Theory crafted supplement for stimulant users

[Crusile]

5-HTP efficacy and contraindications

L-5-hydroxytryptophan (5-HTP) is the immediate precursor of serotonin. It is readily synthesized into serotonin without biochemical feedback. This nutrient has a large and strong following who advocate exaggerated and inaccurate claims relating to its ...

www.ncbi.nlm.nih.gov

• 5-HTP may deplete dopamine.33–37
• l-tyrosine may deplete serotonin.46,47
• l-tyrosine may deplete 5-HTP.47

Stimulants deplete dopamine and serotonin -> tyrosine increases dopamine and depletes serotonin -> htp (supplement) depletes dopamine = net negative balanced neurotransmitters

(Yes its this simple, even if you think its not)

*idc what you have to say, you can buy these supplements for $10 and try it yourself, I legit cba/dc

 

[Bewusst]

No, it's not that simple. Tyrosine is just the precursor to levodopamine, which is the precursor to dopamine, but the conversions depend on the activity/regulation of enzymes (tyrosine hydroxylase and aromatic L-amino acid decarboxylase) and the presence of certain cofactors (BH4, Fe2+, pyridoxal 5'-phosphate).

"Stimulants deplete dopamine and serotonin" is a vague claim that implies all stimulants work in the same manner, which just isn't true. Some stimulants work through catecholamine reuptake inhibition, some mimic endogenous neurotransmitters and directly activate or block adrenergic receptors and others antagonize adenosine receptors. Taking extra tyrosine and tryptophan, which are present in your diet in sufficient amounts anyway if you eat enough protein, won't necessarily increase your DA and 5-HT levels or change neurotransmitter balance. It's way more complex

 

[Lev Peshkov]

No, it's not that simple. Tyrosine is just the precursor to lev

Hi.

 

[Crusile]

No, it's not that simple. Tyrosine is just the precursor to levodopamine, which is the precursor to dopamine, but the conversions depend on the activity/regulation of enzymes (tyrosine hydroxylase and aromatic L-amino acid decarboxylase) and the presence of certain cofactors (BH4, Fe2+, pyridoxal 5'-phosphate).

"Stimulants deplete dopamine and serotonin" is a vague claim that implies all stimulants work in the same manner, which just isn't true. Some stimulants work through catecholamine reuptake inhibition, some mimic endogenous neurotransmitters and directly activate or block adrenergic receptors and others antagonize adenosine receptors. Taking extra tyrosine and tryptophan, which are present in your diet in sufficient amounts anyway if you eat enough protein, won't necessarily increase your DA and 5-HT levels or change neurotransmitter balance. It's way more comple

^ none of this matters, this is the link https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415362/
Its a possible neurotransmitter rebalancing supplement combo if you abuse stimulants and have symptoms of dopamine/ serotonin deficiency. its literally impossible to prove if they will synergize(there is no way to know)**** (theorycrafted)

 

[Crusile]

the evidence doesnt need to be t here because it cant exist in the first place. (for expected value) if you have symptoms of neurotransmitter depletion from meth use, you would take both supplements (expected value)

 

[Bewusst]

^ none of this matters, this is the link https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415362/
Its a possible neurotransmitter rebalancing supplement combo if you abuse stimulants and have symptoms of dopamine/ serotonin deficiency. its literally impossible to prove if they will synergize(there is no way to know)**** (theorycrafted)

All they're saying in the study is that dopamine and serotonin need to be balanced and that treatment with either dopamine or serotonin precursors alone can lead to depletion of nondominant monoamine neurotransmitters since DA and 5-HT and their precursors compete with each other, which is nothing new. But your "theory" doesn't address how different types of stimulant drugs affect the DA/NE/5-HT system because, as I said, different drugs have different effects and to deal with a possible drug-related neurotransmitter imbalance you need to consider which stimulant someone is (ab)using and how the drug works

 

[Bewusst]

What would you recommend as the best method for keeping dopamine levels optimal. Is it zero stimulants, low levels of dopamine in general to keep the dopamine receptors more sensitive for when it matters? I’m not sure, but I still use caffiene every morning.

Nothing. Healthy, balanced diet, good sleeping habits, plenty of sunlight (especially in the morning), regular physical activity and avoiding excessive masturbation and drugs like opiates/opioids, AAS, anti-androgens, antidepressants, DRIs, MAOIs, DA agonists and things that may cause high prolactin

 

[UglyGod360]

Nothing. Healthy, balanced diet, good sleeping habits, plenty of sunlight (especially in the morning), regular physical activity and avoiding excessive masturbation and drugs like opiates/opioids, AAS, anti-androgens, antidepressants, DRIs, MAOIs, DA agonists and things that may cause high prolactin

I masturbate a dozen times a day and take stims like addy, should I quit cold turkey. Stuff that made me happy in the past no longer brings joy

 

[Deleted member 12217]

5-HTP efficacy and contraindications

L-5-hydroxytryptophan (5-HTP) is the immediate precursor of serotonin. It is readily synthesized into serotonin without biochemical feedback. This nutrient has a large and strong following who advocate exaggerated and inaccurate claims relating to its ...

www.ncbi.nlm.nih.gov

• 5-HTP may deplete dopamine.33–37
• l-tyrosine may deplete serotonin.46,47
• l-tyrosine may deplete 5-HTP.47

Stimulants deplete dopamine and serotonin -> tyrosine increases dopamine and depletes serotonin -> htp (supplement) depletes dopamine = net negative balanced neurotransmitters

(Yes its this simple, even if you think its not)

*idc what you have to say, you can buy these supplements for $10 and try it yourself, I legit cba/dc

Could end up deadly if you don’t know what you’re doing is what I heard. If you preload on that shit and then pop heavy stimulants I heard you can pretty easy get serotonin syndrom

 

[Crusile]

All they're saying in the study is that dopamine and serotonin need to be balanced and that treatment with either dopamine or serotonin precursors alone can lead to depletion of nondominant monoamine neurotransmitters since DA and 5-HT and their precursors compete with each other, which is nothing new. But your "theory" doesn't address how different types of stimulant drugs affect the DA/NE/5-HT system because, as I said, different drugs have different effects and to deal with a possible drug-related neurotransmitter imbalance you need to consider which stimulant someone is (ab)using and how the drug works

you can feel if neurotransmitters dumbass. if you know what to look for you can tell if youre low seratonin or dopamine and fix it

these drugs will never be promoted because they cause heart/health problems