Tyra-300 dethroned?, search for the ideal fgfr3 inhib

[Thatsall101]

based off toxicity

we all know erda is the most toxic fgfr3 inhibi, however we all know of other options such as (tyra300, infig, visorotide etc)

enter LOXO-435

an fgfr3 inhibitor with more human clinical data than tyra300 and much much less sides than even tyra300 (all sources in the bottom of this text)

most impressively compared to tyra300 where studies had to be halted at times due to "severe adverse events", (10% of the time)

"No dose-limiting toxicities (DLTs) were observed across dose levels ranging from 6 mg once daily up to 400 mg twice daily."
for LOXO-435

A first-in-human phase 1 study of LY3866288... : Journal of Clinical Oncology

662Background: Activating alterations in FGFR3 (most commonly S249C) occur in 15-20% of metastatic urothelial cancers (mUC) and FGFR3-altered mUC but...

www.ovid.com

ClinicalTrials.gov

clinicaltrials.gov

https://ascopubs.org/doi/10.1200/JCO.2025.43.5_suppl.662 (in pdf look down and download it)



————

lazy post again, just wanted your opinion boyos

 

[Niebvll]

Oh my fucking lord greyfags find shit thats been talked about for months and feel like God

"heh enter loxo435"

 

[Thatsall101]

Oh my fucking lord greyfags find shit thats been talked about for months and feel like God

"heh enter loxo435"

sorry brah js wanted open ended discussion, mb if I'm late to the party

 

[smalldik97]

vepugratinib is even harder to find than tyra, by the time its available everyone's growth plates will have fused

 

[Thatsall101]

vepugratinib is even harder to find than tyra, by the time its available everyone's growth plates will have fused

this is for the next generation of manlets

 

[Niebvll]

vepugratinib is even harder to find than tyra

both arent hard to find
only hard to afford

 

[Thatsall101]

both arent hard to find
only hard to afford

no offense dude but you sound pompous asf, get off your high horse n stop tryna act soo cool

 

[Niebvll]

no offense dude but you sound pompous asf, get off your high horse n stop tryna act soo cool

thats only the case because youre a low IQ RETARD
"this is for the next generation of manlets"

"Tyra-300 dethroned?"​

"enter LOXO-435"

"an fgfr3 inhibitor with more human clinical data than tyra300"
not even true lol vepu is phase 1 only

 

[Thatsall101]

thats only the case because youre a low IQ RETARD
"this is for the next generation of manlets"

"Tyra-300 dethroned?"​

"enter LOXO-435"

"an fgfr3 inhibitor with more human clinical data than tyra300"
not even true lol vepu is phase 1 only

dude how do your read my statement then go on to prove it on your next reply

 

[Thatsall101]

thats only the case because youre a low IQ RETARD
"this is for the next generation of manlets"

"Tyra-300 dethroned?"​

"enter LOXO-435"

"an fgfr3 inhibitor with more human clinical data than tyra300"
not even true lol vepu is phase 1 only

dude i know i can be wrong which is why i invited open ended discussion, and criticism. you're doing too much

 

[Niebvll]

dude how do your read my statement then go on to prove it on your next reply

your statement was completely subjective and can not be proven

dude i know i can be wrong which is why i invited open ended discussion, and criticism. you're doing too much

youre just a fucking retard who was trying to play like you just discovered the next penicillin
gtfo nooone needs iqlets like you on the forum
invited open ended discussion

 

[Thatsall101]

your statement was completely subjective and can not be proven

yeah and hence why you shouldn't be offended which your clearly are, my statement affects you in no way shape it form,

take from it what you will I'm not questioning your intelligence, do you want some sort of approval from me? i saw that you commented on my profile, dude just move on.

 

[Thatsall101]

youre just a fucking retard who was trying to play like you just discovered the next penicillin
gtfo nooone needs iqlets like you on the forum
invited open ended discussion

I'm not even gonna call out the fallacious statements you just put in this, you're clearly tryna be hurtful or "cool" in some way.

i am genuinely telling you it's not worth your energy go to a different forum or the ones you think are worth your time