Tret/Retin A effects on Cartilage

[coppercope]

Hi All,

Apparently after reading the following it seems that Tretinoin / Retin-A degenerates Cartilage and reduces cartilage formation (I maybe reading it wrong). Could someone please explain this further layman's terms. Like to what extent does it do this and would this have any noticeable impact.

Effects of retinoic acid on cartilage differentiation in a chondrogenic cell line - PubMed

Previously we have isolated the monopotential chondrogenic cell line RCJ 3.1 C5.18 from the multipotential mesenchymal cell line RCJ 3.1 [Grigoriadis et al.: Endocrinology, 125:2103-2110, 1989]. When cultured for approximately 20 days under appropriate conditions, these cells from cartilage...

pubmed.ncbi.nlm.nih.gov

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes - PubMed

Retinoic acid can alter the differentiation of a variety of cell types, including chondrocytes. This action may explain the high incidence of craniofacial and limb defects resulting from exposure to retinoic acid during development, and may be the basis for the compound's inhibition of a...

pubmed.ncbi.nlm.nih.gov

 

[Deleted member 7651]

Pills or cream?

 

[coppercope]

Cream (topical) I’m pretty sure, pills are Iso-tret.

 

[MewingJBP]

cope

 

[coppercope]

cope

Is it legit?

 

[coppercope]

H

Is it legit?

How is it cope

 

[randomvanish]

 

[coppercope]

Yes, but still.

View attachment 785035View attachment 785036

Yeah but still? I mean the research papers are still valid regardless of age. My question is basically would the effect be noticeable and to what extend. Also, I’ll try and find more recent papers.

 

[randomvanish]

1. research : " After 48 hr of exposure to retinoic acid chondrocytes stopped synthesizing the chondrocyte-specific pro alpha 1 (II) chain of collagen II and a 370-kDa precursor protein of a cartilage-specific proteoglycan. Instead, the cells synthesized increased amounts of fibronectin and the pro alpha 1 chain of collagen III. These changes could be detected as early as 12 hr after treatment. "
2. Research : " . Pulse treatment with RA for various 4 day periods during a 17-24 day culture period established that RA inhibited differentiation of chondroprogenitors at all periods tested. These effects were reversible, except for part of the effect on early chondroprogenitors. Treatment with RA on days 13-17 in 17 day cultures not only resulted in cessation of cartilage formation, but also in disappearance of pre-existing cartilage nodules. "

this tells nothing. how could this be a valid research ? there wasn't even enough time to comprehend biological effects on the human body.

 

[coppercope]

Retinoic acid-induced cartilage degradation is caused by cartilage cells - Discover Developmental Biology

Cartilage cubes, prepared from the proximal epiphyses of neonatal rat humeri and consisting of cartilage tissue only, were cultured in the presence of retinoic acid. The retinoid induced the loss of metachromatic staining with toluidine blue, which correlates with the loss of proteoglycan...

link.springer.com

https://www.jbc.org/content/285/47/36674.full.pdf

 

[randomvanish]

Retinoic acid-induced cartilage degradation is caused by cartilage cells - Discover Developmental Biology

Cartilage cubes, prepared from the proximal epiphyses of neonatal rat humeri and consisting of cartilage tissue only, were cultured in the presence of retinoic acid. The retinoid induced the loss of metachromatic staining with toluidine blue, which correlates with the loss of proteoglycan...

link.springer.com

https://www.jbc.org/content/285/47/36674.full.pdf

"Focal tissue degradation was observed after only 2 days. "

 

[randomvanish]

@coppercope dude we need comprehensive long studies to understand its effects.

 

[coppercope]

@coppercope dude we need comprehensive long studies to understand its effects.

Yeah, I agree. However, let’s say hypothetically that they were on the right track. What would it mean?

 

[randomvanish]

Yeah, I agree. However, let’s say hypothetically that they were on the right track. What would it mean?

there would be a solid damage biologically, i can understand that. i mean in long term the body would adapt so eliminate its effect or maybe that damage become bigger and bigger but depends on the person too.
it's complicated.
i'm gonna use tret anyway ngl

 

[coppercope]

there would be a solid damage biologically, i can understand that. i mean in long term the body would adapt so eliminate its effect or maybe that damage become bigger and bigger but depends on the person too.
it's complicated.
i'm gonna use tret anyway ngl

Yeah, of course. But to what extent biologically? Like how would it effect you?
Like, It’s like reading another language when trying to decipher these research papers aha.

 

[MewingJBP]

people have been using this stuff for decades and look way younger than their age, even if does have some negative side effects they're insignificant

 

[JosephGarrot123]

doesnt matter niggas used it for decades and stil look young seems insignificant

 

[eduardkoopman]

How servere is this side effect?

How bad is this side effect for overall health? Long TERM?

I never seen people that used it long term. complaining that they can't walk or sport anymore, because no Cartilage anymore in body?

This woman is on retinA / tretinoin for 30 years.
And she is 60 orso in this video. And she moves pretty healthy for a granny, and skin looks awesome for a granny.
or dr. Des Fernandes who is like 70 now, and on it for 30-40years as well. He still moves around healthy for agrandpa.

So I don't see irl examples, of it cuasing alot of problems long term

 

[TITUS]

I will explain it to you in layman's terms, DONT INJECT TRETINOIN IN YOUR CARTILAGE RETARD, there you go.

 

[Deleted member 1751]

Damn so even Tret is dangerous now?

 

[Deleted member 9779]

Our nose are made of cartilage, so will taking Retin A reduce the cartilage formation and thus decrease the size of the nose ?

 

[randomvanish]

isotretinoin is a form of tret and it does create cartilage problems on some people.
however, i used 40mg a day for 8 months and had no side effect at all.

 

[Deleted member 275]

Our nose are made of cartilage, so will taking Retin A reduce the cartilage formation and thus decrease the size of the nose ?

 

[coppercope]

Our nose are made of cartilage, so will taking Retin A reduce the cartilage formation and thus decrease the size of the nose ?

Thats actually a good question? Potentially after years of use, as it would get absorbed. But I doubt it will have any dramatic impact, just very very subtle if at all. However, I’m no expert. Would be interesting to know though.

 

[The Bleach Pill]

Thats actually a good question? Potentially after years of use, as it would get absorbed. But I doubt it will have any dramatic impact, just very very subtle if at all. However, I’m no expert. Would be interesting to know though.

muh muh cope. just put the shit on ur face

 

[Deleted member 4946]

Hi All,

Apparently after reading the following it seems that Tretinoin / Retin-A degenerates Cartilage and reduces cartilage formation (I maybe reading it wrong). Could someone please explain this further layman's terms. Like to what extent does it do this and would this have any noticeable impact.

Effects of retinoic acid on cartilage differentiation in a chondrogenic cell line - PubMed

Previously we have isolated the monopotential chondrogenic cell line RCJ 3.1 C5.18 from the multipotential mesenchymal cell line RCJ 3.1 [Grigoriadis et al.: Endocrinology, 125:2103-2110, 1989]. When cultured for approximately 20 days under appropriate conditions, these cells from cartilage...

pubmed.ncbi.nlm.nih.gov

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes - PubMed

Retinoic acid can alter the differentiation of a variety of cell types, including chondrocytes. This action may explain the high incidence of craniofacial and limb defects resulting from exposure to retinoic acid during development, and may be the basis for the compound's inhibition of a...

pubmed.ncbi.nlm.nih.gov

bump this, accutane has been reported here a few times from members that it made their nose smaller (the point is they both have Vitamin A)

 

[coppercope]

bump this, accutane has been reported here a few times from members that it made their nose smaller (the point is they both have Vitamin A)

Would be interesting to know. Need some high IQ users to jump on this.

 

[Deleted member 4946]

muh muh cope. just put the shit on ur face

 

[coppercope]

Interesting, worth further discussion. Isotret

 

[Deleted member 4946]

Also :

Effects of isotretinoin treatment on cartilage and tendon thicknesses: an ultrasonographic study - PubMed

Effects of retinoic acid on collagen synthesis and cartilage have previously been shown. However, its effects on cartilage and tendons in humans have not been studied yet. Therefore, in order to provide a morphologic insight, the aim of this study was to measure femoral cartilage, Achilles and...

pubmed.ncbi.nlm.nih.gov

'Systemic isotretinoin treatment seems to make cartilage thinner.' this is just systemic btw, local should produce much more targeted results

Accutane – Smaller nose? – Prescription acne medications – Acne.org Forum

I'm on my first week of accutane, and haven't been noticing any changes up till today. Last night my nose was really itchy for some reason. Anyways, I...

www.acne.org

and https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/604850 (arthritis is thinning of cartilage causing inflammation)

 

[coppercope]

Also :

Effects of isotretinoin treatment on cartilage and tendon thicknesses: an ultrasonographic study - PubMed

Effects of retinoic acid on collagen synthesis and cartilage have previously been shown. However, its effects on cartilage and tendons in humans have not been studied yet. Therefore, in order to provide a morphologic insight, the aim of this study was to measure femoral cartilage, Achilles and...

pubmed.ncbi.nlm.nih.gov

'Systemic isotretinoin treatment seems to make cartilage thinner.' this is just systemic btw, local should produce much more targeted results

Accutane – Smaller nose? – Prescription acne medications – Acne.org Forum

I'm on my first week of accutane, and haven't been noticing any changes up till today. Last night my nose was really itchy for some reason. Anyways, I...

www.acne.org

and https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/604850 (arthritis is thinning of cartilage causing inflammation)

Fuck, what if it can cause cartilage deformities. People should know about this before using it.

 

[Deleted member 3130]

Hi All,

Apparently after reading the following it seems that Tretinoin / Retin-A degenerates Cartilage and reduces cartilage formation (I maybe reading it wrong). Could someone please explain this further layman's terms. Like to what extent does it do this and would this have any noticeable impact.

Effects of retinoic acid on cartilage differentiation in a chondrogenic cell line - PubMed

Previously we have isolated the monopotential chondrogenic cell line RCJ 3.1 C5.18 from the multipotential mesenchymal cell line RCJ 3.1 [Grigoriadis et al.: Endocrinology, 125:2103-2110, 1989]. When cultured for approximately 20 days under appropriate conditions, these cells from cartilage...

pubmed.ncbi.nlm.nih.gov

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes - PubMed

Retinoic acid can alter the differentiation of a variety of cell types, including chondrocytes. This action may explain the high incidence of craniofacial and limb defects resulting from exposure to retinoic acid during development, and may be the basis for the compound's inhibition of a...

pubmed.ncbi.nlm.nih.gov

Neither of these studies are examining the effects of retinoic acid on collagen synthesis and maintenance in vivo. TLDR of both is that tret applied DIRECTLY to chondrocytes (which are the cells that create and maintain cartilaginous tissue) affects them negatively. This is highly specific and cannot be generalised to what happens in topical application of tret on skin

 

[Deleted member 3130]

If topical tret application had a significant enough effect on collagen synthesis and maintenance for you to be concerned, it would’ve been documented in studies

 

[Luke LLL]

No cartilage for your face

 

[coppercope]

Neither of these studies are examining the effects of retinoic acid on collagen synthesis and maintenance in vivo. TLDR of both is that tret applied DIRECTLY to chondrocytes (which are the cells that create and maintain cartilaginous tissue) affects them negatively. This is highly specific and cannot be generalised to what happens in topical application of tret on skin

So would it have any effect? (Hypothetically)

 

[Deleted member 3130]

So would it have any effect? (Hypothetically)

Maybe it does but it’s only detectable in very long term (in which case studies would also have to be long term to find out). Seems like it wouldn’t be a good idea to inject it straight into cartilage lol. To answer your original question, no it will not be noticeable

 

[RAITEIII]

,

 

[AscendingHero]

Also :

Effects of isotretinoin treatment on cartilage and tendon thicknesses: an ultrasonographic study - PubMed

Effects of retinoic acid on collagen synthesis and cartilage have previously been shown. However, its effects on cartilage and tendons in humans have not been studied yet. Therefore, in order to provide a morphologic insight, the aim of this study was to measure femoral cartilage, Achilles and...

pubmed.ncbi.nlm.nih.gov

'Systemic isotretinoin treatment seems to make cartilage thinner.' this is just systemic btw, local should produce much more targeted results

Accutane – Smaller nose? – Prescription acne medications – Acne.org Forum

I'm on my first week of accutane, and haven't been noticing any changes up till today. Last night my nose was really itchy for some reason. Anyways, I...

www.acne.org

and https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/604850 (arthritis is thinning of cartilage causing inflammation)

accutane is retarded imo, just eat liver and have a well functioning gut?

But can retin a remove some cartilage from the nose?
Lifefuel if true for us bolbous nose cels

 

[Deleted member 4946]

accutane is retarded imo, just eat liver and have a well functioning gut?

But can retin a remove some cartilage from the nose?
Lifefuel if true for us bolbous nose cels

yes. It did for me and a few other people here. (although Idk how many people actually put some emphasis on putting Retin-A on their nose)

 

[ChristianChad]

Yup one of the main mechanisms is reducing Igf-1.