth hormone increases final height in normal people. I don't need studies that talk about gnomes and elves. Just real people.

 

[JOTAROSON]

Да, вы не реанимировали это "исследование", мы это понимаем.

I don't understand something, please explain where I'm wrong.

 

[JOTAROSON]

Как ты мог быть таким тупым? Серьёзно.

I don't see any point in continuing the dialogue, don't answer me anymore.

 

[tomacōck]

Although I agree with the claim regarding IGF1-LR3 since the arguments given are great, I have to object the "GH is unable to make you taller if you're healthy" part. The study cited, and this is the only study you have, was conducted on children age 4-10 at dosages of just .5IU/kg/week. Not only is the dosage too low but the patient age makes the study irrelevant.

 

[teramoggerMast]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

Does this apply to increlex igf-1 as well which is used to medically treat idiopathic short stature or just the modified versions of igf-1 like des and lr3

 

[JOTAROSON]

Хотя я согласен с утверждением относительно IGF1-LR3, поскольку приведенные аргументы убедительны, я должен возразить против утверждения «гормон роста не способен увеличить рост, если человек здоров». Приведенное исследование, и это единственное исследование, которое у вас есть, проводилось на детях в возрасте от 4 до 10 лет при дозировке всего 0,5 МЕ/кг/неделю. Мало того, что дозировка слишком низкая, так еще и возраст пациентов делает исследование неактуальным.

Growth hormone is not effective after age 14 unless you have a deficiency.

 

[JOTAROSON]

Распространяется ли это также на препарат Increlex IGF-1, используемый для лечения идиопатической низкорослости, или только на модифицированные версии IGF-1, такие как DES и LR3?

Yes, this drug was originally intended for children with deficiency. You won't grow taller than your genetic height.

 

[tomacōck]

Growth hormone is not effective after age 14 unless you have a deficiency.

Based on?

 

[JOTAROSON]

На чём основано?

Studies, almost all of them were done in children with Laron syndrome. After 14, unless you have a deficiency, you will not grow with local growth hormone.

 

[tomacōck]

Studies, almost all of them were done in children with Laron syndrome. After 14, unless you have a deficiency, you will not grow with local growth hormone.

Link then

 

[Zagro]

Replies on his threads arent doing too much either because it’s all just circlejerk slop like “uhh wow so cool youre doing tren and hgh at 15 so cool, mirin brahh”
Easy to understand why he’s so deadlocked on this mindset / belief because if it’s wrong all that money and hard work would have been for nothing (it already is).

As you can see he’s just 15 and still developing his frontal lobe so he probably cant properly understand the
consequences of his actionsView attachment 5208976

Ego / pride is truly the downfall of so many people @Zagro

“Understand the consequences of his actions”

> doesn’t know i started roiding to kill myself

 

[JOTAROSON]

Затем перейдите по ссылке.

Insulin-like growth factor 1 (IGF-1): a growth hormone - PMC

Aim—To contribute to the debate about whether growth hormone (GH) and insulin-like growth factor 1 (IGF-1) act independently on the growth process. Methods—To describe growth in human and animal models of isolated IGF-1 deficiency (IGHD), such as in ...

pmc.ncbi.nlm.nih.gov