TRENBOLONE NEUROPROTECTION 101

[nwed]

First of all: lets understand Tren neurotoxicity

I will start by saying that unlike popular beliefs, tren is NOT the most neurotoxic compound: Nandrolone is actually more neurotoxic than tren milligram to milligram, dont belive me?

https://www.sciencedirect.com/science/article/pii/S0306452218307772

Main neurotoxic pathways, and how to prevent them

Excitotoxic signaling
Reward system desensitization
Hippocampal dendritic atrophy
Oxidative stress
Caspase-3 upregulation

Deunking the: Just pop some Memantine and dwbi, while yes, Memantine is a good compound, it’s not nearly broad spectrum enough for one, as it’s main target is both extrasynaptic NMDA and the calcium ion channel, it does nothing to rescue the neurotoxic cascade upstream (pulled by AR agonism)

And also, more Memantine does not mean more Memantine, start from 1.25mg and only go up if you start forgetting stuff

Clonidine: its an α2-adrenergic receptor agonist, it reduces central sympathetic outflow and norepinephrine release. In experimental model, α2 agonists have shown some potentially neuroprotective effects due to reducing Glutamate release and decreasing neuroinflammation

Genistein: acts as an ER beta agonist, the problem is that it kinda targets ER alpha wich is the receptor responsible for growth plate closure, can still be a good choice if GP are fused

Resveratrol: Very good anti inflammatory proprieties reducing the activation of microglia and suppresses many inflammatory mediators, it also has anti apoptotic effects decreasing caspase-3 activation
It has a shit ton of other neuroprotective benefits, suprisingly niche, just use this

Cerebrolysin: Cortexin is also an option, its a bit better for mood while cere is better for neuroprotection, very good to use in post cycle therapy

 

[hyperandrogenic]

high iq post, you forgot lionsmane mushroom though

 

[Emolifta]

Reserving spot for later

 

[nwed]

high iq post, you forgot lionsmane mushroom though

i forgot a lot of stuff, non non hallucinogenic LSD analogues are cool too

 

[hyperandrogenic]

i forgot a lot of stuff, non non hallucinogenic LSD analogues are cool too

I havent read anything about LSD analogues that could help with neuroprotection besides possibly tabernanthalog (which has very little evidence)

 

[infra.nizar]

First of all: lets understand Tren neurotoxicity

I will start by saying that unlike popular beliefs, tren is NOT the most neurotoxic compound: Nandrolone is actually more neurotoxic than tren milligram to milligram, dont belive me?
View attachment 5419779

https://www.sciencedirect.com/science/article/pii/S0306452218307772

Main neurotoxic pathways, and how to prevent them

Excitotoxic signaling
Reward system desensitization
Hippocampal dendritic atrophy
Oxidative stress
Caspase-3 upregulation

Deunking the: Just pop some Memantine and dwbi, while yes, Memantine is a good compound, it’s not nearly broad spectrum enough for one, as it’s main target is both extrasynaptic NMDA and the calcium ion channel, it does nothing to rescue the neurotoxic cascade upstream (pulled by AR agonism)

And also, more Memantine does not mean more Memantine, start from 1.25mg and only go up if you start forgetting stuff

Clonidine: its an α2-adrenergic receptor agonist, it reduces central sympathetic outflow and norepinephrine release. In experimental model, α2 agonists have shown some potentially neuroprotective effects due to reducing Glutamate release and decreasing neuroinflammation

Genistein: acts as an ER beta agonist, the problem is that it kinda targets ER alpha wich is the receptor responsible for growth plate closure, can still be a good choice if GP are fused

Resveratrol: Very good anti inflammatory proprieties reducing the activation of microglia and suppresses many inflammatory mediators, it also has anti apoptotic effects decreasing caspase-3 activation
It has a shit ton of other neuroprotective benefits, suprisingly niche, just use this

Cerebrolysin: Cortexin is also an option, its a bit better for mood while cere is better for neuroprotection, very good to use in post cycle therapy

you can't protect yourself from the brain damage caused by steroids

I'd personally rather preserve my brain health than gain new bone tissue or get jacked.

 

[nwed]

you can't protect yourself from the brain damage caused by steroids

I'd personally rather preserve my brain health than gain new bone tissue or get jacked.

are you a fucking idiot? genuinely

 

[infra.nizar]

are you a fucking idiot? genuinely

why do you think I'm an idiot ? let's debate

 

[fraudster#1]

le 3mg LDN and 5 mg of Lithium oratate walks in:

 

[Emolifta]

Reserving spot for later

Time limit expired but

TLDR:
Use NACET
High dose melatonin (~50mg)
Memantine 5mg (namenda)
Intranasal slin / Metformin depends on u

Edit: I don’t recommend using intranasal slin while on fast acting slin, refrain from it and substitute it with metformin. And anywho metformin is the BETTER and more accessible drug for combating neurotoxicity of tren

After cycle
Cerebrolysin