
fxntanyl
Iron
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- Sep 2, 2024
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"Excess GH or sex steroids during adolescence can lead to premature closure of the epiphyseal growth plates, which may result in compromised adult height."
→ Reference: Rogol AD, Clark PA, Roemmich JN. “Growth and pubertal development in children and adolescents: effects of diet and physical activity.” Am J Clin Nutr. 2000;72(2 Suppl):521S-528S.
"The use of exogenous GH in adolescents who are not GH-deficient carries the risk of advanced bone age and early fusion of growth plates."
→ Reference: Carel JC, Leger J. “Precocious puberty.” N Engl J Med. 2008;358(22):2366-2377.
Endocrinology textbooks & clinical practice
GH use disrupts the hypothalamic-pituitary-somatotropic axis.
"Exogenous administration of GH can suppress the natural feedback loop, leading to inhibition of endogenous GH production."
→ Reference: Molitch ME. “Diagnosis and Treatment of Pituitary Disorders.” Endocrinol Metab Clin North Am. 2008.
It affects GnRH → LH/FSH → testosterone/estrogen regulation as well, especially in developing bodies.
"Interference with hormonal homeostasis during puberty can have long-term developmental consequences."
→ Source: American Academy of Pediatrics Policy on Performance-Enhancing Substances in Youth (2016)