[THREAD FOR CURRIES AND DARKSKINS] Destroying melanin is not the answer

[BrahminBoss]

I think the reason why Gandy doesnt look shitskin even w tan is his body has a ratio of pheomelanin to eumelanin it does not cross.

I know sulphation, cysteine and tyrosinase all play a role in this. But i dont know how exactly and what variables can change it, i think if we found a way to not entirely stop melanogenesis but shift the pathway towards the pink pheomealnin rather than the black eumelanin, the outcome of skin tine would be much better. I think the so called tyrosinase inhibitors actually change this on a genetic transcription level, indians who use tretinoin for example for a long time actually end up w a somewhat tanned castizo skin tone

You can see from the chart the two pathways by which we change this ratio are:

Increasing glutathione or cysteine (prolly even MSM since it provides a sulfate group) which increases pheomelanin content

decreasing tyronsiane (doable w kojic acid, alpha arbutin, hydroq etc), cu 2 plus (not recommended as copper is vital for enzymatic processes) and TRP1 (again not sure how to, it seems to depend on zinc a lot which is funny as zinc and copper are for the most part antagonistic)

L tryptophan also plays a part, reducing tryptophan absorption through eating meals low in fernstrom ratio can be good

Progesterone lightens and estrogen darkens skin, with testosterone as well slightly darkening skin and hair. I think topical progesterone can also be a good canditate to shift biosynthesis away from eu melanin towards pheomelanin.

You can see Gandy has this pink hue here which cannot be any undertone except lycopene which is the only carotenoid that is darker than eumelanin, so it has to be the pink lighter form of eumelanin

this curry was on tret for 3 years (first pic is before) and his skin seems to have a higher pheo/eumelanin ratio

 

[Narcissus🥀]

TLDR: if you're a curry just stand Infront of a train

 

[sub5c3l]

TLDR: if you're a curry just stand Infront of a train

nigga your pirate crew is filled with indians

 

[wsada]

Thread for the entire userbase bahahahahahhaa

 

[wsada]

nigga your pirate crew is filled with indians

Including u nigga

 

[BrahminBoss]

Brahmins after TRP1 inhibitors come out

 

[BrahminBoss]

Vitamin C also shuts down tyrosinase @RAMU KAKA @Lynxress @sub5c3l @FBI @IndraBC @neverascendcurrycel

so does THFA and NADH

Melanogenesis inhibition due to NADH - PubMed

The effect of NADH on melanogenesis under aerobic conditions involves three types of reaction: (a) acting as tyrosinase substrate (a competitive substrate of L-tyrosine and L-DOPA), (b) irreversible inactivation acting as a suicide substrate of tyrosinase, and (c) non-enzymatic reduction of...

pubmed.ncbi.nlm.nih.gov

Tetrahydrofolic Acid is a potent suicide substrate of mushroom tyrosinase - PubMed

The coenzyme tetrahydrofolic acid is the most rapid suicide substrate of tyrosinase that has been characterized to date. A kinetic study of the suicide inactivation process provides the kinetic constants that characterize it: λ(max), the maximum apparent inactivation constant; r, the partition...

pubmed.ncbi.nlm.nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327992/#CIT0103

 

[Autismcel]

TLDR: at least you're not as obese as @BrahminBoss

 

[Autismcel]

TLDR: at least you're not as obese as @BrahminBoss

Shit i forgot about karma


Sorry bhai

 

[BrahminBoss]

TLDR: at least you're not as obese as @BrahminBoss

Im down to 24 percent bf

 

[Autismcel]

Im down to 24 percent bf

Mogs me.

 

[BrahminBoss]

@horizontallytall @CFW432 @SidharthTheSlayer

 

[BrahminBoss]

v

 

[BrahminBoss]

@the MOUSE thoughts

 

[BrahminBoss]

@kyrre

 

[silencio]

What can be done if you have acne, and want to prevent post inflammatory hyperpigmentation? I can't use topical tyrosinase inhibitors like hydroquinone, so is there something I can take orally do you think?

 

[BrahminBoss]

What can be done if you have acne, and want to prevent post inflammatory hyperpigmentation? I can't use topical tyrosinase inhibitors like hydroquinone, so is there something I can take orally do you think?

liposomal vitamin C, MSM, magnesium glycinate / eating lots of gelatin.

 

[BrahminBoss]

@the MOUSE my final thread and it only contains breadcrumbs not the actual cake after i realised i dont like 98 percent of the pajeets h ere, now i leave

 

[RichardSpencel]

BGM on suicide watch

 

[BrahminBoss]

 

[laaltin]

I know a better oral tyrosinase inhibitor, gatekeeping for now until I try myself and confirm. I only plan to use in summers tho, I don’t want to lighten my skin just maintain it while having fun in the summer

 

[BrahminBoss]

I know a better oral tyrosinase inhibitor, gatekeeping for now until I try myself and confirm

There are many bro melasyl is also good you can throw kitchen sink at it

 

[laaltin]

There are many bro melasyl is also good you can throw kitchen sink at it

Isnt that only available topical, cba w/ topicals anymore

 

[BrahminBoss]

@jeoyw9192

 

[BrahminBoss]

Isnt that only available topical, cba w/ topicals anymore

Tranexemaic acid vs liposomal vit c for oral? I want to reduce PIH alreadu using topicals

 

[laaltin]

Tranexemaic acid vs liposomal vit c for oral? I want to reduce PIH alreadu using topicals

Tranexamic but you gotta cycle it cause it clots blood, one cycle is enough (3 months) to clear all sorts of hyperpigmentation. Maintain with topical then or resume after break. Oral vit C is joke, shit takes too long and at best it will lighten the shade a little bit, hyperpigmentation will persist

 

[BrahminBoss]

O

Tranexamic but you gotta cycle it cause it clots blood, one cycle is enough (3 months) to clear all sorts of hyperpigmentation. Maintain with topical then or resume after break. Oral vit C is joke, shit takes too long and at best it will lighten the shade a little bit, hyperpigmentation will persist

ome Cycle is? How much mg a day

 

[laaltin]

O

ome Cycle is? How much mg a day

250 mg a day, conservative dosage. I'll also run D-Dimer test at 2 months mark to check my blood clot levels and decide if I will continue or take a break

 

[BrahminBoss]

250 mg a day, conservative dosage. I'll also run D-Dimer test at 2 months mark to check my blood clot levels and decide if I will continue or take a break

Did it clear up all ur PIH? Which form did u use , did u stay out of sun when running it

 

[laaltin]

Did it clear up all ur PIH? Which form did u use , did u stay out of sun when running it

No, I just started running the oral form, customs seized my packet twice jfl. I have sun spots on my forehead, topical cleared a lot of that, no other pigmentation issue. It should clear up the remaining stubborn patches, I have seen foids on Reddit with fucked up pigmentation and melasma who tried everything under the sun and oral TxA worked like a charm for them. I'm running 250 mg oral as we speak, might up the dosage after D-Dimer. I just ordered Eucerin sunscreen, summer lasts only few months here, I will be out every day during the summer

 

[BrahminBoss]

No, I just started running the oral form, customs seized my packet twice jfl. I have sun spots on my forehead, topical cleared a lot of that, no other pigmentation issue. It should clear up the remaining stubborn patches, I have seen foids on Reddit with fucked up pigmentation and melasma who tried everything under the sun and oral TxA worked like a charm for them. I'm running 250 mg oral as we speak, might up the dosage after D-Dimer. I just ordered Eucerin sunscreen, summer lasts only few months here, I will be out every day during the summer

Link to brand?

 

[SidharthTheSlayer]

One change of lighting and you’re back to being a green shitskin after months of overdosing on lycopene. Melanin and skin brightness is the ONLY thing that matters.

 

[BrahminBoss]

One change of lighting and you’re back to being a green shitskin after months of overdosing on lycopene. Melanin and skin brightness is the ONLY thing that matters.

Lighting should not affect it the guy in pic 2 wouldn’t look green in the same airport lighting imo

 

[laaltin]

Link to brand?

Trenaxa, Indian brand. I don't think you will have as much problem sourcing it, try your local slum pharmacy. I had to order to a temp parking address in another country and route it from there. I used All Day Chemist.

 

[BrahminBoss]

Trenaxa, Indian brand. I don't think you will have as much problem sourcing it, try your local slum pharmacy. I had to order to a temp parking address in another country and route it from there. I used All Day Chemist.

Fucking hate PIH , unironically melasma would be better

 

[laaltin]

Fucking hate PIH , unironically melasma would be better

Be careful of what you wish for