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First guide hopefully didnt fuck this up tier list of sarms, i put as much info as possible, i used cuck ai to fix formating and fix my grammar since ik retarded ngas on here gon be like “what does this mean 
” if i spelled it wrong, my credibility for this is ive done sarms before, and that i spent a few hours researching this, english is not my first language nor my second, if anything is wrong tell me instead of saying “water” “retard thread” “dnrd” actually if u say dnrd i like u i spam that on every post i see, thats about it do ur own research if u die cuz of me that ain my problem, pls rep my ratio is ass, k go read now
Tier S (Chad Potency and Selectivity):
Ostarine (MK-2866):
How it works:
It binds to androgen receptors (ARs) in muscles and bones, triggering changes that activate genes involved in muscle growth. This process includes pathways like Akt/mTOR, needed for muscle development.
Pharmacokinetics:
It is easily absorbed when taken orally just like when ur sister takes this dick orally, with a long lasting presence in the body cause of its structure. It targets muscles and bones, good effectiveness while minimizing effects on reproductive tissues.
Ligandrol (LGD-4033):
How it works:
Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .
Pharmacokinetics:
Ligandrol quickly enters the system and spreads, because its lipophilic. It undergoes minimal hepatic metabolism and is excreted, minimizing systemic buildup.
RAD-140 (Testolone):
How it works:
It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.
Pharmacokinetics:
It is quickly absorbed, distributed, and eliminated. Its metabolism, facilitated by hepatic enzymes, ends up with minimal systemic exposure.
Ibutamoren (MK-677):
How it works:
Everyone on this forum knows what mk677 is but if you dont it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1 (IGF-1). This activation triggers signaling pathways promoting protein synthesis, nitrogen retention, and muscle growth.
Pharmacokinetics:
Its absorbed faster than my dick in ur sister due to being lipophilic. It distributes widely, with minimal hepatic metabolism and excretion through renal and biliary pathways, for elimination and metabolic balance.
Tier A (Chadlite Efficacy and Target Specificity):
Andarine (S-4):
How it works:
It activates ARs in fat and muscles, inducing changes that promote fat breakdown, adipocyte differentiation, and muscle development.
Pharmacokinetics:
It is easily absorbed and distributed, eased by its lipophilic properties. Its hepatic metabolism generates active metabolites with prolonged effects, contributing to sustained effectiveness.
Cardarine (GW-501516):
How it works:
Cardarine acts as a selective agonist of peroxisome proliferator-activated receptor delta (PPARδ), enhancing endurance and lipid utilization by triggering metabolic adaptations.
Pharmacokinetics:
It is quickly absorbed and distributed, with hepatic metabolism leading to inactive metabolites that are easily eliminated, ending up with metabolic clearance and systemic balance.
YK-11:
How it works:
YK-11 is both a SARM and a myostatin inhibitor, causing muscle growth and differentiation through AR activation and myostatin inhibition.
Pharmacokinetics:
YK-11's lipophilic nature facilitates rapid absorption and distribution. Hepatic metabolism generates active metabolites with prolonged effects, supporting sustained anabolic signaling.
Tier B (Htn Efficacy and Safety Profile):
S-23:
How it works:
S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.
Pharmacokinetics:
S-23's being lipophilic guarantees good oral bioavailability and distribution. Hepatic metabolism leads to active metabolites with prolonged effects, balancing efficacy and safety.
Tier C (Mtn Interpretation Due to Limited Data):
LGD-3303 (Limited Research):
How it works:
Limited data so a low understanding of LGD-3303's mechanism of action and safety profile, use cautiously will need more research done.
Pharmacokinetics:
Limited pharmacokinetic data complicates understanding LGD-3303's metabolic fate and distribution. studies are needed for clarifying its systemic exposure, clearance pathways, and potential accumulation.
Tier D (Not Approved for Human Use):
Other SARMs not approved for human use:
How they work:
I was gonna make a list of sarms to not use but i aint doing allat yall got it tho
Things u should take with sarms:
- Adaptogens: Herbs like Rhodiola rosea, Ashwagandha, and Ginseng help the body adapt to stress, support hormone balance, and enhance physical and mental performance.
- Mitochondrial Support: Supplements like Acetyl-L-Carnitine (ALCAR), PQQ (Pyrroloquinoline quinone), and Nicotinamide Riboside (NR) support mitochondrial function, energy production, and cellular health.
- Anti-Inflammatory Agents: Curcumin (from turmeric), Boswellia serrata, and Quercetin help reduce inflammation, protect tissues from damage, and support joint health.
- Hormonal Support: Compounds like DHEA (Dehydroepiandrosterone), DIM (Diindolylmethane), and Maca root support hormonal balance, particularly testosterone levels, which may be affected by SARMs usage.
- Liver Support: In addition to NAC, TUDCA, and Milk Thistle, supplements like Artichoke extract, Dandelion root, and Schisandra help support liver detoxification pathways and protect liver cells from damage.
- Cellular Repair and Regeneration:
Supplements like Glucosamine, Chondroitin, and MSM (Methylsulfonylmethane) support joint health, cartilage repair, and tissue regeneration.
- Cognitive Enhancement: Omega-3 fatty acids, Phosphatidylserine (PS), and Bacopa monnieri support cognitive function, memory, and focus, which may be beneficial during SARMs usage.
1. Cutting Stack:
- Ostarine + Cardarine: Ideal for cutting, promoting fat loss, and endurance.
2. Lean Muscle Building:
- Rad 140 + Mk 677: Provides fast lean muscle gains and strength.
3. Bulking Stack:
- LGD 4033 + Rad 140 + Mk 677:
Imo the best bulking stack, significant lean mass gains and strength.
4. Muscle Growth and Fat Loss:
- LGD 4033 + Cardarine: balance between muscle growth and fat loss.
5. Strength stack:
- Rad 140 + YK 11: substantial strength gains and improved power output.
6. Endurance stack:
- Cardarine + SR900: Enhances endurance and stamina, so longer and more intense workouts.
7. Recomp Stack
(Muscle Growth and Fat Loss):
- Ostarine + Cardarine + SR9009: Ideal for recomp, promoting simultaneous muscle growth and fat loss while enhancing endurance.
8. Joint Health and Recovery:
- MK-677 + SR9009: Supports joint health and recovery, aiding in overall well-being during intense training periods.
9. Advanced Bulking with Focus on Vascularity:
- LGD 4033 + Rad 140 + YK 11: advanced bulking stack promoting significant lean mass gains with a focus on vascularity and muscle definition.
10. Aggressive Cutting Stack:
- Andarine + Cardarine + SR9009: Combination for aggressive cutting, promoting fat loss, endurance, and muscle preservation.
Around 60+ sources but no links for u faggots go find ur own
Inspired by @Arditi s thread:
looksmax.org
” if i spelled it wrong, my credibility for this is ive done sarms before, and that i spent a few hours researching this, english is not my first language nor my second, if anything is wrong tell me instead of saying “water” “retard thread” “dnrd” actually if u say dnrd i like u i spam that on every post i see, thats about it do ur own research if u die cuz of me that ain my problem, pls rep my ratio is ass, k go read nowTier S (Chad Potency and Selectivity):
Ostarine (MK-2866):
How it works:
It binds to androgen receptors (ARs) in muscles and bones, triggering changes that activate genes involved in muscle growth. This process includes pathways like Akt/mTOR, needed for muscle development.
Pharmacokinetics:
It is easily absorbed when taken orally just like when ur sister takes this dick orally, with a long lasting presence in the body cause of its structure. It targets muscles and bones, good effectiveness while minimizing effects on reproductive tissues.
Ligandrol (LGD-4033):
How it works:
Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .
Pharmacokinetics:
Ligandrol quickly enters the system and spreads, because its lipophilic. It undergoes minimal hepatic metabolism and is excreted, minimizing systemic buildup.
RAD-140 (Testolone):
How it works:
It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.
Pharmacokinetics:
It is quickly absorbed, distributed, and eliminated. Its metabolism, facilitated by hepatic enzymes, ends up with minimal systemic exposure.
Ibutamoren (MK-677):
How it works:
Everyone on this forum knows what mk677 is but if you dont it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1 (IGF-1). This activation triggers signaling pathways promoting protein synthesis, nitrogen retention, and muscle growth.
Pharmacokinetics:
Its absorbed faster than my dick in ur sister due to being lipophilic. It distributes widely, with minimal hepatic metabolism and excretion through renal and biliary pathways, for elimination and metabolic balance.
Tier A (Chadlite Efficacy and Target Specificity):
Andarine (S-4):
How it works:
It activates ARs in fat and muscles, inducing changes that promote fat breakdown, adipocyte differentiation, and muscle development.
Pharmacokinetics:
It is easily absorbed and distributed, eased by its lipophilic properties. Its hepatic metabolism generates active metabolites with prolonged effects, contributing to sustained effectiveness.
Cardarine (GW-501516):
How it works:
Cardarine acts as a selective agonist of peroxisome proliferator-activated receptor delta (PPARδ), enhancing endurance and lipid utilization by triggering metabolic adaptations.
Pharmacokinetics:
It is quickly absorbed and distributed, with hepatic metabolism leading to inactive metabolites that are easily eliminated, ending up with metabolic clearance and systemic balance.
YK-11:
How it works:
YK-11 is both a SARM and a myostatin inhibitor, causing muscle growth and differentiation through AR activation and myostatin inhibition.
Pharmacokinetics:
YK-11's lipophilic nature facilitates rapid absorption and distribution. Hepatic metabolism generates active metabolites with prolonged effects, supporting sustained anabolic signaling.
Tier B (Htn Efficacy and Safety Profile):
S-23:
How it works:
S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.
Pharmacokinetics:
S-23's being lipophilic guarantees good oral bioavailability and distribution. Hepatic metabolism leads to active metabolites with prolonged effects, balancing efficacy and safety.
Tier C (Mtn Interpretation Due to Limited Data):
LGD-3303 (Limited Research):
How it works:
Limited data so a low understanding of LGD-3303's mechanism of action and safety profile, use cautiously will need more research done.
Pharmacokinetics:
Limited pharmacokinetic data complicates understanding LGD-3303's metabolic fate and distribution. studies are needed for clarifying its systemic exposure, clearance pathways, and potential accumulation.
Tier D (Not Approved for Human Use):
Other SARMs not approved for human use:
How they work:
I was gonna make a list of sarms to not use but i aint doing allat yall got it tho
Things u should take with sarms:
- Adaptogens: Herbs like Rhodiola rosea, Ashwagandha, and Ginseng help the body adapt to stress, support hormone balance, and enhance physical and mental performance.
- Mitochondrial Support: Supplements like Acetyl-L-Carnitine (ALCAR), PQQ (Pyrroloquinoline quinone), and Nicotinamide Riboside (NR) support mitochondrial function, energy production, and cellular health.
- Anti-Inflammatory Agents: Curcumin (from turmeric), Boswellia serrata, and Quercetin help reduce inflammation, protect tissues from damage, and support joint health.
- Hormonal Support: Compounds like DHEA (Dehydroepiandrosterone), DIM (Diindolylmethane), and Maca root support hormonal balance, particularly testosterone levels, which may be affected by SARMs usage.
- Liver Support: In addition to NAC, TUDCA, and Milk Thistle, supplements like Artichoke extract, Dandelion root, and Schisandra help support liver detoxification pathways and protect liver cells from damage.
- Cellular Repair and Regeneration:
Supplements like Glucosamine, Chondroitin, and MSM (Methylsulfonylmethane) support joint health, cartilage repair, and tissue regeneration.
- Cognitive Enhancement: Omega-3 fatty acids, Phosphatidylserine (PS), and Bacopa monnieri support cognitive function, memory, and focus, which may be beneficial during SARMs usage.
1. Cutting Stack:
- Ostarine + Cardarine: Ideal for cutting, promoting fat loss, and endurance.
2. Lean Muscle Building:
- Rad 140 + Mk 677: Provides fast lean muscle gains and strength.
3. Bulking Stack:
- LGD 4033 + Rad 140 + Mk 677:
Imo the best bulking stack, significant lean mass gains and strength.
4. Muscle Growth and Fat Loss:
- LGD 4033 + Cardarine: balance between muscle growth and fat loss.
5. Strength stack:
- Rad 140 + YK 11: substantial strength gains and improved power output.
6. Endurance stack:
- Cardarine + SR900: Enhances endurance and stamina, so longer and more intense workouts.
7. Recomp Stack
(Muscle Growth and Fat Loss):
- Ostarine + Cardarine + SR9009: Ideal for recomp, promoting simultaneous muscle growth and fat loss while enhancing endurance.
8. Joint Health and Recovery:
- MK-677 + SR9009: Supports joint health and recovery, aiding in overall well-being during intense training periods.
9. Advanced Bulking with Focus on Vascularity:
- LGD 4033 + Rad 140 + YK 11: advanced bulking stack promoting significant lean mass gains with a focus on vascularity and muscle definition.
10. Aggressive Cutting Stack:
- Andarine + Cardarine + SR9009: Combination for aggressive cutting, promoting fat loss, endurance, and muscle preservation.
Around 60+ sources but no links for u faggots go find ur own
Inspired by @Arditi s thread:
[2023] Latest SARMs guide
Disclaimer - users of these compounds report a lot of side effects. Organ damage, hair loss, acne breakouts, cancer, lethargy, irritability, testosterone shutdown and many other things can be caused by the compounds listed down below. SARMs are mostly used by teens and new lifters. What they...
looksmax.org
Last edited:
