Aryan Incel
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Intro
I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated
Biology
The basics of how it works:
Benefits
Hair growth
Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride
https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251
https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.
Skin collagen/ aging
Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.
https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging
https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr
https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).
https://febs.onlinelibrary.wiley.co...281#:~:text=Many of these pro-growth,[32-34]].
Biological aging
However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.
This more than double Epitalon which @Sadist made a thread about
In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)
https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1
https://pubmed.ncbi.nlm.nih.gov/24341993/
Negative
Fertility
There are many studies showing that Rap can cause birth defects
https://pmc.ncbi.nlm.nih.gov/articl...mechanistic,cardiomyocytes in the adult heart.
Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.
Muscle mass
MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.
Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss
https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/
However not all MTOR is inhibited even at high doses
https://pubmed.ncbi.nlm.nih.gov/19395872/
However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.
Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.
However because of this repa should not be used until you have achieved your goal physique.
In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses
Fluid retention
cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone
https://pubmed.ncbi.nlm.nih.gov/246...ort,transplantation; rapamycine; side effects.
Blood clotting issues
Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function
https://ashpublications.org/blood/a....org/10.1182,was determined by flow cytometry.
High cholesterol
While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.
https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.
Best dosage/ schedule
Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.
Generally aim for 20 mg/ week
But starting slow and slowly increasing is recommended
With a week off week on cycle
For example-
Week 1- 5 mg
Week 2-0 mg
Week 3- 10 mg
Week 4- 0 mg
Week 5- 15 mg
Week 6- 0 mg
Week 7- 20 mg
Week 8- 0 mg
Week 9- 20 mg
Week 10- 0 mg
Week 11- 20 mg
Etc
https://pubmed.ncbi.nlm.nih.gov/25540326/
Conclusion
To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone
I’m going to go over Rapamycin a miracle drug for looksmaxxing and increasing your lifespan. It is truly underrated
Biology
The basics of how it works:
- Cellular binding: Rapamycin enters cells and binds to intracellular proteins called FKBP
- mTOR inhibition: This FKBP-rapamycin complex then interferes with the function of mTOR, a protein kinase that controls many cellular processes. (And one of the main processes that ages you)
- Reduced cell growth: By inhibiting mTOR, rapamycin decreases cell growth and proliferation.
- Enhanced autophagy: It also promotes autophagy, a cellular process of self-cleaning and recycling
Benefits
Hair growth
Can encourage rapamycin stimulates hair follicle growth and pigmentation via increased intrafollicular production of the melanotropic hormone, α‐MSH hair regrowth and repigmentation. This could mean it could be a useful addition to Dutasteride
https://www.jidonline.org/article/S0022-202X(21)00855-1/fulltext# 251
https://pmc.ncbi.nlm.nih.gov/articles/PMC10328083/#:~:text=mTORC1%20inhibition%20by%20rapamycin%20stimulates,melanotropic%20hormone%2C%20α%E2%80%90MSH.
Skin collagen/ aging
Oral Rapamycin has not been studied however to reduce skin aging topical rapamycin has. As well as mTOR inhibitors. With both having very good results for skin collagen / aging. Which is a very good signs that oral will do much the same.
https://drexel.edu/news/archive/2019/november/rapamycin-for-skin-aging
https://scholar.google.co.uk/schola...isig=AAZF9b9Fkc_0Eod7eaHFClaQ3FC4&oi=scholarr
https://pmc.ncbi.nlm.nih.gov/articles/PMC6925069/#:~:text=Clinical improvement of skin photoaging,3b).
https://febs.onlinelibrary.wiley.co...281#:~:text=Many of these pro-growth,[32-34]].
Biological aging
However the most impressive thing about Rapamycin is the increase in lifespan. A recent study shows the combination of Rapamycin and trametinib to increase median lifespan in mice by over 30%. With another showing a 25% increase with Rapamycin alone.
This more than double Epitalon which @Sadist made a thread about
In addition the studies have shown the younger you take rapacymin the better the effects. With a study showing that mice taking at 9 months (equivalent to 30 in humans) had a 25% increase in median lifespan compared to 11% from a 20 month old mouse (equivalent to 60 in humans)
https://www.biorxiv.org/content/10.1101/2024.07.25.605097v1
https://pubmed.ncbi.nlm.nih.gov/24341993/
Negative
Fertility
There are many studies showing that Rap can cause birth defects
https://pmc.ncbi.nlm.nih.gov/articl...mechanistic,cardiomyocytes in the adult heart.
Thus as it has a half life 79 hours you’ll have to wait a couple of weeks before trying to have a kid to be on the safe side.
Muscle mass
MTOR is required for muscle growth and regeneration. And - if you completely inhibited MTOR, All the time, it probably does block muscle growth and benefits of exercise.
Many studies show a long consistent use of ramycin (over 6 months) can lead to significant muscle loss
https://pmc.ncbi.nlm.nih.gov/articles/PMC5103886/
However not all MTOR is inhibited even at high doses
https://pubmed.ncbi.nlm.nih.gov/19395872/
However if you look at the blood levels of rapamycin after taking a dose, and we assume that a person is on an optimal weekly or bi-weekly dosing schedule for their rapamycin. Then, in this case the MTOR inhibition seems to take place mostly during the first half of your higher blood levels period, and as the blood level goes down there is less and less MTOR inhibition.
Exercising during the period of higher MTOR inhibition helps conserve your muscle, and exercising when you are out of there MTOR inhibition period seems to likely be a period of regular / good muscle growth and regeneration.
However because of this repa should not be used until you have achieved your goal physique.
In addition the optimal way to conserve muscle mass and still get the benefits of Repacymin is to do a weekly or biweekly schedule and low doses
Fluid retention
cause fluid retention and swelling, a common side effect known as edema. This occurs because rapamycin is an mTOR inhibitor, and the mTOR pathway plays a role in regulating fluid balance. However this can be sorted with smaller doses, weekly schedule and Epleronone
https://pubmed.ncbi.nlm.nih.gov/246...ort,transplantation; rapamycine; side effects.
Blood clotting issues
Rapamycin (sirolimus) use is associated with increased risks of blood clotting, particularly in the context of rapamycin-eluting stents and organ transplantation. It can promote thrombosis by enhancing the activity of tissue factors in endothelial cells and affecting platelet procoagulant function
https://ashpublications.org/blood/a....org/10.1182,was determined by flow cytometry.
High cholesterol
While rapamycin shows anti-atherosclerotic benefits by reducing inflammation, this cholesterol-raising effect is a recognized side effect and a known cardiovascular risk factor that may necessitate management with cholesterol lowering drugs. I’d recommend taking SR9009.
https://pubmed.ncbi.nlm.nih.gov/28230638/#:~:text=Abstract,remains the most recommended strategy.
Best dosage/ schedule
Dosage is important as wrong dosage can cause many negative outcomes which won’t get the most out of the drug.
Generally aim for 20 mg/ week
But starting slow and slowly increasing is recommended
With a week off week on cycle
For example-
Week 1- 5 mg
Week 2-0 mg
Week 3- 10 mg
Week 4- 0 mg
Week 5- 15 mg
Week 6- 0 mg
Week 7- 20 mg
Week 8- 0 mg
Week 9- 20 mg
Week 10- 0 mg
Week 11- 20 mg
Etc
https://pubmed.ncbi.nlm.nih.gov/25540326/
Conclusion
To conclude Repamycin can be a very helpful drug for looksmaxxing and health maxxing if done right. With good dosing and taken with SR9009 and Epleronone
@edodalic29 @Copercel @SlayerJonas @Iplamephiltrum @Stacyslayerᛉ @iblamegenetics7681 @FlotPSL @FutureExoticChad @Zagro @unon @ybuyhgui
