Warning: Niacin increases estrogen

[Deleted member 773]

Niacin in its acid form is used to treat skin issues like acne but it is a pro-estrogen supplement.

Niacin activates the G protein estrogen receptor (GPER)-mediated signalling - PubMed

Nicotinic acid, also known as niacin, is the water soluble vitamin B3 used for decades for the treatment of dyslipidemic diseases. Its action is mainly mediated by the G protein-coupled receptor (GPR) 109A; however, certain regulatory effects on lipid levels occur in a GPR109A-independent...

pubmed.ncbi.nlm.nih.gov

It activates GPER (G Protein Estrogen Receptor) meaning it indeed makes your body more sensitive to estrogen.

Fair warning to use it in moderation.

 

[Deleted member 6892]

Niacin in its acid form is used to treat skin issues like acne but it is a pro-estrogen supplement.

Niacin activates the G protein estrogen receptor (GPER)-mediated signalling - PubMed

Nicotinic acid, also known as niacin, is the water soluble vitamin B3 used for decades for the treatment of dyslipidemic diseases. Its action is mainly mediated by the G protein-coupled receptor (GPR) 109A; however, certain regulatory effects on lipid levels occur in a GPR109A-independent...

pubmed.ncbi.nlm.nih.gov

It activates GPER (G Protein Estrogen Receptor) meaning it indeed makes your body more sensitive to estrogen.

Fair warning to use it in moderation.

Most people use it for heightmaxxing and it’s cope for that

 

[Deleted member 4053]

Most people use it for heightmaxxing and it’s cope for that

no?????
back in 2019 niacin had a lot of hype for causing gh-release and improving skin tone even tho it's cope

 

[Chadlitecel]

Everything nowadays increase estrogen

 

[Deleted member 773]

Everything nowadays increase estrogen

Niacin is not that harmful unless you have high T and thus lots of E (on Test cycle, have gigacaucasian Italian big balls genetics like I)

 

[Deleted member 6492]

I surely won't sleep tonight after your warning

 

[her]

Do you think Astaxanthin is harmful?

 

[autistic_tendencies]

So does worrying that everything has estrogen

 

[Deleted member 2756]

Another cherrypicked, slightly misinterpreted study by einstein over here.
Niacin and niacinamide both have a slight affinity for the GPER, not enough to greatly affect one's endocrinology.

 

[dmx]

update your collagen thread

 

[Deleted member 773]

Do you think Astaxanthin is harmful?

Idk what that is, gonna have to do ur own research there.

 

[Deleted member 773]

Another cherrypicked, slightly misinterpreted study by einstein over here.
Niacin and niacinamide both have a slight affinity for the GPER, not enough to greatly affect one's endocrinology.

This is why I have you ignored, “slight” isn’t a scientific term and I read the abstract at least, where in the study does it say “slight”? because I’ve taken 500mg niacin myself and felt the estrogen dominance afterwards multiple times.

 

[Deleted member 2756]

This is why I have you ignored, “slight” isn’t a scientific term and I read the abstract at least

It doesn't matter whether or not 'slight' is a scientific word, I was eluding to the fact that it has a very low affinity for the GPER, which isn't even that important of an estrogen receptor. I'm not referring to the study that you linked, I'm talking in general. You aren't gonna feel any different if you take 500mg of niacin, you're placeboing yourself now that you know about this. You have me on ignore because I constantly refute your retardation, kinda pathetic.

Niacin and nicotinamide bind to the receptor in vitro with very low affinity.

 

[eduardkoopman]

The benifits though

NIACIN: GROWTH HORMONE,SKIN,AND HAIR BENIFITS (GTFIH)

Niacin: -Niacin or vitamin B3 is a substance found naturally in foods and beverages. It is a necessary vitamin for good health and longevity, and many studies have noted its potential and efficiency when taken in large doses as supplements. These benefits include: Benefit 1: Increases Growth...

looksmax.org

Copy from that thread

Overall, Niacin has the following benefits
1. Increases of growth hormones (400% increase for 1hour period)
2. Improves cholesterol levels more efficiently than prescription medicine (gemfibrozil), greatly reducing risk of heart disease (number 1 cause of death), which inturn increases life expectancy
3. Decrease in scalp inflammation, increased blood flow, and rebuilds keratin which promotes hair growth
4. Treats acne and acts as oral sunscreen which prevents aging, without causing any irritation. Improving the quality of your skin
5. Helps weightless by suppressing appetite, and increases ketone concentration in blood

 

[RAITEIII]

Dn @Lifeisgood72 did u already minoxidil maxx

 

[Deleted member 773]

Dn @Lifeisgood72 did u already minoxidil maxx

Yes I am using minoxidil right now, it’s an improvement to all my sides but especially the sexual and muscle ones. The only thing not budging is my skin, it’s oily now which is good but the collagen is still shit, probably because it was the most damaged by the first run of minoxidil.

I’m still figuring out the best way to use it, but I’ve yet to use it more than once per day. I think to see my skin return I need to really stack the dosage, use it 2x a day for a week or so, then get off of it for a few days. Still experimenting but overall it’s a good improvement.