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AmbitionBoySchemeingInTheDarkness
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There is a ton of literature indicateing higher IGF-1 accelerates ageing , but this one intrigued me
1. Early postnatal development can have profound effects on life-history traits later in life.
One mechanism hypothesized to mediate this relationship is the anabolic hormone, insulin-like
growth factor-1 (IGF-1). IGF-1 contributes importantly to postnatal growth, and thus offers a
means by which environmental and genetic variation might direct organismal development,
reproduction and survival.
2. We tested whether juvenile concentrations of IGF-1 can predict intraspecific variation in
life-history traits later in life using longitudinal data from free-living female spotted hyenas
(Crocuta crocuta).
3. We found that juvenile concentrations of IGF-1 predicted heavier juvenile mass, which in
turn predicted greater survival to reproductive maturity. However, independent of mass, higher
juvenile concentrations of IGF-1 predicted earlier age at first parturition and reduced longevity
in adulthood.
4. Our results highlight the importance of early postnatal development as a determination per-
iod in mammals and suggest that concentrations of IGF-1 during this sensitive period can be
used to predict important later-life trade-offs between growth, reproductive fitness and life
span in wild, long-lived animals.
1. Early postnatal development can have profound effects on life-history traits later in life.
One mechanism hypothesized to mediate this relationship is the anabolic hormone, insulin-like
growth factor-1 (IGF-1). IGF-1 contributes importantly to postnatal growth, and thus offers a
means by which environmental and genetic variation might direct organismal development,
reproduction and survival.
2. We tested whether juvenile concentrations of IGF-1 can predict intraspecific variation in
life-history traits later in life using longitudinal data from free-living female spotted hyenas
(Crocuta crocuta).
3. We found that juvenile concentrations of IGF-1 predicted heavier juvenile mass, which in
turn predicted greater survival to reproductive maturity. However, independent of mass, higher
juvenile concentrations of IGF-1 predicted earlier age at first parturition and reduced longevity
in adulthood.
4. Our results highlight the importance of early postnatal development as a determination per-
iod in mammals and suggest that concentrations of IGF-1 during this sensitive period can be
used to predict important later-life trade-offs between growth, reproductive fitness and life
span in wild, long-lived animals.
