VPA Hair-Growth Experiment

[Alexanderr]

I've devised the most elaborate hair-growth routine known to man, which should seriously boost my eyebrow and eyelash growth (in density, thickness, length, you name it). Valproic acid (VPA) keeps coming up because it can push follicles into a stronger growth phase by inhibiting GSK3β. Here's a user attempting to use it:

Valproic Acid hair regrowth (problem with soluble Valproic)

I want to test this method of lowering the hairline (only topical). Once a week dermapen Valproic Acid (diy cream) calcipotriol Tretinoin (very low doses) CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5% CD200: topical Calcitirol or Calcipotriol(generic creams...

looksmax.org

For most people, minoxidil or a prostaglandin analog (PGA) alone, or in combination, is enough for impressive brow and lash growth. But after trying oral minoxidil and seeing solid gains that still weren’t quite satisfactory, I’ve decided to jump the gun and go all-in. My goal: super dense, thick eyebrows and eyelashes.

Examples:

If VPA works as well as hoped, maybe I could even artificially lower my hairline. Theoretically, if it works effectively to activate dormant or miniaturized hair follicles in areas just above my existing hairline, it could. Here's someone who seemingly tried, and it kinda worked:

Problem is, most DIY attempts to extract VPA from extended-release tablets (like Amvalor Chrono) turn into a headache: lumps, partial dissolutions, leftover binders, and no guarantee of a proper solution. On the flip side, sourcing “pure” VPA powder from random IndiaMart vendors is risky, there’s no telling if it’s legit.

Meanwhile, there’s also the synergy angle: combining VPA, which activates Wnt/β-catenin for growth, with minoxidil to boost blood flow, PGA2 to extend growth phases, and peptides to strengthen hair and enhance follicle health. Throw in micro-needling to improve absorption, and this stack could hit every pathway for maximizing growth and density. TLDR: If this shit doesn't work, nothing will.

Here’s the cocktail I’m planning:

• VPA: Dissolved in a mild solvent mix (e.g., water + ethanol + PG) at ~1–2% concentration.
• PGA (e.g., Bimatoprost): Extends the growth phase and may enhance pigmentation and thickness, complementing the effects of VPA.
• Peptides: Reinforce hair shafts and pair well with VPA’s growth-pushing effects.
• Topical Minoxidil: Adds synergy with enhanced blood flow.
• Micro-Needling (brows only): Helps the solution penetrate deeper into follicles.

Now, I need to decide whether to:

1. Brave the extended-release tablets (crush, dissolve, filter, hope for the best).
2. Roll the dice on a reasonably credible “pure VPA” supplier.

If I get a stable, decently pure solution, I’ll carefully apply it to my brows and, maybe cautiously, near the lash line (Latisse-style dabs). Brow and lash cycles are shorter than scalp hair, so I should see changes within a couple of months.

If it flops? It's all over.... At least I’ll know I tried the nuclear approach.

 

[Alexanderr]

0 replies, absolutely over for this retarded forum

 

[magdel]

dnr

 

[J99]

Would love an update on this.

 

[Alexanderr]

delete this post no one cares nigger

gtfo out of my thread you room temp iq caveman

 

[magdel]

room temp iq caveman

ive never heard that one before

 

[J99]

if successful you can make a fucking bag holy shit

 

[sarmatian]

Good thread.

 

[Alexanderr]

Would love an update on this.

I’ve got most of the stuff ready, just need some equipment and the main thing: VPA. The other guy struggled with dissolving XR tablets, likely due to their fillers and time release coatings. His process led to clumps, inconsistent solutions, and poor filtration.
Where I’ll improve:

1. Grinding: Use an electric grinder for a fine powder to maximize solubility.
2. Solvent Mix: Dissolve in water + ethanol + PG for better results.
3. Filtering: Use a 0.22-micron syringe filter to remove impurities.
4. pH Adjustment: Balance to 5–7 for stability and skin safety.
5. Heating: Stir at ~40°C to speed up dissolution.

If I nail these steps, I should have a clean, effective solution ready to combine with the rest of my hair-growth stack.

 

[sarmatian]

I’ve got most of the stuff ready, just need some equipment and the main thing: VPA. The other guy struggled with dissolving XR tablets, likely due to their fillers and time release coatings. His process led to clumps, inconsistent solutions, and poor filtration.
Where I’ll improve:

1. Grinding: Use an electric grinder for a fine powder to maximize solubility.
2. Solvent Mix: Dissolve in water + ethanol + PG for better results.
3. Filtering: Use a 0.22-micron syringe filter to remove impurities.
4. pH Adjustment: Balance to 5–7 for stability and skin safety.
5. Heating: Stir at ~40°C to speed up dissolution.

If I nail these steps, I should have a clean, effective solution ready to combine with the rest of my hair-growth stack.

Can it get in your blood stream after micro-needling?

 

[Alexanderr]

Can it get in your blood stream after micro-needling?

Not very likely with shallow micro-needling (0.25 - 0.5mm), since it mainly targets the epidermis without breaking into blood vessels. But if you go deeper (like 1.5mm+), then yeah, there’s a higher chance, but even then, it’s minimal unless you’re soaking your face in the stuff.

 

[Alexanderr]

if successful you can make a fucking bag holy shit

Yeah, I’m surprised this hasn’t been talked about more on here. Probably because VPA is so obscure and such a pain to source. But if it actually works to lower my hairline and even revive miniaturized hairs to bring my eyebrows down a bit? That’d be insane.

 

[J99]

I’ve got most of the stuff ready, just need some equipment and the main thing: VPA. The other guy struggled with dissolving XR tablets, likely due to their fillers and time release coatings. His process led to clumps, inconsistent solutions, and poor filtration.
Where I’ll improve:

1. Grinding: Use an electric grinder for a fine powder to maximize solubility.
2. Solvent Mix: Dissolve in water + ethanol + PG for better results.
3. Filtering: Use a 0.22-micron syringe filter to remove impurities.
4. pH Adjustment: Balance to 5–7 for stability and skin safety.
5. Heating: Stir at ~40°C to speed up dissolution.

If I nail these steps, I should have a clean, effective solution ready to combine with the rest of my hair-growth stack.

yo this is insane why isnt this getting more attention

 

[Alexanderr]

yo this is insane why isnt this getting more attention

This forum doesn't have any mad scientists anymore, a thread like this would've done well 5 years ago, there's no innovation anymore just people rehashing the same old shit

 

[yue]

If you get the indian stuff just test it to see if it's legit

 

[Alexanderr]

If you get the indian stuff just test it to see if it's legit

I wish, but teting isn’t exactly straightforward. There are a few basic ways I could try to verify if it’s legit, like checking density, solubility in ethanol, or maybe even boiling point, but those won’t confirm purity or if it’s actually VPA.
Ideally, I’d send it to a lab for proper analysis, but that’s a whole other hassle.

 

[J99]

This forum doesn't have any mad scientists anymore, a thread like this would've done well 5 years ago, there's no innovation anymore just people rehashing the same old shit

Agreed, I've had a scientific breakthrough in terms of craniofacial aesthetics, but knowing the state of the forum I've decided to gatekeep

 

[yue]

I wish, but teting isn’t exactly straightforward. There are a few basic ways I could try to verify if it’s legit, like checking density, solubility in ethanol, or maybe even boiling point, but those won’t confirm purity or if it’s actually VPA.
Ideally, I’d send it to a lab for proper analysis, but that’s a whole other hassle.

Send it to me and I'll sneak into the orgchem department and test it for you bhai

 

[Cyrus]

0 replies, absolutely over for this retarded forum

do crushed up sodium valproate pills work?

 

[Alexanderr]

do crushed up sodium valproate pills work?

Crushed sodium valproate pills can work, but it’s tricky.
The issue is that the binders and fillers in the pills don’t dissolve well, especially with extended-release formulations. You’d need to crush them into a fine powder, dissolve in a solvent mix (e.g., water/ethanol/PG), stir for ages, filter out the gunk (probably multiple times), and still hope you’re getting a reasonably pure solution.
Even then, it’s hard to know how much active VPA is actually bioavailable.
It’s not impossible, but it’s definitely not straightforward either, I'm still figuring out which route to use.

 

[jefty]

I've devised the most elaborate hair-growth routine known to man, which should seriously boost my eyebrow and eyelash growth (in density, thickness, length, you name it). Valproic acid (VPA) keeps coming up because it can push follicles into a stronger growth phase by inhibiting GSK3β. Here's a user attempting to use it:

Valproic Acid hair regrowth (problem with soluble Valproic)

I want to test this method of lowering the hairline (only topical). Once a week dermapen Valproic Acid (diy cream) calcipotriol Tretinoin (very low doses) CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5% CD200: topical Calcitirol or Calcipotriol(generic creams...

looksmax.org

For most people, minoxidil or a prostaglandin analog (PGA) alone, or in combination, is enough for impressive brow and lash growth. But after trying oral minoxidil and seeing solid gains that still weren’t quite satisfactory, I’ve decided to jump the gun and go all-in. My goal: super dense, thick eyebrows and eyelashes.

Examples:
View attachment 3399131View attachment 3399130View attachment 3399138

If VPA works as well as hoped, maybe I could even artificially lower my hairline. Theoretically, if it works effectively to activate dormant or miniaturized hair follicles in areas just above my existing hairline, it could. Here's someone who seemingly tried, and it kinda worked:
View attachment 3399135

Problem is, most DIY attempts to extract VPA from extended-release tablets (like Amvalor Chrono) turn into a headache: lumps, partial dissolutions, leftover binders, and no guarantee of a proper solution. On the flip side, sourcing “pure” VPA powder from random IndiaMart vendors is risky, there’s no telling if it’s legit.

Meanwhile, there’s also the synergy angle: combining VPA, which activates Wnt/β-catenin for growth, with minoxidil to boost blood flow, PGA2 to extend growth phases, and peptides to strengthen hair and enhance follicle health. Throw in micro-needling to improve absorption, and this stack could hit every pathway for maximizing growth and density. TLDR: If this shit doesn't work, nothing will.

Here’s the cocktail I’m planning:

• VPA: Dissolved in a mild solvent mix (e.g., water + ethanol + PG) at ~1–2% concentration.
• PGA (e.g., Bimatoprost): Extends the growth phase and may enhance pigmentation and thickness, complementing the effects of VPA.
• Peptides: Reinforce hair shafts and pair well with VPA’s growth-pushing effects.
• Topical Minoxidil: Adds synergy with enhanced blood flow.
• Micro-Needling (brows only): Helps the solution penetrate deeper into follicles.

Now, I need to decide whether to:

1. Brave the extended-release tablets (crush, dissolve, filter, hope for the best).
2. Roll the dice on a reasonably credible “pure VPA” supplier.

If I get a stable, decently pure solution, I’ll carefully apply it to my brows and, maybe cautiously, near the lash line (Latisse-style dabs). Brow and lash cycles are shorter than scalp hair, so I should see changes within a couple of months.

If it flops? It's all over.... At least I’ll know I tried the nuclear approach.

I only know so many soft thing like derma roll or Minoxidil or hair inserts

 

[Cyrus]

Crushed sodium valproate pills can work, but it’s tricky.
The issue is that the binders and fillers in the pills don’t dissolve well, especially with extended-release formulations. You’d need to crush them into a fine powder, dissolve in a solvent mix (e.g., water/ethanol/PG), stir for ages, filter out the gunk (probably multiple times), and still hope you’re getting a reasonably pure solution.
Even then, it’s hard to know how much active VPA is actually bioavailable.
It’s not impossible, but it’s definitely not straightforward either, I'm still figuring out which route to use.

what about lyophized powder meant for injection? i can get that too
or just get the amps

also what pga do u think is the best? how does it compare to bimatoprost?

 

[Cyrus]

what about lyophized powder meant for injection? i can get that too
or just get the amps

also what pga do u think is the best? how does it compare to bimatoprost?

fuck i cant get the lyophized powder
but i can get injectable sodium valproate

 

[Alexanderr]

what about lyophized powder meant for injection? i can get that too
or just get the amps

also what pga do u think is the best? how does it compare to bimatoprost?

fuck i cant get the lyophized powder
but i can get injectable sodium valproate

That's a great suggestion, actually. If you can get injectable sodium valproate, that’s a much cleaner starting point than messing with XR tablets. It’s likely already dissolved and sterile, which saves you a ton of hassle. You'd just have dilute it down to the desired concentration carefully. This route seems most promising now, I'll look into it.

For PGAs, bimatoprost is the gold standard, it’s proven to work for lash growth and has some anecdotal success with brows too. Others like latanoprost and travoprost might work similarly, but they’re less studied for cosmetic use. If you can’t get bimatoprost, one of the others could still be worth trying, but bimatoprost is the safest bet for now.

 

[Cyrus]

That's a great suggestion, actually. If you can get injectable sodium valproate, that’s a much cleaner starting point than messing with XR tablets. It’s likely already dissolved and sterile, which saves you a ton of hassle. You'd just have dilute it down to the desired concentration carefully. This route seems most promising now, I'll look into it.

For PGAs, bimatoprost is the gold standard, it’s proven to work for lash growth and has some anecdotal success with brows too. Others like latanoprost and travoprost might work similarly, but they’re less studied for cosmetic use. If you can’t get bimatoprost, one of the others could still be worth trying, but bimatoprost is the safest bet for now.

hit me up after youre done looking into it
ill be a lab rat
i can get bimatoprost but its alot more expensive than the rest
how long do u think 3ml 0.01% is gonna last if im applying everyday?
should u be applying ed? whats the protocol for it?

 

[Alexanderr]

hit me up after youre done looking into it
ill be a lab rat
i can get bimatoprost but its alot more expensive than the rest
how long do u think 3ml 0.01% is gonna last if im applying everyday?
should u be applying ed? whats the protocol for it?

3 mL of bimatoprost should last about a month if you're applying daily to both brows or lash lines (around 0.1 mL/day). If you're spacing it out (every other day) or just focusing on brows, you can stretch it to 6–8 weeks.

Daily use is ideal at first, especially for lashes. For brows, 2–3 times a week might be enough since the hair cycle is slower. Just clean your face, use a fine applicator to hit sparse areas, and avoid dripping to prevent unwanted hair growth.

If bimatoprost feels too pricey, alternatives like 4LongLashes are worth considering. It contains a prostaglandin derivative that mimics bimatoprost’s effects, so it might still deliver decent results for a lower cost.

 

[Alexanderr]

3 mL of bimatoprost should last about a month if you're applying daily to both brows or lash lines (around 0.1 mL/day). If you're spacing it out (every other day) or just focusing on brows, you can stretch it to 6–8 weeks.

Daily use is ideal at first, especially for lashes. For brows, 2–3 times a week might be enough since the hair cycle is slower. Just clean your face, use a fine applicator to hit sparse areas, and avoid dripping to prevent unwanted hair growth.

If bimatoprost feels too pricey, alternatives like 4LongLashes are worth considering. It contains a prostaglandin derivative that mimics bimatoprost’s effects, so it might still deliver decent results for a lower cost.

With 4LongLashes make sure the one you buy contains Isopropyl Cloprostenate, this is the PGA that would mimic bimatoprosts' effects.

 

[Clavicular]

0 replies, absolutely over for this retarded forum

7:51 am pal, the east coast slayers were up until 3 am... give it some time.

 

[Mr.Proper]

PGA (e.g., Bimatoprost)

Don't they tend to decrease fat layer and collagen where applied? Their biggest drawback.

 

[DR. NICKGA]

Reply in dm

 

[nuttheb]

its

I've devised the most elaborate hair-growth routine known to man, which should seriously boost my eyebrow and eyelash growth (in density, thickness, length, you name it). Valproic acid (VPA) keeps coming up because it can push follicles into a stronger growth phase by inhibiting GSK3β. Here's a user attempting to use it:

Valproic Acid hair regrowth (problem with soluble Valproic)

I want to test this method of lowering the hairline (only topical). Once a week dermapen Valproic Acid (diy cream) calcipotriol Tretinoin (very low doses) CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5% CD200: topical Calcitirol or Calcipotriol(generic creams...

looksmax.org

For most people, minoxidil or a prostaglandin analog (PGA) alone, or in combination, is enough for impressive brow and lash growth. But after trying oral minoxidil and seeing solid gains that still weren’t quite satisfactory, I’ve decided to jump the gun and go all-in. My goal: super dense, thick eyebrows and eyelashes.

Examples:
View attachment 3399131View attachment 3399130View attachment 3399138

If VPA works as well as hoped, maybe I could even artificially lower my hairline. Theoretically, if it works effectively to activate dormant or miniaturized hair follicles in areas just above my existing hairline, it could. Here's someone who seemingly tried, and it kinda worked:
View attachment 3399135

Problem is, most DIY attempts to extract VPA from extended-release tablets (like Amvalor Chrono) turn into a headache: lumps, partial dissolutions, leftover binders, and no guarantee of a proper solution. On the flip side, sourcing “pure” VPA powder from random IndiaMart vendors is risky, there’s no telling if it’s legit.

Meanwhile, there’s also the synergy angle: combining VPA, which activates Wnt/β-catenin for growth, with minoxidil to boost blood flow, PGA2 to extend growth phases, and peptides to strengthen hair and enhance follicle health. Throw in micro-needling to improve absorption, and this stack could hit every pathway for maximizing growth and density. TLDR: If this shit doesn't work, nothing will.

Here’s the cocktail I’m planning:

• VPA: Dissolved in a mild solvent mix (e.g., water + ethanol + PG) at ~1–2% concentration.
• PGA (e.g., Bimatoprost): Extends the growth phase and may enhance pigmentation and thickness, complementing the effects of VPA.
• Peptides: Reinforce hair shafts and pair well with VPA’s growth-pushing effects.
• Topical Minoxidil: Adds synergy with enhanced blood flow.
• Micro-Needling (brows only): Helps the solution penetrate deeper into follicles.

Now, I need to decide whether to:

1. Brave the extended-release tablets (crush, dissolve, filter, hope for the best).
2. Roll the dice on a reasonably credible “pure VPA” supplier.

If I get a stable, decently pure solution, I’ll carefully apply it to my brows and, maybe cautiously, near the lash line (Latisse-style dabs). Brow and lash cycles are shorter than scalp hair, so I should see changes within a couple of months.

If it flops? It's all over.... At least I’ll know I tried the nuclear approach.

its good imma try it

 

[tall0ner]

what else are u doing for hair growth

 

[benchcrab]

0 replies, absolutely over for this retarded forum

nigga didn't even wait 10 minutes

 

[LVZZO]

Tret can also have an effect
VPA is not super expensive from legit chem labs