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what would jordan do?
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Niacin:
-Niacin or vitamin B3 is a substance found naturally in foods and beverages. It is a necessary vitamin for good health and longevity, and many studies have noted its potential and efficiency when taken in large doses as supplements. These benefits include:
Benefit 1: Increases Growth Hormone: 400% increase
-Must take without fats ideally on empty stomach.
Niacin works by suppressing Free Fatty Acids and Insulin, which are both critical suppressors for GH release
Suppression of FFA: "Doses administered every 2 hours did not increase GH concentrations significantly. However, at a dose of 500 mg hourly for 4 doses, there was significant suppression of free fatty acids to the pre-specified outcome (<0.2 mEq/L) and detectable increases in growth hormone concentration. "
Suppression of Insulin:
www.ncbi.nlm.nih.gov
Note: Flaws of this study are that patients were obese (mean BMI 26.4)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319738/
Since FM and FFA is directly correlated, the effects of FFA suppression on obese patients is much more pronounced, meaning GH realistically wont increase by 400%
- The age of participants doesn’t really matter, since many studies have shown that suppression of fat free mass also increases GH in adults
https://www.ncbi.nlm.nih.gov/pubmed/18187617 (This is the same reason that Sprinting spikes growth hormones)
Benefit 2: Improves cholesterol levels, and Decreases mortality rates
HDL=Good Cholesterol; high levels reduce risk of heart disease
LDL=Bad Cholesterol; high levels increase risk of heart disease
Niacin is more effective than gemfibrozil (which is a drug used to treat abnormal blood lipids). Unlike gemfibrozil, which increase both HDL and LDL, Niacin increases HDL while Decreasing LDL.
This is reflected in Mortality rates where Niacin users lived on average 2years longer (11% lower mortality rate). https://www.ncbi.nlm.nih.gov/pubmed/3782631)
Benefit 3: Hair health and anti-balding
-Niacin reduces the viscosity, or thickness, of blood (https://www.ncbi.nlm.nih.gov/pubmed/14642410), this promotes circulation to the scalp which is evident through its flushing mechanism. This is important because Balding men have 2.6X less circulation in their scalp (https://www.jidonline.org/article/0022-202X(89)90189-9/pdf) which indicates Naicin treatment could be beneficial
.-Everyone knows DHT is partly responsible for Hairloss, one reason is because it inhibits wound healing (https://jcs.biologists.org/content/119/4/722). Rather than reducing DHT like most oral treatments, Niacin reduces markers of inflammation (hs-CRP) by 20% (https://www.ncbi.nlm.nih.gov/pubmed/17935553) This could counter act the inflammatory anti wound healing effect of high DHT
-Niacin rebuilds Keratin, hair is 95% keratin
-
(mirin art skills?)
-People worry that since Niacin releases pgd2 (which when interacts with GPR44 inhibits hair loss), however Niacin flushes pgd2 to a different receptor which doesn’t inhibit hairloss. Actually by flushing pgd2, it makes less pgd2 available to interact with GPR44, and could therefore slowdown hair loss.
Benefit 4: Prevents Sun damage and Treats acne
-Reverses Sun damage and protects against sun even when used orally (https://www.ncbi.nlm.nih.gov/pubmed/20354654). This is great for collagen, “Collagen I formation was 56 percent less in the papillary dermis of photo damaged skin than in skin protected from the sun (P<0.001)” https://www.nejm.org/doi/full/10.1056/NEJM199308193290803 . This makes it beneficial for reducing risk of skin cancer (https://www.ncbi.nlm.nih.gov/pubmed/26488693)
-Niacin can be used to treat acne, with "Percentage Improvement in the niacin group (82.37±7.837)" Since it is an oral treatment, it can be used in conjunction with your normal acne routine. Unlike Local antibiotics or retinoid, it doesn’t irritate and cause inflammation, therefore will not break you out or cause purging
(https://www.researchgate.net/public..._the_treatment_of_acne_vulgaris_a_pilot_study)
Benefit 4: Weightless
- Supplementation of Niacin increases Leptin concentrations. Leptin is an anti-obesity hormone which signals the brain to reduce food intake (https://www.ncbi.nlm.nih.gov/pubmed/7984236/), in animal models exogenous leptin supplementation led to weight loss (https://www.ncbi.nlm.nih.gov/pubmed/16988703/). Niacin increases leptin levels by (26.8%) (https://www.ncbi.nlm.nih.gov/pubmed/16887123). It also increases Adiponectin by 56% (a hormone which breaks down fatty acids)
- Niacin also increases the concentrations of ketones in the blood (https://www.ncbi.nlm.nih.gov/pubmed/9927497) , ketones have the following benefits “Mood, longer lasting energy, lowering blood pressure, reversing insulin resistance and cognitive enhancements.”
- Another studies showed that “Prolonged niacin treatment leads to increased adipose tissue polyunsaturated fatty acid synthesis” (http://www.jlr.org/content/early/2014/10/15/jlr.M051938.full.pdf)
Overall, Niacin has the following benefits
1. Increases of growth hormones (400% increase for 1hour period)
2. Improves cholesterol levels more efficiently than prescription medicine (gemfibrozil), greatly reducing risk of heart disease (number 1 cause of death), which inturn increases life expectancy
3. Decrease in scalp inflammation, increased blood flow, and rebuilds keratin which promotes hair growth
4. Treats acne and acts as oral sunscreen which prevents aging, without causing any irritation. Improving the quality of your skin
5. Helps weightless by suppressing appetite, and increases ketone concentration in blood
Dosage and safety:
- Most studies note that Niacin benefits occur at higher dosages exceeding 500mg.
- This is one of the safest and most well researched supplements, and a trial with 25,000 individuals over 3 years confirmed its safety (https://www.ncbi.nlm.nih.gov/pubmed/25014686). If anything, Niacin in high dosages benefits health
- Niacin will cause flushing effect, but this will fade with usage. Many users reports that after niacin flush the skin looks more youthful and attractive
for my bros
@Vitruvian @Guest @Soulsmaxx @MadMong @Bluepill @her @You @Gebirgscel @TubOfLard @Arkantos @AspiringChad @dogtown @Dude420 @Krezo @AdamLamberg @Mewisthekey @Saturn @TubOfLard @Arkantos @Currycellmate @randomguy1235 @Alexanderr @x30001 @samm735 @Yummyinmytummy @DidntRead @Wannabe6ft2 @heroinfather @Eclipse @Whyamihere @Pendejo@Pex1992 @AleksVs @LordNorwood @Dr Shekelberg
-Niacin or vitamin B3 is a substance found naturally in foods and beverages. It is a necessary vitamin for good health and longevity, and many studies have noted its potential and efficiency when taken in large doses as supplements. These benefits include:
Benefit 1: Increases Growth Hormone: 400% increase
-Must take without fats ideally on empty stomach.
Niacin works by suppressing Free Fatty Acids and Insulin, which are both critical suppressors for GH release
Suppression of FFA: "Doses administered every 2 hours did not increase GH concentrations significantly. However, at a dose of 500 mg hourly for 4 doses, there was significant suppression of free fatty acids to the pre-specified outcome (<0.2 mEq/L) and detectable increases in growth hormone concentration. "
Suppression of Insulin:
A Pilot Study of the Effects of Niacin Administration on Free Fatty Acid and Growth Hormone Concentrations in Children with Obesity
Children with obesity have low spontaneous growth hormone (GH) secretion. High circulating Free Fatty Acid (FFA) concentration is believed to inhibit GH secretion in those with obesity. In adults, lipolytic inhibition with niacin lowers FFA and increases ...
www.ncbi.nlm.nih.gov
Note: Flaws of this study are that patients were obese (mean BMI 26.4)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319738/
Since FM and FFA is directly correlated, the effects of FFA suppression on obese patients is much more pronounced, meaning GH realistically wont increase by 400%
- The age of participants doesn’t really matter, since many studies have shown that suppression of fat free mass also increases GH in adults
https://www.ncbi.nlm.nih.gov/pubmed/18187617 (This is the same reason that Sprinting spikes growth hormones)
Benefit 2: Improves cholesterol levels, and Decreases mortality rates
HDL=Good Cholesterol; high levels reduce risk of heart disease
LDL=Bad Cholesterol; high levels increase risk of heart disease
Niacin is more effective than gemfibrozil (which is a drug used to treat abnormal blood lipids). Unlike gemfibrozil, which increase both HDL and LDL, Niacin increases HDL while Decreasing LDL.
This is reflected in Mortality rates where Niacin users lived on average 2years longer (11% lower mortality rate). https://www.ncbi.nlm.nih.gov/pubmed/3782631)
Benefit 3: Hair health and anti-balding
-Niacin reduces the viscosity, or thickness, of blood (https://www.ncbi.nlm.nih.gov/pubmed/14642410), this promotes circulation to the scalp which is evident through its flushing mechanism. This is important because Balding men have 2.6X less circulation in their scalp (https://www.jidonline.org/article/0022-202X(89)90189-9/pdf) which indicates Naicin treatment could be beneficial
.-Everyone knows DHT is partly responsible for Hairloss, one reason is because it inhibits wound healing (https://jcs.biologists.org/content/119/4/722). Rather than reducing DHT like most oral treatments, Niacin reduces markers of inflammation (hs-CRP) by 20% (https://www.ncbi.nlm.nih.gov/pubmed/17935553) This could counter act the inflammatory anti wound healing effect of high DHT
-Niacin rebuilds Keratin, hair is 95% keratin
-
-People worry that since Niacin releases pgd2 (which when interacts with GPR44 inhibits hair loss), however Niacin flushes pgd2 to a different receptor which doesn’t inhibit hairloss. Actually by flushing pgd2, it makes less pgd2 available to interact with GPR44, and could therefore slowdown hair loss.
Benefit 4: Prevents Sun damage and Treats acne
-Reverses Sun damage and protects against sun even when used orally (https://www.ncbi.nlm.nih.gov/pubmed/20354654). This is great for collagen, “Collagen I formation was 56 percent less in the papillary dermis of photo damaged skin than in skin protected from the sun (P<0.001)” https://www.nejm.org/doi/full/10.1056/NEJM199308193290803 . This makes it beneficial for reducing risk of skin cancer (https://www.ncbi.nlm.nih.gov/pubmed/26488693)
-Niacin can be used to treat acne, with "Percentage Improvement in the niacin group (82.37±7.837)" Since it is an oral treatment, it can be used in conjunction with your normal acne routine. Unlike Local antibiotics or retinoid, it doesn’t irritate and cause inflammation, therefore will not break you out or cause purging
(https://www.researchgate.net/public..._the_treatment_of_acne_vulgaris_a_pilot_study)
Benefit 4: Weightless
- Supplementation of Niacin increases Leptin concentrations. Leptin is an anti-obesity hormone which signals the brain to reduce food intake (https://www.ncbi.nlm.nih.gov/pubmed/7984236/), in animal models exogenous leptin supplementation led to weight loss (https://www.ncbi.nlm.nih.gov/pubmed/16988703/). Niacin increases leptin levels by (26.8%) (https://www.ncbi.nlm.nih.gov/pubmed/16887123). It also increases Adiponectin by 56% (a hormone which breaks down fatty acids)
- Niacin also increases the concentrations of ketones in the blood (https://www.ncbi.nlm.nih.gov/pubmed/9927497) , ketones have the following benefits “Mood, longer lasting energy, lowering blood pressure, reversing insulin resistance and cognitive enhancements.”
- Another studies showed that “Prolonged niacin treatment leads to increased adipose tissue polyunsaturated fatty acid synthesis” (http://www.jlr.org/content/early/2014/10/15/jlr.M051938.full.pdf)
Overall, Niacin has the following benefits
1. Increases of growth hormones (400% increase for 1hour period)
2. Improves cholesterol levels more efficiently than prescription medicine (gemfibrozil), greatly reducing risk of heart disease (number 1 cause of death), which inturn increases life expectancy
3. Decrease in scalp inflammation, increased blood flow, and rebuilds keratin which promotes hair growth
4. Treats acne and acts as oral sunscreen which prevents aging, without causing any irritation. Improving the quality of your skin
5. Helps weightless by suppressing appetite, and increases ketone concentration in blood
Dosage and safety:
- Most studies note that Niacin benefits occur at higher dosages exceeding 500mg.
- This is one of the safest and most well researched supplements, and a trial with 25,000 individuals over 3 years confirmed its safety (https://www.ncbi.nlm.nih.gov/pubmed/25014686). If anything, Niacin in high dosages benefits health
- Niacin will cause flushing effect, but this will fade with usage. Many users reports that after niacin flush the skin looks more youthful and attractive
for my bros
@Vitruvian @Guest @Soulsmaxx @MadMong @Bluepill @her @You @Gebirgscel @TubOfLard @Arkantos @AspiringChad @dogtown @Dude420 @Krezo @AdamLamberg @Mewisthekey @Saturn @TubOfLard @Arkantos @Currycellmate @randomguy1235 @Alexanderr @x30001 @samm735 @Yummyinmytummy @DidntRead @Wannabe6ft2 @heroinfather @Eclipse @Whyamihere @Pendejo@Pex1992 @AleksVs @LordNorwood @Dr Shekelberg
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