The miracle drug- Rapamycin

Aryan Incel

Aryan Incel

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Intro


I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated

IMG_7571.jpeg




Biology

IMG_7570.jpeg


The basics of how it works:

  1. Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
  2. mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
  3. Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
  4. Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling

Benefits


Hair growth


Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride

https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251

https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.


Skin collagen/ aging

Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.

https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging

https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr

https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).

https://febs.onlinelibrary.wiley.co...281#:~:text=Many of these pro-growth,[32-34]].


Biological aging

However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.

This more than double Epitalon which @Sadist made a thread about

In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)

https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1

https://pubmed.ncbi.nlm.nih.gov/24341993/


Negative


Fertility

There are many studies showing that Rap can cause birth defects

https://pmc.ncbi.nlm.nih.gov/articl...mechanistic,cardiomyocytes in the adult heart.

Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.


Muscle mass

MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.

Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss

https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/

However not all MTOR is inhibited even at high doses

https://pubmed.ncbi.nlm.nih.gov/19395872/

However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.

IMG_7568.jpeg


Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.

However because of this repa should not be used until you have achieved your goal physique.

In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses


Fluid retention

cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone

https://pubmed.ncbi.nlm.nih.gov/246...ort,transplantation; rapamycine; side effects.


Blood clotting issues

Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function

https://ashpublications.org/blood/a....org/10.1182,was determined by flow cytometry.


High cholesterol

While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.

https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.


Best dosage/ schedule


Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.

Generally aim for 20 mg/ week

But starting slow and slowly increasing is recommended

With a week off week on cycle

For example-

Week 1- 5 mg

Week 2-0 mg

Week 3- 10 mg

Week 4- 0 mg

Week 5- 15 mg

Week 6- 0 mg

Week 7- 20 mg

Week 8- 0 mg

Week 9- 20 mg

Week 10- 0 mg

Week 11- 20 mg

Etc

https://pubmed.ncbi.nlm.nih.gov/25540326/


Conclusion


To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone


@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
 
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Seems pretty shit
 
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Intro


I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated

View attachment 4124280




Biology

View attachment 4124281

The basics of how it works:


  1. Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
  2. mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
  3. Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
  4. Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling

Benefits


Hair growth


Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride

https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251

https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.


Skin collagen/ aging

Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.

https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging

https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr

https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).

https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.17281#:~:text=Many of these pro-growth,[32-34]].


Biological aging

However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.

This more than double Epitalon which @Sadist made a thread about

In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)

https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1

https://pubmed.ncbi.nlm.nih.gov/24341993/



Negative


Fertility

There are many studies showing that Rap can cause birth defects

https://pmc.ncbi.nlm.nih.gov/articles/PMC5586418/#:~:text=Clinical Perspective&text=Pharmacological inhibition of the mechanistic,cardiomyocytes in the adult heart.

Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.


Muscle mass

MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.

Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss

https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/

However not all MTOR is inhibited even at high doses

https://pubmed.ncbi.nlm.nih.gov/19395872/

However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.

View attachment 4124282

Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.

However because of this repa should not be used until you have achieved your goal physique.

In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses


Fluid retention

cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone

https://pubmed.ncbi.nlm.nih.gov/24654608/#:~:text=We performed a retrospective cohort,transplantation; rapamycine; side effects.


Blood clotting issues

Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function

https://ashpublications.org/blood/article/140/Supplement 1/8404/492439/Rapamycin-Inhibits-Cytotoxic-T-Lymphocytes#:~:text=https://doi.org/10.1182,was determined by flow cytometry.


High cholesterol

While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.

https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.



Best dosage/ schedule


Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.

Generally aim for 20 mg/ week

But starting slow and slowly increasing is recommended

With a week off week on cycle

For example-

Week 1- 5 mg

Week 2-0 mg

Week 3- 10 mg

Week 4- 0 mg

Week 5- 15 mg

Week 6- 0 mg

Week 7- 20 mg

Week 8- 0 mg

Week 9- 20 mg

Week 10- 0 mg

Week 11- 20 mg

Etc

https://pubmed.ncbi.nlm.nih.gov/25540326/



Conclusion


To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone


@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
Bro is rocking it with the threads lately, unfortunately I DNRd all of them, will read them later tho :ogre:

Bookmarked
 
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dnr but bumped for high effort :owo:
 
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@MaracasMogs @BigBallsLarry @Lars2
 
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This stuff is only worth using if ur like a 50+ year old chad who wants to longevitymaxx with 20 year old Stacy wife
 
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Intro


I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated

View attachment 4124280




Biology

View attachment 4124281

The basics of how it works:


  1. Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
  2. mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
  3. Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
  4. Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling

Benefits


Hair growth


Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride

https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251

https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.


Skin collagen/ aging

Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.

https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging

https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr

https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).

https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.17281#:~:text=Many of these pro-growth,[32-34]].


Biological aging

However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.

This more than double Epitalon which @Sadist made a thread about

In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)

https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1

https://pubmed.ncbi.nlm.nih.gov/24341993/



Negative


Fertility

There are many studies showing that Rap can cause birth defects

https://pmc.ncbi.nlm.nih.gov/articles/PMC5586418/#:~:text=Clinical Perspective&text=Pharmacological inhibition of the mechanistic,cardiomyocytes in the adult heart.

Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.


Muscle mass

MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.

Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss

https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/

However not all MTOR is inhibited even at high doses

https://pubmed.ncbi.nlm.nih.gov/19395872/

However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.

View attachment 4124282

Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.

However because of this repa should not be used until you have achieved your goal physique.

In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses


Fluid retention

cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone

https://pubmed.ncbi.nlm.nih.gov/24654608/#:~:text=We performed a retrospective cohort,transplantation; rapamycine; side effects.


Blood clotting issues

Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function

https://ashpublications.org/blood/article/140/Supplement 1/8404/492439/Rapamycin-Inhibits-Cytotoxic-T-Lymphocytes#:~:text=https://doi.org/10.1182,was determined by flow cytometry.


High cholesterol

While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.

https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.



Best dosage/ schedule


Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.

Generally aim for 20 mg/ week

But starting slow and slowly increasing is recommended

With a week off week on cycle

For example-

Week 1- 5 mg

Week 2-0 mg

Week 3- 10 mg

Week 4- 0 mg

Week 5- 15 mg

Week 6- 0 mg

Week 7- 20 mg

Week 8- 0 mg

Week 9- 20 mg

Week 10- 0 mg

Week 11- 20 mg

Etc

https://pubmed.ncbi.nlm.nih.gov/25540326/



Conclusion


To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone


@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
Just be asian theory:ROFLMAO:
 
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didnt even bring up all of the side effects, its an immunosuppressant and impairs wound healing as well, so not only will you have slow recovery to any surgery or injury, but if it gets infected due to that, youre basically cooked, taking an immunosuppressant for life span is counter intuitive
 
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Intro


I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated

View attachment 4124280




Biology

View attachment 4124281

The basics of how it works:


  1. Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
  2. mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
  3. Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
  4. Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling

Benefits


Hair growth


Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride

https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251

https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.


Skin collagen/ aging

Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.

https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging

https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr

https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).

https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.17281#:~:text=Many of these pro-growth,[32-34]].


Biological aging

However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.

This more than double Epitalon which @Sadist made a thread about

In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)

https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1

https://pubmed.ncbi.nlm.nih.gov/24341993/



Negative


Fertility

There are many studies showing that Rap can cause birth defects

https://pmc.ncbi.nlm.nih.gov/articles/PMC5586418/#:~:text=Clinical Perspective&text=Pharmacological inhibition of the mechanistic,cardiomyocytes in the adult heart.

Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.


Muscle mass

MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.

Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss

https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/

However not all MTOR is inhibited even at high doses

https://pubmed.ncbi.nlm.nih.gov/19395872/

However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.

View attachment 4124282

Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.

However because of this repa should not be used until you have achieved your goal physique.

In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses


Fluid retention

cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone

https://pubmed.ncbi.nlm.nih.gov/24654608/#:~:text=We performed a retrospective cohort,transplantation; rapamycine; side effects.


Blood clotting issues

Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function

https://ashpublications.org/blood/article/140/Supplement 1/8404/492439/Rapamycin-Inhibits-Cytotoxic-T-Lymphocytes#:~:text=https://doi.org/10.1182,was determined by flow cytometry.


High cholesterol

While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.

https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.



Best dosage/ schedule


Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.

Generally aim for 20 mg/ week

But starting slow and slowly increasing is recommended

With a week off week on cycle

For example-

Week 1- 5 mg

Week 2-0 mg

Week 3- 10 mg

Week 4- 0 mg

Week 5- 15 mg

Week 6- 0 mg

Week 7- 20 mg

Week 8- 0 mg

Week 9- 20 mg

Week 10- 0 mg

Week 11- 20 mg

Etc

https://pubmed.ncbi.nlm.nih.gov/25540326/



Conclusion


To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone


@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
High iq DID READ
 
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Intro


I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated

View attachment 4124280




Biology

View attachment 4124281

The basics of how it works:


  1. Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
  2. mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
  3. Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
  4. Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling

Benefits


Hair growth


Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride

https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251

https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.


Skin collagen/ aging

Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.

https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging

https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr

https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).

https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.17281#:~:text=Many of these pro-growth,[32-34]].


Biological aging

However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.

This more than double Epitalon which @Sadist made a thread about

In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)

https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1

https://pubmed.ncbi.nlm.nih.gov/24341993/



Negative


Fertility

There are many studies showing that Rap can cause birth defects

https://pmc.ncbi.nlm.nih.gov/articles/PMC5586418/#:~:text=Clinical Perspective&text=Pharmacological inhibition of the mechanistic,cardiomyocytes in the adult heart.

Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.


Muscle mass

MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.

Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss

https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/

However not all MTOR is inhibited even at high doses

https://pubmed.ncbi.nlm.nih.gov/19395872/

However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.

View attachment 4124282

Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.

However because of this repa should not be used until you have achieved your goal physique.

In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses


Fluid retention

cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone

https://pubmed.ncbi.nlm.nih.gov/24654608/#:~:text=We performed a retrospective cohort,transplantation; rapamycine; side effects.


Blood clotting issues

Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function

https://ashpublications.org/blood/article/140/Supplement 1/8404/492439/Rapamycin-Inhibits-Cytotoxic-T-Lymphocytes#:~:text=https://doi.org/10.1182,was determined by flow cytometry.


High cholesterol

While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.

https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.



Best dosage/ schedule


Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.

Generally aim for 20 mg/ week

But starting slow and slowly increasing is recommended

With a week off week on cycle

For example-

Week 1- 5 mg

Week 2-0 mg

Week 3- 10 mg

Week 4- 0 mg

Week 5- 15 mg

Week 6- 0 mg

Week 7- 20 mg

Week 8- 0 mg

Week 9- 20 mg

Week 10- 0 mg

Week 11- 20 mg

Etc

https://pubmed.ncbi.nlm.nih.gov/25540326/



Conclusion


To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone


@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
Lmfao cons overweigh pros by like 20tons
 
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didnt even bring up all of the side effects, its an immunosuppressant and impairs wound healing as well, so not only will you have slow recovery to any surgery or injury, but if it gets infected due to that, youre basically cooked, taking an immunosuppressant for life span is counter intuitive
Actually, a better description of rapamycin is that it is an immune system modulator.

At lower doses its been shown to improve the immune system function, and at higher doses (with other medications used in concert with rapamycin) it can lower the immune system function.

 
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Actually, a better description of rapamycin is that it is an immune system modulator.

At lower doses its been shown to improve the immune system function, and at higher doses (with other medications used in concert with rapamycin) it can lower the immune system function.

In simple terms it will shut off your immune system temporarily while on but if you cycle it as I recommend and come of it when you’re injured or sick you’ll not get those effects
 
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This stuff is only worth using if ur like a 50+ year old chad who wants to longevitymaxx with 20 year old Stacy wife
The younger you take the better the effects
 
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@chadisbeingmade @Daddy's Home @Jattgymmaxx
 
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Bump
 
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Intro


I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated

View attachment 4124280




Biology

View attachment 4124281

The basics of how it works:


  1. Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
  2. mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
  3. Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
  4. Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling

Benefits


Hair growth


Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride

https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251

https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.


Skin collagen/ aging

Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.

https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging

https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr

https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).

https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.17281#:~:text=Many of these pro-growth,[32-34]].


Biological aging

However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.

This more than double Epitalon which @Sadist made a thread about

In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)

https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1

https://pubmed.ncbi.nlm.nih.gov/24341993/



Negative


Fertility

There are many studies showing that Rap can cause birth defects

https://pmc.ncbi.nlm.nih.gov/articles/PMC5586418/#:~:text=Clinical Perspective&text=Pharmacological inhibition of the mechanistic,cardiomyocytes in the adult heart.

Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.


Muscle mass

MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.

Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss

https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/

However not all MTOR is inhibited even at high doses

https://pubmed.ncbi.nlm.nih.gov/19395872/

However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.

View attachment 4124282

Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.

However because of this repa should not be used until you have achieved your goal physique.

In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses


Fluid retention

cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone

https://pubmed.ncbi.nlm.nih.gov/24654608/#:~:text=We performed a retrospective cohort,transplantation; rapamycine; side effects.


Blood clotting issues

Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function

https://ashpublications.org/blood/article/140/Supplement 1/8404/492439/Rapamycin-Inhibits-Cytotoxic-T-Lymphocytes#:~:text=https://doi.org/10.1182,was determined by flow cytometry.


High cholesterol

While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.

https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.



Best dosage/ schedule


Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.

Generally aim for 20 mg/ week

But starting slow and slowly increasing is recommended

With a week off week on cycle

For example-

Week 1- 5 mg

Week 2-0 mg

Week 3- 10 mg

Week 4- 0 mg

Week 5- 15 mg

Week 6- 0 mg

Week 7- 20 mg

Week 8- 0 mg

Week 9- 20 mg

Week 10- 0 mg

Week 11- 20 mg

Etc

https://pubmed.ncbi.nlm.nih.gov/25540326/



Conclusion


To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone


@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
Mirin
 
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@eon @forwardridge @Gengar @Sadist
 
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Bump
 
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In short, this basically castrates you
 
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Intro


I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated

View attachment 4124280




Biology

View attachment 4124281

The basics of how it works:


  1. Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
  2. mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
  3. Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
  4. Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling

Benefits


Hair growth


Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride

https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251

https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.


Skin collagen/ aging

Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.

https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging

https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr

https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).

https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.17281#:~:text=Many of these pro-growth,[32-34]].


Biological aging

However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.

This more than double Epitalon which @Sadist made a thread about

In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)

https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1

https://pubmed.ncbi.nlm.nih.gov/24341993/



Negative


Fertility

There are many studies showing that Rap can cause birth defects

https://pmc.ncbi.nlm.nih.gov/articles/PMC5586418/#:~:text=Clinical Perspective&text=Pharmacological inhibition of the mechanistic,cardiomyocytes in the adult heart.

Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.


Muscle mass

MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.

Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss

https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/

However not all MTOR is inhibited even at high doses

https://pubmed.ncbi.nlm.nih.gov/19395872/

However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.

View attachment 4124282

Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.

However because of this repa should not be used until you have achieved your goal physique.

In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses


Fluid retention

cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone

https://pubmed.ncbi.nlm.nih.gov/24654608/#:~:text=We performed a retrospective cohort,transplantation; rapamycine; side effects.


Blood clotting issues

Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function

https://ashpublications.org/blood/article/140/Supplement 1/8404/492439/Rapamycin-Inhibits-Cytotoxic-T-Lymphocytes#:~:text=https://doi.org/10.1182,was determined by flow cytometry.


High cholesterol

While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.

https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.



Best dosage/ schedule


Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.

Generally aim for 20 mg/ week

But starting slow and slowly increasing is recommended

With a week off week on cycle

For example-

Week 1- 5 mg

Week 2-0 mg

Week 3- 10 mg

Week 4- 0 mg

Week 5- 15 mg

Week 6- 0 mg

Week 7- 20 mg

Week 8- 0 mg

Week 9- 20 mg

Week 10- 0 mg

Week 11- 20 mg

Etc

https://pubmed.ncbi.nlm.nih.gov/25540326/



Conclusion


To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone


@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
it get boosted by other drugs
Or calaberate with other drug like
  • Trametinib
  • Lithium. Would be far more beneficial than rapamycin alone
 
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it get boosted by other drugs
Or calaberate with other drug like
  • Trametinib
  • Lithium. Would be far more beneficial than rapamycin alone
A recent study on fruit flies found that a triple combination of rapamycin, trametinib, and lithium additively increased their lifespan. This means the drugs, when used together, produced a combined effect equal to the sum of their individual effects.
Each drug targets a different biological pathway associated with aging. Rapamycin is a known longevity agent that inhibits the mTOR pathway, a key regulator of cell metabolism and aging. Trametinib, an anti-cancer drug, works by blocking the MEK pathway, which is involved in cell growth. Finally, the mood stabilizer lithium is thought to extend lifespan by inhibiting the GSK3 enzyme.
The fact that the combined effect was additive, not synergistic, suggests that each drug independently targets a different, distinct mechanism of aging. This is a promising discovery because it supports the idea that simultaneously targeting multiple, separate pathways is a more effective strategy for increasing longevity than focusing on just one. This research opens the door for further studies on using multi-drug cocktails to combat the aging process.
Prove
 
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@Aryan Incel you could create a thread about that I'm going to create my first high iq thread about something else
 
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@Aryan Incel you could create a thread about that I'm going to create my first high iq thread about something else
Mirin tag me when you make it
 
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Are you going to create a thread with the compilation of Rapamycin trametinib lithium
Maybe there are also other good drugs as well but I think I’ll take a break from writing threads for a bit
 
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Bump
 
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@imontheloose @enchanted_elixir @Amnesia @grilldaddy❤️ @renos
 
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mirin the effort
 
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Intro


I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated

View attachment 4124280




Biology

View attachment 4124281

The basics of how it works:


  1. Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
  2. mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
  3. Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
  4. Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling

Benefits


Hair growth


Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride

https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251

https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.


Skin collagen/ aging

Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.

https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging

https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr

https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).

https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.17281#:~:text=Many of these pro-growth,[32-34]].


Biological aging

However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.

This more than double Epitalon which @Sadist made a thread about

In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)

https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1

https://pubmed.ncbi.nlm.nih.gov/24341993/



Negative


Fertility

There are many studies showing that Rap can cause birth defects

https://pmc.ncbi.nlm.nih.gov/articles/PMC5586418/#:~:text=Clinical Perspective&text=Pharmacological inhibition of the mechanistic,cardiomyocytes in the adult heart.

Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.


Muscle mass

MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.

Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss

https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/

However not all MTOR is inhibited even at high doses

https://pubmed.ncbi.nlm.nih.gov/19395872/

However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.

View attachment 4124282

Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.

However because of this repa should not be used until you have achieved your goal physique.

In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses


Fluid retention

cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone

https://pubmed.ncbi.nlm.nih.gov/24654608/#:~:text=We performed a retrospective cohort,transplantation; rapamycine; side effects.


Blood clotting issues

Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function

https://ashpublications.org/blood/article/140/Supplement 1/8404/492439/Rapamycin-Inhibits-Cytotoxic-T-Lymphocytes#:~:text=https://doi.org/10.1182,was determined by flow cytometry.


High cholesterol

While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.

https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.



Best dosage/ schedule


Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.

Generally aim for 20 mg/ week

But starting slow and slowly increasing is recommended

With a week off week on cycle

For example-

Week 1- 5 mg

Week 2-0 mg

Week 3- 10 mg

Week 4- 0 mg

Week 5- 15 mg

Week 6- 0 mg

Week 7- 20 mg

Week 8- 0 mg

Week 9- 20 mg

Week 10- 0 mg

Week 11- 20 mg

Etc

https://pubmed.ncbi.nlm.nih.gov/25540326/



Conclusion


To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone


@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
Read every molecule 🤝

Very interesting thread but i think the down regulation of mTOR would be too big of a looksmin for frame/physiquemaxxing
 
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R

Read every molecule 🤝

Very interesting thread but i think the down regulation of mTOR would be too big of a looksmin for frame/physiquemaxxing
it depends how much muscle loss occurs from down regulation of mTOR especially when you cycle it but generally if it is significant loss of agree
 
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Sheitt ill read this soon seems interesting
If you compined Rapamycin with trametinib and lithium it will be far better
 
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Intro


I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated

View attachment 4124280




Biology

View attachment 4124281

The basics of how it works:


  1. Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
  2. mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
  3. Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
  4. Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling

Benefits


Hair growth


Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride

https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251

https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.


Skin collagen/ aging

Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.

https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging

https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr

https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).

https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.17281#:~:text=Many of these pro-growth,[32-34]].


Biological aging

However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.

This more than double Epitalon which @Sadist made a thread about

In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)

https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1

https://pubmed.ncbi.nlm.nih.gov/24341993/



Negative


Fertility

There are many studies showing that Rap can cause birth defects

https://pmc.ncbi.nlm.nih.gov/articles/PMC5586418/#:~:text=Clinical Perspective&text=Pharmacological inhibition of the mechanistic,cardiomyocytes in the adult heart.

Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.


Muscle mass

MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.

Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss

https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/

However not all MTOR is inhibited even at high doses

https://pubmed.ncbi.nlm.nih.gov/19395872/

However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.

View attachment 4124282

Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.

However because of this repa should not be used until you have achieved your goal physique.

In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses


Fluid retention

cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone

https://pubmed.ncbi.nlm.nih.gov/24654608/#:~:text=We performed a retrospective cohort,transplantation; rapamycine; side effects.


Blood clotting issues

Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function

https://ashpublications.org/blood/article/140/Supplement 1/8404/492439/Rapamycin-Inhibits-Cytotoxic-T-Lymphocytes#:~:text=https://doi.org/10.1182,was determined by flow cytometry.


High cholesterol

While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.

https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.



Best dosage/ schedule


Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.

Generally aim for 20 mg/ week

But starting slow and slowly increasing is recommended

With a week off week on cycle

For example-

Week 1- 5 mg

Week 2-0 mg

Week 3- 10 mg

Week 4- 0 mg

Week 5- 15 mg

Week 6- 0 mg

Week 7- 20 mg

Week 8- 0 mg

Week 9- 20 mg

Week 10- 0 mg

Week 11- 20 mg

Etc

https://pubmed.ncbi.nlm.nih.gov/25540326/



Conclusion


To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone


@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
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