what do you think about meclozine? (heightmax)

[Lipolaksid_Natri]

I found several published studies that said it increases height in rats. Also, “Professor Matsushita from Nagoya University demonstrated an increase in the length of the radius, femur, ulna, tibia and vertebrae in mice. "This suggests that meclozine may influence height, proportionality, and spinal length (and possibly avoid spinal cord compression)." What do you think about this? I also remember a study that said it left the growth plates open longer. Maybe you have some information about meclozine?

 

[Deleted member 70692]

bro thinks he is a rat

 

[ChadGPT]

cope

heighttmaxxing is a myth

 

[Deleted member 71669]

Can u link study I'll take a look

 

[Lipolaksid_Natri]

Can u link study I'll take a look

Meclozine ameliorates skeletal muscle pathology and increases muscle forces in mdx mice - PubMed

We screened pre-approved drugs for the survival of the Hu5/KD3 human myogenic progenitors. We found that meclozine, an anti-histamine drug that has long been used for motion sickness, promoted the proliferation and survival of Hu5/KD3 cells. Meclozine increased expression of MyoD, but reduced...

pubmed.ncbi.nlm.nih.gov

Meclozine Attenuates the MARK Pathway in Mammalian Chondrocytes and Ameliorates FGF2-Induced Bone Hyperossification in Larval Zebrafish - PubMed

Meclozine has been developed as an inhibitor of fibroblast growth factor receptor 3 (FGFR3) to treat achondroplasia (ACH). Extracellular signal regulated kinase (ERK) phosphorylation was attenuated by meclozine in FGF2-treated chondrocyte cell line, but the site of its action has not been...

pubmed.ncbi.nlm.nih.gov

Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X‑linked hypophosphatemia - PubMed

X-linked hypophosphatemic rickets (XLH) is characterized by hypo-mineralization of the bone due to hypophosphatemia. XLH is caused by abnormally high levels of fibroblast growth factor 23, which trigger renal phosphate wasting. Activated fibroblast growth factor receptor 3 (FGFR3) signaling is...

pubmed.ncbi.nlm.nih.gov

Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene - PubMed

Achondroplasia (ACH) is one of the most common skeletal dysplasias causing short stature owing to a gain-of-function mutation in the FGFR3 gene, which encodes the fibroblast growth factor receptor 3. We found that meclozine, an over-the-counter drug for motion sickness, inhibited elevated FGFR3...

pubmed.ncbi.nlm.nih.gov

Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia - PubMed

Achondroplasia (ACH) is one of the most common skeletal dysplasias with short stature caused by gain-of-function mutations in FGFR3 encoding the fibroblast growth factor receptor 3. We used the drug repositioning strategy to identify an FDA-approved drug that suppresses abnormally activated...

pubmed.ncbi.nlm.nih.gov

 

[Lipolaksid_Natri]

bro thinks he is a rat

this is not particularly important since I was studying exactly changes in signaling pathways involving growth