The most BRUTAL study you will ever read ⚠️ NDcels, do NOT enter for your own good ⚠️

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“A Two-Hit Model of Autism: Adolescence as the Second Hit”

The mother of all studies when it comes to the most brutal pill, the NDpill

It explains why NDs are DOOMED for their teenage years

Enter at your own risk

A Two-Hit Model of Autism: Adolescence as the Second Hit - PMC

Adolescence brings dramatic changes in behavior and neural organization. Unfortunately, for some 30% of individuals with autism, there is marked decline in adaptive functioning during adolescence. We propose a two-hit model of autism. First, early ...

pmc.ncbi.nlm.nih.gov

 

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“In our model, we propose that the concomitant pressures of adolescent-specific developmental tasks together with the surge of pubertal hormones create a secondary hit for individuals with autism that their compromised neural circuitry cannot accommodate. The result is a failure to acquire the critical new behaviors that are essential for the transition to adult social roles and levels of adaptive functioning. In what follows, we provide examples of critical domains in which TD adolescents and adolescents with autism fundamentally diverge in their developmental trajectories in ways that are specific to adolescence. We contend that these diverging trajectories provide initial evidence for considering adolescence as a second hit to individuals with autism. These findings begin to reflect the extensive ways in which adolescence may uniquely and negatively affect individuals with autism, thereby setting them on an altered trajectory in their transition into adulthood.”


TLDR: An autists nervous system is set up to fail, and then all of the negative experiences stemming from this failure cause even more failure

 

[L88]

 

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“In sum, adolescents with autism struggle tremendously in their attempts to develop intimate peer relationships (friendship as well as romantic), which is a core developmental task of adolescence that predicts adult levels of adaptive social functioning. We propose that this difficulty likely stems from not only their existing impaired social skills, which are apparent even in childhood, and might be traced back to early aberrant development of neural regions in the social brain, but also a lack of increasing salience and relevance of peers during adolescence.”

 

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This difficulty initiating and maintaining peer relationships may contribute to the awkward attempts to cultivate romantic relationships seen among individuals with autism. According to some reports, 44% of adults with autism never date (Farley et al., 2009), which reflects the enormous challenge that sexual and romantic relationships pose for them (Henault, 2006). The adults with autism who do manage to engage in romantic relationships are often lacking in sexual knowledge (Byers, Nichols, Voyer, & Reilly, 2013). Although there is a paucity of research exploring the nature and frequency of romantic relationships among adolescents with autism, the work that does exist supports the notion that these individuals have immense difficulty initiating and engaging in these relationships. For example, adolescents with autism tend to focus their romantic attention and efforts toward strangers and engage in inappropriate courting behaviors (e.g., stalking behaviors; Stokes et al., 2007). They also do not appear to be able to learn about notions such as personal privacy and appropriate dating behavior even in the context of formal sexual educational training (Stokes & Kaur, 2005).

 

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1. Adolescents with autism struggle in their attempts to develop intimate peer relationships, which may be an indication that adolescent-specific social reorientation is significantly weaker in this population.
2. Peer rejection is disproportionately higher for individuals with autism in adolescence. This may lead to risk for developmental deterioration and increasing depression and anxiety during adolescence.
3. Compared with TD individuals, adolescents with autism appear to exhibit similar, or slightly reduced, levels of risk-taking behavior. However, nothing is known about differences in the context in which risk-taking behaviors occur for adolescents with autism (i.e., social contexts vs. contexts associated with repetitive and restricted interests).
4. The ability to inhibit a prepotent response is particularly difficult for individuals with autism and may be especially true in adolescence. There are also weaknesses in the contribution of the prefrontal cortex to cognitive control, which may contribute to a robust adolescent-specific imbalance between the approach/reward and regulatory systems for individuals with autism.

 

[Pony]

“In our model, we propose that the concomitant pressures of adolescent-specific developmental tasks together with the surge of pubertal hormones create a secondary hit for individuals with autism that their compromised neural circuitry cannot accommodate. The result is a failure to acquire the critical new behaviors that are essential for the transition to adult social roles and levels of adaptive functioning. In what follows, we provide examples of critical domains in which TD adolescents and adolescents with autism fundamentally diverge in their developmental trajectories in ways that are specific to adolescence. We contend that these diverging trajectories provide initial evidence for considering adolescence as a second hit to individuals with autism. These findings begin to reflect the extensive ways in which adolescence may uniquely and negatively affect individuals with autism, thereby setting them on an altered trajectory in their transition into adulthood.”


TLDR: An autists nervous system is set up to fail, and then all of the negative experiences stemming from this failure cause even more failure

damn man, I agree its never been more over for our people

ive heard many stories about how autism affects nervous system just a never losing battle

 

[Pony]

but other than that im pretty much used to all of the side effects at the end of the day it iss what it issssss

 

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