hej1377
Chad-affirming care is a right, not a privilege
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Hello chads and subhumans, in my research i feel like theyre are some compounds that don't get the love thwy deserve on here, there are a million of them but im gonna write shortly about 3 of them today, hope you like it. This was kinda low effort and written very quickly so i apoligize if theres any spelling or grammatical errors or factual mistakes etc, posted this in lm but its relevant here too
Lithium
i think when most people get into and learn about pharmacology regarding the brain people very easily and with good reason get obsessed with trying to increase different neurotransmitters and/or agonise certain receptors with amphetamines or pregabalin for example, and those drugs can be great, they definitely have their place as they work so good so acutely
This study looked at the correlation between autistic traits and metabolite levels of neurotransmitters as well as glutamate/gaba ratio and they found “In cross‑correlation analyses, the Glx/GABA ratio was significantly associated with both autistic traits and sensory responsivity, whereas Glx alone showed fewer associations. Clustering analyses further grouped autistic traits with the Glx/GABA ratio, rather than with the individual metabolite concentrations, suggesting that the ratio may be more behaviorally relevant than either metabolite alone.” so basically stability is law. Its also in pretty much every study linked to depression very very closely as well as well as almost any mental problem while absolute levels of any given compound is poor as an indicator. This is a straight waterfall for anyone who even does slight research so im not gonna write pages and pages of text arguing for why stability is the important metric as if you do not agree you are either not knowledgeable on the subject which is fine but im not gonna practically debate you or you're just an anti intellectualist, and jfl at that.
lithium is also pretty much as good as it gets when it comes to stability, this fucking huge meta analysis shows that lithium fucking terra mogs, manic episode risk fuckign sliced in half and depression reduced by about a fourth
vorinostat/crebinostat/neurinostat
These 3 are all hdac inhibitors, they all work, neuroinostat is ideal but unrealistic to actually source most of the time, crebinostat is definitely doable but might run you a few hundred so it's a bit expensive. Vorinostat is slightly worse than both but the easiest and cheapest to source
What histone deacetylase like the name implies removes acetyl. This tightens DNA which makes transcription harder to accomplish. Therefore when hdac is inhibited more transcription is allowed so genes become expressed more strongly. Hdac does not act everywhere but it does act in the hippocampus which is the part most nootropics revolve around. This is of course theoretically but this study tested it and at least in rats it had significant effects on memory and long term plasticity which is in line with what's been theorized. this studyalso showed vorinostat was able to reverse cognitively declining mice brains.
Imo this is the most promising group of drugs out there, I think a very important suggestion wouls be to not use this alone but with other stuff as this could very well synergize with anything that causes neuronal signaling, directly or indirectly like cerebrolysin or any compound meant to cause synaptogenesis at some point, as a rule of thumb if its used for memory or learning directly and not just focus it probably gets amplified by hdaci, at least in theory. Because all it does is enhance signaling it doesn't cause it on its own.
relacorilant
relacorilant is a glucocorticoid receptor antagonist, so basically it blocks cortisol. This is of course great as cortisol is something most people are gonna have too much of rather than too little which makes you feel stressed and fatigued, but you probably know that as it's known as the stress hormone. Cortisol also is the main cause behind hormone induced loss of elastin and it's also of course a catabolic hormone and tren’s GR antagonism is also the reason it's so anti catabolic and therefore good for cutting. I do not believe it replaces tren or makes tren obsolete but i do think it could be an option to run instead of tren if you might be a beginner, high inhib, super risk adverse, really really need sleep or dread any other tren side etc etc then i think you could pair this with some test maybe and still be well off.
Most gr antagonists throughout the years have like tren also had hormonal effects but relacorilant does not and has been specifically made for that. In both vivo and vitro it has showed effectiveness consistently like a vitro article here . This drug i cant really be fucked to write much about as the effects of cortisol is common knowledge and theres tons of studies to be found on this drug so i think the most valuable thing i can provide is just bringing it into discourse.
since im obviously unemployed would anyone be interested in a seratonin thread? I feel like its kind of missing on here.
Lithium
i think when most people get into and learn about pharmacology regarding the brain people very easily and with good reason get obsessed with trying to increase different neurotransmitters and/or agonise certain receptors with amphetamines or pregabalin for example, and those drugs can be great, they definitely have their place as they work so good so acutely
This study looked at the correlation between autistic traits and metabolite levels of neurotransmitters as well as glutamate/gaba ratio and they found “In cross‑correlation analyses, the Glx/GABA ratio was significantly associated with both autistic traits and sensory responsivity, whereas Glx alone showed fewer associations. Clustering analyses further grouped autistic traits with the Glx/GABA ratio, rather than with the individual metabolite concentrations, suggesting that the ratio may be more behaviorally relevant than either metabolite alone.” so basically stability is law. Its also in pretty much every study linked to depression very very closely as well as well as almost any mental problem while absolute levels of any given compound is poor as an indicator. This is a straight waterfall for anyone who even does slight research so im not gonna write pages and pages of text arguing for why stability is the important metric as if you do not agree you are either not knowledgeable on the subject which is fine but im not gonna practically debate you or you're just an anti intellectualist, and jfl at that.
lithium is also pretty much as good as it gets when it comes to stability, this fucking huge meta analysis shows that lithium fucking terra mogs, manic episode risk fuckign sliced in half and depression reduced by about a fourth
vorinostat/crebinostat/neurinostat
These 3 are all hdac inhibitors, they all work, neuroinostat is ideal but unrealistic to actually source most of the time, crebinostat is definitely doable but might run you a few hundred so it's a bit expensive. Vorinostat is slightly worse than both but the easiest and cheapest to source
What histone deacetylase like the name implies removes acetyl. This tightens DNA which makes transcription harder to accomplish. Therefore when hdac is inhibited more transcription is allowed so genes become expressed more strongly. Hdac does not act everywhere but it does act in the hippocampus which is the part most nootropics revolve around. This is of course theoretically but this study tested it and at least in rats it had significant effects on memory and long term plasticity which is in line with what's been theorized. this studyalso showed vorinostat was able to reverse cognitively declining mice brains.
Imo this is the most promising group of drugs out there, I think a very important suggestion wouls be to not use this alone but with other stuff as this could very well synergize with anything that causes neuronal signaling, directly or indirectly like cerebrolysin or any compound meant to cause synaptogenesis at some point, as a rule of thumb if its used for memory or learning directly and not just focus it probably gets amplified by hdaci, at least in theory. Because all it does is enhance signaling it doesn't cause it on its own.
relacorilant
relacorilant is a glucocorticoid receptor antagonist, so basically it blocks cortisol. This is of course great as cortisol is something most people are gonna have too much of rather than too little which makes you feel stressed and fatigued, but you probably know that as it's known as the stress hormone. Cortisol also is the main cause behind hormone induced loss of elastin and it's also of course a catabolic hormone and tren’s GR antagonism is also the reason it's so anti catabolic and therefore good for cutting. I do not believe it replaces tren or makes tren obsolete but i do think it could be an option to run instead of tren if you might be a beginner, high inhib, super risk adverse, really really need sleep or dread any other tren side etc etc then i think you could pair this with some test maybe and still be well off.
Most gr antagonists throughout the years have like tren also had hormonal effects but relacorilant does not and has been specifically made for that. In both vivo and vitro it has showed effectiveness consistently like a vitro article here . This drug i cant really be fucked to write much about as the effects of cortisol is common knowledge and theres tons of studies to be found on this drug so i think the most valuable thing i can provide is just bringing it into discourse.
since im obviously unemployed would anyone be interested in a seratonin thread? I feel like its kind of missing on here.
