Using DHT gel to grow the mandible

[kiidz24]

MINITHREAD ON DHT GEL AND POTENTIAL GROWTH


Okay so the mandibular condyle contains the condylar cartilage, and contributes to growth during development.
View attachment 1766856639711.png
Growth at the condyle is heavily affected by:
-Mechanical stimuli
-IFG1, TGF-β
-Sex hormones (test, estrogen and DHT).

Theoretically, using a DHT gel capable of penetrating the skin (one with alcohol), on the condyle, would increase local DHT in the area, which would then bind to the androgen receptors in the condyle, leading to enchanced cell proliferation, matrix production and hypertrophic differentiation, causing a thicker cartilage layer.

From there on: thicker cartilage layer ---> more bone formation.

To continue, DHT would increase local IGF1 and TGF-β, which will further stimulate chondrocyte activity, DHT will also simulate osteoblast activity, furtherly enhancing anabolic effects on the condyle.

A false belief many have is that DHT deriverd from DHT gel will only become systemic - only a miniscule amount can do so; the DHT will bind to local AR receptors and is metabolized before entering systemic circulation ---> minimal systemic absortion.

 

[kiidz24]

bump

 

[iblamewerner]

good effort

 

[maxx92765]

MINITHREAD ON DHT GEL AND POTENTIAL GROWTH


Okay so the mandibular condyle contains the condylar cartilage, and contributes to growth during development.
View attachment 4470926
Growth at the condyle is heavily affected by:
-Mechanical stimuli
-IFG1, TGF-β
-Sex hormones (test, estrogen and DHT).

Theoretically, using a DHT gel capable of penetrating the skin (one with alcohol), on the condyle, would increase local DHT in the area, which would then bind to the androgen receptors in the condyle, leading to enchanced cell proliferation, matrix production and hypertrophic differentiation, causing a thicker cartilage layer.

From there on: thicker cartilage layer ---> more bone formation.

To continue, DHT would increase local IGF1 and TGF-β, which will further stimulate chondrocyte activity, DHT will also simulate osteoblast activity, furtherly enhancing anabolic effects on the condyle.

A false belief many have is that DHT deriverd from DHT gel will only become systemic - only a miniscule amount can do so; the DHT will bind to local AR receptors and is metabolized before entering systemic circulation ---> minimal systemic absortion.

i will not be doing this but interested to see anyone that does

 

[Bajio]

hmm maybe if it works for dick it can work for bone? ig

 

[Maisterjoda261]

MINITHREAD ON DHT GEL AND POTENTIAL GROWTH


Okay so the mandibular condyle contains the condylar cartilage, and contributes to growth during development.
View attachment 4470926
Growth at the condyle is heavily affected by:
-Mechanical stimuli
-IFG1, TGF-β
-Sex hormones (test, estrogen and DHT).

Theoretically, using a DHT gel capable of penetrating the skin (one with alcohol), on the condyle, would increase local DHT in the area, which would then bind to the androgen receptors in the condyle, leading to enchanced cell proliferation, matrix production and hypertrophic differentiation, causing a thicker cartilage layer.

From there on: thicker cartilage layer ---> more bone formation.

To continue, DHT would increase local IGF1 and TGF-β, which will further stimulate chondrocyte activity, DHT will also simulate osteoblast activity, furtherly enhancing anabolic effects on the condyle.

A false belief many have is that DHT deriverd from DHT gel will only become systemic - only a miniscule amount can do so; the DHT will bind to local AR receptors and is metabolized before entering systemic circulation ---> minimal systemic absortion.

W