[THREAD FOR CURRIES AND DARKSKINS] Destroying melanin is not the answer

[Deleted member 23558]

I think the reason why Gandy doesnt look shitskin even w tan is his body has a ratio of pheomelanin to eumelanin it does not cross.

I know sulphation, cysteine and tyrosinase all play a role in this. But i dont know how exactly and what variables can change it, i think if we found a way to not entirely stop melanogenesis but shift the pathway towards the pink pheomealnin rather than the black eumelanin, the outcome of skin tine would be much better. I think the so called tyrosinase inhibitors actually change this on a genetic transcription level, indians who use tretinoin for example for a long time actually end up w a somewhat tanned castizo skin tone

You can see from the chart the two pathways by which we change this ratio are:

Increasing glutathione or cysteine (prolly even MSM since it provides a sulfate group) which increases pheomelanin content

decreasing tyronsiane (doable w kojic acid, alpha arbutin, hydroq etc), cu 2 plus (not recommended as copper is vital for enzymatic processes) and TRP1 (again not sure how to, it seems to depend on zinc a lot which is funny as zinc and copper are for the most part antagonistic)

L tryptophan also plays a part, reducing tryptophan absorption through eating meals low in fernstrom ratio can be good

Progesterone lightens and estrogen darkens skin, with testosterone as well slightly darkening skin and hair. I think topical progesterone can also be a good canditate to shift biosynthesis away from eu melanin towards pheomelanin.

You can see Gandy has this pink hue here which cannot be any undertone except lycopene which is the only carotenoid that is darker than eumelanin, so it has to be the pink lighter form of eumelanin

this curry was on tret for 3 years (first pic is before) and his skin seems to have a higher pheo/eumelanin ratio

 

[Narcissus🥀]

TLDR: if you're a curry just stand Infront of a train

 

[Deleted member 56659]

TLDR: if you're a curry just stand Infront of a train

nigga your pirate crew is filled with indians

 

[wsada]

Thread for the entire userbase bahahahahahhaa

 

[wsada]

nigga your pirate crew is filled with indians

Including u nigga

 

[Deleted member 23558]

Brahmins after TRP1 inhibitors come out

 

[Deleted member 23558]

Vitamin C also shuts down tyrosinase @RAMU KAKA @Lynxress @sub5c3l @FBI @IndraBC @neverascendcurrycel

so does THFA and NADH

Melanogenesis inhibition due to NADH - PubMed

The effect of NADH on melanogenesis under aerobic conditions involves three types of reaction: (a) acting as tyrosinase substrate (a competitive substrate of L-tyrosine and L-DOPA), (b) irreversible inactivation acting as a suicide substrate of tyrosinase, and (c) non-enzymatic reduction of...

pubmed.ncbi.nlm.nih.gov

Tetrahydrofolic Acid is a potent suicide substrate of mushroom tyrosinase - PubMed

The coenzyme tetrahydrofolic acid is the most rapid suicide substrate of tyrosinase that has been characterized to date. A kinetic study of the suicide inactivation process provides the kinetic constants that characterize it: λ(max), the maximum apparent inactivation constant; r, the partition...

pubmed.ncbi.nlm.nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327992/#CIT0103

 

[Deleted member 65825]

TLDR: at least you're not as obese as @BrahminBoss

 

[Deleted member 65825]

TLDR: at least you're not as obese as @BrahminBoss

Shit i forgot about karma


Sorry bhai

 

[Deleted member 23558]

TLDR: at least you're not as obese as @BrahminBoss

Im down to 24 percent bf

 

[Deleted member 65825]

Im down to 24 percent bf

Mogs me.

 

[Deleted member 23558]

@horizontallytall @CFW432 @SidharthTheSlayer

 

[Deleted member 23558]

v

 

[Deleted member 23558]

@the MOUSE thoughts

 

[Deleted member 23558]

@kyrre

 

[Deleted member 65576]

What can be done if you have acne, and want to prevent post inflammatory hyperpigmentation? I can't use topical tyrosinase inhibitors like hydroquinone, so is there something I can take orally do you think?

 

[Deleted member 23558]

What can be done if you have acne, and want to prevent post inflammatory hyperpigmentation? I can't use topical tyrosinase inhibitors like hydroquinone, so is there something I can take orally do you think?

liposomal vitamin C, MSM, magnesium glycinate / eating lots of gelatin.

 

[Deleted member 23558]

@the MOUSE my final thread and it only contains breadcrumbs not the actual cake after i realised i dont like 98 percent of the pajeets h ere, now i leave

 

[RichardSpencel]

BGM on suicide watch

 

[Deleted member 23558]

 

[laaltin]

I know a better oral tyrosinase inhibitor, gatekeeping for now until I try myself and confirm. I only plan to use in summers tho, I don’t want to lighten my skin just maintain it while having fun in the summer

 

[Deleted member 23558]

I know a better oral tyrosinase inhibitor, gatekeeping for now until I try myself and confirm

There are many bro melasyl is also good you can throw kitchen sink at it

 

[laaltin]

There are many bro melasyl is also good you can throw kitchen sink at it

Isnt that only available topical, cba w/ topicals anymore

 

[Deleted member 23558]

@jeoyw9192

 

[Deleted member 23558]

Isnt that only available topical, cba w/ topicals anymore

Tranexemaic acid vs liposomal vit c for oral? I want to reduce PIH alreadu using topicals

 

[laaltin]

Tranexemaic acid vs liposomal vit c for oral? I want to reduce PIH alreadu using topicals

Tranexamic but you gotta cycle it cause it clots blood, one cycle is enough (3 months) to clear all sorts of hyperpigmentation. Maintain with topical then or resume after break. Oral vit C is joke, shit takes too long and at best it will lighten the shade a little bit, hyperpigmentation will persist

 

[Deleted member 23558]

O

Tranexamic but you gotta cycle it cause it clots blood, one cycle is enough (3 months) to clear all sorts of hyperpigmentation. Maintain with topical then or resume after break. Oral vit C is joke, shit takes too long and at best it will lighten the shade a little bit, hyperpigmentation will persist

ome Cycle is? How much mg a day

 

[laaltin]

O

ome Cycle is? How much mg a day

250 mg a day, conservative dosage. I'll also run D-Dimer test at 2 months mark to check my blood clot levels and decide if I will continue or take a break

 

[Deleted member 23558]

250 mg a day, conservative dosage. I'll also run D-Dimer test at 2 months mark to check my blood clot levels and decide if I will continue or take a break

Did it clear up all ur PIH? Which form did u use , did u stay out of sun when running it

 

[laaltin]

Did it clear up all ur PIH? Which form did u use , did u stay out of sun when running it

No, I just started running the oral form, customs seized my packet twice jfl. I have sun spots on my forehead, topical cleared a lot of that, no other pigmentation issue. It should clear up the remaining stubborn patches, I have seen foids on Reddit with fucked up pigmentation and melasma who tried everything under the sun and oral TxA worked like a charm for them. I'm running 250 mg oral as we speak, might up the dosage after D-Dimer. I just ordered Eucerin sunscreen, summer lasts only few months here, I will be out every day during the summer

 

[Deleted member 23558]

No, I just started running the oral form, customs seized my packet twice jfl. I have sun spots on my forehead, topical cleared a lot of that, no other pigmentation issue. It should clear up the remaining stubborn patches, I have seen foids on Reddit with fucked up pigmentation and melasma who tried everything under the sun and oral TxA worked like a charm for them. I'm running 250 mg oral as we speak, might up the dosage after D-Dimer. I just ordered Eucerin sunscreen, summer lasts only few months here, I will be out every day during the summer

Link to brand?

 

[SidharthTheSlayer]

One change of lighting and you’re back to being a green shitskin after months of overdosing on lycopene. Melanin and skin brightness is the ONLY thing that matters.

 

[Deleted member 23558]

One change of lighting and you’re back to being a green shitskin after months of overdosing on lycopene. Melanin and skin brightness is the ONLY thing that matters.

Lighting should not affect it the guy in pic 2 wouldn’t look green in the same airport lighting imo

 

[laaltin]

Link to brand?

Trenaxa, Indian brand. I don't think you will have as much problem sourcing it, try your local slum pharmacy. I had to order to a temp parking address in another country and route it from there. I used All Day Chemist.

 

[Deleted member 23558]

Trenaxa, Indian brand. I don't think you will have as much problem sourcing it, try your local slum pharmacy. I had to order to a temp parking address in another country and route it from there. I used All Day Chemist.

Fucking hate PIH , unironically melasma would be better

 

[laaltin]

Fucking hate PIH , unironically melasma would be better

Be careful of what you wish for

 

[Deleted member 23558]

@coispet

 

[coispet]

@coispet

Thanks bhai

 

[Deleted member 23558]

@n9wiff this the thread bhau

 

[LegitUser]

250 mg a day, conservative dosage. I'll also run D-Dimer test at 2 months mark to check my blood clot levels and decide if I will continue or take a break

D-dimer is trash bloodtest. Get a coagulation panel

 

[LegitUser]

Be careful of what you wish for

Fucking hate PIH , unironically melasma would be better

I have melasma on my back I can't take.my shirt off outside anymore. It's much much worse.

 

[Deleted member 23558]

I have melasma on my back I can't take.my shirt off outside anymore. It's much much worse.

On the face is much worse no one gonna see ur back

 

[Nowiff.Belgrade]

Interesting read I didn't know coloring was so complex

I'm not sure how to describe my coloring other than it being very bleak so it would be ideal for me to. I also think I'm fair enough so I would benefit from the tyrosinase inhibition? So i should only do lycopene and supplement MSM?

 

[Deleted member 23558]

Interesting read I didn't know coloring was so complex

I'm not sure how to describe my coloring other than it being very bleak so it would be ideal for me to. I also think I'm fair enough so I would benefit from the tyrosinase inhibition? So i should only do lycopene and supplement MSM?

You need to shift the ratio.
Even if ur light , shifting ratio more towards pheo will encourage contrast

Say it’s 80/20 eu / pheo now

By decreasing eu with tyrosinase inhibitors and increasing pheo with msm / reconverting homocysteine back to cysteine w betaine / vit b6

Your new ratio would be something like 40/60

Getting a slight tan may also work if ur nuclear transcription factor has changed on the genetic level. Then every time you tan you would produce more pheo instead of eumelanin

 

[Nowiff.Belgrade]

You need to shift the ratio.
Even if ur light , shifting ratio more towards pheo will encourage contrast

Say it’s 80/20 eu / pheo now

By decreasing eu with tyrosinase inhibitors and increasing pheo with msm / reconverting homocysteine back to cysteine w betaine / vit b6

Your new ratio would be something like 40/60

Getting a slight tan may also work if ur nuclear transcription factor has changed on the genetic level. Then every time you tan you would produce more pheo instead of eumelanin

so basically controlling the ratio is more ideal than chasing individual parameters and of course sustaining results. Will do more research on this.

Do you think I could get a good ROI on maxing out my coloring? I feel like low MTN rn I want to get to MTN/High MTN as final goal with physique. Could tanning save me or is the return too low for the effort?

 

[Deleted member 23558]

so basically controlling the ratio is more ideal than chasing individual parameters and of course sustaining results. Will do more research on this.

Do you think I could get a good ROI on maxing out my coloring? I feel like low MTN rn I want to get to MTN/High MTN as final goal with physique. Could tanning save me or is the return too low for the effort?

Only tan after a while of implementing this imo. Right now most ethnics have the ratio skewed towards eu , however topical tyrosinase inhibitors included perhaps Tazarotene can change this on a genetic level such that sat after 5 months of implementing this protocol tanning can yield a different result than if you tanned right now. Although you can also tan a bit and see if you’re happy with the result

 

[Deleted member 23558]

@n9wiff just found a thread on another site theorising the same I’ll link iy

 

[Phillybeard1996]

Good thread

 

[Newday*V3]

No, I just started running the oral form, customs seized my packet twice jfl. I have sun spots on my forehead, topical cleared a lot of that, no other pigmentation issue. It should clear up the remaining stubborn patches, I have seen foids on Reddit with fucked up pigmentation and melasma who tried everything under the sun and oral TxA worked like a charm for them. I'm running 250 mg oral as we speak, might up the dosage after D-Dimer. I just ordered Eucerin sunscreen, summer lasts only few months here, I will be out every day during the summer

What happens if you run Tranexamic with blood thinners like aspirin, therefore still reaping the skin effects but reduce the main function which is Blood clotting

 

[laaltin]

What happens if you run Tranexamic with blood thinners like aspirin, therefore still reaping the skin effects but reduce the main function which is Blood clotting

Don’t know man, 250mg is such a low dose I don’t need to worry about it