X
x30001
Kraken
- Joined
- Jan 9, 2019
- Posts
- 3,311
- Reputation
- 4,485
- [Username Hidden]: I wonder if one wanted to induce a second puberty, where should he inject the yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc)?
- Yesterday at 1:41 PM
- [Username Hidden]: And what would be the result of this? a more dimorphic man with double the size, double the bone density, muscular fibers, etc...
- Yesterday at 1:42 PM
- x30001: hey
- Yesterday at 3:38 PM
- [Username Hidden]: yes
- Yesterday at 3:38 PM
- x30001: about inducing second puberty
- Yesterday at 3:38 PM
- x30001: no i don't think it's achievable
- Yesterday at 3:38 PM
- x30001: because the factor in life that's hardest to alter is time
- Yesterday at 3:39 PM
- x30001: and puberty happens as a function of elapsed time since inception
- Yesterday at 3:39 PM
- x30001: which is standardized among everyone
- Yesterday at 3:39 PM
- x30001: You can't inject yamanaka factors, you can only access them and use them to induce pluripotency in cells
- Yesterday at 3:40 PM
- [Username Hidden]: As I quoted earlier, they have been found to create genetic alterations
- Yesterday at 3:42 PM
- x30001: epigenomic alterations though, not alterations to the genome
- Yesterday at 3:43 PM
- [Username Hidden]: Anyway, this is a very advanced field, do you think there's a research lab that can do this to plebeians?
- Yesterday at 3:44 PM
- x30001: reprogramming factors can be used to create changes in the expression of the human genome, without changing the genome itself, simply by changing the epigenome and taking advantage of the way various epigenomes can alter expression of the same genes
- Yesterday at 3:45 PM
- [Username Hidden]: I mean, it's nothing like taking resveratrol, lol.
- Yesterday at 3:45 PM
- x30001: it's like a different computer reading and expressing the same binary differently
- Yesterday at 3:45 PM
- x30001: new epigenome = new cpu
- Yesterday at 3:45 PM
- x30001: if you run instructions/code (being the DNA data) on an old computer, there won't be the same effect as running it on a new hi-spec CPU
- Yesterday at 3:46 PM
- x30001: ie: data gets lost in translation and expression is nullified or corrupted. or the gene(s) are expressed less efficaciously
- Yesterday at 3:47 PM
- x30001: Yeah it's nothing like resveratrol lol
- Yesterday at 3:47 PM
- x30001: You are the .exe file
- Yesterday at 3:48 PM
- x30001: Your genome (DNA make-up: ATCG) is the raw instructions (ie: binary.. 0 1 0 1 etc)
- Yesterday at 3:48 PM
- x30001: while you can change your 0s and 1s with CRISPR
- Yesterday at 3:48 PM
- x30001: you can also reprogram the machine that reads and translates those instructions
- Yesterday at 3:49 PM
- [Username Hidden]: So, is it possible to undergo such treatment, or researchers haven't found yet a safe and predictable way on how to instruct the epigenome?
- Yesterday at 3:49 PM
- x30001: in vivo it would be EXTREMELY hard
- Yesterday at 3:50 PM
- x30001: it's been done in rats
- Yesterday at 3:50 PM
- x30001: Think of what other elements translate binary instructions into high level code (c# etc)
- Yesterday at 3:51 PM
- x30001: Many things
- Yesterday at 3:51 PM
- x30001: Transcription Factors, DNA Methylation etc are comparible to these things
- Yesterday at 3:51 PM
- x30001: You are your executable file. Then it depends how well you "execute" in the world you live in
- Yesterday at 3:52 PM
- x30001: comparable to how a software connects with the internet and other PCs in the world
- Yesterday at 3:53 PM
- x30001: The time you can keep an app running for is usually not long.. because it exhausts your CPU, consumes electricity, requires more processing power etc
- Yesterday at 3:53 PM
- x30001: Same with us as we age
- Yesterday at 3:54 PM
- x30001: Our epigenome degrades
- Yesterday at 3:54 PM
- x30001: it gets exhausted
- Yesterday at 3:54 PM
- [Username Hidden]: it's interesting, but way too far in the future from being applicable to normal people like us. I'm looking for solutions that I can practice now. I have done in the past 20 days straight water fasting, losing 12kg, and going such deep ketosis that I got a keto rush on the chest, I had to use calcium bentonite to get rid of it.
- Yesterday at 3:54 PM
- x30001: like an old PC running an app for 50 years would... it wouldnt be possible, or performance would seriously decline