Way to immortality

notsocommonthumb · Aug 7, 2024

DR. NICKGA said:
Longevity / Antiaging = Gene Editing

Simple, if we remove all gene that put a fire on the aging process them everything is almost fixed , easy

Nigga stfu im not here for your tiktok knowlegde. No one here has access to genome editing, and even if they did it would not grant immortality.

blimp · Aug 7, 2024

I will be dead trying to afford all of this

dbva · Aug 8, 2024

jfl ur getting struck by lightning in a week doing all this bullshit nigger

Dokkaebi · Aug 15, 2024

Thebbcmaxxer said:
DNRD eat primal

Based primalpilled

garoupilled_ · Sep 15, 2024

Genius thread

Ignore the hate comments

Keep it up

looks>books · Sep 15, 2024

Imagine being an immortal curry

$Abomination · Sep 17, 2024

Immortality might actually be possible. You see a lot of old people who look like 30 in their 70s. The Achilles heel seems to be neural tissue. Muscle is pretty resilient especially when trained and fed hormones, that goes double for the bones. But it's the nervous tissue that seems unable to continue past 120 no matter what.

They_are_all_whores · Sep 19, 2024

notsocommonthumb said:
Longevity / Antiaging Information

credits to wil

My Current Regimen
Morning
Breakfast option 1 (smoothie 2.5 servings):
16oz Good Karma unsweetened flaxmilk with protein
4oz kefir
2c frozen chopped kale or spinach (81g/cup)
3 Swiss chard leaves (vitamin A, K, magnesium)
1 green (unripe) banana or plantain (resistant starch)
2 tbsp MCT oil (can also use coconut oil but less potent) (anti-inflammatory, anti-TNF, aid macular carotenoid absorption), also gives more energy from burning fat
2 tbsp frozen flaxseeds (Omega 3 ALA)
Pinch ceylon cinnamon (insulin spike regulation)
1c Blueberries / strawberries (pterostilbene)
Avocado (optional)
Add peanut butter for calories/fats

Relevant Nutrition Data (per serving)
288 calories
7.2g fiber
3.2-6.4g macular carotenoids (lutein / zeaxanthin)
65mg isothiocyanates
14.6g sugar
17g total fat
1.4g omega 3
9.6g protein
1.1 ug vitamin B12
5200IU vitamin A
39mg vitamin C
584mg vitamin K
310 mg calcium
93 mg magnesium

Cost Breakdown (full recipe)
? 16oz Good Karma unsweetened flaxmilk with protein
? 4oz kefir
$3 2c frozen chopped kale or spinach $3/bag 16oz
? 3 Swiss chard leaves
$1.49 plantain
$.62 2 tbsp coconut oil
$.49 2 tbsp frozen flaxseeds .49/oz
$0 Pinch ceylon cinnamon (insulin spike regulation)
$2 1c Blueberries / strawberries (pterostilbene) $4/pint fresh

Breakfast option 2 (scrambled eggs):
2 eggs (balanced protein, choline, some macular carotenoids)
Whole milk
Pinch Ground turmeric (anti-TNF/inflammatory)
Pinch ground black pepper (turmeric absorption aid)
Pinch ground mustard
Cheese to taste
50mg pterostilbene

Lunch
Soccer 2x/week
(low carb, low sugar, moderate protein, high fat)
Green tea + lemon wedge
50mg pterostilbene
B vitamin comple
100mg nonflushing B3 (niacinamide)

Snacks
Walnuts
Almonds / almond butter only take if you are not at risk of kidney stones
Peanut butter

Evening
Bicycling 2x/week
(too many dinner combos to list yet, 80% vegetarian)
With dinner:
Krill oil Omega 3 with astaxanthin (if I ate animal proteins)
Vitamin D3 4000IU with K2 100mcg

Night
Optional Dark chocolate (check toxin section for brands with no lead/cadmium) - Warning: may elevate kidney stone risk from oxalate content
Optional melatonin

Other / As Needed
Periodic well-check blood tests:

CBC/Diff

Complete Metabolic Panel

Lipid Panel

Hemoglobin A1c

IGF-1

serum Vitamin D

Track results in a spreadsheet so you can see trends over time
See Ideal Lab Test Results below

Nutrition Tracking
I use http://cronometer.com
The mobile app connects to FitBit and imports exercise, weight and sleep data
Set custom nutrient targets to optimal nutrient intakes below

Track heart rate, steps, sleep with fitness band
I use the FitBit Charge 2 - NOTE: There is only a 1 year warranty

Foods
Starches
Quinoa
Buckwheat (Complete protein, gluten free. The toasted kind tastes even better. )

Fruits
Blueberries (contain Pterostilbene, anthocyanins)
Avocado (potassium -> blood pressure, reduce kidney stone risk, vitamin E, PUFA)
Lemon
Tomato (lycopene)
Apple peel (quercetin)
Only eat organic apples, conventional ones have many pesticides
Green banana (resistant starch, potassium)
Plantain (resistant starch)

Vegetables
Spinach (folate, magnesium)
Kale (macular carotenoids, magnesium, isothiocyanates)
Collard greens
Chard (vitamin A, K1, magnesium)
Celery (luteolin)
Parsley (luteolin)
Carrots (beta-carotene -> vitamin A)
Chicory root (24g [0.8oz] = 10g inulin -> prebiotic -> butyrate -> intestinal/immune health)
Yacon root (50% inulin+FOS, 30g/day)
Purchase Link ($20/lb => 453 grams)
Jerusalem artichoke

Proteolytic Enzymes (link) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124314/
To be taken together at their daily dose, bi-monthly. Cleans arteries/blood and
post-Covid micro-clots.:

Serrapeptase

Nattokinase

Lumbrokinase

Proteins
Walnuts - (omega 3 ALA)
Salmon (omega 3 DHA/EPA, vitamin D, magnesium)
Eggs (correct amino acid ratios, choline, some macular carotenoids)

Fats
Coconut oil (contains part MCT oil) - anti-inflammatory
Olive oil (many are cut with cheap oils, verify quality)

Ottavio

Kirkland Organic

Corto Olive

Lucero

California Olive Ranch

Bariani Olive Oil

Cobram Estate

Lucini

McEvoy Ranch Organic

Omaggio

Olea Estates

Amphora Nueva

Other
Deuterium depleted water (DDW) - expensive
Ceylon cinnamon - regulates blood sugar
Turmeric + black pepper
Green Tea + lemon wedge
Dark chocolate (check for lead/cadmium content, see toxins list below)
Spirulina?
Flax seeds (ground in freezer) - omega 3 (ALA)
Chia seeds
? KetoChow
Stevia instead of sugar - doesn’t spike insulin

Supplements
Metformin 2000mg/day (need to ramp up to this, requires prescription in the USA. You can buy OTC in Mexico.)
Glucosamine
Curcumin (turmeric) [dosage?]
Need to take with black pepper extract (piperine) for absorption
Anti-TNF
Issue with lead poisoning by companies
Appears brands from India/Bangladesh worst offenders
Likely safe: Starwest Botanicals
Purchase Link (Schwartz Bioresearch brand $17.65/90x 1500mg)
Customer service claims they do regular heavy metal testing
Resveratrol (Pterostilbene is better)
May also be toxic to liver
Pterostilbene (dimethylresveratrol) (100-400mg/day) (more bioavailable than resveratrol)
Purchase Link Jarrow brand $12/60x 50mg (100mg/day best bet?)
Take with Grape Seed Extract (100mg/each time)
May raise LDL levels in some people
Krill Oil (need 1:1 omega 3/6)
Fish Oil vs Krill Oil
Take with Astaxanthin
Algal Oil (algae based)
Fish Oil (not as effective)
Take with meal
Purchase Link (Jarrow brand $15.49/60x 120mg EPA/70mg DHA w/Astaxanthin [2x/day])
Purchase Link (Doctor’s Best brand $25/180x 800mg EPA/400mg DHA [2x/day])
Fresh version Purchase link (recommended by dpao)
Ketone Body Esters
Beta-Hydroxybutyrate (also created from Ketogenic diet)
Melatonin
Creatine
Epitalon (epithalamin) - oral 200mg/serving 2-3x/day (injection is best route)

Probiotics
My current probiotic - Hyperbiotics PRO-15
All strains dead confirmed with microscope
Still researching which one to take
Take with prebiotic/FOS/inulin containing food
Human sourced is better
PrescriptAssist, Bifido Maximus, MegaSporeBiotic (dpao)
Reuteri Pearls + Culturelle + Align + Bimuno
Reuteri + b.infantis from breast milk
Bimuno - prebiotic for the above
Beneficial:
Bifidobacterium infants - from breast milk
Bifidobacterium longum
Bifidiobacterium breve
Lactobacillus reuteri - from breast milk
Lactobacillus rhamnosus GG - reduce rotavirus
Oxalobacter formigenes - low levels lead to kidney stones, break down oxylates
Guide to Probiotics
2nd Guide to Probiotics

B12 2mg ?
Folate? (Rhonda Patrick - prevent DNA replication breakage)
Hydrolized Collagen? (Rhonda Patrick)
makes collagen/cartilage
proline -> glutamate -> ATP
Glycine - anti-inflammatory
CoQ10 100mg/day - ubiquinol version better
Take with meal
Purchase Link ($16/month)
Colostrinin 100mcg? (dpao)
Oxaloacetate 100mg? (dpao) - KetoPrime
Alfatradiol https://en.m.wikipedia.org/wiki/Alfatradiol ?
NAD+ precursors:
Tryptophan (8 steps - inefficient)
B3/nicotinic acid (3 steps) (causes flushing)
Nicotinamide / Niacinamide[non flushing niacin] (2 steps)
28x dri (15mg x 28)
Nicotinamide Riboside NR (2 steps) (250mg/day?)
1000mg/day for 1wk -> 2.7x NAD+
Nicotinamide Mononucleotide NMN (500mg/day) - expensive
Vitamin D3 (4000IU/day -> want a 40-60ng/ml stat)
Delays attrition of telomere length
Take liquid drops with vitamin K2 (mk7)
Take with meal containing fats
Take with vitamin K2 100mcg
Purchase Link
Quercetin
Cancer preventative at 1-40uM cellular concentration, Bad at 40-100uM.
12.5-25mg / kg body weight
Dihydrate most bioavailable
Combos
Elysium - Basis (250mg NR + 50mg Pterostilbene) $40/mo
KetoPrime ?

Brain health (nootropics)
Caffeine + L-theanine (200mg theanine per 100mg caffeine)
Bacopa Monnieri - memory
Creatine (5g in morning) - reasoning
Tolcapone
Levodopa
? SEMAX
Noopept (20mg in afternoon or 10mg 3x/day)

L-glutamine
Taurine ?
Citicoline - Alpha GPC may be better but is under-researched
Alpha Lipolic Acid
Phosphatidylserine (PS)
lion's mane, 7,8-Dihydroxyflavone
Astaxanthin

Combos
Curcubrain
Nootobox: Rise
Axon Labs: Nexus
Qualia ($129/month, longevity and nootropics stack)
Tried it, works pretty well but be wary of amount of caffeine in it

Medicines
Metformin (berberine) - blocks mTOR - may be unnecessary with pterostilbene
Activates AMPK in the liver
Decreases cardiovascular risk, cancer incidence
Rapamycin - blocks mTOR
Dasantinib (needs to be combined with quercetin)
Kills senescent cells, reverses NAFLD
? SEMAX (nootropic, dpao rec.)
? BPC-157 (promotes fast healing, still being researched, dpao rec.)
dosage info
UBX0101 aka Navitoclax (Unity Biotechnology)
AP20187
Copper Sebacate Some evidence it can ‘unwrap’ prions back into ‘normal’ proteins.[pubmed],[research]

Exercise
High-intensity interval biking / training
Body produces more NAD+
Body produces more mitochondria
Magnesium required to make mitochondria
Running
Best time 7am because cortisol spike

Toxins
Antibiotics
Cipro, Levaquin, Floxin - Flouroquinolone causes heart problems
Levaquin production halted

Alternatives
Turnips
Garlic
Echinacea
Oregano oil

Water Pollution
Pretty much universal, get a good RO filter (see my drinking water section)
Bottled Water is bad

Air Pollution
> 10ppb of 2.5um particulates (AQI >41) associated with +7.3% increased mortality
Current Air Pollution Map
Make sure gas stoves/fireplaces are well ventilated
Get high quality air filters
Get air purifier
Get HVAC cleaned once every 2 years
Remove carpeting
Test home for radon
Dust surfaces regularly
Best air cleaning plants
Another list of best air cleaning plants

Triclosan / Microban & Triclocarban
“Triclosan and triclocarban are used as antimicrobials, a class of chemicals present in >2,000 products including soaps, toothpastes, detergents, clothing, toys, carpets, plastics, and paints. In personal care products like hand soap, there is no evidence that use of triclosan or triclocarban improves consumer or patient health or prevents disease”
Usually in products labeled “antibacterial” / “antimicrobial”
Triclosan product list
Triclosan in Colgate as 'antigingivitis'
Triclocarban product list

Lead / Cadmium in Chocolate
http://www.asyousow.org/our-work/environmental-health/toxic-enforcement/lead-and-cadmium-in-food/

PFOA / Teflon & PFOS
Carcinogen
Non stick pan coatings
Carpet cleaners
Food packaging
Microwave popcorn bags
Drinking water
Carbon filtering can remove from water

Carcinogens
Definite
Ciclosporin
Alcohol
Mineral Oil
Paint containing benzene
Processed Meats
Sawdust
Acrylamide (cooking food over 250 degrees F)
Probable
Red meat
Tetrachloroethylene (from dry cleaning)

Nutrition Notes
Omega 3
Heart protector
1:1 Omega 3/Omega 6 Optimal
Too much omega 6 leads to inflammation/arthritis
ALA + B3 + B6 + C + Zinc + Mag = EPA
ALA + ? = DHA
Walnuts/Flax -> ALA
Fish oil -> EPA/DHA

Macular Carotenoids
Lutein, Zeaxanthin (lutein converts into Mesozeaxanthin)
Found in Parsley, Spinach, Kale, Basil, Egg yolk
Food source Table in micrograms/g
1 egg yolk = 18g = 0.18g MC (not a good source)
1 cup frozen chopped kale/spinach = 81g = 4-8g MC
Take with fats, chopping/pureeing/cooking releases more
Slows development of age related macular degeneration
24mg/day protects eyes from damage due to screen time
~3 cups of frozen chopped kale/spinach

Isothiocyanates (glucosinolates)

Highest concentrations: Brussel Sprouts, Garden cress, mustard greens, kale

Cooking eliminates isothiocyanates from the food

Inhibits cancer/carcinogens

Decrease DNA damage by reducing inflammation

Food sources & dosages

Flavonoids
Beneficial at low dosages, may be harmful at high dosages due to hormetic effects between polyphenols

Flavones

Apigenin / Luteolin

Celery, parsley, balsamic sage

Decrease inflammation, slow cognitive decline, ROS scavenging, cell cycle arrest, induce apoptosis, DNA protection

Flavonols

Quercetin / Kaemferol / Fisetin

Apple peel, onion, garlic

Regulate H2AX, blocking agent, caspase activity

Cocoa

Improve cognition

Isoflavones

Daidzein, Genistein

Soybean, kwao krua

Inhibit ROS generation, inhibit p53 expression

Flavanones

Narigenin, Hesperetin

Oranges, grapefruits, tomateos, cherries

ROS scavenging, induce apoptosis, inhibit DNA damage by reducing COX-2

Flavan-3-ols

EGCG (Epigallocatechin-3-gallate), Epicatechin

Green tea (most abundant catechin)

ROS scavenging, cell cycle arrest, induce DNA-PK expression, inhibit H2AX

Anthocyanidins / Anthocyanins

Malvidin

Red wine, blueberry, cranberry, raspberry, blackberry, cherry, grape

Suppress ROS, increase glutathione levels, inhibit DNA adduct formation

Other

Southern ginseng, himalayan may apple, ashwagandha

TMAO (bad for you)
Higher increases heart disease risk
Obesity & type 2 diabetes risk
From Carnitine (red meat), Lecithin / Choline (egg yolks), processed foods
DMB inhibits TMA formation
From balsamic vinegar, red wine, EVOO, grapeseed oil

Sugar/Carbohydrates (bad for you)
Glucose
worst for you
Same sugar directly in blood / measured in labs
highest insulin spike, 100 glycemic index

Fructose
Fruit
Doesn’t spike insulin
Low glycemic index
Causes fatty liver

Sucrose
table sugar
50/50 glucose/fructose
Use stevia instead

High fructose corn syrup
50/50 glucose/fructose

Lactose
doesn’t spike insulin

Starch
long chain glucose
Amylose - lower glucose peak
Usually high in Resistant Starch
Amylopectin
Insulin disables autophagy (cell death) -> senescent cells
Senescent cells -> apoptosis -> disables mitochondria ability to burn fat

Intestinal Health
Prebiotics / Fiber -> beneficial bacteria -> Butyrate -> decreased LPS -> intestinal lining protection
Butyrate -> reduced histone deacetylase -> reduced sarcopenia
Clostridium cluster XIVa, F. prausnitzii, E. rectale
Bifidobacteria

Prebiotic Foods
FOS / Fructan & Inulin
10g/day inulin
Chicory Root (24g)
Jerusalem artichokes (56g)
dandelion greens (74g)
garlic

Resistant Starch
creates most butyrate
Plantains
Banana flour from green bananas (10.5)
Green banana (4.7)
Uncooked rolled oats (4.4)
Legumes (amylose) - must be cooled after cooked
Potatoes (must be cooled after cooked)

Probiotics
Guide to Probiotics
Chronic use of probiotics is bad and leads to a monoculture
Eat seasonally and locally
Human derived ones are better
Treat infectious diarrhea:
Lactobacillus casei
Lactobacillus reuteri
Recover from antibiotics
LGG
S boulardii
Lactubacillus casei
Lactobacillus acidophilus

Anti Tumor Necrosis Factor (TNF) Therapy
Natural: Curcumin, green tea, cannabis

Bad Bacteria
Enterococcus gallinarum - causes autoimmune disease

Lab Tests
http://americangut.org/
http://www.hmpdacc.org/
https://smartgut.ubiome.com

Other Lifestyle
Sickness/Cold/Flu Prevention
UV light (far-UVC) that kills viruses but doesn’t harm people discovered
http://time.com/5142211/uv-light-kills-flu-virus/
https://www.genengnews.com/gen-news...ans-but-bad-for-bacteria-and-viruses/81255478
2 mJ/cm2 222nm light kills 95% H1N1 flu virus but not harmful
1W = 1J/s
Desired power = (light output * seconds) / (distance*distance)
2mJ/cm2 = ((1mW/cm2) * (X seconds))/((2*2)cm2)
(2cm distance) 2mJ/cm2 * ((2*2)cm2) / 1mW/cm2 = 8 seconds
(6in distance) 7.7 minutes
Normal UV 200 - 400nm kills viruses but harmful to humans (skin/eye irritant)
min7 - 30mW*sec/cm2 kills viruses and bacteria
Potential product sources
http://www.edenpark.com/products.html
http://store.uvsolutionsforhome.com/category_s/1817.htm
0.735mJ/cm² of UVC intensity @ 15cm
$20 Eocean UV Sterilization Lamp (+Ozone) - 5W, 185-254nm
5000mW * 15*60sec / X^2 = 30
X = sqrt(5000*15*60/30)
X = 12.7ft effective distance
Ozone is lung irritant - air it out
$20 BriteUV Toothbrush Case Sanitizer – FDA Approved

Drinking Water
APEC Top Tier Alkaline Mineral pH+ 75 GPD 6-Stage Ultra Safe Reverse Osmosis Drinking Water Filter System (ESSENCE ROES-PH75)

Excellent water bottle, drink 2 a day

Skin
Needs PH <= 5 to maintain skin acidity (4.5 - 5.5 normal skin PH)

Soaps
Avecyde 3.61
Gojo Orange 5
pHistoderm 5
Dove Liquid 5.16
Aveeno Active Naturals Moisturizing Bar With Colloidal Oatmeal for Dry Skin, Fragrance Free 5.5
Confirmed with dermatologist, what I currently use
Aderm 6.44

Moisturizers
Aveeno

Chiropractor (as needed)
Sauna
4-7 times/week -> 50% reduction in heart disease
~20min / session
174 degrees
Lowers blood pressure
Best after exercise
Increases IGF-1 -> muscle growth
Raises heart rate (120-150bpm) -> release heat shock proteins (similar to aerobic exercise)
Reduce chance of alzheimers (inhibits amyloid beta 42)

Optimal Stats
DIY Lab Tests
https://thriva.co/
http://aging.ai/

Resting heart rate < 60
VO2 Max > 55

Nutrient Intake

Fiber > 80g/day Maintains good bacteria in gut -> immune function
Inulin 10g/day Maintains good bacteria in gut -> immune function
Protein <= 85g/day Too high and kidneys get taxed (shows up in BUN). Restrict methionine and red meat.
Total Sugar < 30 g/day Less is better
Vitamin D3 2000-4000IU/day Get lab test to make sure in ideal ranges below and adjust
Vitamin K1 1000mcg/day Converts into K2 (Mk4) in the body. Primary source leafy vegetables.
Vitamin B3 (nonflushing) 250-400mg/day Precursor for NAD+
Magnesium 600-900mg/day Flom chlorophyll, in 300 enzyme reactions -> ATP, important in mitochondria creation
Omega 3 1:1 with Omega6 This is hard to do via supplements, eat salmon, nuts, flax

Ideal Lab Test Results
BMI 22
WBC 3.5 - 5 (~4.5 ideal) - higher indicates fighting active infection
IGF-1 106-255 ng/ml Lower is better
CO2 30-32 - electrolyte balance/kidney function

Cholesterol/Sugar
Total Cholesterol < 140
HDL > 60 (clears cholesterol from blood)
LDL < 100 (lowers pulse and blood pressure)
VLDL 8-10
Triglycerides < 90 (~50 hardcore athletes)
Blood sugar(glucose) 75-85

Vitamin D
40-60ng/mL (Rhonda Patrick)
38-48ng/mL (Mike Lustgarten)

Kidney Function
BUN < 15 (9) - high BUN indicates kidney stones/problems
Blood Creatinine 0.66-1.25 - higher indicates kidney stones/problems
Urine PH 6.5-7 - lower is bad, need neutral PH in urine

Low PH for long time will lead to kidney stones

Drink 64oz water/day to neutralize PH

Potassium excretion 2.31-7.51g/day

Liver Function
Albumin ~5
Globulin ~2.5
AGR or TP (albumin / globulin) > 1.5 (prevent inflammation -> cancer)
Bilirubin Total 0.3-1.0
High Bilirubin indicates gallstones

General Diet
Sugars / Carbs
Low fructose
No glucose, sucrose (table sugar), high fructose corn syrup
Moderate Starches -> ideally resistant starches
Protein < 85g/day
more protein taxes kidneys, raises BUN
Fiber > 80g/day
? High fat - > 1g/Kg/day (keto)
Keto ?
Could possibly lead to NAFLD (underresearched)
Vegetable based low carb diet is better than meat based in regards to mortality/cancer
Better to eat more calories in the morning than in the evening

Theories of Aging

Insulin resistance

Inflammation

Telomere Shortening

Telomere length governs how many times a cell can divide

https://en.wikipedia.org/wiki/Hayflick_limit

When cell can’t divide anymore (due to short telomeres), it begins apoptosis (cell death)

Stem and Cancer cells have telomerase which prevents telomere shortening

Oxidative Stress

Weakening of circadian system

Calorie Restriction -> increased circadian amplitude

CS perturbed by

shift work

prolonged hours of artificial light

Erratic eating patterns

Microbial burden / immune system degradation

LPS / endotoxin
LPS -> insulin resistance -> diabetes
LPS -> TLR4 -> inflammation
LPS -> reduced kidney function (BUN/Creatinine)
LPS -> autoimmune disease / GI disorder
Vitamin D -> increases LL-37 -> destroys bacteria
38-48 ng/mL ideal level
LL-37 carbamylation reduces effectiveness

Leading Causes of Death in Elderly

Cardiovascular disease

Cancers

Chronic respiratory disease (COPD)

Chronic bronchitis

Emphysema

Accidents

Stroke

Alzheimers

Caused by buildup of amyloid plaque 10-20 years before symptoms
beta-secretase, gamma-secretase enzymes -> amyloid plaque

Diabetes

Pneumonia / Flu

Nephritis (kidney inflammation)

Bacterial infection, toxicity (including alcohol)

Septicemia (blood poisoning - infection)

TOR - Target of Rapamycin (regulates nutrient sensors)

mTOR - mammalian TOR

Rapalogs

Rapamycin (Sirolimus / Rapacan)

Mouse model 2-8mg/kg/day, / 12.3 to get human dosage

9-36mg/day for me

One person claims 7-8mg one dose per week

https://www.dropshipmd.com/buy/rapacan/ - contact and tell them you want rapamycin

$2/mg

Everolimus (RAD001)

Beneficial effect on immunosenescence

Temsirolimus

Deforolimus

Decides if cell should replicate or stay alive

Decreased signalling

cells live longer

inhibits growth/reproductive ability

lowers body temp

lowers fat

lowers circulating insulin

decreases thyroid hormones

decreases oxidative stress

Amino acids stimulate mTOR directly (increased signalling)

Nutrient Sensors

Insulin/IGF

Leptin

ATP/AGP ratio

NAD+/NADH cytoplasm ratio 700? NAD+ -> NADH

AMPK - enzyme for AMP -> ATP

Genetics/Enzymes/Hormones
PARP1 repairs DNA (related to NAD+/NADH)
SIRT1 (insulin, inflammation regulation, immune function - may make autoimmune disease worse)
Declines with age
FOX01 (insulin regulation, apoptosis in cancel cells)
FOX04 (appears to help regulate insulin?)
TP53 (tumor suppressing gene)
Ghrelin
Secreted in stomach in response to calorie restriction
Activates SIRT1
https://www.foundmyfitness.com/reports/nutrigenomics.pdf

Misc Notes
Reduce calories 30% ideally (1700/day) - CR diet (body produces more NAD+)
Lack of Vitamin D and consumption of cow milk correlates to autoimmune disease
The elevation of ketone bodies increases the energy of ATP hydrolysis by reducing the mitochondrial NAD couple and oxidizing the coenzyme Q couple
Lower blood glucose + lower blood insulin -> better insulin sensitivity

Websites
https://cronometer.com/

Convert Animal dosages to human dosages
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804402/

Nutrition Genetic Report
https://www.foundmyfitness.com/genetics/1
https://promethease.com/

Articles
https://transcend.me/blogs/supplementation/what-supplements-does-ray-kurzweil-take-and-why
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875921/ B12/folic acid

http://www.iflscience.com/health-an...utoimmune-diseases-and-how-we-can-treat-them/ - root of autoimmune diseases discovered - Enterococcus gallinarum

https://fas.org/sgp/crs/misc/R43358.pdf
https://www.reddit.com/r/longevity/comments/5wu9bk/anyone_drinking_deuteriumdepleted_water_link_to_a/
http://stevenm13.weebly.com/water.html (Make DDW)
https://www.technologyreview.com/s/603997/is-this-the-anti-aging-pill-weve-all-been-waiting-for/
http://science.sciencemag.org/content/355/6331/1312 (NAD+, DBC1, PARP1)
http://www.nzherald.co.nz/lifestyle/news/article.cfm?c_id=6&objectid=11830317 (NMN)
https://www.ncbi.nlm.nih.gov/pubmed/21982274 (pterostilbene > resveratrol)
https://www.quora.com/What-is-the-difference-between-nicotinamide-riboside-and-B3-vitamin-niacin
http://onlinelibrary.wiley.com/doi/10.1002/iub.1627/full (Ketosis vs CR)
https://www.ncbi.nlm.nih.gov/pubmed/24598140 (Ketone body supplementation)
1,3-butanediol monoester of βHB and glyceryl-tris-3-hydroxybutyrate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173993/ (Ketone body effects)
https://www.t-nation.com/diet-fat-loss/avoid-this-ketogenic-rip-off (against replacing Keto diet with Ketone supplementation)
(explanation of how nutrition affects aging)
https://michaellustgarten.wordpress.com/
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[0]=18033&path[1]=57761 (mTOR research)

Databases
http://geroprotectors.org/
https://www.foodfraud.org/
http://ctdbase.org/
http://genomics.senescence.info/drugs/ (longetivity drugs/supplements analytics)
https://examine.com/supplements/ (supplement info based off studies)
http://lifehacker.com/this-graphic-shows-the-best-air-cleaning-plants-accord-1705307836
http://learn.eartheasy.com/2009/05/the-top-10-plants-for-removing-indoor-toxins/

Companies Working on Longevity
David Sinclair
http://unitybiotechnology.com/
https://www.elysiumhealth.com/
https://www.erasmusmc.nl/perskamer/archief/2017/6144807/?lang=en
http://puretechhealth.com/news.php
https://www.calicolabs.com/

Information Sources
https://www.ewg.org
Reddit
https://www.reddit.com/r/longevity/
https://www.reddit.com/r/gerontology/
https://www.reddit.com/r/FoodNerds/
https://www.reddit.com/r/sens/
Newsletters/blogs/forums
https://www.fightaging.org/newsletter/
https://www.fightaging.org/
http://www.leafscience.org/blog/
https://www.apoe4.info/forums/index.php
Facebook
https://www.facebook.com/groups/endagingnow/
Books
The China Study
The Longevity Diet
Prescription for Nutritional Healing
Microbial Burden
Other
http://www.vincegiuliano.name/Antiagingfirewalls.htm
https://examine.com/nutrition/ (nutrition guide)

Regimens
Biohacking Bible - huge document with multiple collaborators
Bryan Johnson Blueprint (this guy is hardcore into longevity with an unlimited budget)
https://44uc8dkwa8q3f5b66w13vilg-wp...16/02/BulletproofRoadmap_Rebrand_outlined.pdf
http://i.imgur.com/e4oNg23.jpg
https://www.braintropic.com/best-nootropic-stack/ (nootropic stack)
http://www.vincegiuliano.name/Antiagingfirewalls.htm#SUPPLEMENTSINCOMBINDEDFIREWALLS
smoothie recipe
Kale (8 leaves)
Chard (two rainbow chard leaves and stems)
Spinach (2 cups)
Celery (2)
Parsley (8 pieces)
Carrot (1 large)
Tomato (1)
Apple (1)
Lemon (1)
Frozen organic blueberries (1-2 cups)
Avocado (1)
Hydrolyzed collagen powder (1/4 cup)
Water (2 cups of water)

8 large kale leaves
4-6 rainbow chard leaves with stems
3 cups (~710 ml) of baby spinach
2 medium to large carrots
1 tomato
1 large avocado
1 banana
1 apple
1 cup (~710ml) of blueberries (fresh or frozen)
1 tall shot glass of flaxseed (optional)
and 3 cups (~710 ml) of unsweetened flax milk.

Why avoid meat like the plaig?

notsocommonthumb · Sep 19, 2024

They_are_all_whores said:
Why avoid meat like the plaig?

better for mortality

They_are_all_whores · Sep 19, 2024

notsocommonthumb said:
better for mortality

How,also post blood tests and testeorone Levels

notsocommonthumb · Sep 19, 2024

They_are_all_whores said:
How

processed meat are Carcinogens and as to wether or not red meat is a Carcinogen is unknown at this point. along with it increasing Trimethylamine N-oxide in the body

They_are_all_whores said:
also post blood tests and testeorone Levels

in 3 months

Way to immortality

My Current Regimen​

Morning​

Breakfast option 1 (smoothie 2.5 servings):​

Breakfast option 2 (scrambled eggs):​

Lunch​

Snacks​

Evening​

Night​

Other / As Needed​

Periodic well-check blood tests:​

Nutrition Tracking​

Track heart rate, steps, sleep with fitness band​

Foods​

Starches​

Fruits​

Vegetables​

Proteolytic Enzymes (link) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124314/​

Proteins​

Fats​

Other​

Supplements​

Probiotics​

Brain health (nootropics)​

Combos​

Medicines​

Exercise​

Toxins​

Antibiotics​

Alternatives​

Water Pollution​

Air Pollution​

Triclosan / Microban & Triclocarban​

Lead / Cadmium in Chocolate​

PFOA / Teflon & PFOS​

Carcinogens​

Nutrition Notes​

Omega 3​

Macular Carotenoids​

Isothiocyanates (glucosinolates)​

Flavonoids​

Flavones​

Apigenin / Luteolin​

Flavonols​

Quercetin / Kaemferol / Fisetin​

Cocoa​

Isoflavones​

Daidzein, Genistein​

Flavanones​

Narigenin, Hesperetin​

Flavan-3-ols​

EGCG (Epigallocatechin-3-gallate), Epicatechin​

Anthocyanidins / Anthocyanins​

Malvidin​

Other​

TMAO (bad for you)​

Sugar/Carbohydrates (bad for you)​

Glucose​

Fructose​

Sucrose​

High fructose corn syrup​

Lactose​

Starch​

Intestinal Health​

Prebiotic Foods​

Resistant Starch​

Probiotics​

Anti Tumor Necrosis Factor (TNF) Therapy​

Bad Bacteria​

Lab Tests​

Other Lifestyle​

Sickness/Cold/Flu Prevention​

Drinking Water​

Skin​

Soaps​

Moisturizers​

Chiropractor (as needed)​

Sauna​

Optimal Stats​

DIY Lab Tests​

My Current Regimen

Morning

Breakfast option 1 (smoothie 2.5 servings):

Breakfast option 2 (scrambled eggs):

Lunch

Snacks

Evening

Night

Other / As Needed

Periodic well-check blood tests:

Nutrition Tracking

Track heart rate, steps, sleep with fitness band

Foods

Starches

Fruits

Vegetables

Proteolytic Enzymes (link) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124314/

Proteins

Fats

Other

Supplements

Probiotics

Brain health (nootropics)

Combos

Medicines

Exercise

Toxins

Antibiotics

Alternatives

Water Pollution

Air Pollution

Triclosan / Microban & Triclocarban

Lead / Cadmium in Chocolate

PFOA / Teflon & PFOS

Carcinogens

Nutrition Notes

Omega 3

Macular Carotenoids

Isothiocyanates (glucosinolates)

Flavonoids

Flavones

Apigenin / Luteolin

Flavonols

Quercetin / Kaemferol / Fisetin

Cocoa

Isoflavones

Daidzein, Genistein

Flavanones

Narigenin, Hesperetin

Flavan-3-ols

EGCG (Epigallocatechin-3-gallate), Epicatechin

Anthocyanidins / Anthocyanins

Malvidin

Other

TMAO (bad for you)

Sugar/Carbohydrates (bad for you)

Glucose

Fructose

Sucrose

High fructose corn syrup

Lactose

Starch

Intestinal Health

Prebiotic Foods

Resistant Starch

Probiotics

Anti Tumor Necrosis Factor (TNF) Therapy

Bad Bacteria

Lab Tests

Other Lifestyle

Sickness/Cold/Flu Prevention

Drinking Water

Skin

Soaps

Moisturizers

Chiropractor (as needed)

Sauna

Optimal Stats

DIY Lab Tests

Nutrient Intake