What do you guys think of the drug coming about for expected release for 2030 in Japan for acquired tooth loss to grow brand new teeth? trg-035

[unaligned]

Also keep in mind they pulled the tooth of a mice and a ferret in which both grew a brand new tooth after the previous one was extracted.
Toregem BioPharma's investigational drug TRG035, an anti-USAG-1 antibody, is currently in Phase I clinical trials in Japan, primarily focused on treating severe congenital hypodontia, a rare condition where six or more permanent teeth are missing from birth. While the initial trials target congenital cases, the company's long-term vision includes expanding research into acquired tooth loss caused by trauma, aging, or periodontal disease. The development of TRG035 is supported by Japan’s Agency for Medical Research and Development (AMED) and has received orphan drug designation from Japan’s Ministry of Health, Labor

and Welfare, which provides incentives to accelerate development. The drug works by neutralizing the USAG-1 protein, which inhibits natural tooth development, thereby reactivating dormant tooth buds through the BMP and Wnt signaling pathways. Although the current trials are focused on congenital cases, Toregem BioPharma aims to explore its potential for acquired tooth loss in future phases, with the goal of offering regenerative solutions for adults as well. The company plans to collaborate with medical institutions and universities worldwide to advance this research. If successful, TRG035 could become the first biological therapy capable of regenerating teeth in humans, potentially redefining dental care globally. The projected timeline for general availability is around 2030, pending successful completion of ongoing and future clinical trials.

 

[Bryce]

Interesting

 

[Orka]

Also keep in mind they pulled the tooth of a mice and a ferret in which both grew a brand new tooth after the previous one was extracted.
Toregem BioPharma's investigational drug TRG035, an anti-USAG-1 antibody, is currently in Phase I clinical trials in Japan, primarily focused on treating severe congenital hypodontia, a rare condition where six or more permanent teeth are missing from birth. While the initial trials target congenital cases, the company's long-term vision includes expanding research into acquired tooth loss caused by trauma, aging, or periodontal disease. The development of TRG035 is supported by Japan’s Agency for Medical Research and Development (AMED) and has received orphan drug designation from Japan’s Ministry of Health, LaborView attachment 4344061 and Welfare, which provides incentives to accelerate development. The drug works by neutralizing the USAG-1 protein, which inhibits natural tooth development, thereby reactivating dormant tooth buds through the BMP and Wnt signaling pathways. Although the current trials are focused on congenital cases, Toregem BioPharma aims to explore its potential for acquired tooth loss in future phases, with the goal of offering regenerative solutions for adults as well. The company plans to collaborate with medical institutions and universities worldwide to advance this research. If successful, TRG035 could become the first biological therapy capable of regenerating teeth in humans, potentially redefining dental care globally. The projected timeline for general availability is around 2030, pending successful completion of ongoing and future clinical trials.

I'm not fact checking this, but it does seem interesting

I doubt it'll get to the point where there's any cosmetic use for it, so it doesn't really affect us directly (also fake teeth already look real asf)

BUT the pathways you mentioned might affect bone growth... so maybe its gonna be trendy in 2030 as another thing 14 year olds blast for bonemass (which I doubt will work, since this isnt even proven to do anything for teeth on humans yet.)

 

[MyDreamIsToBe183CM]

ughh

 

[unaligned]

I'm not fact checking this, but it does seem interesting

I doubt it'll get to the point where there's any cosmetic use for it, so it doesn't really affect us directly (also fake teeth already look real asf)

BUT the pathways you mentioned might affect bone growth... so maybe its gonna be trendy in 2030 as another thing 14 year olds blast for bonemass (which I doubt will work, since this isnt even proven to do anything for teeth on humans yet.)

True it hasn't worked yet but they are in trial 1 in Japan currently and it has been ongoing since October 2024. Theoretically it is likely going to work for congenital tooth loss since that is caused by usag-1 being blocked early I believe and they have now found a way to block it which is trg-035 so it should work for missing teeth since birth. It may also work for acquired tooth loss ( tooth loss from decay/extractions). They way it is supposed to work for acquired tooth loss is by activating left over tooth cells. The scientist working on it in Japan had discovered that almost every human on earth has the dormant 3rd tooth buds that could be activated with the drug. The drug would activate dormant tooth cells that were left behind and form a new tooth although it would take around 4 years to grow like normal teeth. They intend it will work for acquired loss and even have a plan on the profits already from it. As long as there are no side effects and you have the dormant cells it SHOULD be able to work, although of course there would be people who don't have them like people who lost all of their teeth many years prior. ://toregem.co.jp/en/technology

 

[Terrortheplug]

Also keep in mind they pulled the tooth of a mice and a ferret in which both grew a brand new tooth after the previous one was extracted.
Toregem BioPharma's investigational drug TRG035, an anti-USAG-1 antibody, is currently in Phase I clinical trials in Japan, primarily focused on treating severe congenital hypodontia, a rare condition where six or more permanent teeth are missing from birth. While the initial trials target congenital cases, the company's long-term vision includes expanding research into acquired tooth loss caused by trauma, aging, or periodontal disease. The development of TRG035 is supported by Japan’s Agency for Medical Research and Development (AMED) and has received orphan drug designation from Japan’s Ministry of Health, LaborView attachment 4344061 and Welfare, which provides incentives to accelerate development. The drug works by neutralizing the USAG-1 protein, which inhibits natural tooth development, thereby reactivating dormant tooth buds through the BMP and Wnt signaling pathways. Although the current trials are focused on congenital cases, Toregem BioPharma aims to explore its potential for acquired tooth loss in future phases, with the goal of offering regenerative solutions for adults as well. The company plans to collaborate with medical institutions and universities worldwide to advance this research. If successful, TRG035 could become the first biological therapy capable of regenerating teeth in humans, potentially redefining dental care globally. The projected timeline for general availability is around 2030, pending successful completion of ongoing and future clinical trials.

first post is high iq im following

 

[Orka]

a new tooth although it would take around 4 years to grow like normal teeth. They intend it will work for acquired loss and even have a plan on the profits already from it.

I'm assuming this would be administered and not a drug to use yourself, in which case you'd have to do sessions for this
I just don't see how waiting 4 years and going for checkups would be more effective or more efficient than getting fake teeth put in from turkey...

although of course there would be people who don't have them like people who lost all of their teeth many years prior. ://

what does the timeframe look like? at what point do you lose the dormant cells?