Understanding Visual Perception in Autism

[Osteogenesis]

 

[Incellectually_Shy]

I'm not sure why this thread was disregarded, but I shall offer this:

Autistic Spectrum Disorder(ASD) and Schizophrenic Spectrum disorder(SSD) are known to influence cognition and processing speed.

Genetic Determinants of Gating Functions: Do We Get Closer to Understanding Schizophrenia Etiopathogenesis?​

Although these variants and genes were all implicated in schizophrenia in research studies, only two polymorphisms (HTR2A rs6311 and TCF4 rs9960767) were also reported to be associated with schizophrenia at a meta-analytic or genome-wide level of evidence

Genetic Determinants of Gating Functions: Do We Get Closer to Understanding Schizophrenia Etiopathogenesis? - PubMed

Deficits in the gating of sensory stimuli, i.e., the ability to suppress the processing of irrelevant sensory input, are considered to play an important role in the pathogenesis of several neuropsychiatric disorders, in particular schizophrenia. Gating is disrupted both in schizophrenia patients...

pubmed.ncbi.nlm.nih.gov

The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability​

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Although the function of TCF4 as transcription factor has been well established, very little is known about the genes regulated by TCF4 in neuronal cells and specifically in cells of human origin. Therefore, to gain a functional insight into the role of TCF4 in schizophrenia other neurodevelopmental disorders, we used a bespoke TCF4 antibody for chromatin immunoprecipitation and next generation sequencing (ChIP-seq) to define the genomic targets of TCF4. We found that TCF4 target genes cluster in neurodevelopmental pathways and are enriched for schizophrenia, ASD, and ID risk genes.

Yes...

Furthermore, haploinsufficiency of Tcf4 in mice affects gene expression and DNA methylation in the brain, leading to enhanced long-term potentiation, learning and memory deficits, and autistic-like behavior.22,25,26 By contrast, mice over-expressing Tcf4 in the brain display deficits in sensorimotor gating, fear conditioning, and circadian processes as well as impairments in attentional and behavioral anticipation.7,27

Haploinsufficiency is "Pitt-Hopkins Syndrome" ASD. Hyper-efficiency is non-PHS ASD/SSD.

Sensorimotor gating deficits of-course affect processing speed:

Sensorimotor gating is the process by which one filters out relevant from irrelevant information, a process that is deficient in multiple neuropsychiatric disorders including TS (Castellanos et al., 1996).

 

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