The effect of IGF-1 and growth hormone injections on Height growth, a detailed analysis.

[JOTAROSON]

Can IGF-1-LR3 be used to influence growth?

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)

This is precisely why growth hormone injections do not increase an adult’s final height

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

 

[JOTAROSON]

 

[JOTAROSON]

.

 

[JOTAROSON]

Бump

 

[daudthe1_]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

Tough

 

[JOTAROSON]

Жесткий

Thank you bro

 

[Noriju]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

Short sweet and simple.
Would probably change the title as it doesn’t clue people in - definitely not me lol

 

[JOTAROSON]

Коротко, ясно и просто.
Наверное, я бы изменил заголовок, так как он ничего не говорит — точно не я, ха-ха.

I don't know what title you want to make?

 

[JOTAROSON]

Можно ли использовать IGF-1-LR3 для влияния на рост?

View attachment 5206959

Краткий ответ: Нет, нельзя. Потому что зона роста — это строго локально регулируемая среда.
View attachment 5206970

Это означает, что аутокринные и паракринные механизмы играют более значительную роль, чем системные факторы (в нашем случае, высокий уровень IGF-1).
View attachment 5206975

Именно поэтому инъекции гормона роста не увеличивают окончательный рост взрослого человека.

View attachment 5206986

Кроме того, сами хондроциты продуцируют IGF-1, который может подвергаться альтернативному сплайсингу с образованием различных изоформ, таких как E, B, I и C.

View attachment 5206996
View attachment 5206997

Альтернативный сплайсинг важен, поскольку зона роста требует различных типов сигнализации IGF-1 в разное время и в разных областях. Именно благодаря этому механизму система обеспечивает столь точную регуляцию; альтернативный сплайсинг определяет стабильность транскрипта, его локализацию и связь с пролиферацией и гипертрофией хондроцитов.

View attachment 5207001

View attachment 5207002

Следовательно, IGF-1 не может связываться с клеточными белками, которые имеют решающее значение для вертикального роста.


Вывод : Превысить свой окончательный рост с помощью инъекций ИФР-1 или гормона роста невозможно без наличия дефицита этого гормона.

@Zagro Bro rate my post

 

[Noriju]

I don't know what title you want to make?

People don’t know that HGH has no influence on final height.
Just say some bullshit clickbait like “hgh is cope and doesn’t make you taller, high effort post GTIFH” etc..

 

[miah]

W post. Surly most people have deficiency in igf-1 though?

 

[JOTAROSON]

В посте W говорится, что у большинства людей наверняка наблюдается дефицит IGF-1?

After 12-14 years, I don't see any point in using growth hormone. There are drugs that have much better results.