what do you guys think of this possible topical replacement to fat grafting

[Thatsall101]

 

[Abdullah Shishani]

Source?

 

[Gudliferr]

what i think: dnr

 

[Thatsall101]

personally im still skeptical since they used DMSO as part of the topical formulation which would greatly enhance the penetration of whatever its mixed with,

however its unlikely that any "skincare" formulation will contain DMSO, but you can always DIY this yourself since all the ingredients are pretty accessible

i personally might DIY this i already have DMSO from when i distilled it from paint thinner, but ill prob just buy 99% DMSO from amazon if im actually gonna go through with this,

i would like to have some criticism and/or pointing out anything ive missed

 

[Thatsall101]

Source?

i was just typing out the reply to my main post ill give you the source as a link and a file

https://www.cell.com/molecular-therapy-family/advances/fulltext/S3117-387X(26)00067-4

 

[Thatsall101]

what i think: dnr

lmao

 

[Abdullah Shishani]

i was just typing out the reply to my main post ill give you the source as a link and a file

https://www.cell.com/molecular-therapy-family/advances/fulltext/S3117-387X(26)00067-4

personally im still skeptical since they used DMSO as part of the topical formulation which would greatly enhance the penetration of whatever its mixed with,

however its unlikely that any "skincare" formulation will contain DMSO, but you can always DIY this yourself since all the ingredients are pretty accessible

i personally might DIY this i already have DMSO from when i distilled it from paint thinner, but ill prob just buy 99% DMSO from amazon if im actually gonna go through with this,

i would like to have some criticism and/or pointing out anything ive missed

Yh same I agree with you

 

[carti lover]

View attachment 5236834

now how much does this cost

 

[Thatsall101]

Yh same I agree with you

lmao thank you i hope this gets more views

i hope the study continues with different formulations and concentrations (this one was with 1% active) , itll be really nice if results were more pronounced at higher conc's and if DMSO wasnt required

 

[Thatsall101]

now how much does this cost

Everythings very cheap, the only thing thats "expensive" is the Rosiglitazone itself

this is the formulation (10% DMSO, 40% PEG300, 5% Tween 20, and 45% normal saline.)

honestly you can replace the Rosiglitazone with other PPAR-gamma agnoists like Pioglitazone which is alot cheaper

 

[carti lover]

Everythings very cheap, the only thing thats "expensive" is the Rosiglitazone itself

this is the formulation (10% DMSO, 40% PEG300, 5% Tween 20, and 45% normal saline.)

honestly you can replace the Rosiglitazone with other PPAR-gamma agnoists like Pioglitazone which is alot cheaper

6 posts and u knowledge me

i dont even know what that shit is

 

[Thatsall101]

6 posts and u knowledge me

i dont even know what that shit is

im js a shyyy lurker but thank you for the compliment

 

[carti lover]

im js a shyyy lurker but thank you for the compliment

how long have you been lurking for

 

[carti lover]

im js a shyyy lurker but thank you for the compliment

make some high iq breakthrough threads worthy of botb

 

[Thatsall101]

make some high iq breakthrough threads worthy of botb

me n u both brody were all gonna make it

 

[birthdefect]

Everythings very cheap, the only thing thats "expensive" is the Rosiglitazone itself

this is the formulation (10% DMSO, 40% PEG300, 5% Tween 20, and 45% normal saline.)

honestly you can replace the Rosiglitazone with other PPAR-gamma agnoists like Pioglitazone which is alot cheaper

good user potential if you know all these solvents

 

[Thatsall101]

good user potential if you know all these solvents

wdym

 

[birthdefect]

wdym

i didnt realise i sent the message
im just saying most users just do fuck all and you actually know something
anyways i bet most of these solvents are unnecessary
dmso and peg400 or tween80 alone are prob enough
need strong solvent and something to thicken it a bit

 

[Thatsall101]

i didnt realise i sent the message
im just saying most users just do fuck all and you actually know something
anyways i bet most of these solvents are unnecessary
dmso and peg400 or tween80 alone are prob enough
need strong solvent and something to thicken it a bit

yeah i replied to some other guy saying i might change up the formulation, but i hope the researchers revisit this with different formulations and just carrying out tests, it would be best to know the tissue concentration of rosiglitazone with and without DMSO