Understanding what genetics are, and why they're only a factor, and not everything

[x30001]

1. [Username Hidden]: I wonder if one wanted to induce a second puberty, where should he inject the yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc)?
2. Yesterday at 1:41 PM
3. [Username Hidden]: And what would be the result of this? a more dimorphic man with double the size, double the bone density, muscular fibers, etc...
4. Yesterday at 1:42 PM
5. x30001: hey
6. Yesterday at 3:38 PM
7. [Username Hidden]: yes
8. Yesterday at 3:38 PM
9. x30001: about inducing second puberty
10. Yesterday at 3:38 PM
11. x30001: no i don't think it's achievable
12. Yesterday at 3:38 PM
13. x30001: because the factor in life that's hardest to alter is time
14. Yesterday at 3:39 PM
15. x30001: and puberty happens as a function of elapsed time since inception
16. Yesterday at 3:39 PM
17. x30001: which is standardized among everyone
18. Yesterday at 3:39 PM
19. x30001: You can't inject yamanaka factors, you can only access them and use them to induce pluripotency in cells
20. Yesterday at 3:40 PM
21. [Username Hidden]: As I quoted earlier, they have been found to create genetic alterations
22. Yesterday at 3:42 PM
23. x30001: epigenomic alterations though, not alterations to the genome
24. Yesterday at 3:43 PM
25. [Username Hidden]: Anyway, this is a very advanced field, do you think there's a research lab that can do this to plebeians?
26. Yesterday at 3:44 PM
27. x30001: reprogramming factors can be used to create changes in the expression of the human genome, without changing the genome itself, simply by changing the epigenome and taking advantage of the way various epigenomes can alter expression of the same genes
28. Yesterday at 3:45 PM
29. [Username Hidden]: I mean, it's nothing like taking resveratrol, lol.
31. Yesterday at 3:45 PM
32. x30001: it's like a different computer reading and expressing the same binary differently
33. Yesterday at 3:45 PM
34. x30001: new epigenome = new cpu
35. Yesterday at 3:45 PM
36. x30001: if you run instructions/code (being the DNA data) on an old computer, there won't be the same effect as running it on a new hi-spec CPU
37. Yesterday at 3:46 PM
38. x30001: ie: data gets lost in translation and expression is nullified or corrupted. or the gene(s) are expressed less efficaciously
39. Yesterday at 3:47 PM
40. x30001: Yeah it's nothing like resveratrol lol
41. Yesterday at 3:47 PM
42. x30001: You are the .exe file
43. Yesterday at 3:48 PM
44. x30001: Your genome (DNA make-up: ATCG) is the raw instructions (ie: binary.. 0 1 0 1 etc)
45. Yesterday at 3:48 PM
46. x30001: while you can change your 0s and 1s with CRISPR
47. Yesterday at 3:48 PM
48. x30001: you can also reprogram the machine that reads and translates those instructions
49. Yesterday at 3:49 PM
50. [Username Hidden]: So, is it possible to undergo such treatment, or researchers haven't found yet a safe and predictable way on how to instruct the epigenome?
51. Yesterday at 3:49 PM
52. x30001: in vivo it would be EXTREMELY hard
53. Yesterday at 3:50 PM
54. x30001: it's been done in rats
55. Yesterday at 3:50 PM
56. x30001: Think of what other elements translate binary instructions into high level code (c# etc)
57. Yesterday at 3:51 PM
58. x30001: Many things
59. Yesterday at 3:51 PM
60. x30001: Transcription Factors, DNA Methylation etc are comparible to these things
61. Yesterday at 3:51 PM
62. x30001: You are your executable file. Then it depends how well you "execute" in the world you live in
63. Yesterday at 3:52 PM
64. x30001: comparable to how a software connects with the internet and other PCs in the world
65. Yesterday at 3:53 PM
66. x30001: The time you can keep an app running for is usually not long.. because it exhausts your CPU, consumes electricity, requires more processing power etc
67. Yesterday at 3:53 PM
68. x30001: Same with us as we age
69. Yesterday at 3:54 PM
70. x30001: Our epigenome degrades
71. Yesterday at 3:54 PM
72. x30001: it gets exhausted
73. Yesterday at 3:54 PM
74. [Username Hidden]: it's interesting, but way too far in the future from being applicable to normal people like us. I'm looking for solutions that I can practice now. I have done in the past 20 days straight water fasting, losing 12kg, and going such deep ketosis that I got a keto rush on the chest, I had to use calcium bentonite to get rid of it.
75. Yesterday at 3:54 PM
76. x30001: like an old PC running an app for 50 years would... it wouldnt be possible, or performance would seriously decline

 

[Overjetcel299]

Low t for username hidden

 

[x30001]

Low t for username hidden

Wasn't gonna just expose DMs

 

[IWantToMax]

High effort thread.
I like it

 

[Overjetcel299]

Wasn't gonna just expose DMs

Good not a snitch

 

[Deleted member 2933]

in

 

[turkproducer]

the title gives off the idea that genetics aren’t everything but what you’re saying is that it means pretty much everything..

 

[Avoidant]

Genes give you your baseline, environment affects how far from your baseline you can go for better or worse.

If your PSL rating is on a number line, your genes are like a window on that line, and your environment determines where in the window you fall.

 

[FatJattMofo]

wtf is this . are you transferring launch codes for an antimatter bomb?

 

[turkproducer]

Genes give you your baseline, environment affects how far from your baseline you can go for better or worse.

If your PSL rating is on a number line, your genes are like a window on that line, and your environment determines where in the window you fall.

How much do you think it’s possible to stunt growth height wise in a first world country?

wtf is this . are you transferring launch codes for an antimatter bomb?

he’s a pseudo intellectual ngl. He linked me some graph like this about anti aging and said it was “basic”

 

[x30001]

High effort thread.
I like it

Thanks. I just copy and pasted a convo I had with someone on here. But thought it might be useful to share some info. Especially sharing the fact that genes are what they are; but they can be expressed differently.

Like a running an application on CPUs with different specs. Sometimes genes can't be expressed correctly, or at all. Even though you have the genes. It's like trying to run an MMORPG game on a low spec laptop that doesn't even have a GPU. You need the GPU. The MMORPG game is made up of static binary, but the machine that determines the level of performance of the game, changes the expression, and how good or bad the outcome is. CPU = Epigenome. Genes = Genome. Gene's can't be expressed without an Epigenome and numerous other factors; just like a computer application can't run properly with, firstly, a Computer (ie: Epigenome), and factors such as CPU & GPU specs, power consumption etc

 

[Avoidant]

How much do you think it’s possible to stunt growth height wise in a first world country?

All depends on diet. Eat healthy and get all the nutrients you can and you will grow to your genetic potential, maybe even above, which is why younger people are getting taller and taller.

 

[FatJattMofo]

How much do you think it’s possible to stunt growth height wise in a first world country?

he’s a pseudo intellectual ngl. He linked me some graph like this about anti aging and said it was “basic”View attachment 161775

i doubt he is a psuedo intellectual his thread title is right

 

[Alt Number 3]

Nice script, when’s the movie coming out?

 

[Aesthetic]

Mfw when i read this entire thread.

Good high effort thread op, so many good points made. Well thought out and good responses.
As expected from @x30001

 

[x30001]

Genes give you your baseline, environment affects how far from your baseline you can go for better or worse.

If your PSL rating is on a number line, your genes are like a window on that line, and your environment determines where in the window you fall.

Yeah. When we age, our genes aren't changing, they can be damaged and Methyl groups can form on Cytosine nucleotides, inhibiting expression. But ultimately our genes retain the same ATCG sequence in our genome. It's our Epigenome that degrades over time, and loses the ability to read and express our DNA code optimally.

Comparing this to a DVD player and DVD Disk:

Scratches on the disk = DNA damage
Overwriting Data on the disk = Genome editing via CRISPR
Damage to the DVD player = Degradation of the Epigenome

So don't let your Epigenome degrade.

Old people don't become different than when they were young because their literal DNA changes. They become old because their Epigenome degrades over time and loses the ability to read and express that same DNA code, which hasn't changed, optimally.

 

[2peasinapod]

genetic resiliance is a thing

 

[DidntRead]

 

[x30001]

Mfw when i read this entire thread.

Good high effort thread op, so many good points made. Well thought out and good responses.
As expected from @x30001

Respect bro

 

[turkproducer]

All depends on diet. Eat healthy and get all the nutrients you can and you will grow to your genetic potential, maybe even above, which is why younger people are getting taller and taller.

Interesting..

I had -
Smoked weed since 14 but regularly since 16 (now 17)
Smoked cigarettes since 15 but regularly for a year
high cortisol
lack of father figure
high BF
high sugar and fat diet but i still ate home cooked food
Video games and not much sport other than school PE lessons (i played basketball 14-16 though)
Pretty sure I was depressed as well most my childhood and puberty, only improved last 2 years

 

[x30001]

How much do you think it’s possible to stunt growth height wise in a first world country?

he’s a pseudo intellectual ngl. He linked me some graph like this about anti aging and said it was “basic”View attachment 161775

Lol what's this. Are you talking about me? I didn't make that graph or send it to you.

 

[NiBBaCel]

Low t for username hidden

Stopped reading after that ngl

 

[turkproducer]

Lol what's this. Are you talking about me? I didn't make that graph or send it to you.

you sent a similar one and called it “basic”
on understanding anti aging.. lmfao

 

[x30001]

you sent a similar one and called it “basic”
on understanding anti aging.. lmfao

What are you taking about ?

 

[turkproducer]

Thanks. I just copy and pasted a convo I had with someone on here. But thought it might be useful to share some info. Especially sharing the fact that genes are what they are; but they can be expressed differently.

Like a running an application on CPUs with different specs. Sometimes genes can't be expressed correctly, or at all. Even though you have the genes. It's like trying to run an MMORPG game on a low spec laptop that doesn't even have a GPU. You need the GPU. The MMORPG game is made up of static binary, but the machine that determines the level of performance of the game, changes the expression, and how good or bad the outcome is. CPU = Epigenome. Genes = Genome. Gene's can't be expressed without an Epigenome and numerous other factors; just like a computer application can't run properly with, firstly, a Computer (ie: Epigenome), and factors such as CPU & GPU specs, power consumption etc

so what you’re saying here for some people if they don’t do certain things throughout their developmental years they fuck themselves over?

 

[2peasinapod]

this is way too black a white, too 1D, its coping beyond belief infact

im out

 

[turkproducer]

What are you taking about ?

Lol bro it’s not my problem if you don’t remember what you said.. if i find it i’ll show you, but i made a thread on anti aging or replied to someone who did asking how can i stop aging, and you said “here’s a basic graph” and linked something like that

this is way too black a white, too 1D, its coping beyond belief infact

im out

What’s your view them

 

[Avoidant]

Yeah. When we age, our genes aren't changing, they can be damaged and Methyl groups can form on Cytosine nucleotides, inhibiting expression. But ultimately our genes retain the same ATCG sequence in our genome. It's our Epigenome that degrades over time, and loses the ability to read and express our DNA code optimally.

Comparing this to a DVD player and DVD Disk:

Scratches on the disk = DNA damage
Overwriting Data on the disk = Genome editing via CRISPR
Damage to the DVD player = Degradation of the Epigenome

So don't let your Epigenome degrade.

Old people don't become different than when they were young because their literal DNA changes. They become old because their Epigenome degrades over time and loses the ability to read and express that same DNA code, which hasn't changed, optimally.

Extremely high IQ biochemistry knowledge.

Interesting..

I had -
Smoked weed since 14 but regularly since 16 (now 17)
Smoked cigarettes since 15 but regularly for a year
high cortisol
lack of father figure
high BF
high sugar and fat diet but i still ate home cooked food
Video games and not much sport other than school PE lessons (i played basketball 14-16 though)
Pretty sure I was depressed as well most my childhood and puberty, only improved last 2 years

Kinda shit environment tbh. How tall are you and your parents?

 

[turkproducer]

Extremely high IQ biochemistry knowledge.


Kinda shit environment tbh. How tall are you and your parents?

My dad and I are same height, 5’8, and my mum is 5’3. My dad might be taller by 1cm and he may have been taller by another 2cm as a young man.

the weird thing is, my uncles are 5’9.5-10 and their parents who are my grandparents are 5’5 and 5’0.. so if they have shorter parents why are they taller?

 

[CopeIsReal]

Good thread op, if ugliness was purely the result of bad genetics, natural selection would've sorted it out already.

 

[CarlSagan96]

Thanks. I just copy and pasted a convo I had with someone on here. But thought it might be useful to share some info. Especially sharing the fact that genes are what they are; but they can be expressed differently.

Like a running an application on CPUs with different specs. Sometimes genes can't be expressed correctly, or at all. Even though you have the genes. It's like trying to run an MMORPG game on a low spec laptop that doesn't even have a GPU. You need the GPU. The MMORPG game is made up of static binary, but the machine that determines the level of performance of the game, changes the expression, and how good or bad the outcome is. CPU = Epigenome. Genes = Genome. Gene's can't be expressed without an Epigenome and numerous other factors; just like a computer application can't run properly with, firstly, a Computer (ie: Epigenome), and factors such as CPU & GPU specs, power consumption etc

None of this is really relevant without an explanation of how this can happen in humans in normal conditions. I liked the computer analogy btw, although technically a CPU can do everything a GPU can but slower...

 

[LordNorwood]

If we could control our epigenome we could solve almost 100% of the issues we think we have. No aging, no hair loss, etc.