TrestIsBest
Eating Finestaride and Adderall for breakfast
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Methylene Blue (or short MB) is a versatile compound (it's actually a dye btw and it stains the hell out of everything that it comes in contact with) that is used medicinally to treat methemoglobinemia, cyanide poisoning and even the 'Rona to name a few. It also shows promise as a treatment for Alzheimers [https://pubmed.ncbi.nlm.nih.gov/20463399/] and as a nootropic [https://pubmed.ncbi.nlm.nih.gov/22067440/; lots of anecdotal reports].
Methylene blue integrates into the mitochondria, enables more efficient energy production and increases ATP yield that way [https://www.researchgate.net/figure...ate-phosphorylation-ofglycogen_fig7_274721127]. It also has antioxidant effects, although it can also be pro-oxidant in high concentrations. It's similar to LLT (low level therapy) in its mechanism and therefore in its benefits [https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4355185/].
Methylene blue integrates into the mitochondria, enables more efficient energy production and increases ATP yield that way [https://www.researchgate.net/figure...ate-phosphorylation-ofglycogen_fig7_274721127]. It also has antioxidant effects, although it can also be pro-oxidant in high concentrations. It's similar to LLT (low level therapy) in its mechanism and therefore in its benefits [https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4355185/].
MB's anti-oxidant and pro cellular respiration effects could also be (part of) the reason why it was shown to be a potent anti-aging compound when applied to the skin!
Anti-Aging Potentials of Methylene Blue for Human Skin Longevity
"Application of MB to this 3D skin model further demonstrated that MB improved skin viability, promoted wound healing and increased skin hydration and dermis thickness. Gene expression analysis showed that MB treatment altered the expression of a subset of extracellular matrix proteins in the skin, including upregulation of elastin and collagen 2A1, two essential components for healthy skin. Altogether, our study suggests that MB has a great potential for skin care."
It also acts a sunscreen!
Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health
"Altogether, our study suggests that MB has the potential to be a coral reef-friendly sunscreen active ingredient that can provide broad-spectrum protection against UVA and UVB."
Anti-Aging Potentials of Methylene Blue for Human Skin Longevity
"Application of MB to this 3D skin model further demonstrated that MB improved skin viability, promoted wound healing and increased skin hydration and dermis thickness. Gene expression analysis showed that MB treatment altered the expression of a subset of extracellular matrix proteins in the skin, including upregulation of elastin and collagen 2A1, two essential components for healthy skin. Altogether, our study suggests that MB has a great potential for skin care."
It also acts a sunscreen!
Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health
"Altogether, our study suggests that MB has the potential to be a coral reef-friendly sunscreen active ingredient that can provide broad-spectrum protection against UVA and UVB."
- MB increases collagen production and it should do so fast
- It also protects against sun damage which adds to its benefits as an anti aging topical
- There's already a product out there that offers skin care products containing MB but it's way too expensive for my taste; MB in the concentrations used in the first skin study is dirt cheap and it could be easily mixed into a moisturizer. I plan on creating my own MB skin cream as soon as I have a few months of Tretinoin under my belt so I can better gauge the individual effects of those substances. But I imagine Tret and MB could have great synergy.
- One last point: YES, there aren't any studies out there yet that tested MB applied topically on actual humans so this is still experimental. It should be safe according to this study tho and the risk of it going systemic shouldn't worry you as only a few micrograms maximum would be going to your bloodstream, and MB is safe (as in: not lethal; it carries some risk because it becomes an MAO inhibitor in larger doses; not relevant to the microdoses we are talking about tho) for oral use and has been used that way for centuries.
- Final point: You need to make sure to get the concentration right. Don't just slap a few mg's of MB on your face hoping it will improve your shitty collagen levels! (It probably would do the opposite by causing a high amount of oxidative stress.
- It also protects against sun damage which adds to its benefits as an anti aging topical
- There's already a product out there that offers skin care products containing MB but it's way too expensive for my taste; MB in the concentrations used in the first skin study is dirt cheap and it could be easily mixed into a moisturizer. I plan on creating my own MB skin cream as soon as I have a few months of Tretinoin under my belt so I can better gauge the individual effects of those substances. But I imagine Tret and MB could have great synergy.
- One last point: YES, there aren't any studies out there yet that tested MB applied topically on actual humans so this is still experimental. It should be safe according to this study tho and the risk of it going systemic shouldn't worry you as only a few micrograms maximum would be going to your bloodstream, and MB is safe (as in: not lethal; it carries some risk because it becomes an MAO inhibitor in larger doses; not relevant to the microdoses we are talking about tho) for oral use and has been used that way for centuries.
- Final point: You need to make sure to get the concentration right. Don't just slap a few mg's of MB on your face hoping it will improve your shitty collagen levels! (It probably would do the opposite by causing a high amount of oxidative stress.
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