Weed and Testosterone (Final Thoughts)

[Deleted member 6403]

Cannabis and Male Fertility: A Systematic Review​

Results: The strongest evidence of cannabis induced alterations in male fertility is in the category of semen parameters. Research supports a role for cannabis in reducing sperm count and concentration, inducing abnormalities in sperm morphology, reducing sperm motility and viability, and inhibiting capacitation and fertilizing capacity.

Animal models demonstrate a role for cannabis in testicular atrophy, and reduced libido and sexual function but to our knowledge these results have not yet been replicated in human studies. Studies of hormonal changes suggest inconclusive effects on testosterone levels, lowered luteinizing hormone levels and unchanged follicle-stimulating hormone levels.

Conclusions: Current research suggests that cannabis may negatively impact male fertility. Further studies are needed to validate that robust findings in animal models will carry over into human experience. Clinicians should be aware of these potential effects when prescribing medical marijuana therapies to men of reproductive age, and they should consider the degree of cannabis use as a possible component of a complete male infertility workup.

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Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility​

Marijuana has the highest consumption rate among all of the illicit drugs used in the USA, and its popularity as both a recreational and medicinal drug is increasing especially among men of reproductive age.

Male factor infertility is on the increase, and the exposure to the cannabinoid compounds released by marijuana could be a contributing cause.

The endocannabinoid system (ECS) is deeply involved in the complex regulation of male reproduction through the endogenous release of endocannabinoids and binding to cannabinoid receptors. Disturbing the delicate balance of the ECS due to marijuana use can negatively impact reproductive potential.

Various in vivo and in vitro studies have reported on the empirical role that marijuana plays in disrupting the hypothalamus-pituitary-gonadal axis, spermatogenesis, and sperm function such as motility, capacitation, and the acrosome reaction. In this review, we highlight the latest evidence regarding the effect of marijuana use on male fertility and also provide a detailed insight into the ECS and its significance in the male reproductive system.

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Adverse Effects of Cannabis on Male Reproduction​

The use of cannabis use is likely to increase as regulations on its consumption are diminishing throughout the world. Coinciding with an increase in the use of cannabis is an observation that semen quality appears to be declining in developed countries, and couples are delaying conception more often than previous generations.

Therefore, it is important to study the effects of cannabis on male reproductive potential in order to better counsel infertile couples and men of reproductive age. In this mini-review, we highlight the known effects of cannabis on clinical markers of male fertility potential and review the role of the endocannabinoid system as it pertains to sex hormone and sperm production, as well as sperm function.

Overall, current evidence is contradictory regarding the effects of cannabis on male reproductive hormone production. However, most studies associate cannabis use with lower sperm concentrations, suggesting a negative impact on fertility potential.

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Depression of Plasma Testosterone Levels after Chronic Intensive Marihuana Use​

Twenty heterosexual men 18 to 28 years of age who used marihuana at least four days a week for a minimum of six months without use of other drugs during that interval were studied.

Mean (± S.E.M.) plasma testosterone — 416 ± 34 ng per 100 ml — was significantly lower in this group than that in the control-group mean — 742 ± 29 ng per 100 ml — for age-matched men who had never used marihuana.

Decreased testosterone was dose related. Abstention from marihuana use and stimulation with human chorionic gonadotropin during continued marihuana use produced marked increases in testosterone.

Measurements of liver function, circulating gonadotropins, prolactin, Cortisol and thyroxine were within normal limits. Six of 17 men (35 per cent) showed oligospermia, and two men were impotent.

The data suggest that chronic intensive use of marihuana may produce alterations in male reproductive physiology through central (hypothalamic or pituitary) action. (N Engl J Med 290:872–874, 1974)

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TLDR: Results are mixed regarding T, but fertility is negatively impacted.

Why else do you think (((they're))) legalizing and spreading propaganda about it.

 

[Deleted member 6403]

@moonblunt

 

[Warlow]

but I love muh weed man

 

[volcelfatcel]

Over for weedcels, alcoholcels, sugarcels and smokecels that do it to appear nt but nuke t levels just LDAR

 

[Sophist]

Sometimes I smoke multiple times a day. I'm such an addicted subhuman.

 

[Posmo]

Def an interesting drug but for when you’re trying to be dominant/aggressive/go getter it ain’t it... also damper on athletics and respiratory when you smoking errday. Fucks w serotonin so has effect on the way you interpret situations and their threat levels. Still a helluva drug tho I think it’s best to get blazed couple times a month.