The effect of PEPCK-C overexpression in muscle in mice.

[tomacōck]

Recently watched this interview with a random russian dude and he mentioned this.

Found the study:

https://www.jbc.org/article/S0021-9258(20)61295-9/fulltext

This is just wonderful:
"On a mouse treadmill, PEPCK-Cmus mice ran up to 6 km at a speed of 20 m/min, whereas controls stopped at 0.2 km."
A-fucking-mazing. 30 times the endurance.


"PEPCK-Cmus mice had an enhanced exercise capacity, with a VO2max of 156 ± 8.0 ml/kg/min, a maximal respiratory exchange ratio of 0.91 ± 0.03, and a blood lactate concentration of 3.7 ± 1.0 mm after running for 32 min at a 25° grade; the values for control animals were 112 ± 21 ml/kg/min, 0.99 ± 0.08, and 8.1 ± 5.0 mm respectively."
Almost 1.5 the VO2max!



But what's the catch??

Food. God were those mice hungry.
"The PEPCK-Cmus mice ate 60% more than controls but had half the body weight and 10% the body fat as determined by magnetic resonance imaging."
Yeye, lower body fat whatever, but they're light as fuck and eat a shitton.

In addition, if normal mice died only after like 4-5 days of not eating, the modified mice died in just 24hrs.

PEPCK, full name Phosphoenolpyruvate Carboxykinase, is a mandatory ferment that is a must for gluconeogenesis to work. That's why it made shit change so much, and that's why you'll fucking die if you don't eat enough.

 

[Idontknow-]

Recently watched this interview with a random russian dude and he mentioned this.

Found the study:

https://www.jbc.org/article/S0021-9258(20)61295-9/fulltext

This is just wonderful:
"On a mouse treadmill, PEPCK-Cmus mice ran up to 6 km at a speed of 20 m/min, whereas controls stopped at 0.2 km."
A-fucking-mazing. 30 times the endurance.


"PEPCK-Cmus mice had an enhanced exercise capacity, with a VO2max of 156 ± 8.0 ml/kg/min, a maximal respiratory exchange ratio of 0.91 ± 0.03, and a blood lactate concentration of 3.7 ± 1.0 mm after running for 32 min at a 25° grade; the values for control animals were 112 ± 21 ml/kg/min, 0.99 ± 0.08, and 8.1 ± 5.0 mm respectively."
Almost 1.5 the VO2max!



But what's the catch??

Food. God were those mice hungry.
"The PEPCK-Cmus mice ate 60% more than controls but had half the body weight and 10% the body fat as determined by magnetic resonance imaging."
Yeye, lower body fat whatever, but they're light as fuck and eat a shitton.

In addition, if normal mice died only after like 4-5 days of not eating, the modified mice died in just 24hrs.

Meaning?

 

[ICL]

bvmp nigger

 

[ICL]

Meaning?

gene that boosts endurance 30 fold in mice which we can try in humans to reap the benefit [although there's no way we're gonna get a 30 gold boost in humans as well]

 

[tomacōck]

peptide that boosts endurance 30 fold in mice which we can try in humans to reap the benefit [although there's no way we're gonna get a 30 gold boost in humans as well]

1. Not peptide but an altered gene.
2. You'll fucking die if you don't eat.

 

[dirittomarco]

im not taking perc cum nigga

 

[Idontknow-]

gene that boosts endurance 30 fold in mice which we can try in humans to reap the benefit [although there's no way we're gonna get a 30 gold boost in humans as well]

 

[Genio]

1. Not peptide but an altered gene.
2. You'll fucking die if you don't eat.

You'll die if you eat on DNP
You'll die if you don't eat on PEPCK-Mus

Match made in heaven

 

[tomacōck]

You'll die if you eat on DNP
You'll die if you don't eat on PEPCK-Mus

Match made in heaven

One makes your mitochondria peak
One makes your mitochondria dead
Truly!

 

[tomacōck]

You'll die if you eat on DNP
You'll die if you don't eat on PEPCK-Mus

Match made in heaven

bvmp nigger

Oh God this might actually be insane

 

[ICL]

Oh God this might actually be insane

You'll die if you eat on DNP
You'll die if you don't eat on PEPCK-Mus

Match made in heaven

And you take Ghrelin to spike appetite but then use Retatrutide to suppress appetite so you know you reached flow state

 

[sherry12]

Recently watched this interview with a random russian dude and he mentioned this.

Found the study:

https://www.jbc.org/article/S0021-9258(20)61295-9/fulltext

This is just wonderful:
"On a mouse treadmill, PEPCK-Cmus mice ran up to 6 km at a speed of 20 m/min, whereas controls stopped at 0.2 km."
A-fucking-mazing. 30 times the endurance.


"PEPCK-Cmus mice had an enhanced exercise capacity, with a VO2max of 156 ± 8.0 ml/kg/min, a maximal respiratory exchange ratio of 0.91 ± 0.03, and a blood lactate concentration of 3.7 ± 1.0 mm after running for 32 min at a 25° grade; the values for control animals were 112 ± 21 ml/kg/min, 0.99 ± 0.08, and 8.1 ± 5.0 mm respectively."
Almost 1.5 the VO2max!



But what's the catch??

Food. God were those mice hungry.
"The PEPCK-Cmus mice ate 60% more than controls but had half the body weight and 10% the body fat as determined by magnetic resonance imaging."
Yeye, lower body fat whatever, but they're light as fuck and eat a shitton.

In addition, if normal mice died only after like 4-5 days of not eating, the modified mice died in just 24hrs.

PEPCK, full name Phosphoenolpyruvate Carboxykinase, is a mandatory ferment that is a must for gluconeogenesis to work. That's why it made shit change so much, and that's why you'll fucking die if you don't eat enough.

interesting asf