Tips for addyrall optimization?

[TeenAscender]

Anyone experienced w studying and drums to maximize effects?

 

[Alexanderr]

Anyone experienced w studying and drums to maximize effects?

Yes I think I had an entire page on how to maximize it

 

[TeenAscender]

Yes I think I had an entire page on how to maximize it

differential equations proofs are going to kill me

 

[Alexanderr]

This isn't everything, not sure where I left the rest though, haven't touched it in a year, I can see the the notes below don't contain L-tyrosine, but you can take 1000mg of that in advance as well. Oh yeah, do take it on an empty stomach as well, to increase bioavailability.

Spoiler

Amphetamine optimization



Lower doses // 5-10mg

• Low enough doses that do not warrant dopamine downregulation in your brain
• More dextroamphetamine as opposed to levoamphetamine, less andrenergic effects such as increased blood pressure and heart rate
• Low-doses of amphetamine increase neuroplasticity
• Neurotrophic factors not only make the brain more plastic but also increase neuroprotection

Weekly time-off // 2-3 days

• Gives your brain time to rehabilitate from the increased dopaminergic releases from the amphetamine.
• Mitigates dopamine downregulation and tolerance

Instant release

• Taking XR agonises adrenaline release for an extended period of time, possibly while sleeping inhibiting deep sleep
• Crushing XR pill could possibly turn it into IR, use a metal dressing holder and something big to crush it. The dressing holder prevents the crushed powder from escaping

Dopamine detox

• This can be used in your benefit; by downregulating everything in your life
• You can optimize the use of the amphetamine during an activity you would usually find unpleasent say reading, studying or practicing

Sigma-1 agonist

• Sigma-1 agonism upregulates dopamine activity in the brain
• DHEA stimulates the sigma-1 receptor, you need 100mg - 300mg
• Fluvoxamine (SSRI)
• Donapezil (Acetylcholesterase inhibitor), potent sigma-1 agonist

Ghrelin receptor agonism

• Agonism of the growth-hormone-secretagogue-receptor (GHSR) directly upregulates dopamine
• It increases cyclic adenosine monophoshate, which is how it increase dopamine

Monoamineoxidase B Inhibitor

• Reduces glutamatergic activity in the body by lowering the acitivty of calcicum channels
• Anti-epileptic drugs, lowers general glutametergic activity in the brain and increases the dopaminergic effect
• Dexedrine increases dopaminergic (which is excitatory and can kill neurons) and glutamatergic activity in the brain
• It also ameliorates the BBB

Angiotensin II receptor blockers (ARB)

• Blockade of the AT-1 receptor nullifies apoptotic effect of metamphetamine (in rodents)
• The ARB blocks the AT-1 receptor